LTIP386A - Inclusion complexes of n-ethoxycarbonyl-3-morpholinosydnonimine or salts formed with cyclodextrine-derivatives, preparation thereof and pharmaceutical compositions containing the same a - Google Patents

Inclusion complexes of n-ethoxycarbonyl-3-morpholinosydnonimine or salts formed with cyclodextrine-derivatives, preparation thereof and pharmaceutical compositions containing the same a

Info

Publication number
LTIP386A
LTIP386A LTIP386A LTIP386A LTIP386A LT IP386 A LTIP386 A LT IP386A LT IP386 A LTIP386 A LT IP386A LT IP386 A LTIP386 A LT IP386A LT IP386 A LTIP386 A LT IP386A
Authority
LT
Lithuania
Prior art keywords
cyclodextrin
ethoxycarbonyl
beta
morpholinosydnonimine
cyclodextrine
Prior art date
Application number
LTIP386A
Inventor
Maria Vikmon
Jozsef Szejtli
Jozsef Gaal
Istvan Hermecz
Agnes Horvath
Katalin Marmarosi
Gabor Horvath
Iren Munkacsi
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of LTIP386A publication Critical patent/LTIP386A/en
Publication of LT3394B publication Critical patent/LT3394B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Clathrates (I) of N-ethoxycarbonyl-3- morpholino-sydnonimine (II) or its salts with cyclodextrin derivs. (III) are new. N.B., cpds. (III) include unsubstd. beta- and gamma-cyclodextrins. (II) is an anti-angina and anti-ischaemic agent (molsidomin) useful for prevention and treatment of angina pectoris. It also has antiarrhythmic, fibrinolytic, platelet aggregation inhibitory and hypotensive activity. Pref. (III) are selected from beta-cyclodextrin (BCD), gamma-cyclodextrin, heptakis-2,6,O-dimethyl -beta-cyclodextrin and hydroxypropyl- beta-cyclodextrin.
LTIP386A 1990-03-28 1993-03-05 Inclusion complexes of n-ethoxycarbonyl-3-morpholinosydnonimine or salts formed with cyclodextrine-derivatives, preparation thereof and pharmaceutical compositions containing the same a LT3394B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU901868A HU210921B (en) 1990-03-28 1990-03-28 Process for preparing inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine formed with cyclodextrines and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
LTIP386A true LTIP386A (en) 1994-12-27
LT3394B LT3394B (en) 1995-09-25

Family

ID=10956592

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP386A LT3394B (en) 1990-03-28 1993-03-05 Inclusion complexes of n-ethoxycarbonyl-3-morpholinosydnonimine or salts formed with cyclodextrine-derivatives, preparation thereof and pharmaceutical compositions containing the same a

Country Status (34)

Country Link
US (1) US5403840A (en)
EP (1) EP0477315B1 (en)
JP (1) JP2582497B2 (en)
KR (1) KR950004705B1 (en)
CN (1) CN1051080C (en)
AT (1) ATE138656T1 (en)
AU (1) AU638824B2 (en)
BG (1) BG61689B1 (en)
BR (1) BR9105136A (en)
CA (1) CA2054188C (en)
CZ (1) CZ287353B6 (en)
DE (1) DE69119853T2 (en)
DK (1) DK0477315T3 (en)
ES (1) ES2090320T3 (en)
FI (1) FI102460B1 (en)
GE (1) GEP19991832B (en)
GR (1) GR3020684T3 (en)
HR (1) HRP920561B1 (en)
HU (1) HU210921B (en)
IL (1) IL97714A (en)
LT (1) LT3394B (en)
LV (1) LV10245B (en)
MC (1) MC2185A1 (en)
MD (1) MD679G2 (en)
NO (1) NO179611C (en)
OA (1) OA10029A (en)
PL (1) PL165868B1 (en)
RO (1) RO109649B1 (en)
RU (1) RU2111216C1 (en)
SI (1) SI9110908A (en)
SK (1) SK279891B6 (en)
TJ (1) TJ231R3 (en)
UA (1) UA27226C2 (en)
WO (1) WO1991014680A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA949182B (en) * 1993-12-02 1995-07-26 South African Druggists Ltd Pharmaceutical composition
GB2290964A (en) * 1994-07-08 1996-01-17 Arto Olavi Urtti Transdermal drug delivery system
US6046177A (en) * 1997-05-05 2000-04-04 Cydex, Inc. Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations
GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
FR2805462B1 (en) * 2000-02-24 2003-08-15 Therabel Res NEW ORAL GALENIC FORM WITH EXTENDED RELEASE OF MOLSIDOMINE
ITTO20120056A1 (en) * 2012-01-24 2013-07-25 Borla Ind CONNECTOR FOR MEDICAL LINES OF INFUSION, TRANSFUSION AND THE LIKE
ITTO20130433A1 (en) * 2013-05-29 2014-11-30 Borla Ind CONNECTOR FOR MEDICAL LINES
BE1028879B1 (en) 2020-12-11 2022-07-12 Europharmaceuticals Molsidomine Sustained-Release Tablet

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1695897C3 (en) * 1966-07-04 1979-02-15 Takeda Chemical Industries Ltd N-acyl-sydnonimines, their salts, processes for their preparation and medicaments containing these compounds
DE3221425A1 (en) * 1982-06-07 1983-12-08 Boehringer Ingelheim KG, 6507 Ingelheim HYDROLYSIS-SENSITIVE ACTIVE SUBSTANCE CONTAINING STORAGE TABLET
DK243084A (en) * 1983-05-26 1984-11-27 Takeda Chemical Industries Ltd PERCUTANEOUS PHARMACEUTICAL PREPARATIONS FOR EXTERNAL USE
DE3346614A1 (en) * 1983-12-23 1985-07-04 Anton Hummel Gmbh Metallwarenfabrik, 7808 Waldkirch VENTILATION VALVE, IN PARTICULAR FOR VENTILATING HEATING SYSTEMS
GB8506792D0 (en) * 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
DE3522191A1 (en) * 1985-06-21 1987-01-15 Cassella Ag PHOTOSTABILIZATION OF SYDNONIMINES
GB8613688D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
JPH0819004B2 (en) * 1986-12-26 1996-02-28 日清製粉株式会社 Sustained-release pharmaceutical preparation
IT1204725B (en) * 1987-06-17 1989-03-10 Edmond Pharma Srl DIPYRIDAMOL INCLUSION COMPLEXES WITH CYCLODESTRINE
EP0326196B1 (en) * 1988-01-14 1992-03-25 Akzo N.V. Aqueous pharmaceutical preparation
US5120732A (en) * 1988-06-14 1992-06-09 Cassella Aktiengesellschaft Substituted 3-aminosyndone imines, a process for their preparation and their use
IT1227626B (en) * 1988-11-28 1991-04-23 Vectorpharma Int SUPPORTED DRUGS WITH INCREASED DISSOLUTION SPEED AND PROCEDURE FOR THEIR PREPARATION
SE8904296D0 (en) * 1989-12-21 1989-12-21 Pharmacia Ab TRANSDERMAL SYSTEM
HU211648A9 (en) * 1990-03-28 1995-12-28 Chinoin Gyogyszer Es Vegyeszet Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
HU901868D0 (en) 1990-08-28
TJ231R3 (en) 1999-11-24
RO109649B1 (en) 1995-04-28
BG95531A (en) 1993-12-24
DE69119853D1 (en) 1996-07-04
HRP920561B1 (en) 1999-12-31
HUT58109A (en) 1992-01-28
LV10245B (en) 1995-08-20
JP2582497B2 (en) 1997-02-19
CA2054188C (en) 1996-07-23
OA10029A (en) 1996-10-14
MC2185A1 (en) 1992-09-16
FI915569A0 (en) 1991-11-26
US5403840A (en) 1995-04-04
ATE138656T1 (en) 1996-06-15
FI102460B (en) 1998-12-15
IL97714A0 (en) 1992-06-21
SK279891B6 (en) 1999-05-07
KR920701182A (en) 1992-08-11
LT3394B (en) 1995-09-25
CN1056688A (en) 1991-12-04
BG61689B1 (en) 1998-03-31
DK0477315T3 (en) 1996-09-30
EP0477315A1 (en) 1992-04-01
NO179611B (en) 1996-08-05
CA2054188A1 (en) 1991-09-29
PL165868B1 (en) 1995-02-28
UA27226C2 (en) 2000-08-15
RU2111216C1 (en) 1998-05-20
CZ287353B6 (en) 2000-11-15
NO179611C (en) 1996-11-13
HRP920561A2 (en) 1994-04-30
LV10245A (en) 1994-10-20
SI9110908A (en) 1998-06-30
HU210921B (en) 1995-09-28
MD679F1 (en) 1997-02-28
EP0477315B1 (en) 1996-05-29
WO1991014680A1 (en) 1991-10-03
GEP19991832B (en) 1999-11-05
FI102460B1 (en) 1998-12-15
JPH04506362A (en) 1992-11-05
PL293022A1 (en) 1992-12-28
ES2090320T3 (en) 1996-10-16
CN1051080C (en) 2000-04-05
MD679G2 (en) 1997-11-30
IL97714A (en) 1995-03-30
AU7574591A (en) 1991-10-21
AU638824B2 (en) 1993-07-08
DE69119853T2 (en) 1996-10-10
GR3020684T3 (en) 1996-10-31
KR950004705B1 (en) 1995-05-04
BR9105136A (en) 1992-08-04
NO914649L (en) 1991-11-27
NO914649D0 (en) 1991-11-27
CS85191A3 (en) 1991-11-12

Similar Documents

Publication Publication Date Title
RU94028890A (en) COMPOSITIONS OF DERIVATIVES OF CYCLODEXTRIN, COMPOSITIONS, CONTAINING MEDICINES AND DERIVATIVES OF CYCLODEXTRINS
LTIP386A (en) Inclusion complexes of n-ethoxycarbonyl-3-morpholinosydnonimine or salts formed with cyclodextrine-derivatives, preparation thereof and pharmaceutical compositions containing the same a
CA2074186A1 (en) Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
HUT62198A (en) Erythropoietin compositions comprising cyclodextrin
CA2119154A1 (en) Derivatives of Cyclodextrins Exhibiting Enhanced Aqueous Solubility and the Use Thereof
EP0300526A3 (en) Antiviral pharmaceutical compositions containing cyclodextrins
EP1690552A3 (en) Radiopharmaceutical kits stabilised by means of cyclodextrins
AU3854095A (en) Novel complexes and their compositions
EP0931545A3 (en) Droloxifene pharmaceutical compositions
EP0274444A3 (en) Solution inbuprofen complexes, compositions and processes for preparing the same
BR0212027A (en) Container having improved barrier organoleptic properties
ATE71633T1 (en) INCLUSION COMPLEXES OF DIPYRIDAMOLE AND CYCLODEXTRINS.
DE59909196D1 (en) COMBINATION OF NORPREGNAN DERIVATIVES AND CYCLODEXTRIN
AU5535900A (en) Complexes of paroxetine, with cyclodextrins or cyclodextrin derivatives
ES2094080B1 (en) PROCEDURE FOR THE PREPARATION OF COMPLEXES FOR INCLUSION OF TENOXICAM WITH CYCLODEXTRINS.
刘勇 et al. Water-soluble crosslinked β-cyclodextrin polymer inclusion complexes with C60

Legal Events

Date Code Title Description
PC9A Transfer of patents

Free format text: THERABEL INDUSTRIES S.A.,ZE LES PALYES-JEAN MONNET, AVENUE DE BRUXELLES 274, F-83500 LA SEYNE-SUR-MER,FR,970828

MM9A Lapsed patents

Effective date: 20030305