MD679G2 - Inclusion complex of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin or its derivatives, preparation thereof and pharmaceutical compositions containing them, method for preparation thereof and treatment method - Google Patents

Inclusion complex of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin or its derivatives, preparation thereof and pharmaceutical compositions containing them, method for preparation thereof and treatment method

Info

Publication number
MD679G2
MD679G2 MD94-0333A MD940333A MD679G2 MD 679 G2 MD679 G2 MD 679G2 MD 940333 A MD940333 A MD 940333A MD 679 G2 MD679 G2 MD 679G2
Authority
MD
Moldova
Prior art keywords
preparation
morpholinsydnonimine
ethoxycarbonyl
salts
cyclodextrin
Prior art date
Application number
MD94-0333A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD679F1 (en
Inventor
Andrasne Vikmon
Jozsef Szejtli
Jozsef Gaal
Istvan Hermecz
Agnes Horvath
Katalin Marmarosi
Gabor Horvath
Iren Munkacsi
Original Assignee
Chinoin Gyogyszer -Es Vegyeszeti Termekek Gyara Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer -Es Vegyeszeti Termekek Gyara Rt. filed Critical Chinoin Gyogyszer -Es Vegyeszeti Termekek Gyara Rt.
Publication of MD679F1 publication Critical patent/MD679F1/en
Publication of MD679G2 publication Critical patent/MD679G2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Materials Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to the inclusion complex of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin or its derivatives, preparation thereof and pharmaceutical compositions containing them, method of preparation thereof and treatment method.Inclusion complex of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin or its derivatives are prepared by:a) interaction of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin derivative into the solvent and extraction of the complex from the solution by dehydration orb) fast milling of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin derivative.
MD94-0333A 1990-03-28 1994-08-25 Inclusion complex of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin or its derivatives, preparation thereof and pharmaceutical compositions containing them, method for preparation thereof and treatment method MD679G2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU901868A HU210921B (en) 1990-03-28 1990-03-28 Process for preparing inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine formed with cyclodextrines and pharmaceutical compositions containing them
PCT/HU1991/000012 WO1991014680A1 (en) 1990-03-28 1991-03-28 Inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine or salts formed with cyclodextrin derivatives, preparation thereof and pharmaceutical compositions containing the same

Publications (2)

Publication Number Publication Date
MD679F1 MD679F1 (en) 1997-02-28
MD679G2 true MD679G2 (en) 1997-11-30

Family

ID=10956592

Family Applications (1)

Application Number Title Priority Date Filing Date
MD94-0333A MD679G2 (en) 1990-03-28 1994-08-25 Inclusion complex of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin or its derivatives, preparation thereof and pharmaceutical compositions containing them, method for preparation thereof and treatment method

Country Status (34)

Country Link
US (1) US5403840A (en)
EP (1) EP0477315B1 (en)
JP (1) JP2582497B2 (en)
KR (1) KR950004705B1 (en)
CN (1) CN1051080C (en)
AT (1) ATE138656T1 (en)
AU (1) AU638824B2 (en)
BG (1) BG61689B1 (en)
BR (1) BR9105136A (en)
CA (1) CA2054188C (en)
CZ (1) CZ287353B6 (en)
DE (1) DE69119853T2 (en)
DK (1) DK0477315T3 (en)
ES (1) ES2090320T3 (en)
FI (1) FI102460B1 (en)
GE (1) GEP19991832B (en)
GR (1) GR3020684T3 (en)
HR (1) HRP920561B1 (en)
HU (1) HU210921B (en)
IL (1) IL97714A (en)
LT (1) LT3394B (en)
LV (1) LV10245B (en)
MC (1) MC2185A1 (en)
MD (1) MD679G2 (en)
NO (1) NO179611C (en)
OA (1) OA10029A (en)
PL (1) PL165868B1 (en)
RO (1) RO109649B1 (en)
RU (1) RU2111216C1 (en)
SI (1) SI9110908A (en)
SK (1) SK279891B6 (en)
TJ (1) TJ231R3 (en)
UA (1) UA27226C2 (en)
WO (1) WO1991014680A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3119C2 (en) * 2000-02-24 2007-04-30 Therabel Pharmaceuticals Limited Drug form for oral use with prolonged release of molsidomine

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA949182B (en) * 1993-12-02 1995-07-26 South African Druggists Ltd Pharmaceutical composition
GB2290964A (en) * 1994-07-08 1996-01-17 Arto Olavi Urtti Transdermal drug delivery system
GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
ITTO20120056A1 (en) * 2012-01-24 2013-07-25 Borla Ind CONNECTOR FOR MEDICAL LINES OF INFUSION, TRANSFUSION AND THE LIKE
ITTO20130433A1 (en) * 2013-05-29 2014-11-30 Borla Ind CONNECTOR FOR MEDICAL LINES
BE1028879B1 (en) 2020-12-11 2022-07-12 Europharmaceuticals Molsidomine Sustained-Release Tablet

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127468A2 (en) * 1983-05-26 1984-12-05 CASSELLA Aktiengesellschaft Percutaneous pharmaceutical preparations for external use
HUT52366A (en) * 1988-11-28 1990-07-28 Vectorpharma Int Process for producing pharmaceutical compositions with gradually soluble carrier

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1695897C3 (en) * 1966-07-04 1979-02-15 Takeda Chemical Industries Ltd N-acyl-sydnonimines, their salts, processes for their preparation and medicaments containing these compounds
DE3221425A1 (en) * 1982-06-07 1983-12-08 Boehringer Ingelheim KG, 6507 Ingelheim HYDROLYSIS-SENSITIVE ACTIVE SUBSTANCE CONTAINING STORAGE TABLET
GB8506792D0 (en) * 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
DE3522191A1 (en) * 1985-06-21 1987-01-15 Cassella Ag PHOTOSTABILIZATION OF SYDNONIMINES
GB8613688D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
JPH0819004B2 (en) * 1986-12-26 1996-02-28 日清製粉株式会社 Sustained-release pharmaceutical preparation
IT1204725B (en) * 1987-06-17 1989-03-10 Edmond Pharma Srl DIPYRIDAMOL INCLUSION COMPLEXES WITH CYCLODESTRINE
EP0326196B1 (en) * 1988-01-14 1992-03-25 Akzo N.V. Aqueous pharmaceutical preparation
US5120732A (en) * 1988-06-14 1992-06-09 Cassella Aktiengesellschaft Substituted 3-aminosyndone imines, a process for their preparation and their use
SE8904296D0 (en) * 1989-12-21 1989-12-21 Pharmacia Ab TRANSDERMAL SYSTEM
HU211648A9 (en) * 1990-03-28 1995-12-28 Chinoin Gyogyszer Es Vegyeszet Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127468A2 (en) * 1983-05-26 1984-12-05 CASSELLA Aktiengesellschaft Percutaneous pharmaceutical preparations for external use
HUT52366A (en) * 1988-11-28 1990-07-28 Vectorpharma Int Process for producing pharmaceutical compositions with gradually soluble carrier

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3119C2 (en) * 2000-02-24 2007-04-30 Therabel Pharmaceuticals Limited Drug form for oral use with prolonged release of molsidomine

Also Published As

Publication number Publication date
RU2111216C1 (en) 1998-05-20
RO109649B1 (en) 1995-04-28
DE69119853D1 (en) 1996-07-04
NO914649L (en) 1991-11-27
IL97714A (en) 1995-03-30
WO1991014680A1 (en) 1991-10-03
HRP920561A2 (en) 1994-04-30
CN1056688A (en) 1991-12-04
SK279891B6 (en) 1999-05-07
AU7574591A (en) 1991-10-21
PL293022A1 (en) 1992-12-28
US5403840A (en) 1995-04-04
EP0477315A1 (en) 1992-04-01
EP0477315B1 (en) 1996-05-29
CA2054188A1 (en) 1991-09-29
ATE138656T1 (en) 1996-06-15
IL97714A0 (en) 1992-06-21
HU210921B (en) 1995-09-28
DE69119853T2 (en) 1996-10-10
DK0477315T3 (en) 1996-09-30
FI102460B (en) 1998-12-15
TJ231R3 (en) 1999-11-24
CA2054188C (en) 1996-07-23
UA27226C2 (en) 2000-08-15
AU638824B2 (en) 1993-07-08
HU901868D0 (en) 1990-08-28
BR9105136A (en) 1992-08-04
KR920701182A (en) 1992-08-11
OA10029A (en) 1996-10-14
GEP19991832B (en) 1999-11-05
JPH04506362A (en) 1992-11-05
MC2185A1 (en) 1992-09-16
SI9110908A (en) 1998-06-30
BG61689B1 (en) 1998-03-31
ES2090320T3 (en) 1996-10-16
NO179611B (en) 1996-08-05
BG95531A (en) 1993-12-24
PL165868B1 (en) 1995-02-28
LV10245A (en) 1994-10-20
HRP920561B1 (en) 1999-12-31
LV10245B (en) 1995-08-20
CZ287353B6 (en) 2000-11-15
LT3394B (en) 1995-09-25
GR3020684T3 (en) 1996-10-31
KR950004705B1 (en) 1995-05-04
FI102460B1 (en) 1998-12-15
FI915569A0 (en) 1991-11-26
NO914649D0 (en) 1991-11-27
NO179611C (en) 1996-11-13
LTIP386A (en) 1994-12-27
HUT58109A (en) 1992-01-28
MD679F1 (en) 1997-02-28
CN1051080C (en) 2000-04-05
CS85191A3 (en) 1991-11-12
JP2582497B2 (en) 1997-02-19

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Legal Events

Date Code Title Description
PC3A Transfer or assignment (patent for invention)

Free format text: 19970812 TERABEL INDUSTRIES S.A., FR

IF99 Valid patent on 19990615

Free format text: EXPIRES: 20110328

KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees