HRP920560B1 - Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same - Google Patents

Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same

Info

Publication number
HRP920560B1
HRP920560B1 HRP-909/91A HRP920560A HRP920560B1 HR P920560 B1 HRP920560 B1 HR P920560B1 HR P920560 A HRP920560 A HR P920560A HR P920560 B1 HRP920560 B1 HR P920560B1
Authority
HR
Croatia
Prior art keywords
sydnonimine
morpholino
salts
preparation
pharmaceutical compositions
Prior art date
Application number
HRP-909/91A
Other languages
English (en)
Inventor
Iren Munkacsi-Nee-Geczy
Original Assignee
Iren Munkacsi Nee Geczy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU904013A external-priority patent/HUT59399A/hu
Priority claimed from YU90991A external-priority patent/YU48694B/sh
Application filed by Iren Munkacsi Nee Geczy filed Critical Iren Munkacsi Nee Geczy
Publication of HRP920560A2 publication Critical patent/HRP920560A2/hr
Publication of HRP920560B1 publication Critical patent/HRP920560B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HRP-909/91A 1990-03-28 1992-09-28 Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same HRP920560B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU901869A HU212730B (en) 1990-03-28 1990-03-28 Process for producing inclusion complexes of cyclodextrine or its derivative and 3-morpholino-sydnonimine or its salt or its tautomer and pharmaceutical compositions containing them
HU904013A HUT59399A (en) 1989-11-30 1990-06-27 Process for producing substituted 3-aminosydnone imine derivatives and pharmaceutical compositions comprising same
YU90991A YU48694B (sh) 1990-03-28 1991-03-28 Inkluzioni kompleks 3-morfolino-sidnonimina, njegove soli ili tautomernog izomera i postupak za dobijanje istih

Publications (2)

Publication Number Publication Date
HRP920560A2 HRP920560A2 (hr) 1994-04-30
HRP920560B1 true HRP920560B1 (en) 1999-12-31

Family

ID=10956597

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP-909/91A HRP920560B1 (en) 1990-03-28 1992-09-28 Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same

Country Status (33)

Country Link
US (1) US5298496A (xx)
EP (1) EP0478732B1 (xx)
JP (1) JP2549961B2 (xx)
KR (1) KR950004706B1 (xx)
CN (1) CN1051081C (xx)
AT (1) ATE170849T1 (xx)
AU (1) AU635835B2 (xx)
BG (1) BG61812B1 (xx)
BR (1) BR9105137A (xx)
CA (1) CA2054213C (xx)
CZ (1) CZ285695B6 (xx)
DE (1) DE69130146T2 (xx)
DK (1) DK0478732T3 (xx)
ES (1) ES2121780T3 (xx)
FI (1) FI104882B (xx)
GE (1) GEP19991743B (xx)
HK (1) HK1011688A1 (xx)
HR (1) HRP920560B1 (xx)
HU (2) HU211648A9 (xx)
LT (1) LT3257B (xx)
LV (1) LV10087B (xx)
MC (1) MC2186A1 (xx)
MD (1) MD776C2 (xx)
MW (1) MW6891A1 (xx)
NO (1) NO303634B1 (xx)
OA (1) OA09522A (xx)
PL (1) PL165866B1 (xx)
RO (1) RO109336B1 (xx)
RU (1) RU2107695C1 (xx)
SI (1) SI9110909B (xx)
TJ (1) TJ189R3 (xx)
UA (1) UA27242C2 (xx)
WO (1) WO1991014681A1 (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU210921B (en) * 1990-03-28 1995-09-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine formed with cyclodextrines and pharmaceutical compositions containing them
DE4117249C2 (de) * 1991-05-27 1998-05-14 Christian Dr Stief Linsidomin zur Behandlung erektiler Dysfunktionen
HU213200B (en) 1993-05-12 1997-03-28 Chinoin Gyogyszer Es Vegyeszet The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production
HU218280B (en) * 1994-04-26 2000-07-28 Cyclodextrin inclusion complexes containing sin-1a which are stable intheir solid state, process for their preparation and pharmaceutical compositions containing the comlexes
GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
FR2805462B1 (fr) * 2000-02-24 2003-08-15 Therabel Res Nouvelle forme galenique orale a liberation prolongee de la molsidomine
WO2001085218A2 (en) * 2000-05-11 2001-11-15 Eastman Chemical Company Acylated cyclodextrin guest inclusion complexes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1496056A (fr) * 1964-06-08 1967-09-29 Takeda Chemical Industries Ltd Nouveaux composés chimiques du type sydnonimine
DE3221425A1 (de) * 1982-06-07 1983-12-08 Boehringer Ingelheim KG, 6507 Ingelheim Hydrolyseempfindlichen wirkstoff enthaltende, lagerstabile tablette
DE3346638A1 (de) * 1983-12-23 1985-07-04 Cassella Ag, 6000 Frankfurt Photostabilisierung von molsidomin
GB8506792D0 (en) * 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
DE3522191A1 (de) * 1985-06-21 1987-01-15 Cassella Ag Photostabilisierung von sydnoniminen
GB8613688D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
JPH0819004B2 (ja) * 1986-12-26 1996-02-28 日清製粉株式会社 徐放性医薬製剤
IT1204725B (it) * 1987-06-17 1989-03-10 Edmond Pharma Srl Complessi di inclusione del dipiridamolo con ciclodestrine
SE8904296D0 (sv) * 1989-12-21 1989-12-21 Pharmacia Ab Transdermal system
WO1991015346A1 (de) * 1990-04-06 1991-10-17 Gerhard Blatt Anlage zur behandlung von betonsteinen

