AR061619A1 - Inhibidores de proteasa de hiv de 2-(amino-sustituido)- benzotiazol sulfonamida - Google Patents
Inhibidores de proteasa de hiv de 2-(amino-sustituido)- benzotiazol sulfonamidaInfo
- Publication number
- AR061619A1 AR061619A1 ARP070102776A ARP070102776A AR061619A1 AR 061619 A1 AR061619 A1 AR 061619A1 AR P070102776 A ARP070102776 A AR P070102776A AR P070102776 A ARP070102776 A AR P070102776A AR 061619 A1 AR061619 A1 AR 061619A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- ring members
- substituted
- amino
- optionally
- Prior art date
Links
- 239000004030 hiv protease inhibitor Substances 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 150000003456 sulfonamides Chemical class 0.000 title 1
- -1 hydroxy, acetyl Chemical group 0.000 abstract 7
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000002619 bicyclic group Chemical group 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical class *C#N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 125000000169 tricyclic heterocycle group Chemical group 0.000 abstract 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06116003 | 2006-06-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR061619A1 true AR061619A1 (es) | 2008-09-10 |
Family
ID=37596252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102776A AR061619A1 (es) | 2006-06-23 | 2007-06-22 | Inhibidores de proteasa de hiv de 2-(amino-sustituido)- benzotiazol sulfonamida |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8202887B2 (enExample) |
| EP (1) | EP2035432B1 (enExample) |
| JP (1) | JP5232776B2 (enExample) |
| KR (1) | KR101419320B1 (enExample) |
| CN (1) | CN101479275B (enExample) |
| AP (1) | AP2069A (enExample) |
| AR (1) | AR061619A1 (enExample) |
| AT (1) | ATE544769T1 (enExample) |
| AU (1) | AU2007262943B2 (enExample) |
| BR (1) | BRPI0713487B1 (enExample) |
| CA (1) | CA2653233C (enExample) |
| CL (1) | CL2007001826A1 (enExample) |
| CY (1) | CY1112971T1 (enExample) |
| DK (1) | DK2035432T3 (enExample) |
| EA (1) | EA016387B1 (enExample) |
| ES (1) | ES2381129T3 (enExample) |
| IL (1) | IL195381A (enExample) |
| JO (1) | JO2841B1 (enExample) |
| MX (1) | MX2009000160A (enExample) |
| MY (1) | MY146805A (enExample) |
| NZ (1) | NZ573286A (enExample) |
| PE (1) | PE20080342A1 (enExample) |
| PL (1) | PL2035432T3 (enExample) |
| PT (1) | PT2035432E (enExample) |
| SI (1) | SI2035432T1 (enExample) |
| TW (1) | TWI415851B (enExample) |
| UA (1) | UA96445C2 (enExample) |
| UY (1) | UY30416A1 (enExample) |
| WO (1) | WO2007147884A1 (enExample) |
| ZA (1) | ZA200810350B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3090B1 (ar) | 2009-12-11 | 2017-03-15 | Janssen Sciences Ireland Uc | 5- امينو-4- هيدروكسي-بنتويل اميدات |
| EP2588455B1 (en) | 2010-07-02 | 2018-04-04 | Gilead Sciences, Inc. | 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds |
| CN103140474A (zh) | 2010-07-02 | 2013-06-05 | 吉里德科学公司 | 治疗aids的萘-2-基乙酸衍生物 |
| US9024038B2 (en) * | 2010-12-27 | 2015-05-05 | Purdue Research Foundation | Compunds and methods for treating HIV |
| MX2013012266A (es) | 2011-04-21 | 2013-11-22 | Gilead Sciences Inc | Compuestos de benzotiazol y su uso farmaceutico. |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
| ES2571479T3 (es) | 2012-04-20 | 2016-05-25 | Gilead Sciences Inc | Derivados del ácido benzotiazol-6-il acético y su uso para tratar una infección por VIH |
| WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1370543B1 (en) * | 2001-02-14 | 2006-10-25 | Tibotec Pharmaceuticals Ltd. | Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors |
| AR037797A1 (es) * | 2001-12-12 | 2004-12-01 | Tibotec Pharm Ltd | Combinacion de inhibidores de proteasa dependientes del citocromo p450 |
| BR0305717A (pt) * | 2002-08-02 | 2004-09-28 | Tibotec Pharm Ltd | Inibidores da protease do hiv 2-amino-benzotiazol sulfonamida de amplo espectro |
| PT1670448E (pt) * | 2003-09-30 | 2008-02-11 | Tibotec Pharm Ltd | Sulfonamidas inibidoras de hcv |
-
2007
- 2007-06-04 JO JO2007212A patent/JO2841B1/en active
- 2007-06-15 UY UY30416A patent/UY30416A1/es not_active Application Discontinuation
- 2007-06-21 CL CL2007001826A patent/CL2007001826A1/es unknown
- 2007-06-22 AR ARP070102776A patent/AR061619A1/es active IP Right Grant
- 2007-06-22 EA EA200970052A patent/EA016387B1/ru not_active IP Right Cessation
- 2007-06-22 PT PT07765554T patent/PT2035432E/pt unknown
- 2007-06-22 TW TW096122406A patent/TWI415851B/zh not_active IP Right Cessation
- 2007-06-22 AT AT07765554T patent/ATE544769T1/de active
- 2007-06-22 AU AU2007262943A patent/AU2007262943B2/en not_active Ceased
- 2007-06-22 UA UAA200813950A patent/UA96445C2/ru unknown
- 2007-06-22 NZ NZ573286A patent/NZ573286A/en not_active IP Right Cessation
- 2007-06-22 WO PCT/EP2007/056235 patent/WO2007147884A1/en not_active Ceased
- 2007-06-22 KR KR1020097000754A patent/KR101419320B1/ko not_active Expired - Fee Related
- 2007-06-22 MY MYPI20085209A patent/MY146805A/en unknown
- 2007-06-22 US US12/304,990 patent/US8202887B2/en not_active Expired - Fee Related
- 2007-06-22 AP AP2008004679A patent/AP2069A/en active
- 2007-06-22 BR BRPI0713487-8A patent/BRPI0713487B1/pt not_active IP Right Cessation
- 2007-06-22 MX MX2009000160A patent/MX2009000160A/es active IP Right Grant
- 2007-06-22 CA CA2653233A patent/CA2653233C/en active Active
- 2007-06-22 PE PE2007000802A patent/PE20080342A1/es active IP Right Grant
- 2007-06-22 CN CN2007800236807A patent/CN101479275B/zh active Active
- 2007-06-22 SI SI200730904T patent/SI2035432T1/sl unknown
- 2007-06-22 PL PL07765554T patent/PL2035432T3/pl unknown
- 2007-06-22 DK DK07765554.6T patent/DK2035432T3/da active
- 2007-06-22 ES ES07765554T patent/ES2381129T3/es active Active
- 2007-06-22 EP EP07765554A patent/EP2035432B1/en active Active
- 2007-06-22 JP JP2009515891A patent/JP5232776B2/ja not_active Expired - Fee Related
-
2008
- 2008-11-19 IL IL195381A patent/IL195381A/en active IP Right Grant
- 2008-12-05 ZA ZA200810350A patent/ZA200810350B/xx unknown
-
2012
- 2012-05-08 CY CY20121100429T patent/CY1112971T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO6210724A2 (es) | Compuesto heterociclico y composicion farmaceutica del mismo | |
| MX2013012079A (es) | Emulsion de cera para uso en productos para la construccion. | |
| AR073369A1 (es) | Derivados de 2-carboxamida-cicloamino-urea como inhibidores de pi-3 | |
| ECSP088965A (es) | Derivados de 2-tioxantina que actúan como inhibidores de la mpo | |
| AR061548A1 (es) | 3-aminopirrolidino-4-lactamas sustituidas como inhibidoras de dipeptidilpeptidasa iv (dpp-iv), composiciones farmaceuticas que las comprenden y el uso de las mismas en el tratamiento de la diabetes ii. | |
| CO6230986A2 (es) | Compuesto de 4-piridinona y su uso para cancer | |
| NI201400099A (es) | Composición para el control de plagas que incluye un derivado de iminopiridina novedoso | |
| AR084588A1 (es) | Compuesto heterociclico fusionado y su uso para el control de plagas | |
| ES2722409T3 (es) | Moduladores de ROR gamma (RORy) | |
| CO6321230A2 (es) | Compuesto espiro, una sal aceptable para uso farmaceutico y un solvato del mismo y composicion farmaceutica que lo contenga | |
| CO5611131A2 (es) | Derivados de 5-feniltiazol y su uso como inhibidores de pi3 cinasa | |
| AR079205A1 (es) | Morfolinotiazoles como moduladores alostericos positivos alfa 7 | |
| AR087196A1 (es) | Metodos plaguicidas que utilizan compuestos de 3-piridil tiazol sustituido y derivados para combatir las plagas de animales ii | |
| AR064635A1 (es) | Derivados de benzotiazolona | |
| CO5611167A2 (es) | Composiciones farmaceuticas para inhibidores de proteasa viral de la hepatitis c | |
| CO2018010787A2 (es) | Compuesto de griseofulvina | |
| CO4940477A1 (es) | Inhibidores de proteasa | |
| CO6351734A2 (es) | Compuestos de amida utiles en terapia | |
| ES2663717T3 (es) | Síntesis de derivados de 2-carboxamida-cicloamino-urea | |
| AR124379A1 (es) | N-(2-(4-cianotiazolidin-3-il)-2-oxoetil)-quinolin-4-carboxamidas | |
| CO6260009A2 (es) | Derivados de ariloxiacetamida bi-o triciclicos saturados e insaturados y su uso como fungicidas | |
| AR077525A1 (es) | 4-aril-butan-1,3-diamidas y composiciones farmaceuticas | |
| AR088816A1 (es) | Proceso para preparar derivados de 1-acil-4-fenilsulfonilprolinamida y compuestos intermediarios | |
| CO6321159A2 (es) | Compuestos pirazina fusionados utiles para el tratamiento de enfermedades degenerativas e inflamatorias | |
| AR049770A1 (es) | Derivados de piperidina como moduladores de la actividad de quimioquinas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |