AR095342A1 - Piridinas 2,3-sustituidas y su uso para la modulación de hemoglobina - Google Patents

Piridinas 2,3-sustituidas y su uso para la modulación de hemoglobina

Info

Publication number
AR095342A1
AR095342A1 ARP140101046A ARP140101046A AR095342A1 AR 095342 A1 AR095342 A1 AR 095342A1 AR P140101046 A ARP140101046 A AR P140101046A AR P140101046 A ARP140101046 A AR P140101046A AR 095342 A1 AR095342 A1 AR 095342A1
Authority
AR
Argentina
Prior art keywords
alkyl
optionally substituted
independently
hydrogen
ring
Prior art date
Application number
ARP140101046A
Other languages
English (en)
Inventor
R Harris Jason
W Metcalf Brian
Xu Qing
W Yee Calvin
L Gwaltney Stephen
Li Zhe
Original Assignee
Global Blood Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Global Blood Therapeutics Inc filed Critical Global Blood Therapeutics Inc
Publication of AR095342A1 publication Critical patent/AR095342A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente fue refiere a compuestos y composiciones farmacéuticas adecuados como moduladores de hemoglobina, y su uso en el tratamiento de trastornos mediados por hemoglobina y trastornos que se beneficiarían de la oxigenación de tejido y/o celular. Reivindicación 1: En ciertos aspectos de la presente, se provee un compuesto de fórmula (1) o uno de sus tautómeros, o una sal farmacéuticamente aceptable de cada uno de ellos, caracterizado porque: el anillo A es un cicloalquilo opcionalmente sustituido de 4 a 10 miembros o un heterociclo de 4 a 10 miembros que contienen heteroátomos de hasta 5 anillos, donde el heteroátomo se selecciona entre el grupo que consiste en O, N, S, y formas oxidizadas de N y S; o el anillo B es un arilo C₆₋₁₀ o un heteroarilo de 5 a 10 miembros con entre 1 y 3 átomos de nitrógeno, de preferencia entre 1 y 2 átomos de nitrógeno y de mayor preferencia de 1 átomo de nitrógeno, o sus versiones oxidizadas, donde el arilo o el heteroarilo es opcionalmente sustituido; ⁻ ⁻ ⁻ ⁻ ⁻ es una unión simple o doble; cada Y y Z es, independientemente, CR¹⁰R¹¹, O, S, SO, SO NR¹²; cada R¹⁰ y R¹¹ independientemente es hidrógeno o alquilo C₁₋₃ opcionalmente sustituido con halo, OH, o alcoxi C₁₋₆, o CR¹⁰R¹¹ es C=O; R¹² es hidrógeno o alquilo C₁₋₆; siempre que si uno entre Y y Z es O, S, SO, SO₂, entonces el otro no sea CO, y siempre que Y y Z no sean, ambos, heteroátomos o sus formas oxidizadas; el anillo C es arilo C₆₋₁₀, opcionalmente sustituido; V¹ y V² son, independientemente, alcoxi C₁₋₆; o V¹ y V², junto con el átomo de carbono, están unidos para formar un anillo de fórmula (2), donde cada uno entre V³ y V⁴ son, independientemente O, S, o NH, siempre que, cuando V³ y V⁴ son S, el otro sea NH, y siempre que V³ y V⁴ no sean ambos NH; q es 1 ó 2; cada V⁵ es, independientemente, alquilo C₁₋₆ o CO₂R⁶⁰, donde cada R⁶⁰ es, independientemente, alquilo C₁₋₆ o hidrógeno; t es 0, 1, 2, ó 4; o CV¹V² es C=V, donde V es O, NOR⁸⁰, o NNR⁸¹R⁸²; R⁸⁰ es alquilo C₁₋₆ opcionalmente sustituido; R⁸⁰ y R⁸¹, independientemente, se seleccionan entre el grupo que consiste en hidrógeno, alquilo C₁₋₆ opcionalmente sustituido, COR⁸³ o CO₂R⁸⁴; R⁸³ es hidrógeno o alquilo C₁₋₆ opcionalmente sustituido; y R⁸⁴ es alquilo C₁₋₆ opcionalmente sustituido.
ARP140101046A 2013-03-15 2014-03-14 Piridinas 2,3-sustituidas y su uso para la modulación de hemoglobina AR095342A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13/815,874 US9604999B2 (en) 2013-03-15 2013-03-15 Compounds and uses thereof for the modulation of hemoglobin

Publications (1)

Publication Number Publication Date
AR095342A1 true AR095342A1 (es) 2015-10-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140101046A AR095342A1 (es) 2013-03-15 2014-03-14 Piridinas 2,3-sustituidas y su uso para la modulación de hemoglobina

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Country Link
US (2) US9604999B2 (es)
AR (1) AR095342A1 (es)

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CA2860323C (en) 2011-12-28 2022-03-08 The Regents Of The University Of California Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
SG11201507453VA (en) 2013-03-15 2015-10-29 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US20160083343A1 (en) 2013-03-15 2016-03-24 Global Blood Therapeutics, Inc Compounds and uses thereof for the modulation of hemoglobin
AU2014237348C1 (en) 2013-03-15 2019-02-07 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
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