MD776B2 - Inclusion complexes of 3-morpholinesydnonimine or its salts,or its tautomeric isomer with cyclodextrine or its derivatives, method for preparation thereof, pharmaceutical composition thereof, method for preparation thereof and for treatment of stenocardia or ishemic desease - Google Patents
Inclusion complexes of 3-morpholinesydnonimine or its salts,or its tautomeric isomer with cyclodextrine or its derivatives, method for preparation thereof, pharmaceutical composition thereof, method for preparation thereof and for treatment of stenocardia or ishemic deseaseInfo
- Publication number
- MD776B2 MD776B2 MD94-0334A MD940334A MD776B2 MD 776 B2 MD776 B2 MD 776B2 MD 940334 A MD940334 A MD 940334A MD 776 B2 MD776 B2 MD 776B2
- Authority
- MD
- Moldova
- Prior art keywords
- preparation
- morpholinesydnonimine
- derivatives
- cyclodextrine
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
The invention relates to the inclusion complexes of 3- morpholinesydnonimine or its salts, or its tautomeric isomer with cyclodextrine or its derivatives, method for preparation thereof, containing their pharmaceutical compositions, method for preparation thereof and for treatment of stenocardia or ishemic desease. Inclusion complexes of 3-morpholinesydnonimine or its salts with cyclodextrine or its derivatives are prepared: a) by 3-morpholinesydnonimine or its salts interaction in the aqueous medium with cyclodextrine or its derivatives and by the further isolation of complexes from the solution by dehydrotation, or b) there is carried out the intensive grounding 3- morpholinesydnonimine or its salts with cyclodextrine or its derivatives. The technical result of the invention consists in the stabilisation of 3-morpholinesydnonimine and its derivatives with cyclodextrines.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU901869A HU212730B (en) | 1990-03-28 | 1990-03-28 | Process for producing inclusion complexes of cyclodextrine or its derivative and 3-morpholino-sydnonimine or its salt or its tautomer and pharmaceutical compositions containing them |
PCT/HU1991/000013 WO1991014681A1 (en) | 1990-03-28 | 1991-03-28 | Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same |
Publications (3)
Publication Number | Publication Date |
---|---|
MD940334A MD940334A (en) | 1996-10-31 |
MD776B2 true MD776B2 (en) | 1997-07-31 |
MD776C2 MD776C2 (en) | 1998-05-31 |
Family
ID=10956597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD94-0334A MD776C2 (en) | 1990-03-28 | 1991-03-28 | Inclusion complexes of 3-morpholinesydnonimine or its salts, or its tautomeric isomer with cyclodextrine or its derivatives, method for preparation thereof, pharmaceutical composition thereof, method for preparation thereof and for treatment of stenocardia or ishemic desease |
Country Status (33)
Country | Link |
---|---|
US (1) | US5298496A (en) |
EP (1) | EP0478732B1 (en) |
JP (1) | JP2549961B2 (en) |
KR (1) | KR950004706B1 (en) |
CN (1) | CN1051081C (en) |
AT (1) | ATE170849T1 (en) |
AU (1) | AU635835B2 (en) |
BG (1) | BG61812B1 (en) |
BR (1) | BR9105137A (en) |
CA (1) | CA2054213C (en) |
CZ (1) | CZ285695B6 (en) |
DE (1) | DE69130146T2 (en) |
DK (1) | DK0478732T3 (en) |
ES (1) | ES2121780T3 (en) |
FI (1) | FI104882B (en) |
GE (1) | GEP19991743B (en) |
HK (1) | HK1011688A1 (en) |
HR (1) | HRP920560B1 (en) |
HU (2) | HU211648A9 (en) |
LT (1) | LT3257B (en) |
LV (1) | LV10087B (en) |
MC (1) | MC2186A1 (en) |
MD (1) | MD776C2 (en) |
MW (1) | MW6891A1 (en) |
NO (1) | NO303634B1 (en) |
OA (1) | OA09522A (en) |
PL (1) | PL165866B1 (en) |
RO (1) | RO109336B1 (en) |
RU (1) | RU2107695C1 (en) |
SI (1) | SI9110909B (en) |
TJ (1) | TJ189R3 (en) |
UA (1) | UA27242C2 (en) |
WO (1) | WO1991014681A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU210921B (en) * | 1990-03-28 | 1995-09-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine formed with cyclodextrines and pharmaceutical compositions containing them |
DE4117249C2 (en) * | 1991-05-27 | 1998-05-14 | Christian Dr Stief | Linsidomine used to treat erectile dysfunction |
HU213200B (en) | 1993-05-12 | 1997-03-28 | Chinoin Gyogyszer Es Vegyeszet | The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production |
HU218280B (en) | 1994-04-26 | 2000-07-28 | Cyclodextrin inclusion complexes containing sin-1a which are stable intheir solid state, process for their preparation and pharmaceutical compositions containing the comlexes | |
GB9915231D0 (en) | 1999-06-29 | 1999-09-01 | Pfizer Ltd | Pharmaceutical complex |
FR2805462B1 (en) * | 2000-02-24 | 2003-08-15 | Therabel Res | NEW ORAL GALENIC FORM WITH EXTENDED RELEASE OF MOLSIDOMINE |
EP1280559B1 (en) * | 2000-05-11 | 2006-03-08 | Eastman Chemical Company | Acylated cyclodextrin guest inclusion complexes |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1496056A (en) * | 1964-06-08 | 1967-09-29 | Takeda Chemical Industries Ltd | New chemical compounds of the sydnonimine type |
DE3221425A1 (en) * | 1982-06-07 | 1983-12-08 | Boehringer Ingelheim KG, 6507 Ingelheim | HYDROLYSIS-SENSITIVE ACTIVE SUBSTANCE CONTAINING STORAGE TABLET |
DE3346638A1 (en) * | 1983-12-23 | 1985-07-04 | Cassella Ag, 6000 Frankfurt | PHOTOSTABILIZATION OF MOLSIDOMIN |
GB8506792D0 (en) * | 1985-03-15 | 1985-04-17 | Janssen Pharmaceutica Nv | Derivatives of y-cyclodextrin |
DE3522191A1 (en) * | 1985-06-21 | 1987-01-15 | Cassella Ag | PHOTOSTABILIZATION OF SYDNONIMINES |
GB8613688D0 (en) * | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
JPH0819004B2 (en) * | 1986-12-26 | 1996-02-28 | 日清製粉株式会社 | Sustained-release pharmaceutical preparation |
IT1204725B (en) * | 1987-06-17 | 1989-03-10 | Edmond Pharma Srl | DIPYRIDAMOL INCLUSION COMPLEXES WITH CYCLODESTRINE |
SE8904296D0 (en) * | 1989-12-21 | 1989-12-21 | Pharmacia Ab | TRANSDERMAL SYSTEM |
WO1991015346A1 (en) * | 1990-04-06 | 1991-10-17 | Gerhard Blatt | Installation for conditioning concrete blocks |
-
1990
- 1990-03-28 HU HU90P/P00224P patent/HU211648A9/en unknown
- 1990-03-28 HU HU901869A patent/HU212730B/en unknown
-
1991
- 1991-03-28 US US07/793,389 patent/US5298496A/en not_active Expired - Lifetime
- 1991-03-28 RU SU5010582A patent/RU2107695C1/en active
- 1991-03-28 ES ES91907217T patent/ES2121780T3/en not_active Expired - Lifetime
- 1991-03-28 EP EP91907217A patent/EP0478732B1/en not_active Expired - Lifetime
- 1991-03-28 PL PL91293020A patent/PL165866B1/en unknown
- 1991-03-28 MC MC@@@@D patent/MC2186A1/en unknown
- 1991-03-28 UA UA93060611A patent/UA27242C2/en unknown
- 1991-03-28 BR BR919105137A patent/BR9105137A/en not_active Application Discontinuation
- 1991-03-28 MD MD94-0334A patent/MD776C2/en active IP Right Grant
- 1991-03-28 SI SI9110909A patent/SI9110909B/en unknown
- 1991-03-28 CZ CS91852A patent/CZ285695B6/en not_active IP Right Cessation
- 1991-03-28 RO RO148828A patent/RO109336B1/en unknown
- 1991-03-28 DK DK91907217T patent/DK0478732T3/en active
- 1991-03-28 JP JP3506356A patent/JP2549961B2/en not_active Expired - Lifetime
- 1991-03-28 WO PCT/HU1991/000013 patent/WO1991014681A1/en active IP Right Grant
- 1991-03-28 AU AU75493/91A patent/AU635835B2/en not_active Expired
- 1991-03-28 CA CA002054213A patent/CA2054213C/en not_active Expired - Lifetime
- 1991-03-28 AT AT91907217T patent/ATE170849T1/en not_active IP Right Cessation
- 1991-03-28 DE DE69130146T patent/DE69130146T2/en not_active Expired - Lifetime
- 1991-03-28 CN CN91102699A patent/CN1051081C/en not_active Expired - Fee Related
- 1991-03-28 KR KR1019910701671A patent/KR950004706B1/en not_active IP Right Cessation
- 1991-11-08 OA OA60095A patent/OA09522A/en unknown
- 1991-11-13 MW MW6891A patent/MW6891A1/en unknown
- 1991-11-26 FI FI915570A patent/FI104882B/en active
- 1991-11-27 BG BG95530A patent/BG61812B1/en unknown
- 1991-11-27 NO NO914650A patent/NO303634B1/en not_active IP Right Cessation
-
1992
- 1992-09-28 HR HRP-909/91A patent/HRP920560B1/en not_active IP Right Cessation
- 1992-12-30 LV LVP-92-588A patent/LV10087B/en unknown
-
1993
- 1993-03-05 LT LTIP387A patent/LT3257B/en not_active IP Right Cessation
- 1993-06-16 GE GEAP1993880A patent/GEP19991743B/en unknown
-
1994
- 1994-11-28 TJ TJ94000008A patent/TJ189R3/en unknown
-
1998
- 1998-12-07 HK HK98112917A patent/HK1011688A1/en not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20110328 |