ATE277936T1 - Verfahren zur herstellung von adefovir dipivoxil - Google Patents

Verfahren zur herstellung von adefovir dipivoxil

Info

Publication number
ATE277936T1
ATE277936T1 AT02016428T AT02016428T ATE277936T1 AT E277936 T1 ATE277936 T1 AT E277936T1 AT 02016428 T AT02016428 T AT 02016428T AT 02016428 T AT02016428 T AT 02016428T AT E277936 T1 ATE277936 T1 AT E277936T1
Authority
AT
Austria
Prior art keywords
adefovir dipivoxil
producing
producing adefovir
dipivoxil
adefovir
Prior art date
Application number
AT02016428T
Other languages
German (de)
English (en)
Inventor
Murty N Arimilli
Thomas T K Lee
Lawrence V Manes
John D Munger Jr
Ernest J Prisbe
Lisa M Schultze
Daphne E Kelly
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26732226&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE277936(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Application granted granted Critical
Publication of ATE277936T1 publication Critical patent/ATE277936T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Transplanting Machines (AREA)
AT02016428T 1997-07-25 1998-07-23 Verfahren zur herstellung von adefovir dipivoxil ATE277936T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5377197P 1997-07-25 1997-07-25
US90074597A 1997-07-25 1997-07-25

Publications (1)

Publication Number Publication Date
ATE277936T1 true ATE277936T1 (de) 2004-10-15

Family

ID=26732226

Family Applications (3)

Application Number Title Priority Date Filing Date
AT02016429T ATE277937T1 (de) 1997-07-25 1998-07-23 Verfahren zur herstellung von 9-(2- (diethylphosphonomethoxy)ethyl)-adenin
AT02016428T ATE277936T1 (de) 1997-07-25 1998-07-23 Verfahren zur herstellung von adefovir dipivoxil
AT98937988T ATE228357T1 (de) 1997-07-25 1998-07-23 Nukleotid-analoge zusammensetzung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT02016429T ATE277937T1 (de) 1997-07-25 1998-07-23 Verfahren zur herstellung von 9-(2- (diethylphosphonomethoxy)ethyl)-adenin

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT98937988T ATE228357T1 (de) 1997-07-25 1998-07-23 Nukleotid-analoge zusammensetzung

Country Status (24)

