ATE145064T1 - Biosensoren, die elektrische, optische und mechanische signale verwenden - Google Patents

Biosensoren, die elektrische, optische und mechanische signale verwenden

Info

Publication number
ATE145064T1
ATE145064T1 AT90111238T AT90111238T ATE145064T1 AT E145064 T1 ATE145064 T1 AT E145064T1 AT 90111238 T AT90111238 T AT 90111238T AT 90111238 T AT90111238 T AT 90111238T AT E145064 T1 ATE145064 T1 AT E145064T1
Authority
AT
Austria
Prior art keywords
biosensors
optical
electrical
layer
mechanical signals
Prior art date
Application number
AT90111238T
Other languages
English (en)
Inventor
Hans O Ribi
Original Assignee
Biocircuits Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocircuits Corp filed Critical Biocircuits Corp
Application granted granted Critical
Publication of ATE145064T1 publication Critical patent/ATE145064T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00734—Lipids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Holo Graphy (AREA)
  • Transmission And Conversion Of Sensor Element Output (AREA)
  • Arrangements For Transmission Of Measured Signals (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT90111238T 1989-06-15 1990-06-13 Biosensoren, die elektrische, optische und mechanische signale verwenden ATE145064T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/366,651 US5156810A (en) 1989-06-15 1989-06-15 Biosensors employing electrical, optical and mechanical signals

Publications (1)

Publication Number Publication Date
ATE145064T1 true ATE145064T1 (de) 1996-11-15

Family

ID=23443928

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90111238T ATE145064T1 (de) 1989-06-15 1990-06-13 Biosensoren, die elektrische, optische und mechanische signale verwenden

Country Status (6)

Country Link
US (1) US5156810A (de)
EP (1) EP0402917B1 (de)
JP (1) JP2874964B2 (de)
AT (1) ATE145064T1 (de)
CA (1) CA2019039A1 (de)
DE (1) DE69029060T2 (de)

Families Citing this family (219)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5491097A (en) * 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
US5268305A (en) * 1989-06-15 1993-12-07 Biocircuits Corporation Multi-optical detection system
US5204884A (en) * 1991-03-18 1993-04-20 University Of Rochester System for high-speed measurement and sorting of particles
US5510481A (en) * 1990-11-26 1996-04-23 The Regents, University Of California Self-assembled molecular films incorporating a ligand
US5199576A (en) * 1991-04-05 1993-04-06 University Of Rochester System for flexibly sorting particles
IL103674A0 (en) * 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
CA2139242A1 (en) * 1992-07-17 1994-02-03 Richard Calvin Ebersole Analyte detection by means of an analyte-responsive polymer
JPH0634596A (ja) * 1992-07-20 1994-02-08 Fujitsu Ltd 酸素電極、バイオセンサ、及び、その製造方法
US6660484B2 (en) * 1992-11-13 2003-12-09 Regents Of The University Of California Colorimetric glycopolythiophene biosensors
US5399486A (en) * 1993-02-18 1995-03-21 Biocircuits Corporation Disposable unit in diagnostic assays
US5539100A (en) * 1993-07-01 1996-07-23 The United States Of America As Represented By The United States Department Of Energy Organic solid state switches incorporating porphyrin compounds and method for producing organic solid state optical switches
US5494831A (en) * 1993-08-30 1996-02-27 Hughes Aircraft Company Electrochemical immunosensor system and methods
US6726880B1 (en) * 1993-11-01 2004-04-27 Nanogen, Inc. Electronic device for performing active biological operations and method of using same
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
DE4338732C2 (de) * 1993-11-12 2003-12-11 Thomas Dandekar Biosensor (neuer Bauart)
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5527711A (en) * 1993-12-13 1996-06-18 Hewlett Packard Company Method and reagents for binding chemical analytes to a substrate surface, and related analytical devices and diagnostic techniques
BE1008221A3 (fr) * 1994-03-28 1996-02-20 Anda Biolog Sa Support solide fixant au moins un composant a activite biologique comprenant un site reactionnel, stabilise et procede pour son obtention.
US5477519A (en) * 1994-06-07 1995-12-19 The Board Of Regents Of The University Of Michigan Data storage using pulsed optical domain reversal
CA2199149A1 (en) * 1994-09-13 1996-03-21 Hans O. Ribi Direct and indirect modulation of spectrophotometric changes in lipid layer in measuring analytes
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6613560B1 (en) * 1994-10-19 2003-09-02 Agilent Technologies, Inc. PCR microreactor for amplifying DNA using microquantities of sample fluid
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
KR100314996B1 (ko) * 1994-11-10 2002-01-15 윌리암 제이. 버크 액체분배시스템
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
JP3094880B2 (ja) * 1995-03-01 2000-10-03 住友金属工業株式会社 有機化合物の結晶化制御方法およびそれに用いる結晶化制御用固体素子
SE9501236D0 (sv) * 1995-04-04 1995-04-04 Sven Oscarsson Metod för kvantitativ och kvalitativ och kvalitativ diagnosticering av analyter med STM/SFM
DE19512117A1 (de) 1995-04-04 1996-10-10 Itt Ind Gmbh Deutsche Meßeinrichtung
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US6127127A (en) * 1995-06-27 2000-10-03 The University Of North Carolina At Chapel Hill Monolayer and electrode for detecting a label-bearing target and method of use thereof
US6387625B1 (en) 1995-06-27 2002-05-14 The University Of North Carolina At Chapel Hill Monolayer and electrode for detecting a label-bearing target and method of use thereof
US5968745A (en) * 1995-06-27 1999-10-19 The University Of North Carolina At Chapel Hill Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof
AU6628696A (en) * 1995-08-22 1997-03-19 Philips Electronics N.V. Method and device for investigating non-linear optical behavior of a layer formed from first and second reactants e.g. antibody and antigen
FR2739448B1 (fr) * 1995-09-29 1997-10-24 Thomson Csf Dispositif de detection et de controle de biofilms
US5736330A (en) * 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
AU7398996A (en) 1995-10-11 1997-04-30 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
GB9604292D0 (en) * 1996-02-29 1996-05-01 Hybaid Ltd Estimation of a nucleic acid
WO1997048977A2 (en) * 1996-06-20 1997-12-24 New York University Detection of ligand interaction with polymeric material
EP0909841A4 (de) 1996-06-26 2001-12-19 Sumitomo Metal Ind Verfahren zur kristallzüchtung und festkörperelement und hierzu verwendete vorrichtung zur kristallzüchtung
EP0913507A4 (de) 1996-07-15 2002-03-13 Sumitomo Metal Ind Anlage zur kristallzüchtung und diese verwendendes verfahren zur kristallzüchtung
US6136274A (en) * 1996-10-07 2000-10-24 Irori Matrices with memories in automated drug discovery and units therefor
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
GB9622304D0 (en) * 1996-10-26 1996-12-18 Univ Manchester Sensor
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7014992B1 (en) * 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7045285B1 (en) * 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US7381525B1 (en) * 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
AU5432798A (en) * 1996-11-08 1998-05-29 Morphogenesis, Inc. Materials and procedures for the purification of cells
EP0965033A1 (de) * 1997-03-03 1999-12-22 The Regents of the University of California Direkter kolorimetrischer nachweis von biokatalysatoren
ATE290211T1 (de) * 1997-04-11 2005-03-15 Univ New Mexico Modulare anordnung zur reagenzlosen affinitätsseparation und detektion von analyten
US6060327A (en) 1997-05-14 2000-05-09 Keensense, Inc. Molecular wire injection sensors
US6699667B2 (en) 1997-05-14 2004-03-02 Keensense, Inc. Molecular wire injection sensors
US7220550B2 (en) * 1997-05-14 2007-05-22 Keensense, Inc. Molecular wire injection sensors
US7626192B2 (en) 1997-05-27 2009-12-01 State of Oregon Acting by the Through the State Board of Higher Education on Behalf of the University of Oregon Scaffold-organized clusters and electronic devices made using such clusters
WO1998053841A1 (en) * 1997-05-27 1998-12-03 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Scaffold-organized metal, alloy, semiconductor and/or magnetic clusters and electronic devices made using such clusters
US6730537B2 (en) * 2000-03-24 2004-05-04 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Scaffold-organized clusters and electronic devices made using such clusters
JP4124830B2 (ja) * 1997-06-12 2008-07-23 クリニカル・マイクロ・センサーズ・インコーポレイテッド 分析物の検出のための電気的方法
NZ502303A (en) 1997-06-18 2002-02-01 Ulrich J Krull Nucleic acid biosensor system & diagnostic use
IL121312A (en) * 1997-07-14 2001-09-13 Technion Res & Dev Foundation Microelectronic components, their manufacture and electronic networks containing them
WO1999006835A1 (en) * 1997-07-31 1999-02-11 The Uab Research Foundation REGENERABLE BIOSENSOR USING ELECTROCHEMICAL CONTROLLED FLUORESCENCE WITH INTERNAL REFLECTION
US6511854B1 (en) 1997-07-31 2003-01-28 The Uab Research Foundation Regenerable biosensor using total internal reflection fluorescence with electrochemical control
US6048692A (en) * 1997-10-07 2000-04-11 Motorola, Inc. Sensors for electrically sensing binding events for supported molecular receptors
US6123819A (en) * 1997-11-12 2000-09-26 Protiveris, Inc. Nanoelectrode arrays
DE19751658A1 (de) * 1997-11-21 1999-07-29 Wolfbeis Otto S Prof Dr Verfahren zur Bildung lateral organisierter Strukturen auf Trägeroberflächen
DE19822123C2 (de) * 1997-11-21 2003-02-06 Meinhard Knoll Verfahren und Vorrichtung zum Nachweis von Analyten
US6221673B1 (en) * 1997-11-25 2001-04-24 Microsensor Systems Inc. Materials, method and apparatus for detection and monitoring of chemical species
US7090804B2 (en) 1998-01-27 2006-08-15 Clinical Mirco Sensors, Inc. Amplification of nucleic acids with electronic detection
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6287874B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Methods for analyzing protein binding events
US6287776B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
US6338968B1 (en) * 1998-02-02 2002-01-15 Signature Bioscience, Inc. Method and apparatus for detecting molecular binding events
US6395480B1 (en) 1999-02-01 2002-05-28 Signature Bioscience, Inc. Computer program and database structure for detecting molecular binding events
WO1999039190A1 (en) * 1998-02-02 1999-08-05 Signature Bioscience Inc. Method and apparatus for detecting molecular binding events
US6485905B2 (en) * 1998-02-02 2002-11-26 Signature Bioscience, Inc. Bio-assay device
US20020177175A1 (en) * 1998-02-02 2002-11-28 Hefti John J. Coplanar waveguide biosensor for detecting molecular or cellular events
US7347974B1 (en) 1998-05-04 2008-03-25 The United States Of America As Represented By The Secretary Of The Navy Materials, method and apparatus for detection and monitoring of chemical species
US6284197B1 (en) * 1998-06-05 2001-09-04 The Regents Of The University Of California Optical amplification of molecular interactions using liquid crystals
US6322963B1 (en) 1998-06-15 2001-11-27 Biosensor Systems Design., Inc. Sensor for analyte detection
IL124903A0 (en) * 1998-06-15 1999-01-26 Bauer Alan Josef An enzyme biosensor
