AR100154A1 - Compuesto heterocíclico que contiene nitrógeno - Google Patents

Compuesto heterocíclico que contiene nitrógeno

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Publication number
AR100154A1
AR100154A1 ARP150101206A ARP150101206A AR100154A1 AR 100154 A1 AR100154 A1 AR 100154A1 AR P150101206 A ARP150101206 A AR P150101206A AR P150101206 A ARP150101206 A AR P150101206A AR 100154 A1 AR100154 A1 AR 100154A1
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AR
Argentina
Prior art keywords
optionally substituted
group
optionally
substituted
alkyl group
Prior art date
Application number
ARP150101206A
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English (en)
Inventor
Yamada Masami
Suzuki Shinkichi
Sugimoto Takahiro
Nakamura Minoru
Sakamoto Hiroki
Kamata Makoto
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Takeda Pharmaceuticals Co
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53276227&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR100154(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of AR100154A1 publication Critical patent/AR100154A1/es

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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/325Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035Isoindoles, e.g. phthalimide
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07D471/04Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La presente proporciona un compuesto que tiene una actividad del receptor colinérgico muscarínico M1 del modulador alostérico positivo y útil como un agente para la profilaxis o el tratamiento de la enfermedad de Alzheimer, la esquizofrenia, el dolor, el trastorno del sueño, la demencia de la enfermedad de Parkinson o la demencia con cuerpos de Lewy, y similares. Reivindicación 1: Un compuesto representado por la fórmula (1), caracterizado porque R¹ un grupo cíclico de 5 o 6 miembros sustituido en forma opcional o un grupo alquilo C₁₋₆ sustituido en forma opcional; R² y R³ son iguales o diferentes y cada uno es un átomo de hidrógeno, un átomo de halógeno, un grupo ciano, un grupo alquilo C₁₋₆ sustituido en forma opcional, un grupo alcoxi C₁₋₆ sustituido en forma opcional o un grupo cicloalquilo C₃₋₆ sustituido en forma opcional; R⁴ es un átomo de halógeno, un grupo ciano, un grupo alquilo C₁₋₆ sustituido en forma opcional, un grupo alcoxi C₁₋₆ sustituido en forma opcional, un grupo carbamoilo sustituido en forma opcional o un grupo cíclico de 3 a 8 miembros sustituido en forma opcional; y el Anillo A es un anillo aromático de 6 miembros sustituido en forma opcional y adicional; o una sal del mismo.
ARP150101206A 2014-04-23 2015-04-22 Compuesto heterocíclico que contiene nitrógeno AR100154A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2014089585 2014-04-23

Publications (1)

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AR100154A1 true AR100154A1 (es) 2016-09-14

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ID=53276227

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Country Status (36)

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US (16) US9315458B2 (es)
EP (1) EP3134386B1 (es)
JP (1) JP6517239B2 (es)
KR (1) KR102349237B1 (es)
CN (1) CN106536508B (es)
AR (1) AR100154A1 (es)
AU (1) AU2015250610B2 (es)
BR (1) BR112016024472B1 (es)
CA (1) CA2946519C (es)
CL (1) CL2016002661A1 (es)
CR (1) CR20160544A (es)
CY (1) CY1123569T1 (es)
DK (1) DK3134386T3 (es)
DO (1) DOP2016000286A (es)
EA (1) EA030373B1 (es)
EC (1) ECSP16090152A (es)
ES (1) ES2811088T3 (es)
HR (1) HRP20201171T1 (es)
HU (1) HUE050543T2 (es)
IL (1) IL248393B (es)
LT (1) LT3134386T (es)
MX (1) MX2016013810A (es)
MY (1) MY195742A (es)
NZ (1) NZ725921A (es)
PE (1) PE20161400A1 (es)
PH (1) PH12016502095A1 (es)
PL (1) PL3134386T3 (es)
PT (1) PT3134386T (es)
RS (1) RS60524B1 (es)
SG (1) SG11201608785PA (es)
SI (1) SI3134386T1 (es)
TN (1) TN2016000455A1 (es)
TW (1) TWI664165B (es)
UA (1) UA122391C2 (es)
UY (1) UY36091A (es)
WO (1) WO2015163485A1 (es)

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