AR062533A1 - Inhibidores de tipo i 11- beta hidroxiesteroide deshidrogenasa ciclicos - Google Patents

Inhibidores de tipo i 11- beta hidroxiesteroide deshidrogenasa ciclicos

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Publication number
AR062533A1
AR062533A1 ARP070103783A ARP070103783A AR062533A1 AR 062533 A1 AR062533 A1 AR 062533A1 AR P070103783 A ARP070103783 A AR P070103783A AR P070103783 A ARP070103783 A AR P070103783A AR 062533 A1 AR062533 A1 AR 062533A1
Authority
AR
Argentina
Prior art keywords
alkyl
heterocyclyl
cycloalkyl
aryl
heterocyclylalkyl
Prior art date
Application number
ARP070103783A
Other languages
English (en)
Inventor
Ramesh N Patel
Xiang-Yang Ye
Jeffrey A Robi
Ronald L Hanson
Zhiwei Guo
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR062533A1 publication Critical patent/AR062533A1/es

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Abstract

Compuestos inhibidores 11-beta-hidroxiesteroide deshidrogenasa tipo 1. Los inhibidores 11-beta-hidroxiesteroide deshidrogenasa tipo 1 son utiles para tratar, prevenir o disminuir la progresion de enfermedades que requieren la terapia del inhibidor 11-beta-hidroxiesteroide deshidrogenasa tipo 1, tales como diabetes tipo II, enfermedades cardiovasculares, obesidad y osteoporosis. También se divulga una composicion farmacéutica que comprende al compuesto y un proceso de preparacion del mismo. Reivindicacion 1: Un compuesto caracterizado porque tiene la formula (1), enantiomeros, diaestereomeros, solvatos o sales de los mismos en donde: A es un sistema de anillo bi, tri o policíclico no aromático de 5 hasta 20 miembros que opcionalmente contiene 1-3 heteroátomos seleccionados de N, O, S, S(O) y S(O)2, los cuales pueden opcionalmente substituirse con uno o más R4; X es -C(=O)OH, -C(=O)C(=O)OH, -C(=O)NR9R9, tetrazolilo, o -C(=O)NHS(O)2R9; W está ausente, -(CR8aR8b)m, -(CR8aR8b)m-O, - (CR8aR8b)m-N(R14)-, cicloalquilo C3-6, alquenilo o alquinilo, en donde el cicloalquilo o alquenilo puede ser opcionalmente substituido con uno o más R8a; m es 1-3; Z es -CN, alquilo C3-10, cicloalquilo, arilo, arilalquilo, heterociclilo o heterociclilalquilo, todos los cuales pueden opcionalmente substituirse con uno o más R4, y el heterociclilo y heterociclilalquilo contiene 1-4 heteroátomos seleccionados de N, O, y S; con la condicion de que W y Z, o cuando W está ausente, X y Z, se enlazan al mismo carbono en el Anillo A; R4, cada vez que se presenta, es independientemente seleccionado de hidrogeno, alquilo, arilo, alquenilo, alquinilo, cicloalquilo, heterociclilo, halo, =O, -NH2, -CN, -NO2, - C(=O)OH, -C(=O)OR10, -OR10, - OH, -OCF3, -SH, -SR10, -C(=O)NR9R9, -NR9R9, - S(O)2NR9R9, -NR9S(O)2CF3, -C(=O)NR9S(O)2R9, -S(O)2NR9C(=O)OR9, -S(O)2NR9C(=O)NR9R9, -C(=O)NR9S(O)2CF3 -C(=O)R10, -NR9C(=O)R10, -OC(=O)R10, -S(=O)R10, -S(O)2R10, -O-S(O)2R10, -NR9C(=O)OR8 o -NR9S(O2)R8, en donde el alquilo, arilo, alquenilo, alquinilo, cicloalquilo, o heterociclilo puede ser opcionalmente substituido con uno o más R5; R5, cada vez que se presenta, es independientemente seleccionado de hidrogeno, alquilo, haloalquilo, arilo, alquenilo, alquinilo, cicloalquilo, cicloalquilalquilo, heterociclilo, heterociclilalquilo, halo, -NH2, -CN, -NO2, -C(=O)OH, -C(=O)OR10, -OCF3, -OR10, -OH, -SH, -SR10, -C(=O)NR9R9, -NR9R9, -S(O)2NR9R9, -NR9S(O)2CF3, -C(=O)NR9S(O)2R9, - S(O)2NR9C(=O)OR9, -S(O)2NR9C(=O)NR9R9, C(=O)NR9S(O)2CF3, -C(=O)R10, -NR9C(=O)R10, -OC(=O)R10, -S(=O)R10, -S(O)2R10, -O-S(O)2R10, -NR9C(=O)OR8 o -NR9S(O2)R8; R8, cada vez que se presenta, es independientemente alquilo, arilo o heterociclilo; R8a, cada vez que se presenta, es independientemente hidrogeno, alquilo o arilo; R8b, cada vez que se presenta, es independientemente hidrogeno, -C(=O)OH, alquilo, -OH, halo, -CN, -OR10, -C(=O)R10 o -C(=O)NR9R9, en donde el alquilo puede ser opcionalmente substituido con uno o más R9a, o R8a y R8b se toman junto con el carbono al cual ambos se enlazan para formar un anillo de 3 hasta 7 miembros, el cual puede opcionalmente contener 1-4 heteroátomos seleccionados de N, O, y S y ser opcionalmente substituido con 0-3 R9a; R9, cada vez que se presenta, es independientemente hidrogeno, alquilo, alcoxi, cicloalquilo, arilo, arilalquilo, heterociclilo o heterociclilalquilo, en donde el alquilo, cicloalquilo, arilo, arilalquilo, heterociclilo o heterociclilalquilo puede ser opcionalmente substituido con 0-5 R9a, y el heterociclilo o heterociclilalquilo contiene 1-4 heteroátomos seleccionados de N, O, y S; o dos R9 junto con el nitrogeno al cual se enlazan forman un sistema de anillo cíclico insaturado, saturado o parcialmente saturado que contiene desde 2-10 átomos de carbono y desde 0-4 heteroátomos adicionales seleccionados de N, O, S, S(O) y S(O)2, en donde el sistema de anillo puede ser opcionalmente substituido o fusionado con uno o más R9a; R9a, cada vez que se presenta, es independientemente seleccionado de alquilo, haloalquilo, arilo, alquenilo, alquinilo, cicloalquilo, cicloalquilalquilo, heterociclilo, heterociclilalquilo, halo, =O, -NH2, -CN, -NO2, - C(=O)OH, -C(=O)OR14, -OCF3, -OR10, -OH, -OCF3, -SH, -SR14, -C(=O)NR14R14, -NR14R14, -S(O)2NR14R14, -NR14S(O)2CF3, -C(=O)NR14S(O)2R10, -S(O)2NR14C(=O)OR10, -S(O)2NR14C(=O)NR14R14, -C(=O)NR14S(O)2R14, -C(=O)R14, -NR14C(=O)R14, -OC(=O)R14, - C(=NR14)NR14R14, - NHC(=NR14)NR14R14, -S(=O)R14, -S(O)2R14, -OS(O)2R14, -NR14C(=O)OR10, -NR14S(O2)R8, -C(=O)R10, -OC(=O)NR14R14, -NR14C(=O)NR14R14 o arilalquilo, en donde el alquilo, arilo, cicloalquilo, cicloalquilalquilo, heterociclilo, y heterociclilalquilo puede ser opcionalmente substituido con 0-3 R10a; R10, cada vez que se presenta, es independientemente seleccionado de alquilo, cicloalquilo, alquenilo, alquinilo, arilo, arilalquilo, heterociclilo o heterociclilalquilo, en donde el alquilo, cicloalquilo, arilo, arilalquilo, heterociclilo o heterociclilalquilo puede ser opcionalmente substituido con 0-3 R10a, y el heterociclilo y heterociclilalquilo contiene 1-4 heteroátomos seleccionados de N, O, y S; R10a, cada vez que se presenta, es independientemente seleccionado de alquilo, haloalquilo, arilo, alquenilo, alquinilo, cicloalquilo, cicloalquilalquilo, heterociclilo, heterociclilalquilo, halo, -NH2, -CN, -NO2, -C(=O)OH, -C(=O)OR14, -OCF3, -OR14, -OH, -SH, -SR14, - C(=O)NR14R14, -NR14R14, -S(O)2NR14R14, -NR14S(O)2CF3, -C(=O)NR14S(O)2R14, -S(O)2NR14C(=O)OR14, -S(O)2NR14C(=O)NR14R14, -C(=O)NR14S(O)2CF3 -C(=O)R14, -NR14C(=O)R14, -OC(=O)R14, -C(=NR14)NR14R14, -NHC(=NR14)NR14R14, -S(=O)R14, -S(O)2R14, - NR14C(=O)OR8, -NR14S(O2)R8 o arilalquilo; R14, cada vez que se presenta, es independientemente seleccionado de hidrogeno, alquilo, cicloalquilo, arilo o arilalquilo, en donde el alquilo, cicloalquilo, arilo o arilalquilo puede ser opcionalmente substituido con 0-3 R14a; R14a, cada vez que se presenta, es independientemente seleccionado de alquilo, haloalquilo, arilo, alquenilo, alquinilo, cicloalquilo, cicloalquilalquilo, heterociclilo, heterociclilalquilo, halo, -NH2, -CN, -NO2, -C(=O)OH, -C(=O)OR15, -OCF3, -OR15, -OH, -SH, -SR15, -C(=O)NR15R15, -NR15R15, -S(O)2NR15R15, -NR15S(O)2CF3, -C(=O)NR15S(O)2R15, -S(O)2NR15C(=O)OR15, -S(O)2NR15C(=O)NR15R15, -C(=O)NR15S(O)2CF3, -C(=O)R15, -NR15C(=O)R15, -OC(=O)R15, -C(=NR15)NR15R15, - NHC(=NR15)NR15R15, -S(=O)R15, -S(O)2R15, -NR15C(=O)OR8, -NR15S(O2)R8 o arilalquilo; R15, cada vez que se presenta, es independientemente seleccionado de hidrogeno, alquilo, cicloalquilo, arilo o arilalquilo; y con la condicion de que: (i) cuando W está ausente, Z es fenilo, X es -C(=O)OH, alquilo inferior o tetrazolilo, A no es biciclo(2,2,1)heptanilo, biciclo(2,2,1 )heptenilo, biciclo(2,2,2)octanilo, o biciclo(2,2,2)octenilo; (ii) cuando W está ausente, Z es fenilo opcionalmente substituido, o heterociclilo, X es -C(=O)OH o -C(=O)NR9R9 y R9 es hidrogeno o alquilo inferior, A no es 8-azabiciclo(3.2.1))octanilo; (iii) el compuesto no es un compuesto de la estructura (2) en donde R es fenilo opcionalmente substituido; (iv) el compuesto no es un compuesto de la estructura (3); (v) el compuesto no es un compuesto de la estructura (4); (vi) el compuesto no es un compuesto de la estructura (5); y (vii) el compuesto no es un compuesto de la estructura (6).
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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7727978B2 (en) * 2006-08-24 2010-06-01 Bristol-Myers Squibb Company Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US8119658B2 (en) 2007-10-01 2012-02-21 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
AU2009225647C1 (en) * 2008-03-19 2015-11-19 Aurimmed Pharma, Inc. Novel compounds advantageous in the treatment of central nervous system diseases and disorders
GB0811643D0 (en) 2008-06-25 2008-07-30 Cancer Rec Tech Ltd New therapeutic agents
JP5600104B2 (ja) 2008-08-01 2014-10-01 ベンティアールエックス ファーマシューティカルズ， インコーポレイテッド Ｔｏｌｌ様受容体アゴニスト処方物およびその使用
ES2705101T3 (es) 2008-11-06 2019-03-21 Ventirx Pharmaceuticals Inc Métodos de síntesis de derivados de benzazepinas
EP2243479A3 (en) 2009-04-20 2011-01-19 Abbott Laboratories Novel amide and amidine derivates and uses thereof
EP2467380B1 (en) 2009-08-18 2016-11-30 Ventirx Pharmaceuticals, Inc. Substituted benzoazepines as toll-like receptor modulators
CN105669553A (zh) 2009-08-18 2016-06-15 文蒂雷克斯药品公司 作为toll样受体调节剂的取代的苯并氮杂*
US8871208B2 (en) * 2009-12-04 2014-10-28 Abbvie Inc. 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN104144927B (zh) 2011-12-23 2016-08-24 明治制果药业株式会社 S1p受体调节剂
WO2015061272A1 (en) 2013-10-22 2015-04-30 Bristol-Myers Squibb Company Isotopically labeled triazolopyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors
GB201517217D0 (en) 2015-09-29 2015-11-11 Astex Therapeutics Ltd And Cancer Res Technology Ltd Pharmaceutical compounds
GB201517216D0 (en) 2015-09-29 2015-11-11 Cancer Res Technology Ltd And Astex Therapeutics Ltd Pharmaceutical compounds
GB201704965D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
GB201704966D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
WO2019018185A1 (en) 2017-07-15 2019-01-24 Arisan Therapeutics Inc. ENANTIOMERICALLY PURE ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTIONS

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL99113C (es) * 1956-06-16
US3674836A (en) 1968-05-21 1972-07-04 Parke Davis & Co 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
US4027009A (en) 1973-06-11 1977-05-31 Merck & Co., Inc. Compositions and methods for depressing blood serum cholesterol
JPS5612114B2 (es) 1974-06-07 1981-03-18
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
US4450171A (en) 1980-08-05 1984-05-22 Merck & Co., Inc. Antihypercholesterolemic compounds
US4448784A (en) 1982-04-12 1984-05-15 Hoechst-Roussel Pharmaceuticals, Inc. 1-(Aminoalkylphenyl and aminoalkylbenzyl)-indoles and indolines and analgesic method of use thereof
US5354772A (en) 1982-11-22 1994-10-11 Sandoz Pharm. Corp. Indole analogs of mevalonolactone and derivatives thereof
FR2547814B1 (fr) 1983-06-22 1985-10-18 Sanofi Sa Derives de l'acide bicyclo (3.2.1.) octane carboxylique, leur procede de preparation et leur application therapeutique
US4691051A (en) * 1985-01-04 1987-09-01 Pennwalt Corporation Adamantyl phenyl β-alanines
US4681893A (en) 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4759923A (en) 1987-06-25 1988-07-26 Hercules Incorporated Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
JP2569746B2 (ja) 1987-08-20 1997-01-08 日産化学工業株式会社 キノリン系メバロノラクトン類
NO177005C (no) 1988-01-20 1995-07-05 Bayer Ag Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5177080A (en) 1990-12-14 1993-01-05 Bayer Aktiengesellschaft Substituted pyridyl-dihydroxy-heptenoic acid and its salts
WO1992018132A1 (en) 1991-04-17 1992-10-29 Merck & Co., Inc. Pharmaceutical combination for the treatment of benign prostatic hyperplasia comtaining a 5 alpha-reductase inhibitor
JP2648897B2 (ja) 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
US5595872A (en) 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
US5594016A (en) 1992-12-28 1997-01-14 Mitsubishi Chemical Corporation Naphthalene derivatives
ATE178794T1 (de) 1993-01-19 1999-04-15 Warner Lambert Co Stabilisierte, oral anzuwendende zusammensetzung enthaltend die verbindung ci-981 und verfahren
US5739135A (en) 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
IL111175A0 (en) 1993-10-07 1994-12-29 Du Pont Merck Pharma Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them
