ATE145204T1 - Benzo(b)thiophen-5-ylderivat und verfahren zu seiner herstellung - Google Patents

Benzo(b)thiophen-5-ylderivat und verfahren zu seiner herstellung

Info

Publication number
ATE145204T1
ATE145204T1 AT93105441T AT93105441T ATE145204T1 AT E145204 T1 ATE145204 T1 AT E145204T1 AT 93105441 T AT93105441 T AT 93105441T AT 93105441 T AT93105441 T AT 93105441T AT E145204 T1 ATE145204 T1 AT E145204T1
Authority
AT
Austria
Prior art keywords
benzo
protecting
thiophen
formula
optically active
Prior art date
Application number
AT93105441T
Other languages
English (en)
Inventor
Joji Nakano
Nobuhisa Taya
Hisaaki Chaki
Tetsuo Yamafuji
Kaishu Momonoi
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Application granted granted Critical
Publication of ATE145204T1 publication Critical patent/ATE145204T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Furan Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Seasonings (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
AT93105441T 1992-04-13 1993-04-01 Benzo(b)thiophen-5-ylderivat und verfahren zu seiner herstellung ATE145204T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11974092 1992-04-13
JP5090934A JP2873898B2 (ja) 1992-04-13 1993-03-25 ベンゾ［ｂ］チオフェン−５−イル誘導体もしくはその光学活性体またはそれらの塩並びにそれらの製造法

Publications (1)

Publication Number Publication Date
ATE145204T1 true ATE145204T1 (de) 1996-11-15

Family

ID=26432339

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93105441T ATE145204T1 (de) 1992-04-13 1993-04-01 Benzo(b)thiophen-5-ylderivat und verfahren zu seiner herstellung

Country Status (19)

Country Link
US (1) US5380878A (de)
EP (1) EP0565965B1 (de)
JP (1) JP2873898B2 (de)
KR (1) KR960005955B1 (de)
AT (1) ATE145204T1 (de)
AU (1) AU643634B1 (de)
BE (1) BE1006403A3 (de)
CA (1) CA2093048C (de)
CZ (2) CZ290421B6 (de)
DE (1) DE69305904T2 (de)
DK (1) DK0565965T3 (de)
ES (1) ES2060545B1 (de)
FR (1) FR2689890B1 (de)
HU (1) HU213631B (de)
IT (1) IT1261440B (de)
NZ (1) NZ247301A (de)
PL (1) PL172191B1 (de)
RO (1) RO115445B1 (de)
TW (1) TW232690B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5606076A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
AU2576797A (en) * 1996-04-22 1997-11-12 Toyama Chemical Co. Ltd. Patch containing 1,2-ethanediol derivatives or salts thereof
JP4245668B2 (ja) * 1997-03-31 2009-03-25 富山化学工業株式会社 ２−（ベンゾ〔ｂ〕チオフェン−５−イル）−２−ヒドロキシ酢酸誘導体もしくはその光学活性体またはそれらの塩の製造法
PL196773B1 (pl) * 1999-06-11 2008-01-31 Toyama Chemical Co Ltd Pochodna N-alkiloksyalkilo-N,N-dialkiloaminy lub jej sole oraz środek zawierający ten związek stosowany do leczenia chorób neurodegeneratywnych
KR100710564B1 (ko) * 2003-07-30 2007-04-24 에스케이 주식회사 연속 모사 이동층 흡착분리공정을 이용한 광학활성티오펜계 화합물의 분리방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981001408A1 (en) * 1979-11-15 1981-05-28 Sorex Ltd Substituted acetic acid esters as pesticides
EP0179383B1 (de) * 1984-10-25 1991-05-29 Hoechst-Roussel Pharmaceuticals Incorporated 9-Amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte Verbindungen, Verfahren zu ihrer Herstellung und Verwendung als Arzneimittel
DK167393B1 (da) * 1985-12-30 1993-10-25 Roussel Uclaf 1-sulfonyl-2-oxo-pyrrolidinderivater, deres fremstilling og farmaceutiske praeparater med indhold deraf
IT1204494B (it) * 1986-03-28 1989-03-01 Roussel Maestretti Spa Derivati della 1-stirene solfonil 2-osso 5-alcossi pirrolidina,loro procedimento di preparazione e loro applicazione come farmaci
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
JPH0813741B2 (ja) * 1987-08-10 1996-02-14 協和醗酵工業株式会社 抗痴呆剤
US4877790A (en) * 1987-12-15 1989-10-31 Kanebo Limited Quinazoline derivative, processes for its production, and cerebral dysfunction remedying agent comprising it as active ingredient
US4859666A (en) * 1988-07-06 1989-08-22 Bristol-Myers Company THAZ derivatives for enhancement of cerebral function
JPH085790B2 (ja) * 1988-11-11 1996-01-24 杏林製薬株式会社 記憶障害改善薬
NZ232493A (en) * 1989-02-14 1992-06-25 Toyama Chemical Co Ltd Aryl- or heterocyclyl-substituted 1,2-ethanediol derivatives and pharmaceutical compositions
JP3044055B2 (ja) * 1990-08-09 2000-05-22 富山化学工業株式会社 １，２―エタンジオール誘導体およびその塩

Also Published As

Publication number Publication date
DK0565965T3 (da) 1997-04-21
IT1261440B (it) 1996-05-23
FR2689890A1 (fr) 1993-10-15
BE1006403A3 (fr) 1994-08-16
HU213631B (en) 1997-08-28
CA2093048A1 (en) 1993-10-14
CA2093048C (en) 1996-10-08
ES2060545A1 (es) 1994-11-16
DE69305904D1 (de) 1996-12-19
TW232690B (de) 1994-10-21
ITRM930232A1 (it) 1994-10-09
KR960005955B1 (ko) 1996-05-06
ITRM930232A0 (it) 1993-04-09
JP2873898B2 (ja) 1999-03-24
KR930021632A (ko) 1993-11-22
AU643634B1 (en) 1993-11-18
JPH069615A (ja) 1994-01-18
PL298494A1 (en) 1993-12-27
NZ247301A (en) 1994-07-26
FR2689890B1 (fr) 1995-01-06
EP0565965B1 (de) 1996-11-13
HUT64319A (en) 1993-12-28
HU9301052D0 (en) 1993-07-28
CZ290864B6 (cs) 2002-11-13
CZ290421B6 (cs) 2002-07-17
US5380878A (en) 1995-01-10
DE69305904T2 (de) 1997-03-13
CZ61093A3 (en) 1993-12-15
EP0565965A2 (de) 1993-10-20
EP0565965A3 (de) 1994-03-02
ES2060545B1 (es) 1997-12-01
PL172191B1 (pl) 1997-08-29
RO115445B1 (ro) 2000-02-28

Similar Documents

Publication Publication Date Title
ATE147734T1 (de) Neues verfahren zur veresterung von baccatin iii und 10-deacetylbaccatin iii
ATE177150T1 (de) Verfahren zur herstellung von 2-arylpropionsäuren
KR890008137A (ko) 3-[4(1-치환된-4-피페라지닐)부틸]-4-티아졸리디노 이의 제조방법 및 약제로서의 이의 용도
FI880742A (fi) Menetelmä uusien, terapeuttisesti käyttökelpoisten, 7-asemassa substituoitujen 19-norsteroidien valmistamiseksi
IE34235L (en) 6, 7-benzomorphans
ATE145204T1 (de) Benzo(b)thiophen-5-ylderivat und verfahren zu seiner herstellung
DE69229402T2 (de) Verfahren zur hestellung von pharmazeutisch aktiven thiazolidin oder oxazolidin verbindungen unter verwendung einer hefe-reduktase
DK470181A (da) Fremgangsmaade til fremstilling af beta-lactamer
FI102679B1 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten sertindoli-prodrugjohdannaisten valmistamiseksi
PT100863A (pt) Esteres de 3-quinuclidinilo uteis como broncodilatadores antimuscarinicos
KR910020015A (ko) 비-라세미형의 푸로[3,4-c] 피리딘 유도체의 제조방법
DE69103087D1 (de) N-substituierte Trifluormethylphenyltetrahydropyridine, Verfahren zur Herstellung, Zwischenprodukte, sowie Arzneimittel, die solche enthalten.
KR960004336A (ko) 3-(4-아미노 에톡시-벤조일) 벤조[b]- 티오펜의 개선된 제조방법
DE68903405T2 (de) Verfahren zur herstellung von 2-alpha-methyl-2-beta-(1,2,3-triazol-1-yl)methylpenam-3-alpha-carbonsaeurederivaten.
ATE110068T1 (de) 4-aminophenol-derivate und verfahren zu ihrer herstellung.
FI940999A0 (fi) Piperidin-2-alkyylikarboksylaattien entsymaattinen toisiintuminen ja saatujen yhdisteiden käyttö synteesin välituotteina
GB1433131A (en) Penicillins
PT86547A (fr) Procede pour preparer des agents edulcorantes derives des acides guanidinoacetique et ethanamidinoacetique et compositions contenant de tels agents edulcorants
FR2566405B1 (fr) Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
ATE136033T1 (de) Photochrome und photoempfindliche spiroindolinoxazinverbindungen und verfahren zu ihrer herstellung
KR880008972A (ko) 카르복실산 유도체
ATE384706T1 (de) Verfahren zur kontinuierlichen herstellung von substituierten oxazolen
KR900006344A (ko) 페넴의 제조방법
DK0663901T3 (da) Fremgangsmåde til stereoselektiv fremstilling af et derivat af beta-phenylisoserin samt anvendelse deraf til fremstilling af taxanderivater
DE69123402T2 (de) Verfahren zur Herstellung optisch aktiver Alpha-Hydroxyalkenderivate

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee