MD679F1 - Inclusion complex of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin or its derivatives, preparation thereof and pharmaceutical compositions containing them, method of preparation thereof and treatment method - Google Patents
Inclusion complex of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin or its derivatives, preparation thereof and pharmaceutical compositions containing them, method of preparation thereof and treatment methodInfo
- Publication number
- MD679F1 MD679F1 MD94-0333A MD940333A MD679F1 MD 679 F1 MD679 F1 MD 679F1 MD 940333 A MD940333 A MD 940333A MD 679 F1 MD679 F1 MD 679F1
- Authority
- MD
- Moldova
- Prior art keywords
- preparation
- morpholinsydnonimine
- ethoxycarbonyl
- salts
- cyclodextrin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
Abstract
The invention relates to the inclusion complex of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin or its derivatives, preparation thereof and pharmaceutical compositions containing them, method of preparation thereof and treatment method. Inclusion complex of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin or its derivatives are prepared by: a) interaction of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin derivative into the solvent and extraction of the complex from the solution by dehydration or b) fast milling of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin derivative.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU901868A HU210921B (en) | 1990-03-28 | 1990-03-28 | Process for preparing inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine formed with cyclodextrines and pharmaceutical compositions containing them |
PCT/HU1991/000012 WO1991014680A1 (en) | 1990-03-28 | 1991-03-28 | Inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine or salts formed with cyclodextrin derivatives, preparation thereof and pharmaceutical compositions containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
MD679F1 true MD679F1 (en) | 1997-02-28 |
MD679G2 MD679G2 (en) | 1997-11-30 |
Family
ID=10956592
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD94-0333A MD679G2 (en) | 1990-03-28 | 1994-08-25 | Inclusion complex of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin or its derivatives, preparation thereof and pharmaceutical compositions containing them, method for preparation thereof and treatment method |
Country Status (34)
Country | Link |
---|---|
US (1) | US5403840A (en) |
EP (1) | EP0477315B1 (en) |
JP (1) | JP2582497B2 (en) |
KR (1) | KR950004705B1 (en) |
CN (1) | CN1051080C (en) |
AT (1) | ATE138656T1 (en) |
AU (1) | AU638824B2 (en) |
BG (1) | BG61689B1 (en) |
BR (1) | BR9105136A (en) |
CA (1) | CA2054188C (en) |
CZ (1) | CZ287353B6 (en) |
DE (1) | DE69119853T2 (en) |
DK (1) | DK0477315T3 (en) |
ES (1) | ES2090320T3 (en) |
FI (1) | FI102460B (en) |
GE (1) | GEP19991832B (en) |
GR (1) | GR3020684T3 (en) |
HR (1) | HRP920561B1 (en) |
HU (1) | HU210921B (en) |
IL (1) | IL97714A (en) |
LT (1) | LT3394B (en) |
LV (1) | LV10245B (en) |
MC (1) | MC2185A1 (en) |
MD (1) | MD679G2 (en) |
NO (1) | NO179611C (en) |
OA (1) | OA10029A (en) |
PL (1) | PL165868B1 (en) |
RO (1) | RO109649B1 (en) |
RU (1) | RU2111216C1 (en) |
SI (1) | SI9110908A (en) |
SK (1) | SK279891B6 (en) |
TJ (1) | TJ231R3 (en) |
UA (1) | UA27226C2 (en) |
WO (1) | WO1991014680A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA949182B (en) * | 1993-12-02 | 1995-07-26 | South African Druggists Ltd | Pharmaceutical composition |
GB2290964A (en) * | 1994-07-08 | 1996-01-17 | Arto Olavi Urtti | Transdermal drug delivery system |
GB9915231D0 (en) | 1999-06-29 | 1999-09-01 | Pfizer Ltd | Pharmaceutical complex |
FR2805462B1 (en) * | 2000-02-24 | 2003-08-15 | Therabel Res | NEW ORAL GALENIC FORM WITH EXTENDED RELEASE OF MOLSIDOMINE |
ITTO20120056A1 (en) * | 2012-01-24 | 2013-07-25 | Borla Ind | CONNECTOR FOR MEDICAL LINES OF INFUSION, TRANSFUSION AND THE LIKE |
ITTO20130433A1 (en) * | 2013-05-29 | 2014-11-30 | Borla Ind | CONNECTOR FOR MEDICAL LINES |
BE1028879B1 (en) | 2020-12-11 | 2022-07-12 | Europharmaceuticals | Molsidomine Sustained-Release Tablet |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1695897C3 (en) * | 1966-07-04 | 1979-02-15 | Takeda Chemical Industries Ltd | N-acyl-sydnonimines, their salts, processes for their preparation and medicaments containing these compounds |
DE3221425A1 (en) * | 1982-06-07 | 1983-12-08 | Boehringer Ingelheim KG, 6507 Ingelheim | HYDROLYSIS-SENSITIVE ACTIVE SUBSTANCE CONTAINING STORAGE TABLET |
DK243084A (en) | 1983-05-26 | 1984-11-27 | Takeda Chemical Industries Ltd | PERCUTANEOUS PHARMACEUTICAL PREPARATIONS FOR EXTERNAL USE |
GB8506792D0 (en) * | 1985-03-15 | 1985-04-17 | Janssen Pharmaceutica Nv | Derivatives of y-cyclodextrin |
DE3522191A1 (en) * | 1985-06-21 | 1987-01-15 | Cassella Ag | PHOTOSTABILIZATION OF SYDNONIMINES |
GB8613688D0 (en) * | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
JPH0819004B2 (en) * | 1986-12-26 | 1996-02-28 | 日清製粉株式会社 | Sustained-release pharmaceutical preparation |
IT1204725B (en) * | 1987-06-17 | 1989-03-10 | Edmond Pharma Srl | DIPYRIDAMOL INCLUSION COMPLEXES WITH CYCLODESTRINE |
EP0326196B1 (en) * | 1988-01-14 | 1992-03-25 | Akzo N.V. | Aqueous pharmaceutical preparation |
US5120732A (en) * | 1988-06-14 | 1992-06-09 | Cassella Aktiengesellschaft | Substituted 3-aminosyndone imines, a process for their preparation and their use |
IT1227626B (en) * | 1988-11-28 | 1991-04-23 | Vectorpharma Int | SUPPORTED DRUGS WITH INCREASED DISSOLUTION SPEED AND PROCEDURE FOR THEIR PREPARATION |
SE8904296D0 (en) * | 1989-12-21 | 1989-12-21 | Pharmacia Ab | TRANSDERMAL SYSTEM |
HU211648A9 (en) * | 1990-03-28 | 1995-12-28 | Chinoin Gyogyszer Es Vegyeszet | Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same |
-
1990
- 1990-03-28 HU HU901868A patent/HU210921B/en unknown
-
1991
- 1991-03-28 PL PL91293022A patent/PL165868B1/en unknown
- 1991-03-28 SI SI9110908A patent/SI9110908A/en unknown
- 1991-03-28 JP JP3507012A patent/JP2582497B2/en not_active Expired - Lifetime
- 1991-03-28 US US07/807,852 patent/US5403840A/en not_active Expired - Lifetime
- 1991-03-28 KR KR1019910701670A patent/KR950004705B1/en not_active IP Right Cessation
- 1991-03-28 SK SK851-91A patent/SK279891B6/en unknown
- 1991-03-28 RU SU5010581A patent/RU2111216C1/en active
- 1991-03-28 DE DE69119853T patent/DE69119853T2/en not_active Expired - Lifetime
- 1991-03-28 AT AT91906726T patent/ATE138656T1/en not_active IP Right Cessation
- 1991-03-28 IL IL9771491A patent/IL97714A/en not_active IP Right Cessation
- 1991-03-28 EP EP91906726A patent/EP0477315B1/en not_active Expired - Lifetime
- 1991-03-28 UA UA5010581A patent/UA27226C2/en unknown
- 1991-03-28 RO RO148827A patent/RO109649B1/en unknown
- 1991-03-28 BR BR919105136A patent/BR9105136A/en not_active Application Discontinuation
- 1991-03-28 MC MC@@@@D patent/MC2185A1/en unknown
- 1991-03-28 ES ES91906726T patent/ES2090320T3/en not_active Expired - Lifetime
- 1991-03-28 CN CN91102687A patent/CN1051080C/en not_active Expired - Fee Related
- 1991-03-28 AU AU75745/91A patent/AU638824B2/en not_active Expired
- 1991-03-28 WO PCT/HU1991/000012 patent/WO1991014680A1/en active IP Right Grant
- 1991-03-28 DK DK91906726.4T patent/DK0477315T3/en active
- 1991-03-28 CA CA002054188A patent/CA2054188C/en not_active Expired - Lifetime
- 1991-03-28 CZ CS1991851A patent/CZ287353B6/en not_active IP Right Cessation
- 1991-11-08 OA OA60094A patent/OA10029A/en unknown
- 1991-11-26 FI FI915569A patent/FI102460B/en active
- 1991-11-27 BG BG95531A patent/BG61689B1/en unknown
- 1991-11-27 NO NO914649A patent/NO179611C/en not_active IP Right Cessation
-
1992
- 1992-09-28 HR HRP-908/91A patent/HRP920561B1/en not_active IP Right Cessation
- 1992-12-30 LV LVP-92-590A patent/LV10245B/en unknown
-
1993
- 1993-03-05 LT LTIP386A patent/LT3394B/en not_active IP Right Cessation
- 1993-06-16 GE GEAP1993884A patent/GEP19991832B/en unknown
-
1994
- 1994-08-25 MD MD94-0333A patent/MD679G2/en not_active IP Right Cessation
- 1994-11-28 TJ TJ94000007A patent/TJ231R3/en unknown
-
1996
- 1996-07-31 GR GR960402042T patent/GR3020684T3/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC3A | Transfer or assignment (patent for invention) |
Free format text: 19970812 TERABEL INDUSTRIES S.A., FR |
|
IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20110328 |
|
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |