AR062508A1 - Derivados de 4-(n-azacicloaquil) anilidas como moduladores de los canales de potasio - Google Patents
Derivados de 4-(n-azacicloaquil) anilidas como moduladores de los canales de potasioInfo
- Publication number
- AR062508A1 AR062508A1 ARP070103756A ARP070103756A AR062508A1 AR 062508 A1 AR062508 A1 AR 062508A1 AR P070103756 A ARP070103756 A AR P070103756A AR P070103756 A ARP070103756 A AR P070103756A AR 062508 A1 AR062508 A1 AR 062508A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- chr6
- cycloalkyl
- independently selected
- 3alkyl
- Prior art date
Links
- 102000004257 Potassium Channel Human genes 0.000 title abstract 3
- 108020001213 potassium channel Proteins 0.000 title abstract 3
- 229940051881 anilide analgesics and antipyretics Drugs 0.000 title 1
- 150000003931 anilides Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 13
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 229910052760 oxygen Inorganic materials 0.000 abstract 5
- 229910052717 sulfur Inorganic materials 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- -1 2- (N, N-dimethylamino) ethyl Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 1
- 108010081348 HRT1 protein Hairy Proteins 0.000 abstract 1
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83994106P | 2006-08-23 | 2006-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062508A1 true AR062508A1 (es) | 2008-11-12 |
Family
ID=39107384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103756A AR062508A1 (es) | 2006-08-23 | 2007-08-23 | Derivados de 4-(n-azacicloaquil) anilidas como moduladores de los canales de potasio |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8293911B2 (enExample) |
| EP (1) | EP2061465B1 (enExample) |
| JP (1) | JP5419691B2 (enExample) |
| KR (1) | KR20090079191A (enExample) |
| CN (1) | CN101563085A (enExample) |
| AR (1) | AR062508A1 (enExample) |
| AU (1) | AU2007288253B2 (enExample) |
| BR (1) | BRPI0716715B1 (enExample) |
| CA (1) | CA2661462C (enExample) |
| CL (1) | CL2007002455A1 (enExample) |
| DK (1) | DK2061465T3 (enExample) |
| ES (1) | ES2420960T3 (enExample) |
| IL (1) | IL197161A (enExample) |
| MX (1) | MX2009002002A (enExample) |
| NO (1) | NO343575B1 (enExample) |
| NZ (1) | NZ575652A (enExample) |
| PL (1) | PL2061465T3 (enExample) |
| PT (1) | PT2061465E (enExample) |
| RU (1) | RU2009110172A (enExample) |
| SG (1) | SG174095A1 (enExample) |
| TW (1) | TW200827339A (enExample) |
| WO (1) | WO2008024398A2 (enExample) |
| ZA (1) | ZA200901977B (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050089559A1 (en) * | 2003-10-23 | 2005-04-28 | Istvan Szelenyi | Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
| WO2006020049A2 (en) | 2004-07-15 | 2006-02-23 | Amr Technology, Inc. | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| US7960436B2 (en) | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
| US20080045534A1 (en) * | 2006-08-18 | 2008-02-21 | Valeant Pharmaceuticals North America | Derivatives of 1,3-diamino benzene as potassium channel modulators |
| EP2061465B1 (en) | 2006-08-23 | 2013-04-10 | Valeant Pharmaceuticals International | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
| US8993593B2 (en) * | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| US8722929B2 (en) * | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
| JP2010511052A (ja) | 2006-11-28 | 2010-04-08 | バレアント ファーマシューティカルズ インターナショナル | カリウムチャネル調節因子としての１，４ジアミノ二環式レチガビンアナログ |
| US8367684B2 (en) * | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| US8563566B2 (en) * | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| US7786146B2 (en) | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| US8188314B2 (en) * | 2008-06-24 | 2012-05-29 | Valeant Pharmaceuticals International | Benzyloxy anilide derivatives useful as potassium channel modulators |
| TW201041857A (en) * | 2009-05-11 | 2010-12-01 | Lundbeck & Co As H | Stable forms of N-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl-butyramide |
| WO2010132487A1 (en) | 2009-05-12 | 2010-11-18 | Bristol-Myers Squibb Company | CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF |
| WO2010132442A1 (en) | 2009-05-12 | 2010-11-18 | Albany Molecular Reserch, Inc. | 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof |
| US9034899B2 (en) | 2009-05-12 | 2015-05-19 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
| MX2013000138A (es) * | 2010-07-08 | 2013-03-05 | Pfizer | Amidas de piperidinil pirimidina como abridores de canales de potasio de kv7. |
| IN2014CN02805A (enExample) | 2011-10-14 | 2015-07-03 | Bristol Myers Squibb Co | |
| UY34393A (es) | 2011-10-14 | 2013-04-30 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Compuestos de tetrahidroisoquinolina sustituidos como inhibidores del factor xia |
| CN103987697B (zh) | 2011-10-14 | 2017-04-26 | 百时美施贵宝公司 | 作为因子xia抑制剂的取代的四氢异喹啉化合物 |
| CN103073455B (zh) | 2011-10-25 | 2015-08-19 | 中国科学院上海药物研究所 | 一类新型的kcnq钾通道激动剂、其制备方法和用途 |
| CN108250128A (zh) * | 2012-09-27 | 2018-07-06 | 江苏先声药业有限公司 | 作为钾通道调节剂的化合物 |
| US9738655B2 (en) | 2013-03-25 | 2017-08-22 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor XIa inhibitors |
| MX2018015251A (es) * | 2016-06-10 | 2019-04-25 | Scifluor Life Sciences Inc | Derivados de 2-amino-4-(amino sustituido)fenil carbamato fluorinado. |
| US10329516B2 (en) * | 2016-12-20 | 2019-06-25 | International Flavors & Fragrances Inc. | Organoleptic compounds |
| AU2018384803A1 (en) * | 2017-12-13 | 2020-06-25 | Scifluor Life Sciences, Inc. | Fluorinated 4-(substituted amino)phenyl carbamate derivatives |
| EP3737677B1 (en) | 2018-01-10 | 2021-11-03 | Allinky Biopharma | Tetrahydroisoquinoline compounds |
| CN120549929A (zh) * | 2018-05-11 | 2025-08-29 | 泽农医药公司 | 用于增强生物利用度和电压门控钾离子通道开放暴露的方法 |
| CN110511220B (zh) | 2018-05-22 | 2022-04-01 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的对二氨基苯衍生物、其制备方法及其在医药上的应用 |
| WO2020086456A1 (en) | 2018-10-22 | 2020-04-30 | Cadent Therapeutics, Inc. | Crystalline forms of potassium channel modulators |
| ES3034157T3 (en) | 2019-01-29 | 2025-08-13 | Univ Degli Studi Di Salerno | Modulators of potassium ion channels and uses thereof |
| TWI886158B (zh) * | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| BR112022008580A2 (pt) | 2019-11-08 | 2022-08-09 | Xenon Pharmaceuticals Inc | Métodos para tratar transtornos depressivos |
| CR20220318A (es) * | 2019-12-06 | 2022-10-07 | Xenon Pharmaceuticals Inc | Uso de un abridor de canal de potasio kv7 para tratar el dolor |
| CN114057641B (zh) * | 2020-08-07 | 2025-02-18 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的四氢异喹啉类化合物及其制备和应用 |
| WO2022173853A1 (en) | 2021-02-09 | 2022-08-18 | Xenon Pharmaceuticals Inc. | Conjoint therapy for treating seizure disorders |
| IL304920A (en) | 2021-02-09 | 2023-10-01 | Xenon Pharmaceuticals Inc | A voltage-gated potassium channel opener for use in the treatment of anhedonia |
| US20240317689A1 (en) * | 2021-08-26 | 2024-09-26 | Neushen Therapeutics (Shanghai) Co., Ltd | Potassium channel modulator, composition and application |
| KR102694996B1 (ko) * | 2021-10-27 | 2024-08-13 | 상하이 지멍 바이오파마 아이엔씨 | 칼륨 채널 조절제로 사용되는 화합물 및 이의 제조 및 응용 |
| CN113698345B (zh) * | 2021-10-27 | 2022-02-01 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的化合物及其制备和应用 |
| TW202333693A (zh) * | 2021-12-31 | 2023-09-01 | 大陸商上海翰森生物醫藥科技有限公司 | 苯并哌啶衍生物調節劑、其製備方法和應用 |
| CN116478068A (zh) | 2022-01-14 | 2023-07-25 | 中国科学院上海药物研究所 | 一种高选择性kcnq4钾通道激动剂、其制备方法和用途 |
| CN116535353A (zh) * | 2022-01-25 | 2023-08-04 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的酰胺类化合物及其制备和应用 |
| US20240101531A1 (en) * | 2022-06-08 | 2024-03-28 | Xenon Pharmaceuticals Inc. | Pyridinamine derivatives and their use as potassium channel modulators |
| JP2025529129A (ja) * | 2022-08-30 | 2025-09-04 | バイオヘイブン・セラピューティクス・リミテッド | 金属チャネル活性化剤及びｎｍｄａ受容体拮抗薬を含む併用療法 |
| CN119948023A (zh) * | 2022-09-30 | 2025-05-06 | 上海翰森生物医药科技有限公司 | 含哌啶多环类衍生物调节剂、其制备方法和应用 |
| WO2025038920A1 (en) | 2023-08-17 | 2025-02-20 | Xenon Pharmaceuticals, Inc. | Heteroaryl amine compounds and uses thereof |
| TW202521516A (zh) | 2023-08-17 | 2025-06-01 | 加拿大商再諾製藥公司 | 氮雜環庚烷及吡咯啶化合物及其用途 |
| WO2025064502A1 (en) * | 2023-09-19 | 2025-03-27 | Xenon Pharmaceuticals Inc. | Deuterium and aryl amine compounds and uses thereof |
| WO2025167886A1 (zh) * | 2024-02-08 | 2025-08-14 | 上海挚盟医药科技有限公司 | 四氢异喹啉基化合物的晶型及其应用 |
| WO2025179128A1 (en) | 2024-02-22 | 2025-08-28 | Xenon Pharmaceuticals Inc. | Azetukalner for use in the treatment of depression, anhedonia or a seizure disorder such as epilepsy in pediatric subjects |
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2007
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- 2007-08-22 CA CA2661462A patent/CA2661462C/en active Active
- 2007-08-22 US US11/894,877 patent/US8293911B2/en active Active
- 2007-08-22 BR BRPI0716715-6A patent/BRPI0716715B1/pt active IP Right Grant
- 2007-08-22 KR KR1020097005943A patent/KR20090079191A/ko not_active Withdrawn
- 2007-08-22 MX MX2009002002A patent/MX2009002002A/es active IP Right Grant
- 2007-08-22 AU AU2007288253A patent/AU2007288253B2/en active Active
- 2007-08-22 PT PT78371994T patent/PT2061465E/pt unknown
- 2007-08-22 NZ NZ575652A patent/NZ575652A/en unknown
- 2007-08-22 WO PCT/US2007/018571 patent/WO2008024398A2/en not_active Ceased
- 2007-08-22 SG SG2011060944A patent/SG174095A1/en unknown
- 2007-08-22 RU RU2009110172/15A patent/RU2009110172A/ru not_active Application Discontinuation
- 2007-08-22 DK DK07837199.4T patent/DK2061465T3/da active
- 2007-08-22 PL PL07837199T patent/PL2061465T3/pl unknown
- 2007-08-22 JP JP2009525618A patent/JP5419691B2/ja active Active
- 2007-08-22 ES ES07837199T patent/ES2420960T3/es active Active
- 2007-08-22 CN CNA2007800392650A patent/CN101563085A/zh active Pending
- 2007-08-23 TW TW096131287A patent/TW200827339A/zh unknown
- 2007-08-23 CL CL200702455A patent/CL2007002455A1/es unknown
- 2007-08-23 AR ARP070103756A patent/AR062508A1/es unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0716715A2 (pt) | 2013-09-03 |
| ZA200901977B (en) | 2010-02-24 |
| PT2061465E (pt) | 2013-07-15 |
| EP2061465B1 (en) | 2013-04-10 |
| JP5419691B2 (ja) | 2014-02-19 |
| WO2008024398B1 (en) | 2008-08-14 |
| AU2007288253A1 (en) | 2008-02-28 |
| MX2009002002A (es) | 2009-07-22 |
| CA2661462A1 (en) | 2008-02-28 |
| ES2420960T3 (es) | 2013-08-28 |
| NZ575652A (en) | 2011-08-26 |
| JP2010501568A (ja) | 2010-01-21 |
| RU2009110172A (ru) | 2010-09-27 |
| SG174095A1 (en) | 2011-09-29 |
| DK2061465T3 (da) | 2013-07-08 |
| TW200827339A (en) | 2008-07-01 |
| CA2661462C (en) | 2015-09-29 |
| WO2008024398A3 (en) | 2008-06-26 |
| IL197161A (en) | 2015-07-30 |
| AU2007288253B2 (en) | 2013-05-02 |
| NO343575B1 (no) | 2019-04-08 |
| CN101563085A (zh) | 2009-10-21 |
| WO2008024398A2 (en) | 2008-02-28 |
| KR20090079191A (ko) | 2009-07-21 |
| BRPI0716715B1 (pt) | 2021-07-06 |
| IL197161A0 (en) | 2009-12-24 |
| EP2061465A2 (en) | 2009-05-27 |
| EP2061465A4 (en) | 2011-03-16 |
| PL2061465T3 (pl) | 2014-03-31 |
| CL2007002455A1 (es) | 2008-04-18 |
| US8293911B2 (en) | 2012-10-23 |
| US20080139610A1 (en) | 2008-06-12 |
| NO20091183L (no) | 2009-05-08 |
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