ATE170849T1 - Einschlusskomplexe des 3-morpholino-sydnonimins oder seine salze oder seine isomeren tautomere, verfahren zur herstellung dieser komplexe und pharmazeutische zusammensetzungen die diese komplexe enthalten - Google Patents

Einschlusskomplexe des 3-morpholino-sydnonimins oder seine salze oder seine isomeren tautomere, verfahren zur herstellung dieser komplexe und pharmazeutische zusammensetzungen die diese komplexe enthalten

Info

Publication number
ATE170849T1
ATE170849T1 AT91907217T AT91907217T ATE170849T1 AT E170849 T1 ATE170849 T1 AT E170849T1 AT 91907217 T AT91907217 T AT 91907217T AT 91907217 T AT91907217 T AT 91907217T AT E170849 T1 ATE170849 T1 AT E170849T1
Authority
AT
Austria
Prior art keywords
complexes
morpholino
salts
pharmaceutical compositions
compositions containing
Prior art date
Application number
AT91907217T
Other languages
English (en)
Inventor
Maria Vikmon
Jozsef Szejtli
Lajos Szente
Jozsef Gaal
Istvan Hermecz
Agnes Horvath
Katalin Marmarosi
Gabor Horvath
Iren Munkacsi
Original Assignee
Therabel Research Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therabel Research Sa filed Critical Therabel Research Sa
Application granted granted Critical
Publication of ATE170849T1 publication Critical patent/ATE170849T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT91907217T 1990-03-28 1991-03-28 Einschlusskomplexe des 3-morpholino-sydnonimins oder seine salze oder seine isomeren tautomere, verfahren zur herstellung dieser komplexe und pharmazeutische zusammensetzungen die diese komplexe enthalten ATE170849T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU901869A HU212730B (en) 1990-03-28 1990-03-28 Process for producing inclusion complexes of cyclodextrine or its derivative and 3-morpholino-sydnonimine or its salt or its tautomer and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ATE170849T1 true ATE170849T1 (de) 1998-09-15

Family

ID=10956597

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91907217T ATE170849T1 (de) 1990-03-28 1991-03-28 Einschlusskomplexe des 3-morpholino-sydnonimins oder seine salze oder seine isomeren tautomere, verfahren zur herstellung dieser komplexe und pharmazeutische zusammensetzungen die diese komplexe enthalten

Country Status (33)

Country Link
US (1) US5298496A (de)
EP (1) EP0478732B1 (de)
JP (1) JP2549961B2 (de)
KR (1) KR950004706B1 (de)
CN (1) CN1051081C (de)
AT (1) ATE170849T1 (de)
AU (1) AU635835B2 (de)
BG (1) BG61812B1 (de)
BR (1) BR9105137A (de)
CA (1) CA2054213C (de)
CZ (1) CZ285695B6 (de)
DE (1) DE69130146T2 (de)
DK (1) DK0478732T3 (de)
ES (1) ES2121780T3 (de)
FI (1) FI104882B (de)
GE (1) GEP19991743B (de)
HK (1) HK1011688A1 (de)
HR (1) HRP920560B1 (de)
HU (2) HU211648A9 (de)
LT (1) LT3257B (de)
LV (1) LV10087B (de)
MC (1) MC2186A1 (de)
MD (1) MD776C2 (de)
MW (1) MW6891A1 (de)
NO (1) NO303634B1 (de)
OA (1) OA09522A (de)
PL (1) PL165866B1 (de)
RO (1) RO109336B1 (de)
RU (1) RU2107695C1 (de)
SI (1) SI9110909B (de)
TJ (1) TJ189R3 (de)
UA (1) UA27242C2 (de)
WO (1) WO1991014681A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU210921B (en) * 1990-03-28 1995-09-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine formed with cyclodextrines and pharmaceutical compositions containing them
DE4117249C2 (de) * 1991-05-27 1998-05-14 Christian Dr Stief Linsidomin zur Behandlung erektiler Dysfunktionen
HU213200B (en) 1993-05-12 1997-03-28 Chinoin Gyogyszer Es Vegyeszet The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production
HU218280B (en) * 1994-04-26 2000-07-28 Cyclodextrin inclusion complexes containing sin-1a which are stable intheir solid state, process for their preparation and pharmaceutical compositions containing the comlexes
GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
FR2805462B1 (fr) * 2000-02-24 2003-08-15 Therabel Res Nouvelle forme galenique orale a liberation prolongee de la molsidomine
EP1280559B1 (de) * 2000-05-11 2006-03-08 Eastman Chemical Company Acylierte zyklodextrin guest-inklusion komplexe

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1496056A (fr) * 1964-06-08 1967-09-29 Takeda Chemical Industries Ltd Nouveaux composés chimiques du type sydnonimine
DE3221425A1 (de) * 1982-06-07 1983-12-08 Boehringer Ingelheim KG, 6507 Ingelheim Hydrolyseempfindlichen wirkstoff enthaltende, lagerstabile tablette
DE3346638A1 (de) * 1983-12-23 1985-07-04 Cassella Ag, 6000 Frankfurt Photostabilisierung von molsidomin
GB8506792D0 (en) * 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
DE3522191A1 (de) * 1985-06-21 1987-01-15 Cassella Ag Photostabilisierung von sydnoniminen
GB8613688D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
JPH0819004B2 (ja) * 1986-12-26 1996-02-28 日清製粉株式会社 徐放性医薬製剤
IT1204725B (it) * 1987-06-17 1989-03-10 Edmond Pharma Srl Complessi di inclusione del dipiridamolo con ciclodestrine
SE8904296D0 (sv) * 1989-12-21 1989-12-21 Pharmacia Ab Transdermal system
AU7574391A (en) * 1990-04-06 1991-10-30 Gerhard Blatt Installation for conditioning concrete blocks

Also Published As

Publication number Publication date
MC2186A1 (fr) 1992-09-16
MD776C2 (ro) 1998-05-31
LV10087A (lv) 1994-05-10
ES2121780T3 (es) 1998-12-16
EP0478732A1 (de) 1992-04-08
AU7549391A (en) 1991-10-21
CN1051081C (zh) 2000-04-05
MW6891A1 (en) 1993-07-14
JPH04506221A (ja) 1992-10-29
DK0478732T3 (da) 1999-06-07
CA2054213A1 (en) 1991-09-29
JP2549961B2 (ja) 1996-10-30
DE69130146T2 (de) 1999-04-01
MD940334A (en) 1996-10-31
CZ285695B6 (cs) 1999-10-13
HU212730B (en) 1996-10-28
HUT58110A (en) 1992-01-28
NO303634B1 (no) 1998-08-10
CZ85291A3 (en) 1993-11-17
RO109336B1 (ro) 1995-01-30
OA09522A (en) 1992-11-15
NO914650D0 (no) 1991-11-27
CN1055928A (zh) 1991-11-06
AU635835B2 (en) 1993-04-01
DE69130146D1 (de) 1998-10-15
PL293020A1 (en) 1992-12-28
SI9110909A (sl) 1998-06-30
GEP19991743B (en) 1999-09-10
PL165866B1 (pl) 1995-02-28
FI915570A0 (fi) 1991-11-26
HU211648A9 (en) 1995-12-28
RU2107695C1 (ru) 1998-03-27
FI104882B (fi) 2000-04-28
HRP920560B1 (en) 1999-12-31
SI9110909B (sl) 1999-02-28
TJ189R3 (en) 1998-10-28
LT3257B (en) 1995-05-25
LTIP387A (en) 1994-09-25
KR920701183A (ko) 1992-08-11
HU901869D0 (en) 1990-07-28
MD776B2 (en) 1997-07-31
UA27242C2 (uk) 2000-08-15
KR950004706B1 (ko) 1995-05-04
CA2054213C (en) 1998-12-01
BG95530A (bg) 1993-12-24
WO1991014681A1 (en) 1991-10-03
BG61812B1 (bg) 1998-06-30
HRP920560A2 (hr) 1994-04-30
EP0478732B1 (de) 1998-09-09
US5298496A (en) 1994-03-29
NO914650L (no) 1991-11-27
LV10087B (en) 1995-02-20
BR9105137A (pt) 1992-08-04
HK1011688A1 (en) 1999-07-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time