BRPI0713487A8 - compostos 2-(amino)-benzotiazol sulfonamida substituído, composição e composição farmacêutica contendo-os, método de preparação desta e uso dos mesmos - Google Patents
compostos 2-(amino)-benzotiazol sulfonamida substituído, composição e composição farmacêutica contendo-os, método de preparação desta e uso dos mesmosInfo
- Publication number
- BRPI0713487A8 BRPI0713487A8 BRPI0713487A BRPI0713487A BRPI0713487A8 BR PI0713487 A8 BRPI0713487 A8 BR PI0713487A8 BR PI0713487 A BRPI0713487 A BR PI0713487A BR PI0713487 A BRPI0713487 A BR PI0713487A BR PI0713487 A8 BRPI0713487 A8 BR PI0713487A8
- Authority
- BR
- Brazil
- Prior art keywords
- amino
- substituted
- preparation
- sulfonamide compounds
- benzothiazole sulfonamide
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Chemical class 0.000 title abstract 3
- XFMNXQKCYJXARU-UHFFFAOYSA-N 2-amino-3h-1,3-benzothiazole-2-sulfonamide Chemical class C1=CC=C2SC(N)(S(N)(=O)=O)NC2=C1 XFMNXQKCYJXARU-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000203 mixture Chemical class 0.000 title abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 229940124530 sulfonamide Drugs 0.000 abstract 2
- 229940124522 antiretrovirals Drugs 0.000 abstract 1
- 239000003903 antiretrovirus agent Substances 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 abstract 1
- 239000004030 hiv protease inhibitor Substances 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
compostos 2-(amino)-benzotiazol sulfonamida substituído, composição e composição farmacêutica contendo-os, método de preparação desta e uso dos mesmos. a presente invenção refere-se a compostos 2-(amino-substituído)-benzotiazol sulfonamida e derivados, seu uso como inibidores de protease, em particular como inibidores da protease do hiv de amplo espectro, processos para sua preparação bem como composições farmacêuticas e estojos de diagnóstico compreedendo-os. a presente invenção refere-se também a combinações dos presentes compostos 2-(amino-substituído)-benzotiazol sulfonamida e derivados com outro agente anti-retroviral. a invenção refere-se ainda ao seu uso em ensaios como compostos de referência ou como reagentes.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06116003.2 | 2006-06-23 | ||
| EP06116003 | 2006-06-23 | ||
| PCT/EP2007/056235 WO2007147884A1 (en) | 2006-06-23 | 2007-06-22 | 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0713487A2 BRPI0713487A2 (pt) | 2012-11-13 |
| BRPI0713487A8 true BRPI0713487A8 (pt) | 2018-01-02 |
| BRPI0713487B1 BRPI0713487B1 (pt) | 2022-07-26 |
Family
ID=37596252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0713487-8A BRPI0713487B1 (pt) | 2006-06-23 | 2007-06-22 | Compostos 2-(amino)-benzotiazol sulfonamida substituído, composição e composição farmacêutica compreendendo-os, e uso dos mesmos |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US8202887B2 (pt) |
| EP (1) | EP2035432B1 (pt) |
| JP (1) | JP5232776B2 (pt) |
| KR (1) | KR101419320B1 (pt) |
| CN (1) | CN101479275B (pt) |
| AP (1) | AP2069A (pt) |
| AR (1) | AR061619A1 (pt) |
| AT (1) | ATE544769T1 (pt) |
| AU (1) | AU2007262943B2 (pt) |
| BR (1) | BRPI0713487B1 (pt) |
| CA (1) | CA2653233C (pt) |
| CL (1) | CL2007001826A1 (pt) |
| CY (1) | CY1112971T1 (pt) |
| DK (1) | DK2035432T3 (pt) |
| EA (1) | EA016387B1 (pt) |
| ES (1) | ES2381129T3 (pt) |
| HK (1) | HK1125633A1 (pt) |
| IL (1) | IL195381A (pt) |
| JO (1) | JO2841B1 (pt) |
| MX (1) | MX2009000160A (pt) |
| MY (1) | MY146805A (pt) |
| NZ (1) | NZ573286A (pt) |
| PE (1) | PE20080342A1 (pt) |
| PL (1) | PL2035432T3 (pt) |
| PT (1) | PT2035432E (pt) |
| SI (1) | SI2035432T1 (pt) |
| TW (1) | TWI415851B (pt) |
| UA (1) | UA96445C2 (pt) |
| UY (1) | UY30416A1 (pt) |
| WO (1) | WO2007147884A1 (pt) |
| ZA (1) | ZA200810350B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3090B1 (ar) * | 2009-12-11 | 2017-03-15 | Janssen Sciences Ireland Uc | 5- امينو-4- هيدروكسي-بنتويل اميدات |
| US9102614B2 (en) | 2010-07-02 | 2015-08-11 | Gilead Sciences, Inc. | Naphth-2-ylacetic acid derivatives to treat AIDS |
| JP5806735B2 (ja) | 2010-07-02 | 2015-11-10 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖ抗ウイルス化合物としての２−キノリニル−酢酸誘導体 |
| US9024038B2 (en) * | 2010-12-27 | 2015-05-05 | Purdue Research Foundation | Compunds and methods for treating HIV |
| AP2015008931A0 (en) * | 2011-04-21 | 2015-12-31 | Gilead Sciences Inc | Benzothiazole compounds and their pharmaceutical use |
| WO2013103724A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids |
| US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
| UY34750A (es) | 2012-04-20 | 2013-11-29 | Gilead Sciences Inc | ?compuestos para el tratamiento del hiv, composiciones,métodos de preparación, intermediarios y métodos terapéuticos?. |
| US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE05385B1 (et) * | 2001-02-14 | 2011-02-15 | Tibotec�Pharmaceuticals�Ltd. | LaiaspektrilisedÁ2-(asendatudÁamino)bensotiasoolsulfoonamiididÁkuiÁHIVÁproteaasiÁinhibiitorid,ÁnendeÁvalmistamismeetodÁjaÁkasutamineÁningÁfarmatseutilineÁkompositsioon |
| AR037797A1 (es) * | 2001-12-12 | 2004-12-01 | Tibotec Pharm Ltd | Combinacion de inhibidores de proteasa dependientes del citocromo p450 |
| AU2003262561B2 (en) * | 2002-08-02 | 2008-10-16 | Tibotec Pharmaceuticals Ltd. | Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors |
| WO2005030194A1 (en) * | 2003-09-30 | 2005-04-07 | Tibotec Pharmaceuticals Ltd. | Hcv inhibitiing sulfonamides |
-
2007
- 2007-06-04 JO JO2007212A patent/JO2841B1/en active
- 2007-06-15 UY UY30416A patent/UY30416A1/es not_active Application Discontinuation
- 2007-06-21 CL CL2007001826A patent/CL2007001826A1/es unknown
- 2007-06-22 TW TW096122406A patent/TWI415851B/zh active
- 2007-06-22 BR BRPI0713487-8A patent/BRPI0713487B1/pt not_active IP Right Cessation
- 2007-06-22 NZ NZ573286A patent/NZ573286A/en not_active IP Right Cessation
- 2007-06-22 DK DK07765554.6T patent/DK2035432T3/da active
- 2007-06-22 UA UAA200813950A patent/UA96445C2/ru unknown
- 2007-06-22 US US12/304,990 patent/US8202887B2/en active Active
- 2007-06-22 EP EP07765554A patent/EP2035432B1/en active Active
- 2007-06-22 AT AT07765554T patent/ATE544769T1/de active
- 2007-06-22 PT PT07765554T patent/PT2035432E/pt unknown
- 2007-06-22 EA EA200970052A patent/EA016387B1/ru not_active IP Right Cessation
- 2007-06-22 PE PE2007000802A patent/PE20080342A1/es active IP Right Grant
- 2007-06-22 AU AU2007262943A patent/AU2007262943B2/en not_active Ceased
- 2007-06-22 MX MX2009000160A patent/MX2009000160A/es active IP Right Grant
- 2007-06-22 AR ARP070102776A patent/AR061619A1/es active IP Right Grant
- 2007-06-22 CN CN2007800236807A patent/CN101479275B/zh active Active
- 2007-06-22 CA CA2653233A patent/CA2653233C/en active Active
- 2007-06-22 AP AP2008004679A patent/AP2069A/en active
- 2007-06-22 ES ES07765554T patent/ES2381129T3/es active Active
- 2007-06-22 PL PL07765554T patent/PL2035432T3/pl unknown
- 2007-06-22 WO PCT/EP2007/056235 patent/WO2007147884A1/en active Application Filing
- 2007-06-22 KR KR1020097000754A patent/KR101419320B1/ko active IP Right Grant
- 2007-06-22 JP JP2009515891A patent/JP5232776B2/ja active Active
- 2007-06-22 SI SI200730904T patent/SI2035432T1/sl unknown
- 2007-06-22 MY MYPI20085209A patent/MY146805A/en unknown
-
2008
- 2008-11-19 IL IL195381A patent/IL195381A/en active IP Right Grant
- 2008-12-05 ZA ZA200810350A patent/ZA200810350B/xx unknown
-
2009
- 2009-04-30 HK HK09104046.7A patent/HK1125633A1/xx not_active IP Right Cessation
-
2012
- 2012-05-08 CY CY20121100429T patent/CY1112971T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: TIBOTEC PHARMACEUTICALS (IE) |
|
| B25D | Requested change of name of applicant approved |
Owner name: JANSSEN R AND D IRELAND (IE) |
|
| B25A | Requested transfer of rights approved |
Owner name: JANSSEN SCIENCES IRELAND UC (IE) |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/06/2007, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 17A ANUIDADE. |