Also Published As

Publication number Publication date
PL165866B1 (pl) 1995-02-28
UA27242C2 (uk) 2000-08-15
FI915570A0 (fi) 1991-11-26
DE69130146T2 (de) 1999-04-01
FI104882B (fi) 2000-04-28
ATE170849T1 (de) 1998-09-15
MW6891A1 (en) 1993-07-14
RU2107695C1 (ru) 1998-03-27
OA09522A (en) 1992-11-15
HU211648A9 (en) 1995-12-28
MD776C2 (ro) 1998-05-31
LT3257B (en) 1995-05-25
ES2121780T3 (es) 1998-12-16
JP2549961B2 (ja) 1996-10-30
JPH04506221A (ja) 1992-10-29
LV10087A (lv) 1994-05-10
HUT58110A (en) 1992-01-28
AU635835B2 (en) 1993-04-01
MD940334A (en) 1996-10-31
HK1011688A1 (en) 1999-07-16
CN1055928A (zh) 1991-11-06
AU7549391A (en) 1991-10-21
EP0478732A1 (en) 1992-04-08
HRP920560A2 (hr) 1994-04-30
DE69130146D1 (de) 1998-10-15
WO1991014681A1 (en) 1991-10-03
CZ285695B6 (cs) 1999-10-13
TJ189R3 (en) 1998-10-28
EP0478732B1 (en) 1998-09-09
SI9110909B (sl) 1999-02-28
HU212730B (en) 1996-10-28
LTIP387A (en) 1994-09-25
CZ85291A3 (en) 1993-11-17
KR950004706B1 (ko) 1995-05-04
PL293020A1 (en) 1992-12-28
HU901869D0 (en) 1990-07-28
DK0478732T3 (da) 1999-06-07
LV10087B (en) 1995-02-20
MC2186A1 (fr) 1992-09-16
RO109336B1 (ro) 1995-01-30
GEP19991743B (en) 1999-09-10
SI9110909A (sl) 1998-06-30
MD776B2 (en) 1997-07-31
BG61812B1 (bg) 1998-06-30
BR9105137A (pt) 1992-08-04
CA2054213C (en) 1998-12-01
KR920701183A (ko) 1992-08-11
US5298496A (en) 1994-03-29
NO914650D0 (no) 1991-11-27
NO914650L (no) 1991-11-27
BG95530A (bg) 1993-12-24
NO303634B1 (no) 1998-08-10
CA2054213A1 (en) 1991-09-29
CN1051081C (zh) 2000-04-05

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
PPPP Transfer of rights

Owner name: THERABEL INDUSTRIES S.A., FR

B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20000328

Year of fee payment: 10

PBON Lapse due to non-payment of renewal fee

Effective date: 20010329