US5776983A (en) 1993-12-21 1998-07-07 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
US5488064A (en) 1994-05-02 1996-01-30 Bristol-Myers Squibb Company Benzo 1,3 dioxole derivatives
US5385929A (en) 1994-05-04 1995-01-31 Warner-Lambert Company [(Hydroxyphenylamino) carbonyl] pyrroles
FR2723317B1 (fr) 1994-08-04 1996-10-31 Sanofi Sa Utilisation d'antagonistes de la neurotensine pour la preparation de medicaments diuretiques
US5612359A (en) 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
US5491134A (en) 1994-09-16 1996-02-13 Bristol-Myers Squibb Company Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives
US5541204A (en) 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
US5620997A (en) 1995-05-31 1997-04-15 Warner-Lambert Company Isothiazolones
AU6966696A (en) 1995-10-05 1997-04-28 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
WO1997021993A2 (en) 1995-12-13 1997-06-19 The Regents Of The University Of California Nuclear receptor ligands and ligand binding domains
NZ331142A (en) 1996-03-14 2001-04-27 Warner Lambert Co Bridged cyclic amino acids as pharmaceutical agents
US5770615A (en) 1996-04-04 1998-06-23 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
US5962440A (en) 1996-05-09 1999-10-05 Bristol-Myers Squibb Company Cyclic phosphonate ester inhibitors of microsomal triglyceride transfer protein and method
US5885983A (en) 1996-05-10 1999-03-23 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5827875A (en) 1996-05-10 1998-10-27 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
DZ2285A1 (fr) 1996-08-08 2002-12-25 Smithkline Beecham Corp Inhibiteurs de protéase de la cystéine.
GB9624611D0 (en) 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
US5760246A (en) 1996-12-17 1998-06-02 Biller; Scott A. Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
TW536540B (en) 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
US6242615B1 (en) * 1997-03-28 2001-06-05 Zeneca Limited Process for the preparation of N-(3-hydroxy-succinyl)-amino acid derivatives
GB9713739D0 (en) 1997-06-27 1997-09-03 Karobio Ab Thyroid receptor ligands
JP2001526178A (ja) 1997-08-28 2001-12-18 メルク エンド カムパニー インコーポレーテッド ピロリジン系およびピペリジン系ケモカイン受容体活性調節剤
UA57811C2 (uk) 1997-11-21 2003-07-15 Пфайзер Продактс Інк. Фармацевтична композиція, що містить інгібітор альдозоредуктази та інгібітор глікогенфосфорилази (варіанти), комплект, який її включає, та способи лікування ссавців зі станом інсулінорезистентності
PL341291A1 (en) 1997-12-16 2001-04-09 Warner Lambert Co 1-substituted derivatives of 1-aminomethyl-ccycloalkanes (gabapentin analogues), their production and application of them in treating neurological disorders
EP1051431A1 (de) 1998-01-26 2000-11-15 Basf Aktiengesellschaft Thrombininhibitoren
IL136588A0 (en) 1998-02-27 2001-06-14 Pfizer Prod Inc N-[(substituted five-membered di-or triaza diunsaturated ring) carbonyl] guanidine derivatives for the treatment of ischemia
AU767456B2 (en) 1998-07-06 2003-11-13 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
GB9828442D0 (en) 1998-12-24 1999-02-17 Karobio Ab Novel thyroid receptor ligands and method II
HUP9900445A2 (hu) * 1999-02-24 2001-06-28 EGIS Gyógyszergyár Rt. Eljárás (1R,2S,4R)-(-)-N,N-(dimetilamino-etoxi)-2-fenil-1,7,7-trimetil-biciklo[2.2.1]heptán előállítására és ennek köztiterméke
US6548529B1 (en) 1999-04-05 2003-04-15 Bristol-Myers Squibb Company Heterocyclic containing biphenyl aP2 inhibitors and method
TWI260321B (en) 1999-09-22 2006-08-21 Bristol Myers Squibb Co Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
PH12000002657B1 (en) 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
WO2001060818A1 (en) 2000-02-14 2001-08-23 Tularik Inc. Lxr modulators
US6620829B2 (en) * 2000-10-17 2003-09-16 Warner-Lambert Company Method of treating noninflammatory cartilage damage
ATE366248T1 (de) * 2001-03-27 2007-07-15 Eisai R&D Man Co Ltd N-aryl-substituiertes cyclisches aminderivat und medizin, die dieses als wirkstoff enthält
JP4776810B2 (ja) 2001-05-30 2011-09-21 日本曹達株式会社 α位トリ置換酢酸の製造方法
MXPA03011566A (es) * 2001-06-11 2004-10-28 Xenoport Inc Formas de dosificacion de profarmacos de analogos de gaba administrados oralmente que tienen toxicidad reducida.
US20030114460A1 (en) * 2001-12-14 2003-06-19 Allergan Sales, Inc. Pharmaceutical conjugates with enhanced pharmacokinetic characteristics
MXPA04004105A (es) 2002-01-31 2004-11-29 Warner Lambert Co Metodo de tratamiento de tinnitus.
WO2003065983A2 (en) 2002-02-01 2003-08-14 Merck & Co., Inc. 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia
TW200401635A (en) * 2002-07-23 2004-02-01 Yamanouchi Pharma Co Ltd 2-Cyano-4-fluoropyrrolidine derivative or salt thereof
JP4012016B2 (ja) * 2002-08-29 2007-11-21 キヤノン株式会社 画像処理装置、画像処理方法、記憶媒体、及びプログラム
US20040209858A1 (en) * 2002-10-22 2004-10-21 Bennani Youssef L. Cycloalkylamides and their therapeutic applications
WO2004056744A1 (en) * 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
TW200503994A (en) 2003-01-24 2005-02-01 Novartis Ag Organic compounds
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
US20060094699A1 (en) * 2003-04-11 2006-05-04 Kampen Gita Camilla T Combination therapy using an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist to minimize the side effects associated with glucocorticoid receptor agonist therapy
US7501405B2 (en) * 2003-04-11 2009-03-10 High Point Pharmaceuticals, Llc Combination therapy using an 11β-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders
WO2004089416A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S Combination of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent
EP1615698B1 (en) 2003-04-11 2010-09-29 High Point Pharmaceuticals, LLC New amide derivatives and pharmaceutical use thereof
US7700583B2 (en) * 2003-04-11 2010-04-20 High Point Pharmaceuticals, Llc 11β-hydroxysteroid dehydrogenase type 1 active compounds
WO2004089415A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S COMBINATIONS OF AN 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST
TW200528440A (en) * 2003-10-31 2005-09-01 Fujisawa Pharmaceutical Co 2-cyanopyrrolidinecarboxamide compound
WO2005097738A1 (ja) * 2004-04-06 2005-10-20 Dainippon Sumitomo Pharma Co., Ltd. 新規スルホンアミド誘導体
US7880001B2 (en) * 2004-04-29 2011-02-01 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
US20090062401A1 (en) 2004-12-31 2009-03-05 Universitat Dortmund Decaline-derived compounds as pharmaceutically active agents
CN102816081A (zh) * 2005-01-05 2012-12-12 雅培制药有限公司 11-β-羟甾类脱氢酶1型酶的抑制剂
EP1846363B1 (en) 2005-01-05 2012-04-25 Abbott Laboratories Adamantyl derivatives as inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US20060148871A1 (en) * 2005-01-05 2006-07-06 Rohde Jeffrey J Metabolic stabilization of substituted adamantane
WO2007038452A1 (en) 2005-09-28 2007-04-05 Merck & Co., Inc. Process for synthesizing 1,2,4-triazoles
BRPI0617501A2 (pt) 2005-10-20 2011-07-26 Merck & Co Inc composto ou um sal ou solvato farmaceuticamente aceitÁvel do mesmo, composiÇço farmacÊutica, e, uso de um composto
EP1801098A1 (en) 2005-12-16 2007-06-27 Merck Sante 2-Adamantylurea derivatives as selective 11B-HSD1 inhibitors
US8217177B2 (en) * 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
PE20080403A1 (es) * 2006-07-14 2008-04-25 Amgen Inc Derivados heterociclicos fusionados y metodos de uso
US7727978B2 (en) * 2006-08-24 2010-06-01 Bristol-Myers Squibb Company Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors

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