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6429023B1 (en) 1998-07-20 2002-08-06 Shayda Technologies, Inc. Biosensors with polymeric optical waveguides
FR2781886B1 (fr) 1998-07-31 2001-02-16 Commissariat Energie Atomique Micro-systeme a multiple points d'analyse chimique ou biologique
FR2784466B1 (fr) * 1998-10-13 2002-10-18 Commissariat Energie Atomique Micro-systeme a multiple points d'analyse chimique ou biologique mettant en oeuvre un couplage entre les sondes et un substrat
US6833267B1 (en) * 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
US6468785B1 (en) 1999-02-19 2002-10-22 New Mexico State University Technology Transfer Corporation Doped conducting polymers applications and methods
DE19915310A1 (de) * 1999-04-03 2000-10-05 Bayer Ag Diffusionskontrollierende Sensorschicht
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US20040053290A1 (en) * 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
US7312087B2 (en) * 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6485690B1 (en) 1999-05-27 2002-11-26 Orchid Biosciences, Inc. Multiple fluid sample processor and system
US6342347B1 (en) 1999-10-22 2002-01-29 Biosensor Systems Design., Inc. Electromagnetic sensor
US6503701B1 (en) 1999-06-15 2003-01-07 Biosensor Systems Design, Inc. Analytic sensor apparatus and method
EP1192466B1 (de) 1999-06-23 2004-08-11 Cornell Research Foundation, Inc. Entwässerung/rehydratisierung von markierten liposomen auf einer prüfeinrichtung
EP1204859B1 (de) 1999-07-16 2006-11-22 The Board Of Regents, The University Of Texas System Verfahren und vorrichtung zur zuführung von proben zu einer chemischen sensormatrix
US7022517B1 (en) 1999-07-16 2006-04-04 Board Of Regents, The University Of Texas System Method and apparatus for the delivery of samples to a chemical sensor array
JP3926625B2 (ja) 1999-07-26 2007-06-06 クリニカル・マイクロ・センサーズ・インコーポレイテッド 電子検出を用いる核酸の配列決定
EP1204842A4 (de) * 1999-08-19 2003-04-02 Univ California Apparat und verfahren zur visuellen identifikation von mikrokräften mittels einer palette von auslegerblöcken
US6336368B1 (en) * 1999-09-10 2002-01-08 The United States Of America As Represented By The Secretary Of The Navy Method and apparatus for energy efficient tacking of resonant devices
EP1218098A1 (de) * 1999-09-09 2002-07-03 Ben-Gurion University Of The Negev Probenmatrizen und deren herstellung
AU1067001A (en) * 1999-10-08 2001-04-23 Mamea Imaging Ab Method and arrangement relating to x-ray imaging
US6576460B1 (en) 1999-10-28 2003-06-10 Cornell Research Foundation, Inc. Filtration-detection device and method of use
US7316899B2 (en) * 2000-01-31 2008-01-08 The Board Of Regents Of The University Of Texas System Portable sensor array system
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
US20030103905A1 (en) * 2000-06-23 2003-06-05 Ribi Hans O. Methods and compositions for preparing consumables with optical shifting properties
US6607744B1 (en) 2000-06-23 2003-08-19 Segan Industries Ingestibles possessing intrinsic color change
AU2001271195A1 (en) * 2000-07-10 2002-01-21 Mamea Imaging Ab Method and arrangement relating to x-ray imaging
JP4382265B2 (ja) * 2000-07-12 2009-12-09 日本電気株式会社 酸化シリコン膜の形成方法及びその形成装置
US7205347B2 (en) * 2000-10-19 2007-04-17 Trans Photonics, Llc. Substituted-polyaryl chromophoric compounds
US20020137074A1 (en) * 2000-11-21 2002-09-26 Piunno Paul A.E. Selectivity of nucleic acid diagnostic and microarray technologies by control of interfacial nucleic acid film chemistry
DE10062244A1 (de) * 2000-12-14 2002-07-04 Infineon Technologies Ag Sensor zur Detektion von makromolekularen Biopolymeren, Sensoranordnung, Verfahren zur Detektion von makromolekularen Biopolymeren und Verfahren zum Herstellen eines Sensors zur Detektion von makromolekularen Biopolymeren
WO2002054052A1 (en) * 2001-01-08 2002-07-11 Leonard Fish Diagnostic instruments and methods for detecting analytes
WO2002054071A1 (en) * 2001-01-08 2002-07-11 Salafsky Joshua S Method and apparatus using a surface-selective nonlinear optical technique
WO2002066983A2 (en) * 2001-02-01 2002-08-29 Signature Bioscience, Inc. Bioassay device for detecting molecular events
AU2002255515A1 (en) * 2001-02-05 2002-08-19 Board Of Regents, The University Of Texas System The use of mesoscale self-assembly and recognition to effect delivery of sensing reagent for arrayed sensors
US7049152B2 (en) * 2001-03-13 2006-05-23 The Regents Of The University Of California Color and shape changing polymeric ribbons and sheets
WO2002073673A1 (en) 2001-03-13 2002-09-19 Rochester Institute Of Technology A micro-electro-mechanical switch and a method of using and making thereof
US6627461B2 (en) 2001-04-18 2003-09-30 Signature Bioscience, Inc. Method and apparatus for detection of molecular events using temperature control of detection environment
US7195393B2 (en) 2001-05-31 2007-03-27 Rochester Institute Of Technology Micro fluidic valves, agitators, and pumps and methods thereof
US8323956B2 (en) * 2001-06-01 2012-12-04 Colorado State University Research Foundation Distal tip of biosensor transducer comprising enzyme for deamination
US9493806B2 (en) 2001-06-01 2016-11-15 Colorado State University Research Foundation Enzymatic biosensing systems
US7381538B2 (en) 2001-06-01 2008-06-03 Colorado State University Research Foundation (Csurf) Optical biosensor with enhanced activity retention for detection of halogenated organic compounds
US9493805B2 (en) * 2001-06-01 2016-11-15 Colorado State University Research Foundation Enzymatic biosensors with enhanced activity retention for detection of organic compounds
US6461808B1 (en) 2001-06-12 2002-10-08 Signature Bioscience, Inc. Pipette-loaded bioassay assembly for detecting molecular or cellular events
FR2827386B1 (fr) * 2001-07-11 2003-10-31 Centre Nat Rech Scient Biopuce et son procede de fabrication
US20040146460A1 (en) * 2001-07-17 2004-07-29 Salafsky Joshua S Design of labels for detection with a surface-seletive nonlinear optical technique
DE10156329A1 (de) * 2001-07-17 2003-02-06 Frieder Breitling Verfahren und Anordnung zum Anbringen von in Transportmittel immobilisierten Substanzen sowie Monomerpartikel
US20030032000A1 (en) * 2001-08-13 2003-02-13 Signature Bioscience Inc. Method for analyzing cellular events
US20030068655A1 (en) * 2001-09-12 2003-04-10 Protiveris, Inc. Microcantilever apparatus and methods for detection of enzymes
WO2003031953A2 (en) * 2001-10-12 2003-04-17 University Of Florida Method and apparatus for sensing nitroaromatics
EP1466014A4 (de) * 2001-10-26 2006-03-15 Integrated Nano Tech Llc Sensorsystem für chemische und biologische gefahren und verfahren dafür
US7211923B2 (en) 2001-10-26 2007-05-01 Nth Tech Corporation Rotational motion based, electrostatic power source and methods thereof
US7378775B2 (en) 2001-10-26 2008-05-27 Nth Tech Corporation Motion based, electrostatic power source and methods thereof
US20030148391A1 (en) * 2002-01-24 2003-08-07 Salafsky Joshua S. Method using a nonlinear optical technique for detection of interactions involving a conformational change
EP1467948A1 (de) * 2002-01-24 2004-10-20 Cantion A/S Sensor
US20030154149A1 (en) * 2002-02-13 2003-08-14 Dilip Gajendragadkar System and method of creating and executing a restricted stock sale plan
US20050220673A1 (en) * 2002-02-22 2005-10-06 Jacob Thaysen Sensor comprising an array of pieroresistors
DE10211741B4 (de) * 2002-03-14 2005-12-01 November Ag Verfahren zum elektrochemischen Detektieren eines Analyten
US8257967B2 (en) 2002-04-26 2012-09-04 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
FR2839364B1 (fr) * 2002-05-03 2004-12-24 Commissariat Energie Atomique Procede de detection d'une reconnaissance molecukaire par electrochimiluminescence
DE10221885B4 (de) * 2002-05-16 2005-12-29 Infineon Technologies Ag Sensor-Einheit, Sensor-Anordnung und Verfahren zum Betreiben einer Sensor-Einheit
EP1939627B1 (de) 2002-05-31 2010-08-18 Cornell Research Foundation, Inc. Methoden zum Nachweis Analyten in Proben
US6958132B2 (en) * 2002-05-31 2005-10-25 The Regents Of The University Of California Systems and methods for optical actuation of microfluidics based on opto-electrowetting
EP1376111A1 (de) 2002-06-24 2004-01-02 Universite Catholique De Louvain Verfahren und Vorrichtung für die hochempfindliche Bestimmung von DNA und anderen Testsubstanzen
DE10229210A1 (de) * 2002-06-28 2004-01-29 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Vorrichtung zur Detektion eines Analyten
AU2003256742A1 (en) * 2002-07-24 2004-02-09 Board Of Regents, The University Of Texas System Capture and detection of microbes by membrane methods
US7387889B2 (en) * 2002-08-22 2008-06-17 Massachusetts Institute Of Technology Measurement of concentrations and binding energetics
DE10251757B4 (de) * 2002-11-05 2006-03-09 Micronas Holding Gmbh Vorrichtung zur Bestimmung der Konzentration von in einer zu untersuchenden Probe enthaltenen Liganden
RU2229118C1 (ru) * 2002-11-10 2004-05-20 Лукин Марк Анатольевич Сенсор для детекции макромолекул
US6963007B2 (en) 2002-12-19 2005-11-08 3M Innovative Properties Company Diacetylenic materials for sensing applications
US20040126897A1 (en) * 2002-12-19 2004-07-01 3M Innovative Properties Company Colorimetric sensors constructed of diacetylene materials
US7138121B2 (en) * 2003-01-23 2006-11-21 Spangler Brenda D Biosensors utilizing dendrimer-immobilized ligands and there use thereof
US20040197821A1 (en) * 2003-04-04 2004-10-07 Bauer Alan Joseph Rapid-detection biosensor
WO2004097371A2 (en) * 2003-04-25 2004-11-11 Board Of Regents, The University Of Texas System System and method for the detection of analytes
US7651850B2 (en) * 2003-05-16 2010-01-26 Board Of Regents, The University Of Texas System Image and part recognition technology
US9317922B2 (en) 2003-05-16 2016-04-19 Board Of Regents The University Of Texas System Image and part recognition technology
US7287328B2 (en) 2003-08-29 2007-10-30 Rochester Institute Of Technology Methods for distributed electrode injection
US7217582B2 (en) 2003-08-29 2007-05-15 Rochester Institute Of Technology Method for non-damaging charge injection and a system thereof
DE10340275B3 (de) * 2003-08-29 2005-05-25 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Verfahren zur Herstellung einer Elektrode
US7276351B2 (en) 2003-09-10 2007-10-02 Seahorse Bioscience Method and device for measuring multiple physiological properties of cells
IL158173A0 (en) * 2003-09-30 2004-03-28 Univ Ben Gurion Nanopatch-containing cells
US8658349B2 (en) 2006-07-13 2014-02-25 Seahorse Bioscience Cell analysis apparatus and method
WO2005045409A1 (ja) * 2003-11-07 2005-05-19 Osaka Prefecture 電気抵抗型検出センサおよび検出方法
EP1695082A2 (de) 2003-12-11 2006-08-30 Board of Regents, The University of Texas System Verfahren und vorrichtung für die analyse von speichel unter verwendung eines sensorarrays
US8581308B2 (en) 2004-02-19 2013-11-12 Rochester Institute Of Technology High temperature embedded charge devices and methods thereof
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US20060257854A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Membrane assay system including preloaded particles
US7781226B2 (en) * 2004-02-27 2010-08-24 The Board Of Regents Of The University Of Texas System Particle on membrane assay system
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US20060257941A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle and membrane sensor elements
US20060257991A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
DE102004024364A1 (de) * 2004-05-17 2005-12-15 Apibio Sas Verfahren zur Herstellung von Polymeren
US7371511B2 (en) * 2004-08-19 2008-05-13 3M Innovative Properties Company Polydiacetylene polymer blends
US7816472B2 (en) * 2004-08-19 2010-10-19 3M Innovative Properties Company Polydiacetylene polymer compositions and methods of manufacture
CN101080637A (zh) * 2004-12-17 2007-11-28 3M创新有限公司 由二乙炔材料构成的比色传感器
US8377398B2 (en) 2005-05-31 2013-02-19 The Board Of Regents Of The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
JP5008046B2 (ja) * 2005-06-14 2012-08-22 ローム株式会社 半導体デバイス
EP1913393A4 (de) * 2005-06-16 2010-03-03 Univ California Paralleler allergietest auf immunbasis im grossmassstab und vorrichtung zur fluoreszenzanregung mit evaneszenzfeld
US8709740B2 (en) * 2005-08-11 2014-04-29 The United States Of America, As Represented By The Secretary Of The Navy Control of protein activity using a conducting polymer
EP2549269A1 (de) * 2005-10-04 2013-01-23 Headway Technologies, Inc. Mikrofluidischer Nachweis von Analyten
KR100663713B1 (ko) * 2005-12-16 2007-01-03 성균관대학교산학협력단 신규한 폴리디아세틸렌 초분자체 색 전이 센서
US20080011058A1 (en) * 2006-03-20 2008-01-17 The Regents Of The University Of California Piezoresistive cantilever based nanoflow and viscosity sensor for microchannels
WO2008051550A2 (en) * 2006-10-23 2008-05-02 Segan Industries, Inc. Absorbant/compliant solution-free cleaning and multiactive compositions
US20100247223A1 (en) * 2006-12-22 2010-09-30 Ribi Hans O Stylus-substrate system for direct imaging, drawing, and recording
US7980000B2 (en) 2006-12-29 2011-07-19 Applied Materials, Inc. Vapor dryer having hydrophilic end effector
US8191403B2 (en) * 2007-03-27 2012-06-05 Richmond Chemical Corporation Petroleum viscosity measurement and communication system and method
US9796998B2 (en) 2007-04-09 2017-10-24 Colorado State University Research Foundation Oxygenase-based biosensing systems for measurement of halogenated alkene concentrations
FR2916367B1 (fr) * 2007-05-25 2009-07-31 Commissariat Energie Atomique Procede de fixation sur un microsysteme de composes a liaisons peptidiques, tels que des proteines, et microsysteme incorporant ces composes.
WO2008157325A2 (en) * 2007-06-15 2008-12-24 Charles Stark Draper Laboratory, Inc. Devices, systems, and methods for measuring glucose
WO2009045208A1 (en) * 2007-10-01 2009-04-09 Arizona Board Of Regents, On Behalf Of The University Of Arizona Method of detection/extraction, and related detection/extraction device
JP2011504236A (ja) * 2007-11-20 2011-02-03 スリーエム イノベイティブ プロパティズ カンパニー ジアセチレンを含むポリマーセンサーを用いる細菌試料の分析方法
US8181531B2 (en) * 2008-06-27 2012-05-22 Edwin Carlen Accessible stress-based electrostatic monitoring of chemical reactions and binding
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
US9011670B2 (en) * 2008-08-14 2015-04-21 The Charles Stark Draper Laboratory, Inc. Three-dimensional metal ion sensor arrays on printed circuit boards
US20100055718A1 (en) * 2008-08-29 2010-03-04 Kwangyeol Lee Nanoplate dye platform and methods of making and using the same
US20100112719A1 (en) * 2008-11-06 2010-05-06 Amihood Doron Electronic signal amplification in field effect device based chemical sensors
US20100244820A1 (en) * 2009-03-26 2010-09-30 Biomimetics Technologies Inc Microchip for detection of poor sources of electrical and magnetic fields
US10024797B2 (en) 2010-11-22 2018-07-17 Colorado State University Research Foundation Biosensing systems for measurement of lactose
US9428789B2 (en) 2011-03-21 2016-08-30 Biodesy, Inc. Classification of kinase inhibitors using nonlinear optical techniques
DE102011017572A1 (de) * 2011-04-27 2012-10-31 Siemens Aktiengesellschaft Bauteil mit orientiertem organischem Halbleiter
EP2729820A4 (de) * 2011-07-08 2015-04-01 Acreo Swedish Ict Ab Verfahren zur verwendung einer sonde zur überwachung der grenzflächenveränderungen von kapazität und widerstand
WO2013019982A2 (en) 2011-08-02 2013-02-07 Colorado State University Research Foundation Biosensing system with extended lifetime via cofactor recycling
US9746380B2 (en) 2011-09-30 2017-08-29 Segan Industries, Inc. Advanced multi-element consumable-disposable products
US9395358B2 (en) 2012-02-05 2016-07-19 Biodesy, Inc. Methods for detecting allosteric modulators of protein
WO2013115867A1 (en) 2012-02-05 2013-08-08 Biodesy, Llc Methods for identifying modulators of ras using nonlinear techniques
US20130288271A1 (en) 2012-04-25 2013-10-31 Biodesy, Llc Methods for detecting allosteric modulators of protein
CN104471052B (zh) 2012-11-13 2017-06-13 海马生物科学公司 用于基于控制介质流动的三维组织测量的装置和方法
CN105283317B (zh) 2013-03-15 2018-02-06 西甘产业股份有限公司 用于在颜色变化组合物中降低背景色的化合物
CN116809131A (zh) 2014-06-02 2023-09-29 安捷伦科技有限公司 用于分析生物样本的单列微板系统和载体
US9989534B2 (en) 2014-06-30 2018-06-05 Biodesy, Inc. Systems and methods for high throughput analysis of conformation in biological entities
EP3237906B8 (de) 2014-12-23 2020-10-28 Bluelight Therapeutics, Inc. Befestigung von proteinen an schnittstellen zur verwendung in nicht-linearer optischer detektion
EP3278087A4 (de) 2015-04-02 2018-12-19 Biodesy, Inc. Verfahren zur bestimmung der proteinstruktur anhand einer oberflächenselektiven nichtlinearen optischen technik
WO2017196891A1 (en) 2016-05-09 2017-11-16 Biodesy, Inc. Methods and devices for detection of peripheral membrane protein interactions using nonlinear optical techniques
KR102400291B1 (ko) * 2020-06-22 2022-05-19 아주대학교산학협력단 수소 검출 센서 및 이의 제조방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444892A (en) * 1980-10-20 1984-04-24 Malmros Mark K Analytical device having semiconductive organic polymeric element associated with analyte-binding substance
US4444878A (en) * 1981-12-21 1984-04-24 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
US4489133A (en) * 1982-11-16 1984-12-18 The Board Of Trustees Of The Leland Stanford Jr. University Two-dimensional crystallization technique
US4490216A (en) * 1983-02-03 1984-12-25 Molecular Devices Corporation Lipid membrane electroanalytical elements and method of analysis therewith
US4560534A (en) * 1983-11-02 1985-12-24 Miles Laboratories, Inc. Polymer catalyst transducers
FR2564004B1 (fr) * 1984-05-10 1993-04-09 Commissariat Energie Atomique Procede de fabrication d'un film mince comportant au moins une couche monomoleculaire de molecules non amphiphiles
US4661235A (en) * 1984-08-03 1987-04-28 Krull Ulrich J Chemo-receptive lipid based membrane transducers
GB8509491D0 (en) * 1985-04-12 1985-05-15 Plessey Co Plc Optic waveguide biosensors
EP0214805B1 (de) * 1985-08-29 1993-05-26 Matsushita Electric Industrial Co., Ltd. Einen Feldeffekttransistor benutzender Fühler und dessen Herstellungsverfahren
US4859538A (en) * 1986-11-20 1989-08-22 Ribi Hans O Novel lipid-protein compositions and articles and methods for their preparation
US4824529A (en) * 1987-11-27 1989-04-25 Allied-Signal Inc. Lipid membrane-based device
EP0324455A3 (de) * 1988-01-15 1991-03-27 Hans O. Ribi Neue polymerische Immuno-Adjuvans

Also Published As

Publication number Publication date
DE69029060D1 (de) 1996-12-12
EP0402917A2 (de) 1990-12-19
JP2874964B2 (ja) 1999-03-24
EP0402917B1 (de) 1996-11-06
JPH03128449A (ja) 1991-05-31
US5156810A (en) 1992-10-20
EP0402917A3 (de) 1993-03-03
CA2019039A1 (en) 1990-12-15
DE69029060T2 (de) 1997-04-30

Similar Documents

Publication Publication Date Title
ATE145064T1 (de) Biosensoren, die elektrische, optische und mechanische signale verwenden
DE3888577D1 (de) Gerät zur Messung von Elektrolyten.
DE3873787D1 (de) Analytischer teststreifen.
FI911536A7 (fi) Nukleiinihappokoettimet, jotka sisältävät parannetun molekyylikytkimen , sekä niitä sisältävät määritysmenetelmät ja testipakkaukset
WO2001023885A8 (en) Test device
ATE69888T1 (de) Testverfahren.
DK265688D0 (da) Fastfaseanalyse under anvendelse af kapillarstroemning
NL191397B (nl) Bemonster- en houdschakeling.
DE3851744D1 (de) Membran-Untersuchung mit fokussierendem Probeauflegen.
FI873356A7 (fi) Analyysilaite liuosmaisten näytteiden sisältämien analyyttien automaattiseksi määrittämiseksi
IT1091166B (it) Procedimento e dispositivo per il montaggio dei campioni biologici su vetrini da microscopio
DE3583330D1 (de) Temperaturmessprobe.
DE3687123D1 (de) Ionenempfindlicher fet-fuehler.
DE3484588D1 (de) Schaltung zur erfassung von pruefeingaben.
ATE79679T1 (de) Diagnostische probe.
DE3763885D1 (de) Probe fuer kontakt-sensor.
DE3863133D1 (de) Urinproben-sammler.
DE3861095D1 (de) Optischer kraftmess-sensor.
DE3764850D1 (de) Messprobe fuer werkstuecke und dazu gehoerige elektrische schaltungen.
ES8609705A1 (es) Un aparato para percibir el movimiento de rotacion relativo entre dos miembros
DE69023071D1 (de) Elektrische Vorrichtung mit Glasdichtungen enthaltenden Durchführungen.
DE3578098D1 (de) Randdetektionsvorrichtung in optischem messinstrument.
DE3482995D1 (de) Nukleinsaeure-hybridisierungstest mittels antikoerper gegen einschaltungskomplexe.
DK0470164T3 (da) Analyseindretning
DE69729185D1 (de) Sensor und modifizierte Membran für diesen Sensor

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee