ATE234116T1 - Agglomerate oder sphärische teilchen aus polyvalenten metall-alginaten, an die agglomerate gebundene zusammensetzungen für die kontrollierte freisetzung, die schwerlösliche medikamente enthalten, und verfahren für ihre herstellung - Google Patents

Agglomerate oder sphärische teilchen aus polyvalenten metall-alginaten, an die agglomerate gebundene zusammensetzungen für die kontrollierte freisetzung, die schwerlösliche medikamente enthalten, und verfahren für ihre herstellung

Info

Publication number
ATE234116T1
ATE234116T1 AT98950454T AT98950454T ATE234116T1 AT E234116 T1 ATE234116 T1 AT E234116T1 AT 98950454 T AT98950454 T AT 98950454T AT 98950454 T AT98950454 T AT 98950454T AT E234116 T1 ATE234116 T1 AT E234116T1
Authority
AT
Austria
Prior art keywords
agglomerates
production
methods
controlled release
spherical particles
Prior art date
Application number
AT98950454T
Other languages
English (en)
Inventor
Takeshi Hom-Ma
Nagayoshi Myo
Takaya Sato
Hironobu Nanbu
Original Assignee
Nisshin Spinning
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Spinning filed Critical Nisshin Spinning
Application granted granted Critical
Publication of ATE234116T1 publication Critical patent/ATE234116T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/04—Alginic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
AT98950454T 1997-10-31 1998-10-29 Agglomerate oder sphärische teilchen aus polyvalenten metall-alginaten, an die agglomerate gebundene zusammensetzungen für die kontrollierte freisetzung, die schwerlösliche medikamente enthalten, und verfahren für ihre herstellung ATE234116T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9314591A JPH11130698A (ja) 1997-10-31 1997-10-31 アルギン酸多価金属塩球状微粒子集合体、該球状微粒子集合体に難溶性薬剤を担持した放出制御製剤及びそれらの製造方法
PCT/JP1998/004910 WO1999022767A1 (fr) 1997-10-31 1998-10-29 Agglomerat de particules spheriques d'alginate de metaux polyvalents, preparation a liberation retardee comprenant un medicament difficilement soluble, supporte par cet agglomerat, et procede de production de l'agglomerat et de la preparation

Publications (1)

Publication Number Publication Date
ATE234116T1 true ATE234116T1 (de) 2003-03-15

Family

ID=18055148

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98950454T ATE234116T1 (de) 1997-10-31 1998-10-29 Agglomerate oder sphärische teilchen aus polyvalenten metall-alginaten, an die agglomerate gebundene zusammensetzungen für die kontrollierte freisetzung, die schwerlösliche medikamente enthalten, und verfahren für ihre herstellung

Country Status (7)

Country Link
US (1) US6274174B1 (de)
EP (1) EP0970705B1 (de)
JP (1) JPH11130698A (de)
AT (1) ATE234116T1 (de)
CA (1) CA2276436A1 (de)
DE (1) DE69812078T2 (de)
WO (1) WO1999022767A1 (de)

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US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
EP1423175B1 (de) * 2001-08-08 2013-10-02 Brown University Research Foundation Verfahren zur mikronisierung von hydrophoben arzneistoffen
US6974592B2 (en) * 2002-04-11 2005-12-13 Ocean Nutrition Canada Limited Encapsulated agglomeration of microcapsules and method for the preparation thereof
US20050067726A1 (en) * 2002-11-04 2005-03-31 Nianxi Yan Microcapsules having multiple shells and method for the preparation thereof
AU2003297561A1 (en) * 2002-11-26 2004-06-18 Garry R. Hollenbeck Aqueous sustained-release drug delivery system for highly water-soluble electrolytic drugs
CN1310954C (zh) * 2003-04-15 2007-04-18 哈尔滨工程大学 海藻酸铬的制备方法
US6969530B1 (en) 2005-01-21 2005-11-29 Ocean Nutrition Canada Ltd. Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof
US8034450B2 (en) * 2005-01-21 2011-10-11 Ocean Nutrition Canada Limited Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof
ATE452120T1 (de) * 2005-01-27 2010-01-15 Ocean Nutrition Canada Ltd Fettsäure-benzenediol-derivate sowie herstellungs-und verwendungsverfahren dafür
EP1848729A2 (de) * 2005-01-27 2007-10-31 Ocean Nutrition Canada Limited Chrom-fettsäureverbindungen und verfahren zu ihrer herstellung und verwendung
US9968120B2 (en) * 2006-05-17 2018-05-15 Dsm Nutritional Products Ag Homogenized formulations containing microcapsules and methods of making and using thereof
DE102005061965A1 (de) * 2005-12-23 2007-07-05 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Oxidische Agglomeratpartikel, Verfahren zur Herstellung von Nanokompositen sowie deren Verwendung
NZ572529A (en) * 2006-04-07 2010-11-26 Ocean Nutrition Canada Ltd Emulsions and microcapsules with substances having low interfacial tension, methods of making and using thereof
WO2007125915A1 (ja) * 2006-04-24 2007-11-08 Kaneka Corporation 補酵素ｑ含有固形物
CN107362154B (zh) * 2006-06-05 2020-10-30 帝斯曼营养品股份公司 具有改进壳层的微胶囊
WO2008014060A2 (en) * 2006-07-27 2008-01-31 Boston Scientific Limited Microparticle
ES2604081T3 (es) 2007-01-10 2017-03-02 Dsm Nutritional Products Ag Microcápsulas que incluyen proteína de guisante
CN101168572B (zh) * 2007-11-08 2010-06-02 青岛明月海藻集团有限公司 酸奶专用藻酸丙二醇酯的生产方法
JP4626829B2 (ja) * 2007-11-15 2011-02-09 Ｔｏｔｏ株式会社 多孔質複合構造物の作製方法及びその作製に用いる多孔質微粒子
ES2319158B1 (es) 2008-12-23 2010-01-26 Grifols, S.A Composicion de microparticulas biocompatibles de acido alginico para la liberacion controlada de principios activos por via intravenosa.
BRPI1014275B8 (pt) 2009-04-24 2021-05-25 Iceutica Pty Ltd composição que compreende partículas de indometacina dispersas em pelo menos dois materiais de moagem parcialmente moídos
JP2012035233A (ja) * 2010-08-11 2012-02-23 Seiko Epson Corp ゲル形成性溶液及びゲル製造方法
CN102823585B (zh) * 2012-08-28 2014-06-25 中国农业科学院农业环境与可持续发展研究所 一种水溶性农药缓控释制剂及其制备方法
CN102977224B (zh) * 2012-12-21 2014-08-13 青岛明月海藻集团有限公司 一种海藻酸钙的制备方法
WO2016012564A1 (en) * 2014-07-23 2016-01-28 Roche Diagnostics Gmbh Method and apparatus for generation of microparticles containing immobilized enzyme
CN104474779B (zh) * 2014-12-12 2016-05-11 青岛明月海藻集团有限公司 一种过滤用硅藻土的回收利用方法
WO2017097844A1 (en) * 2015-12-07 2017-06-15 Schlumberger Norge As Microsphere compositions and methods for production in oil-based drilling fluids

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DE68915494T2 (de) 1988-03-09 1995-01-05 Snow Brand Milk Prod Co Ltd Zubereitung mit verzögerter freigabe durch verwendung von alginaten.
JP2818220B2 (ja) * 1988-11-04 1998-10-30 フロイント産業株式会社 食品用の含水有機溶剤抽出物含有組成物および医薬用の含水有機溶剤抽出物含有組成物、並びにそれらの製造方法
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JP4162729B2 (ja) * 1996-06-13 2008-10-08 アクロス株式会社 ワイパーブレードゴム用塗料組成物

Also Published As

Publication number Publication date
DE69812078T2 (de) 2003-11-13
CA2276436A1 (en) 1999-05-14
EP0970705A4 (de) 2001-07-25
WO1999022767A1 (fr) 1999-05-14
DE69812078D1 (de) 2003-04-17
EP0970705B1 (de) 2003-03-12
EP0970705A1 (de) 2000-01-12
US6274174B1 (en) 2001-08-14
JPH11130698A (ja) 1999-05-18

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