Country Link
EP (1) EP0996430B1 (en, 2012)
JP (4) JP3573713B2 (en, 2012)
KR (3) KR100618663B1 (en, 2012)
CN (2) CN1274700C (en, 2012)
AR (1) AR016548A1 (en, 2012)
AT (3) ATE277937T1 (en, 2012)
AU (1) AU747163B2 (en, 2012)
BR (1) BR9811552A (en, 2012)
CA (3) CA2596497C (en, 2012)
CO (1) CO4980869A1 (en, 2012)
DE (3) DE69809749T2 (en, 2012)
DK (1) DK0996430T3 (en, 2012)
ES (3) ES2187991T3 (en, 2012)
HK (1) HK1046357B (en, 2012)
ID (1) ID28006A (en, 2012)
IL (1) IL133461A (en, 2012)
IN (1) IN190037B (en, 2012)
MY (1) MY129451A (en, 2012)
NZ (1) NZ501659A (en, 2012)
PT (3) PT996430E (en, 2012)
SI (2) SI1256584T1 (en, 2012)
TR (3) TR200200137T2 (en, 2012)
TW (1) TW584635B (en, 2012)
WO (1) WO1999004774A2 (en, 2012)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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PT996430E (pt) * 1997-07-25 2003-03-31 Gilead Sciences Inc Composicoes de analogos nucleotidicos
US6635278B1 (en) * 1998-12-15 2003-10-21 Gilead Sciences, Inc. Pharmaceutical formulations
TWI230618B (en) * 1998-12-15 2005-04-11 Gilead Sciences Inc Pharmaceutical compositions of 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine and tablets or capsules containing the same
CZ304886B6 (cs) 2000-07-21 2015-01-07 Gilead Sciences, Inc. Prekurzory léčiv na bázi fosfonátových analogů nukleotidů a způsoby jejich výběru a přípravy
EP1532157A4 (en) 2002-05-13 2009-02-25 Metabasis Therapeutics Inc NEW PRODRUGS FROM PMEA TO PHOSPHONIC ACID BASE AND ITS ANALOG
WO2003095665A2 (en) 2002-05-13 2003-11-20 Metabasis Therapeutics, Inc. Pmea and pmpa cyclic producing synthesis
US7417036B2 (en) 2002-11-12 2008-08-26 Tianjin Kinsly Pharmaceutical Co. Ltd. Crystal form of adefovir dipivoxil and its preparation
CN100383149C (zh) * 2002-11-12 2008-04-23 天津帝士力投资控股集团有限公司 一种新的晶状埃地双酯及其组合物
CN1303089C (zh) * 2002-11-19 2007-03-07 天津药物研究院 阿德福韦酯结晶形态及其制备方法
CN100415756C (zh) * 2003-10-14 2008-09-03 沈阳药科大学 草酸阿地福韦酯及其晶型和制备方法及用途
CN100358907C (zh) * 2004-03-31 2008-01-02 河北医科大学生物医学工程中心 一种非晶状阿德福韦酯的制备方法
CN100374118C (zh) * 2004-05-20 2008-03-12 江苏吴中中药研发有限公司 含有阿德福韦酯的滴丸剂及其制备方法
JP5142716B2 (ja) 2004-06-08 2013-02-13 リガンド・ファーマシューティカルズ・インコーポレイテッド サイクリックエステルのルイス酸介在合成法
CN102228463B (zh) * 2005-06-13 2012-12-19 博瑞生物医药技术(苏州)有限公司 泰诺福韦的晶体
CN100395248C (zh) * 2006-05-26 2008-06-18 华东理工大学 一种9-(二乙氧基磷酰基甲氧基乙基)-腺嘌啉的制备方法
ITMI20071594A1 (it) * 2007-08-02 2009-02-03 Solmag Spa Forma cristallina monoidrata di adefovir dipivoxil
CN101343290B (zh) * 2008-05-24 2011-02-02 广东肇庆星湖生物科技股份有限公司 一种阿德福韦酯无水结晶物的制备方法、所得的阿德福韦酯无水结晶物及其应用
WO2010005195A2 (ko) * 2008-07-07 2010-01-14 (주)아모레퍼시픽 아데포버 디피복실의 결정형 ｌ의 제조방법
KR20100031045A (ko) 2008-09-11 2010-03-19 씨제이제일제당 (주) 아데포비어 디피복실의 정제방법
KR100983322B1 (ko) * 2008-09-17 2010-09-20 씨제이제일제당 (주) 아데포비어 디피복실의 안정화된 고체 분산체 및 이의 제조 방법
KR20100032803A (ko) 2008-09-18 2010-03-26 씨제이제일제당 (주) 아데포비어디피복실의 개선된 제조방법
KR20100061401A (ko) * 2008-11-28 2010-06-07 (주)아모레퍼시픽 아데포버 디피복실의 결정형, 그 제조방법 및 그를 포함하는 약제학적 조성물
TR201109333T1 (tr) * 2009-03-26 2012-01-23 Daewoong Pharmaceutical Co. Ltd. Adefovir dipivoksilin yeni kristal formları ve bunların hazırlama işlemleri.
KR20100113302A (ko) * 2009-04-13 2010-10-21 한미홀딩스 주식회사 결정형 아데포비어 디피복실의 제조방법 및 이에 사용되는 아데포비어 디피복실 부탄올레이트
KR101528754B1 (ko) * 2009-04-14 2015-06-17 중앙대학교 산학협력단 신규한 복합결정형의 화합물, 그 제조방법 및 이를 포함하는 약제학적 조성물
KR100971486B1 (ko) * 2009-06-11 2010-07-21 주식회사 셀트리온화학연구소 아데포비어 다이피복실 말론산염 및 이를 포함하는 약제학적 조성물
KR101089620B1 (ko) * 2009-07-20 2011-12-06 경희대학교 산학협력단 무수결정형 아데포비어 디피복실 및 이온성 액체를 사용한 이의 제조 방법
WO2011016611A2 (ko) * 2009-08-03 2011-02-10 제일약품주식회사 새로운 결정형을 갖는 아데포비어 디피복실, 이의 제조방법 및 이를 유효성분으로 함유하는 만성 ｂ형 간염의 예방 또는 치료용 조성물
KR101129575B1 (ko) * 2009-09-02 2012-03-28 경희대학교 산학협력단 반수화물 아데포비어 디피복실 및 이온성 액체를 사용한 이의 제조 방법
KR101048024B1 (ko) * 2009-10-09 2011-07-13 주식회사 삼오제약 9-(2-포스포닐메톡시에틸)아데닌, 아데포비아 디피복실 및 무정형 아데포비아 디피복실의 제조방법
EP2343056A1 (en) 2009-12-30 2011-07-13 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Producing stable adefovir dipivoxil solid dispersions
WO2012032541A1 (en) * 2010-09-06 2012-03-15 Matrix Laboratories Ltd "adefovir dipivoxil pseudopolymorph"
WO2012062835A1 (en) 2010-11-12 2012-05-18 Glaxo Wellcome Manufacturing Pte Ltd Novel pharmaceutical compositions
CN102250146A (zh) * 2011-05-27 2011-11-23 扬州三友合成化工有限公司 抗乙肝药物阿德福韦的一种合成方法
KR101357687B1 (ko) * 2011-11-25 2014-02-05 숭실대학교산학협력단 고분자 첨가제를 이용한 아데포비어 디피복실 복합체의 결정입자 제어방법 및 이의 응용
KR101258678B1 (ko) 2012-02-29 2013-04-26 제일약품주식회사 새로운 결정형을 갖는 아데포비어 디피복실, 이의 제조방법 및 이를 유효성분으로 함유하는 만성 β형 간염의 예방 또는 치료용 조성물
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
CN102816184B (zh) * 2012-09-07 2015-11-18 山东大学 (2-(2-氧基-4-硫代嘧啶)乙氧基)甲基膦酸酯类衍生物及其制备与应用
CN103709198A (zh) * 2012-09-28 2014-04-09 江苏天士力帝益药业有限公司 一种阿德福韦酯的结晶方法
CN103333208B (zh) * 2013-06-04 2016-05-11 广州晶莱医药科技有限公司 阿德福韦酯马来酸盐及其制备方法和组合物
EP3105238A4 (en) 2014-02-13 2017-11-08 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
EP3164136A4 (en) 2014-07-02 2018-04-04 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
EP3372227A1 (en) 2017-03-06 2018-09-12 MH10 Spolka z ograniczona odpowiedzialnoscia Tablet formulation of adefovir dipivoxil
CA3087932A1 (en) 2018-01-09 2019-07-18 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2118069T3 (es) * 1990-09-14 1998-09-16 Acad Of Science Czech Republic Profarmacos de fosfonatos.
EP0632048B1 (en) * 1993-06-29 2001-03-21 Mitsubishi Chemical Corporation Phosphonate-nucleotide ester derivatives
JP4033494B2 (ja) * 1996-07-26 2008-01-16 ギリヤド サイエンシーズ， インコーポレイテッド ヌクレオチドアナログ
PT996430E (pt) * 1997-07-25 2003-03-31 Gilead Sciences Inc Composicoes de analogos nucleotidicos

Also Published As

Publication number Publication date
DK0996430T3 (da) 2003-03-10
ID28006A (id) 2001-05-03
ATE228357T1 (de) 2002-12-15
JP4452034B2 (ja) 2010-04-21
SI1256585T1 (en) 2005-02-28
CN1274700C (zh) 2006-09-13
PT1256585E (pt) 2005-01-31
CA2298057C (en) 2008-11-18
EP0996430B1 (en) 2002-11-27
AU747163B2 (en) 2002-05-09
TR200000224T2 (tr) 2000-07-21
NZ501659A (en) 2004-12-24
CA2596320A1 (en) 1999-02-04
DE69826734D1 (de) 2004-11-04
CA2596497C (en) 2008-12-23
ATE277937T1 (de) 2004-10-15
HK1051693A1 (en) 2003-08-15
TW584635B (en) 2004-04-21
MY129451A (en) 2007-04-30
DE69826735D1 (de) 2004-11-04
ES2229030T3 (es) 2005-04-16
CA2298057A1 (en) 1999-02-04
IL133461A0 (en) 2001-04-30
JP2005306879A (ja) 2005-11-04
DE69809749T2 (de) 2003-09-11
IN190037B (en, 2012) 2003-05-31
ES2187991T3 (es) 2003-06-16
IL133461A (en) 2005-05-17
JP2003342283A (ja) 2003-12-03
CN1216062C (zh) 2005-08-24
CN1347695A (zh) 2002-05-08
WO1999004774A3 (en) 1999-04-15
EP0996430A2 (en) 2000-05-03
DE69826735T2 (de) 2005-10-06
HK1046357B (zh) 2007-08-24
PT1256584E (pt) 2004-12-31
AR016548A1 (es) 2001-07-25
TR200200117T2 (tr) 2002-06-21
HK1091211A1 (en) 2007-01-12
KR20060038364A (ko) 2006-05-03
HK1051694A1 (en) 2003-08-15
CO4980869A1 (es) 2000-11-27
KR100700089B1 (ko) 2007-03-28
CA2596497A1 (en) 1999-02-04
KR100700087B1 (ko) 2007-03-28
HK1046357A1 (en) 2003-01-10
KR20010014284A (ko) 2001-02-26
KR100618663B1 (ko) 2006-09-08
PT996430E (pt) 2003-03-31
JP2001512712A (ja) 2001-08-28
ES2229029T3 (es) 2005-04-16
WO1999004774A2 (en) 1999-02-04
BR9811552A (pt) 2000-08-29
TR200200137T2 (tr) 2002-09-23
CA2596320C (en) 2008-12-23
HK1091212A1 (en) 2007-01-12
DE69826734T2 (de) 2005-10-06
JP2009263389A (ja) 2009-11-12
CN1251592A (zh) 2000-04-26
KR20060038363A (ko) 2006-05-03
SI1256584T1 (en) 2005-02-28
DE69809749D1 (de) 2003-01-09
JP3573713B2 (ja) 2004-10-06
AU8660998A (en) 1999-02-16

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