DK0608313T3 - Formuleringer af blodkoagel-polymer-matrix ved afgivelse af osteogene proteiner - Google Patents
Formuleringer af blodkoagel-polymer-matrix ved afgivelse af osteogene proteinerInfo
- Publication number
- DK0608313T3 DK0608313T3 DK92921634T DK92921634T DK0608313T3 DK 0608313 T3 DK0608313 T3 DK 0608313T3 DK 92921634 T DK92921634 T DK 92921634T DK 92921634 T DK92921634 T DK 92921634T DK 0608313 T3 DK0608313 T3 DK 0608313T3
- Authority
- DK
- Denmark
- Prior art keywords
- polymer matrix
- blood clot
- delivery
- matrix formulations
- osteogenic proteins
- Prior art date
Links
- 230000002188 osteogenic effect Effects 0.000 title abstract 3
- 208000007536 Thrombosis Diseases 0.000 title abstract 2
- 239000011159 matrix material Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title 1
- 230000010874 maintenance of protein location Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/776,514 US5171579A (en) | 1991-10-11 | 1991-10-11 | Formulations of blood clot-polymer matrix for delivery of osteogenic proteins |
PCT/US1992/008628 WO1993006872A1 (en) | 1991-10-11 | 1992-10-09 | Formulations of blood clot-polymer matrix for delivery of osteogenic proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0608313T3 true DK0608313T3 (da) | 2000-05-15 |
Family
ID=25107596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92921634T DK0608313T3 (da) | 1991-10-11 | 1992-10-09 | Formuleringer af blodkoagel-polymer-matrix ved afgivelse af osteogene proteiner |
Country Status (11)
Country | Link |
---|---|
US (1) | US5171579A (da) |
EP (1) | EP0608313B1 (da) |
JP (1) | JP3336010B2 (da) |
KR (1) | KR0181984B1 (da) |
AT (1) | ATE189611T1 (da) |
AU (1) | AU669133B2 (da) |
DE (1) | DE69230670T2 (da) |
DK (1) | DK0608313T3 (da) |
ES (1) | ES2145013T3 (da) |
GR (1) | GR3033204T3 (da) |
WO (1) | WO1993006872A1 (da) |
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US6054122A (en) * | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
US7189410B1 (en) * | 1990-11-27 | 2007-03-13 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
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US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
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US5962427A (en) * | 1994-02-18 | 1999-10-05 | The Regent Of The University Of Michigan | In vivo gene transfer methods for wound healing |
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US6074840A (en) * | 1994-02-18 | 2000-06-13 | The Regents Of The University Of Michigan | Recombinant production of latent TGF-beta binding protein-3 (LTBP-3) |
US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
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US20040132653A1 (en) * | 1997-01-30 | 2004-07-08 | Biopharm Gmbh | Lyophilized composition of bone morphogenetic factor human MP52 |
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US6762336B1 (en) | 1998-01-19 | 2004-07-13 | The American National Red Cross | Hemostatic sandwich bandage |
US20040081704A1 (en) | 1998-02-13 | 2004-04-29 | Centerpulse Biologics Inc. | Implantable putty material |
US6004937A (en) | 1998-03-09 | 1999-12-21 | Genetics Institute, Inc. | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
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US7189392B1 (en) | 1999-10-15 | 2007-03-13 | Genetics Institute, Llc | Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins |
DE10043151A1 (de) * | 2000-08-31 | 2002-03-28 | Peter Steinruecke | Knochenzement mit antimikrobieller Wirksamkeit |
US6648911B1 (en) | 2000-11-20 | 2003-11-18 | Avantec Vascular Corporation | Method and device for the treatment of vulnerable tissue site |
US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
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TWI267378B (en) * | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
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CA2488059C (en) * | 2002-06-06 | 2014-05-06 | Arnulf Pascher | Non-polymeric hematopoietic cell clots for delivery of active agents |
CA2498212C (en) * | 2002-09-10 | 2012-07-17 | American National Red Cross | Multi-layered hemostatic dressing comprising thrombin and fibrinogen |
DE10340277B4 (de) * | 2003-08-29 | 2006-11-23 | Bio-Gate Bioinnovative Materials Gmbh | Körperpflegemittel mit Silber-Agglomeraten |
DK1675608T3 (da) | 2003-09-12 | 2007-07-09 | Wyeth Corp | Injicerbare faste calciumphosphatstave til indgivelse af osteogene proteiner |
CA2541018A1 (en) * | 2003-10-02 | 2005-04-14 | The Regents Of The University Of Michigan | Human prostate cancer cell factor(s) that induce stem cell commitment and osteogenesis |
JP4694163B2 (ja) * | 2004-07-26 | 2011-06-08 | 株式会社ジーシー | 生体吸収性顆粒状多孔質骨補填材の製造方法 |
JP2008527033A (ja) * | 2005-01-19 | 2008-07-24 | ボンオス・メディカル・アー・ベー | 増殖因子組成物 |
JP2009539767A (ja) | 2006-06-02 | 2009-11-19 | ワイス | 精製および治療方法のためのTGF−βスーパーファミリータンパク質およびペプチドの使用 |
US7754689B2 (en) * | 2006-06-02 | 2010-07-13 | Wyeth Llc | Finger-1 peptide analogs of the TGF-β superfamily |
WO2008011192A2 (en) * | 2006-07-21 | 2008-01-24 | Genera Doo | Whole blood-derived coagulum device for treating bone defects |
PL2056756T3 (pl) * | 2006-08-04 | 2014-05-30 | Stb Ltd | Stały opatrunek do leczenia zranionej tkanki |
US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
US20090075891A1 (en) * | 2007-08-06 | 2009-03-19 | Macphee Martin | Methods and dressings for sealing internal injuries |
CA2817584C (en) | 2010-11-15 | 2018-01-02 | Zimmer Orthobiologics, Inc. | Bone void fillers |
US8398611B2 (en) | 2010-12-28 | 2013-03-19 | Depuy Mitek, Inc. | Compositions and methods for treating joints |
US8455436B2 (en) | 2010-12-28 | 2013-06-04 | Depuy Mitek, Llc | Compositions and methods for treating joints |
US9682099B2 (en) | 2015-01-20 | 2017-06-20 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
CN107753138A (zh) * | 2017-11-09 | 2018-03-06 | 中山大学附属口腔医院 | 一种评估微量元素成骨作用的方法及其动物模型的构建方法 |
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US4186448A (en) * | 1976-04-16 | 1980-02-05 | Brekke John H | Device and method for treating and healing a newly created bone void |
US4526909A (en) * | 1984-01-09 | 1985-07-02 | Regents Of The University Of California | Polymethylmethacrylate delivery system for bone morphogenetic protein |
US4563489A (en) * | 1984-02-10 | 1986-01-07 | University Of California | Biodegradable organic polymer delivery system for bone morphogenetic protein |
US4609551A (en) * | 1984-03-20 | 1986-09-02 | Arnold Caplan | Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites |
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US4620327A (en) * | 1984-07-05 | 1986-11-04 | Caplan Arnold I | Process of adapting soluble bone protein for use in stimulating osteoinduction |
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US4743259A (en) * | 1986-10-29 | 1988-05-10 | The University Of Virginia Alumni Patents Foundation | Use of demineralized bone matrix in the repair of segmental defects |
US4902296A (en) * | 1986-10-29 | 1990-02-20 | The University Of Virginia Alumni Patents Foundation | Use of demineralized bone matrix in the repair of segmental defects |
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US5206023A (en) * | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
WO1993000050A1 (en) * | 1991-06-21 | 1993-01-07 | Genetics Institute, Inc. | Pharmaceutical formulations of osteogenic proteins |
-
1991
- 1991-10-11 US US07/776,514 patent/US5171579A/en not_active Expired - Lifetime
-
1992
- 1992-10-09 WO PCT/US1992/008628 patent/WO1993006872A1/en active IP Right Grant
- 1992-10-09 JP JP50721193A patent/JP3336010B2/ja not_active Expired - Fee Related
- 1992-10-09 EP EP92921634A patent/EP0608313B1/en not_active Expired - Lifetime
- 1992-10-09 AT AT92921634T patent/ATE189611T1/de not_active IP Right Cessation
- 1992-10-09 KR KR1019940701180A patent/KR0181984B1/ko not_active IP Right Cessation
- 1992-10-09 ES ES92921634T patent/ES2145013T3/es not_active Expired - Lifetime
- 1992-10-09 AU AU27885/92A patent/AU669133B2/en not_active Ceased
- 1992-10-09 DK DK92921634T patent/DK0608313T3/da active
- 1992-10-09 DE DE69230670T patent/DE69230670T2/de not_active Expired - Fee Related
-
2000
- 2000-04-12 GR GR20000400898T patent/GR3033204T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69230670D1 (de) | 2000-03-16 |
ATE189611T1 (de) | 2000-02-15 |
AU669133B2 (en) | 1996-05-30 |
US5171579A (en) | 1992-12-15 |
EP0608313B1 (en) | 2000-02-09 |
KR0181984B1 (ko) | 1999-04-01 |
EP0608313A1 (en) | 1994-08-03 |
JPH07500038A (ja) | 1995-01-05 |
ES2145013T3 (es) | 2000-07-01 |
AU2788592A (en) | 1993-05-03 |
WO1993006872A1 (en) | 1993-04-15 |
JP3336010B2 (ja) | 2002-10-21 |
GR3033204T3 (en) | 2000-08-31 |
DE69230670T2 (de) | 2000-09-21 |
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