AR124379A1 - N-(2-(4-cianotiazolidin-3-il)-2-oxoetil)-quinolin-4-carboxamidas - Google Patents
N-(2-(4-cianotiazolidin-3-il)-2-oxoetil)-quinolin-4-carboxamidasInfo
- Publication number
- AR124379A1 AR124379A1 ARP210103519A ARP210103519A AR124379A1 AR 124379 A1 AR124379 A1 AR 124379A1 AR P210103519 A ARP210103519 A AR P210103519A AR P210103519 A ARP210103519 A AR P210103519A AR 124379 A1 AR124379 A1 AR 124379A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- ring
- halogen
- ring atoms
- Prior art date
Links
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 18
- 229910052736 halogen Inorganic materials 0.000 abstract 10
- 125000006413 ring segment Chemical group 0.000 abstract 9
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 6
- 229910052799 carbon Inorganic materials 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 5
- 150000002367 halogens Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000002431 hydrogen Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 3
- 125000004043 oxo group Chemical group O=* 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002393 azetidinyl group Chemical group 0.000 abstract 2
- 125000002619 bicyclic group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 125000002757 morpholinyl group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 abstract 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 2
- 125000003944 tolyl group Chemical group 0.000 abstract 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 102000056251 Prolyl Oligopeptidases Human genes 0.000 abstract 1
- 101710178372 Prolyl endopeptidase Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 abstract 1
- 210000002950 fibroblast Anatomy 0.000 abstract 1
- -1 haloC1−6alkyl Chemical group 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Compuestos que tienen la estructura de fórmula (1), y sales farmacéuticamente aceptables de los mismos, en donde X¹, R¹, R², R³, R⁴, R⁵ y R⁶ son como se definen en la memoria descriptiva; composiciones farmacéuticas que comprenden dichos compuestos y sales; uso de dichos compuestos y sales para tratar o prevenir afecciones mediadas por la proteína de activación de fibroblastos prolil endopeptidasa (FAP); kits que comprenden dichos compuestos y sales; y métodos para fabricar dichos compuestos y sales. Reivindicación 1: Un compuesto caracterizado porque tiene la estructura de fórmula (2), o una sal farmacéuticamente aceptable del mismo, en donde X¹ es -S-; R¹ se selecciona entre el grupo que consiste en hidrógeno, halógeno, hidroxi, alquilo C₁₋₃ y alcoxi C₁₋₆; R² se selecciona ente el grupo que consiste en: (a) heterociclilo que contiene un total de 4 a 10 átomos en el anillo, en donde el anillo heterociclilo: (i) es un anillo monocíclico saturado, parcialmente insaturado o completamente insaturado, o bicíclico condensado, (ii) tiene uno, dos o tres átomos de nitrógeno en el anillo, siendo los átomos restantes en el anillo carbono, y (iii) está opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre el grupo que consiste en halógeno, hidroxi, oxo, ciano, alquilo C₁₋₆, cicloalquilo C₃₋₆-alquilo C₁₋₃, cicloalquilo C₃₋₆-alquilo C₁₋₃ alcoxi C₁₋₆, cicloalcoxi C₃₋₆, alcoxi C₁₋₃-alquilo C₁₋₃, alcoxi C₁₋₃-alcoxi C₂₋₃, alcoxi C₁₋₃-alcoxi C₂₋₃-alquilo C₁₋₃, alquilcarbonilo C₁₋₃, cicloalquilcarbonilo C₃₋₆, alquil C₁₋₃-carbonilamino-alquilo C₁₋₃, alquilsulfonil C₁₋₃-alquilo C₁₋₃, fenilo, tolilo, alcoxifenilo C₁₋₃, fenil-alquilo C₁₋₃, alcoxifenil C₁₋₃-alquilo C₁₋₃, azetidinilo, pirrolidinilo, piperidinilo, morfolinilo, tetrahidrofuranilo, tetrahidropiranilo y tetrahidrooxepanilo, y en donde: (a) el alquilo C₁₋₆, cicloalquilo C₃₋₆, cicloalquil C₃₋₆-alquilo C₁₋₃, alcoxi C₁₋₆, cicloalcoxi C₃₋₆, alcoxi C₁₋₃-alquilo C₁₋₃, alcoxi C₁₋₃-alcoxi C₂₋₃, alcoxi C₁₋₃-alcoxi C₂₋₃-alquilo C₁₋₃, alquilcarbonilo C₁₋₃, cicloalquilcarbonilo C₃₋₆, alquil C₁₋₃-carbonilamino-alquilo C₁₋₃, alquilsulfonil C₁₋₃-alquilo C₁₋₃, fenilo, tolilo, alcoxifenilo C₁₋₃, fenil-alquilo C₁₋₃, alcoxifenil C₁₋₃-alquilo C₁₋₃, azetidinilo, pirrolidinilo, piperidinilo, morfolinilo, tetrahidrofuranilo, tetrahidropiranilo y tetrahidrooxepanilo pueden estar sustituidos adicionalmente con uno o más halógenos, y (b) el alquilo C₁₋₆ puede estar sustituido adicionalmente con uno o más hidroxi; (b) heterociclilo que contiene un total de 5 a 10 átomos en el anillo, en donde el anillo heterociclilo: (i) es un anillo monocíclico saturado, parcialmente insaturado o completamente insaturado, o bicíclico condensado, (ii) tiene (a) un átomo de nitrógeno en el anillo y un átomo de oxígeno en el anillo, siendo los átomos restantes en el anillo carbono, o (b) un átomo de nitrógeno en el anillo y un átomo de azufre en el anillo, siendo los átomos restantes en el anillo carbono, y (iii) está opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre el grupo que consiste en halógeno, ciano, oxo, alquilo C₁₋₆, cicloalquilo C₃₋₆, alcoxi C₁₋₆, alcoxi C₁₋₃-alquilo C₁₋₃, alquilcarbonil C₁₋₃-alquilo C₁₋₃ y alquilsulfonil C₁₋₃-alquilo C₁₋₃, y en donde el alquilo C₁₋₆, cicloalquilo C₃₋₆, alcoxi C₁₋₆, alcoxi C₁₋₃-alquilo C₁₋₃, alquilcarbonil C₁₋₃-alquilo C₁₋₃ y alquilsulfonil C₁₋₃-alquilo C₁₋₃ pueden estar sustituidos adicionalmente con uno o más halógenos; y (c) espiro heterociclilo que contiene un total de 6 a 11 átomos en el anillo, en donde el espiro heterociclilo: (i) comprende dos anillos saturados, (ii) tiene: (a) uno o dos átomos de nitrógeno en el anillo, siendo los átomos restantes en el anillo carbono, (b) uno o dos átomos de nitrógeno en el anillo y uno o dos átomos de oxígeno en el anillo, siendo los átomos restantes en el anillo carbono, o (c) un átomo de nitrógeno en el anillo y un átomos de azufre en el anillo, siendo los átomos restantes en el anillo carbono, y (iii) está opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre el grupo que consiste en halógeno, oxo, alquilo C₁₋₆, haloalquilo C₁₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆ y alquilcarbonilo C₁₋₆; R³ se selecciona entre el grupo que consiste en hidrógeno, halógeno y alquilo C₁₋₃; R⁴ se selecciona entre el grupo que consiste en hidrógeno, halógeno y alquilo C₁₋₃; R⁵ se selecciona entre el grupo que consiste en hidrógeno, halógeno y alquilo C₁₋₃; y R⁶ se selecciona entre el grupo que consiste en hidrógeno, halógeno y alquilo C₁₋₃.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063126593P | 2020-12-17 | 2020-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR124379A1 true AR124379A1 (es) | 2023-03-22 |
Family
ID=79164845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP210103519A AR124379A1 (es) | 2020-12-17 | 2021-12-16 | N-(2-(4-cianotiazolidin-3-il)-2-oxoetil)-quinolin-4-carboxamidas |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20240101549A1 (es) |
| EP (1) | EP4263535A1 (es) |
| JP (1) | JP2023554405A (es) |
| KR (1) | KR20230122080A (es) |
| CN (1) | CN116745291A (es) |
| AR (1) | AR124379A1 (es) |
| AU (1) | AU2021403827A1 (es) |
| CA (1) | CA3204318A1 (es) |
| CL (1) | CL2023001763A1 (es) |
| CO (1) | CO2023008921A2 (es) |
| CR (1) | CR20230314A (es) |
| DO (1) | DOP2023000124A (es) |
| EC (1) | ECSP23053033A (es) |
| IL (1) | IL303655A (es) |
| MX (1) | MX2023007287A (es) |
| PE (1) | PE20232046A1 (es) |
| TW (1) | TW202239407A (es) |
| UY (1) | UY39569A (es) |
| WO (1) | WO2022130270A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20232046A1 (es) | 2020-12-17 | 2023-12-27 | Astrazeneca Ab | N-(2-(4-cianotiazolidin-3-il)-2-oxoetil)-quinolin-4-carboxamidas |
| WO2023247489A1 (en) * | 2022-06-21 | 2023-12-28 | Astrazeneca Ab | N-(2-(4-cyanothiazolidin-3-yl)-2-oxoethyl)- quinoline-4-carboxamides |
| WO2023247487A1 (en) * | 2022-06-21 | 2023-12-28 | Astrazeneca Ab | Solid-state forms of n-(2-(4-cyanothiazolidin-3-yl)-2-oxoethyl)- 6-morpholinoquinoline-4-carboxamide |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW521072B (en) | 1997-06-02 | 2003-02-21 | Meiji Seika Kaisha | 4-quinolinol derivatives and fungicides containing the same as an active ingredient used for agriculture and horticulture |
| FR2795726A1 (fr) | 1999-06-30 | 2001-01-05 | Aventis Cropscience Sa | Nouveaux pyrazoles fongicides |
| DE10006453A1 (de) | 2000-02-14 | 2001-08-16 | Bayer Ag | Piperidylcarbonsäuren als Integrinantagonisten |
| GB0010188D0 (en) | 2000-04-26 | 2000-06-14 | Ferring Bv | Inhibitors of dipeptidyl peptidase IV |
| GB0010183D0 (en) | 2000-04-26 | 2000-06-14 | Ferring Bv | Inhibitors of dipeptidyl peptidase IV |
| BRPI0113146B8 (pt) | 2000-08-10 | 2021-05-25 | Mitsubishi Pharma Corp | "derivados de prolina e composição farmacêutica que os compreende". |
| JP2003026698A (ja) | 2000-09-27 | 2003-01-29 | Tokyo Inst Of Technol | 新規化合物、固定化物及び蛋白質のスクリーニング方法 |
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| US20240101549A1 (en) | 2024-03-28 |
| KR20230122080A (ko) | 2023-08-22 |
| CO2023008921A2 (es) | 2023-07-21 |
| CR20230314A (es) | 2023-08-18 |
| AU2021403827A1 (en) | 2023-07-27 |
| IL303655A (en) | 2023-08-01 |
| UY39569A (es) | 2022-07-29 |
| DOP2023000124A (es) | 2023-07-09 |
| TW202239407A (zh) | 2022-10-16 |
| CN116745291A (zh) | 2023-09-12 |
| EP4263535A1 (en) | 2023-10-25 |
| CA3204318A1 (en) | 2022-06-23 |
| MX2023007287A (es) | 2023-07-03 |
| PE20232046A1 (es) | 2023-12-27 |
| CL2023001763A1 (es) | 2023-11-17 |
| US11858924B2 (en) | 2024-01-02 |
| JP2023554405A (ja) | 2023-12-27 |
| ECSP23053033A (es) | 2023-08-31 |
| US20230312550A1 (en) | 2023-10-05 |
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