TR201109333T1 - Adefovir dipivoksilin yeni kristal formları ve bunların hazırlama işlemleri. - Google Patents
Adefovir dipivoksilin yeni kristal formları ve bunların hazırlama işlemleri.Info
- Publication number
- TR201109333T1 TR201109333T1 TR2011/09333T TR201109333T TR201109333T1 TR 201109333 T1 TR201109333 T1 TR 201109333T1 TR 2011/09333 T TR2011/09333 T TR 2011/09333T TR 201109333 T TR201109333 T TR 201109333T TR 201109333 T1 TR201109333 T1 TR 201109333T1
- Authority
- TR
- Turkey
- Prior art keywords
- crystal forms
- preparation processes
- new crystal
- adefovir dipivoxil
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Abstract
Bu buluş, kristal 9-[2-[fosfonometoksi]etil]adenin bis-pivaloiloksimetil esterin, yani adefovir dipivoksil, yeni Formları A, B, C, D, E, F ve G ve bunların hazırlanmasına yönelik işlemler ile ilgilidir. Bu buluşa göre, yüksek saflığa sahip olan söz konusu yeni kristal formlar basit bir yöntem ile ve yüksek bir verimde elde edilebilmektedir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20090025879 | 2009-03-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201109333T1 true TR201109333T1 (tr) | 2012-01-23 |
Family
ID=42781689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2011/09333T TR201109333T1 (tr) | 2009-03-26 | 2010-03-26 | Adefovir dipivoksilin yeni kristal formları ve bunların hazırlama işlemleri. |
Country Status (8)
Country | Link |
---|---|
US (1) | US9169257B2 (tr) |
EP (1) | EP2411392B1 (tr) |
JP (1) | JP5642766B2 (tr) |
KR (1) | KR20100108297A (tr) |
CN (1) | CN102365283B (tr) |
RU (1) | RU2485121C1 (tr) |
TR (1) | TR201109333T1 (tr) |
WO (1) | WO2010110622A2 (tr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20071594A1 (it) * | 2007-08-02 | 2009-02-03 | Solmag Spa | Forma cristallina monoidrata di adefovir dipivoxil |
KR20100108297A (ko) | 2009-03-26 | 2010-10-06 | 주식회사 대웅제약 | 신규 결정형의 아데포비어 디피복실 및 그의 제조방법 |
CN102716136A (zh) * | 2012-06-25 | 2012-10-10 | 上海益生源药业有限公司 | 高剂量三斜晶阿德福韦酯制剂、其制备方法及其应用 |
CN103665044B (zh) * | 2013-12-20 | 2015-07-15 | 悦康药业集团有限公司 | 一种阿德福韦酯化合物 |
CN107663217B (zh) * | 2016-07-28 | 2021-03-02 | 苏州朗科生物技术股份有限公司 | 替诺福韦艾拉酚胺结晶化合物及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS263951B1 (en) | 1985-04-25 | 1989-05-12 | Antonin Holy | 9-(phosponylmethoxyalkyl)adenines and method of their preparation |
CS263952B1 (en) | 1985-04-25 | 1989-05-12 | Holy Antonin | Remedy with antiviral effect |
DE10399025I2 (de) | 1990-09-14 | 2007-11-08 | Acad Of Science Czech Republic | Wirkstoffvorläufer von Phosphonaten |
ATE277936T1 (de) * | 1997-07-25 | 2004-10-15 | Gilead Sciences Inc | Verfahren zur herstellung von adefovir dipivoxil |
ZA986614B (en) * | 1997-07-25 | 1999-01-27 | Gilead Sciences | Nucleotide analog composition |
KR101101962B1 (ko) | 2002-11-12 | 2012-01-02 | 티안진 디실리 인베스트먼트 홀딩 그룹, 리미티드 | 새로운 결정 형태를 가진 아데포비어 디피복실의 제조 방법 |
JP4447603B2 (ja) * | 2003-05-21 | 2010-04-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | C型肝炎インヒビター化合物 |
CN1580060A (zh) * | 2004-05-21 | 2005-02-16 | 四川倍达尔新技术开发有限公司 | 药用化合物阿德福韦酯的一种晶体结构及其制备方法和药物 |
KR20100108297A (ko) | 2009-03-26 | 2010-10-06 | 주식회사 대웅제약 | 신규 결정형의 아데포비어 디피복실 및 그의 제조방법 |
-
2010
- 2010-03-26 KR KR1020100027523A patent/KR20100108297A/ko active Search and Examination
- 2010-03-26 CN CN201080013954.6A patent/CN102365283B/zh not_active Expired - Fee Related
- 2010-03-26 JP JP2012501942A patent/JP5642766B2/ja not_active Expired - Fee Related
- 2010-03-26 RU RU2011143166/04A patent/RU2485121C1/ru not_active IP Right Cessation
- 2010-03-26 WO PCT/KR2010/001867 patent/WO2010110622A2/en active Application Filing
- 2010-03-26 TR TR2011/09333T patent/TR201109333T1/tr unknown
- 2010-03-26 EP EP10756377.7A patent/EP2411392B1/en not_active Not-in-force
- 2010-03-26 US US13/256,197 patent/US9169257B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2012521417A (ja) | 2012-09-13 |
US20120101273A1 (en) | 2012-04-26 |
JP5642766B2 (ja) | 2014-12-17 |
WO2010110622A9 (en) | 2011-02-03 |
EP2411392A2 (en) | 2012-02-01 |
CN102365283B (zh) | 2014-04-09 |
WO2010110622A2 (en) | 2010-09-30 |
EP2411392B1 (en) | 2014-02-26 |
RU2485121C1 (ru) | 2013-06-20 |
KR20100108297A (ko) | 2010-10-06 |
CN102365283A (zh) | 2012-02-29 |
RU2011143166A (ru) | 2013-05-10 |
EP2411392A4 (en) | 2012-10-10 |
WO2010110622A3 (en) | 2011-03-24 |
US9169257B2 (en) | 2015-10-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR201109333T1 (tr) | Adefovir dipivoksilin yeni kristal formları ve bunların hazırlama işlemleri. | |
EP3778606A3 (en) | Condensed imidazolylimidazoles as antiviral compounds | |
CO6831982A2 (es) | Pirazolo[4,3-d]pirimidinas útiles como inhibidores de cinasas | |
DK2057126T3 (da) | Fremgangsmåde til fremstilling af 3-dihalomethyl-pyrazol-4-carboxylsyrederivater | |
BR122021003805B8 (pt) | Pirimidinas modificadas na posição 5 | |
NZ592125A (en) | Use of an oxalic acid dianilide derivative in the production of solar cell modules | |
IN2014DN09244A (tr) | ||
CU24354B1 (es) | Procedimiento de obtención de derivados de tetrafluoropropilmorfolina | |
TR201905687T4 (tr) | Travoprost hazırlanışına yönelik proses. | |
DK2390914T3 (da) | Indretning af to forbindelsespartnere med en lavtemperatur-tryksinterforbindelse samt fremgangsmåde til dens fremstilling | |
WO2012144844A3 (en) | Substrate for sensing battery cell | |
SG195111A1 (en) | Process for preparing methacrylic acid | |
NZ601805A (en) | Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same | |
CL2011000296A1 (es) | Proceso de preparación del ester metílico del ácido 4-oxo-octahidro-indol-1-carboxílico y compuestos intermediarios utilizados. | |
TN2013000369A1 (en) | Preventing or reducing scale in wet-process phosphoric acid production | |
CY1121055T1 (el) | Μεθοδος για την παρασκευη φορτισμενων διασυνδετων | |
DK2548949T3 (da) | Mikroorganisme med forbedret produktion af 5'-xanthosinmonophosphat og 5'-guaninmonophosphat samt fremgangsmåde til fremstilling af 5'-xanthosinmonophosphat og 5'-guaninmonophosphat under anvendelse af samme | |
MX342273B (es) | Proceso para la preparacion de esteres de acido (5-fluoro-2-metil-3-quinolina-2-ilmetil-indol-1-il)-acetico. | |
PH12014501353B1 (en) | Method for preparing cysteine or a derivative thereof using a novel o-phosphoserine sulfhydrylase | |
IL227321A0 (en) | Pre-dilution of the aggregation factor gypsum filtration to produce phosphoric acid with post-filtration | |
MY164880A (en) | Process for the preparation of isoxazolyl-methoxy-nicotinic acids | |
RU2015118152A (ru) | Новое сложноэфирное соединение алициклической дикарбоновой кислоты и способ его изготовления | |
IN2014DN09234A (tr) | ||
MX356231B (es) | Procedimiento multietapa para la preparación de sales de metales alcalinos de ésteres 4-hidroxi-2-oxo-2,5-dihidrofuran-3-carboxílic os específicos. | |
MY166708A (en) | Method for performing a frit firing cycle in the manufacturing of a vacuum solar thermal panel |