TR201109333T1 - Adefovir dipivoksilin yeni kristal formları ve bunların hazırlama işlemleri. - Google Patents
Adefovir dipivoksilin yeni kristal formları ve bunların hazırlama işlemleri.Info
- Publication number
- TR201109333T1 TR201109333T1 TR2011/09333T TR201109333T TR201109333T1 TR 201109333 T1 TR201109333 T1 TR 201109333T1 TR 2011/09333 T TR2011/09333 T TR 2011/09333T TR 201109333 T TR201109333 T TR 201109333T TR 201109333 T1 TR201109333 T1 TR 201109333T1
- Authority
- TR
- Turkey
- Prior art keywords
- crystal forms
- preparation processes
- new crystal
- adefovir dipivoxil
- present
- Prior art date
Links
- WOZSCQDILHKSGG-UHFFFAOYSA-N adefovir depivoxil Chemical compound N1=CN=C2N(CCOCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C=NC2=C1N WOZSCQDILHKSGG-UHFFFAOYSA-N 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229960003205 adefovir dipivoxil Drugs 0.000 title 1
- 239000013078 crystal Substances 0.000 title 1
- -1 9- [2- [phosphonomethoxy] ethyl] adenine bis-pivaloyloxymethyl ester Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Bu buluş, kristal 9-[2-[fosfonometoksi]etil]adenin bis-pivaloiloksimetil esterin, yani adefovir dipivoksil, yeni Formları A, B, C, D, E, F ve G ve bunların hazırlanmasına yönelik işlemler ile ilgilidir. Bu buluşa göre, yüksek saflığa sahip olan söz konusu yeni kristal formlar basit bir yöntem ile ve yüksek bir verimde elde edilebilmektedir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20090025879 | 2009-03-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201109333T1 true TR201109333T1 (tr) | 2012-01-23 |
Family
ID=42781689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2011/09333T TR201109333T1 (tr) | 2009-03-26 | 2010-03-26 | Adefovir dipivoksilin yeni kristal formları ve bunların hazırlama işlemleri. |
Country Status (8)
Country | Link |
---|---|
US (1) | US9169257B2 (tr) |
EP (1) | EP2411392B1 (tr) |
JP (1) | JP5642766B2 (tr) |
KR (1) | KR20100108297A (tr) |
CN (1) | CN102365283B (tr) |
RU (1) | RU2485121C1 (tr) |
TR (1) | TR201109333T1 (tr) |
WO (1) | WO2010110622A2 (tr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20071594A1 (it) * | 2007-08-02 | 2009-02-03 | Solmag Spa | Forma cristallina monoidrata di adefovir dipivoxil |
EP2411392B1 (en) | 2009-03-26 | 2014-02-26 | Daewoong Pharmaceutical Co., Ltd. | Novel crystal forms of adefovir dipivoxil and processes for preparing the same |
CN102716136A (zh) * | 2012-06-25 | 2012-10-10 | 上海益生源药业有限公司 | 高剂量三斜晶阿德福韦酯制剂、其制备方法及其应用 |
CN103665044B (zh) * | 2013-12-20 | 2015-07-15 | 悦康药业集团有限公司 | 一种阿德福韦酯化合物 |
CN107663217B (zh) * | 2016-07-28 | 2021-03-02 | 苏州朗科生物技术股份有限公司 | 替诺福韦艾拉酚胺结晶化合物及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS263952B1 (en) | 1985-04-25 | 1989-05-12 | Holy Antonin | Remedy with antiviral effect |
CS263951B1 (en) | 1985-04-25 | 1989-05-12 | Antonin Holy | 9-(phosponylmethoxyalkyl)adenines and method of their preparation |
DK0481214T3 (da) | 1990-09-14 | 1999-02-22 | Acad Of Science Czech Republic | Prolægemidler af phosphonater |
KR100700087B1 (ko) | 1997-07-25 | 2007-03-28 | 길리애드 사이언시즈, 인코포레이티드 | 뉴클레오티드 동족체의 제조 방법 |
ZA986614B (en) * | 1997-07-25 | 1999-01-27 | Gilead Sciences | Nucleotide analog composition |
AU2003284800A1 (en) | 2002-11-12 | 2004-06-03 | Tianjin Kinsly Pharmaceutical Co., Ltd. | A new crystal form of adefovir dipivoxil and its composition |
CN1791599A (zh) * | 2003-05-21 | 2006-06-21 | 贝林格尔.英格海姆国际有限公司 | 丙型肝炎抑制剂化合物 |
CN1580060A (zh) * | 2004-05-21 | 2005-02-16 | 四川倍达尔新技术开发有限公司 | 药用化合物阿德福韦酯的一种晶体结构及其制备方法和药物 |
EP2411392B1 (en) | 2009-03-26 | 2014-02-26 | Daewoong Pharmaceutical Co., Ltd. | Novel crystal forms of adefovir dipivoxil and processes for preparing the same |
-
2010
- 2010-03-26 EP EP10756377.7A patent/EP2411392B1/en not_active Not-in-force
- 2010-03-26 US US13/256,197 patent/US9169257B2/en not_active Expired - Fee Related
- 2010-03-26 JP JP2012501942A patent/JP5642766B2/ja not_active Expired - Fee Related
- 2010-03-26 CN CN201080013954.6A patent/CN102365283B/zh not_active Expired - Fee Related
- 2010-03-26 WO PCT/KR2010/001867 patent/WO2010110622A2/en active Application Filing
- 2010-03-26 TR TR2011/09333T patent/TR201109333T1/tr unknown
- 2010-03-26 KR KR1020100027523A patent/KR20100108297A/ko active Search and Examination
- 2010-03-26 RU RU2011143166/04A patent/RU2485121C1/ru not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN102365283B (zh) | 2014-04-09 |
JP2012521417A (ja) | 2012-09-13 |
JP5642766B2 (ja) | 2014-12-17 |
WO2010110622A2 (en) | 2010-09-30 |
WO2010110622A9 (en) | 2011-02-03 |
RU2485121C1 (ru) | 2013-06-20 |
CN102365283A (zh) | 2012-02-29 |
EP2411392A4 (en) | 2012-10-10 |
US20120101273A1 (en) | 2012-04-26 |
KR20100108297A (ko) | 2010-10-06 |
EP2411392A2 (en) | 2012-02-01 |
US9169257B2 (en) | 2015-10-27 |
EP2411392B1 (en) | 2014-02-26 |
RU2011143166A (ru) | 2013-05-10 |
WO2010110622A3 (en) | 2011-03-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR201109333T1 (tr) | Adefovir dipivoksilin yeni kristal formları ve bunların hazırlama işlemleri. | |
CR20140132A (es) | Derivados de pirrolopirimidina y purina | |
BR112013001267A2 (pt) | métodos para a preparação de pró-fármacos de fosforamidato diasteromericamente puro | |
CO6831982A2 (es) | Pirazolo[4,3-d]pirimidinas útiles como inhibidores de cinasas | |
DK2057126T3 (da) | Fremgangsmåde til fremstilling af 3-dihalomethyl-pyrazol-4-carboxylsyrederivater | |
NZ592125A (en) | Use of an oxalic acid dianilide derivative in the production of solar cell modules | |
MX2012011779A (es) | Pirimidinas modificadas en la posicion 5 y su uso. | |
IN2014DN09244A (tr) | ||
TR201902476T4 (tr) | Kaplamalı Substratların Üretim Süreci | |
BRPI0817747A8 (pt) | Processo para a preparação de derivados de ácido 2-di-halogenoacil-3-amino-acrílico | |
TR201905687T4 (tr) | Travoprost hazırlanışına yönelik proses. | |
DK2390914T3 (da) | Indretning af to forbindelsespartnere med en lavtemperatur-tryksinterforbindelse samt fremgangsmåde til dens fremstilling | |
MX358775B (es) | Prevencion o reduccion de incrustaciones en produccion de acido fosforico de proceso humedo. | |
MX2016006241A (es) | Formas morficas de esteres de hexadeciloxipropil-fosfonato. | |
EP3760637A3 (en) | Stable solid forms of regadenoson | |
DK2548949T3 (da) | Mikroorganisme med forbedret produktion af 5'-xanthosinmonophosphat og 5'-guaninmonophosphat samt fremgangsmåde til fremstilling af 5'-xanthosinmonophosphat og 5'-guaninmonophosphat under anvendelse af samme | |
MX342273B (es) | Proceso para la preparacion de esteres de acido (5-fluoro-2-metil-3-quinolina-2-ilmetil-indol-1-il)-acetico. | |
PH12014501353A1 (en) | Method for preparing cysteine or a derivative thereof using a novel o-phosphoserine sulfhydrylase | |
UA106886C2 (uk) | Спосіб одержання 1-бензил-3-гідроксиметил-1h-індазолу і його похідних та проміжні сполуки магнію | |
EA201370151A1 (ru) | Высокопродуктивная суспензионная клеточная линия, система и способ ее получения | |
MY164880A (en) | Process for the preparation of isoxazolyl-methoxy-nicotinic acids | |
RU2015118152A (ru) | Новое сложноэфирное соединение алициклической дикарбоновой кислоты и способ его изготовления | |
NZ708442A (en) | Process for manufacturing biofuels | |
MX2015001455A (es) | Procedimiento multietapa para la preparacion de sales de metales alcalinos de esteres 4-hidroxi-2-oxo-2,5-dihidrofuran-3-carboxilicos especificos. | |
MY166708A (en) | Method for performing a frit firing cycle in the manufacturing of a vacuum solar thermal panel |