CY1112971T1 - Σουλφοναμιδια 2-(υποκατεστημενο-αμινο)-βενζοθειαζολης ως αναστολεις της πρωτεασης ηiv - Google Patents

Σουλφοναμιδια 2-(υποκατεστημενο-αμινο)-βενζοθειαζολης ως αναστολεις της πρωτεασης ηiv

Info

Publication number
CY1112971T1
CY1112971T1 CY20121100429T CY121100429T CY1112971T1 CY 1112971 T1 CY1112971 T1 CY 1112971T1 CY 20121100429 T CY20121100429 T CY 20121100429T CY 121100429 T CY121100429 T CY 121100429T CY 1112971 T1 CY1112971 T1 CY 1112971T1
Authority
CY
Cyprus
Prior art keywords
amino
substituted
inhibitors
present
benzothiothiazole
Prior art date
Application number
CY20121100429T
Other languages
English (en)
Inventor
Kock Herman De
Tim Hugo Maria Jonckers
Paul Jozef Gabriel Maria Boonants
Stefaan Julien Last
Inge Dierynck
Judith Eva Baumeister
Klooster Gerben Albert Eleutherius Van´T
Original Assignee
Tibotec Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharmaceuticals filed Critical Tibotec Pharmaceuticals
Publication of CY1112971T1 publication Critical patent/CY1112971T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Η παρούσα εφεύρεση αφορά στις ενώσεις και στα παράγωγα σουλφοναμιδίου 2-(υποκατεστημένο-αμινο)-βενζοθειαζόλης, στη χρήση τους ως αναστολείς της πρωτεάσης, ιδίως ως αναστολείς της πρωτεάσης ΗIV ευρέος φάσματος, στις διαδικασίες για την παρασκευή τους, καθώς και σε φαρμακευτικές συνθέσεις και διαγνωστικά κιτ που τις περιλαμβάνουν. Η παρούσα εφεύρεση αφορά επίσης στους συνδυασμούς των παρουσών ενώσεων και παραγώγων σουλφοναμιδίου 2-(υποκατεστημένο-αμινο)-βενζοθειαζόλης με έναν άλλον αντι-ρετροϊικό παράγοντα. Αφορά περαιτέρω στη χρήση τους σε δοκιμασίες, ως ενώσεις αναφοράς ή ως αντιδραστήρια.
CY20121100429T 2006-06-23 2012-05-08 Σουλφοναμιδια 2-(υποκατεστημενο-αμινο)-βενζοθειαζολης ως αναστολεις της πρωτεασης ηiv CY1112971T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06116003 2006-06-23
EP07765554A EP2035432B1 (en) 2006-06-23 2007-06-22 2-(Substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors

Publications (1)

Publication Number Publication Date
CY1112971T1 true CY1112971T1 (el) 2016-04-13

Family

ID=37596252

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100429T CY1112971T1 (el) 2006-06-23 2012-05-08 Σουλφοναμιδια 2-(υποκατεστημενο-αμινο)-βενζοθειαζολης ως αναστολεις της πρωτεασης ηiv

Country Status (31)

Country Link
US (1) US8202887B2 (el)
EP (1) EP2035432B1 (el)
JP (1) JP5232776B2 (el)
KR (1) KR101419320B1 (el)
CN (1) CN101479275B (el)
AP (1) AP2069A (el)
AR (1) AR061619A1 (el)
AT (1) ATE544769T1 (el)
AU (1) AU2007262943B2 (el)
BR (1) BRPI0713487B1 (el)
CA (1) CA2653233C (el)
CL (1) CL2007001826A1 (el)
CY (1) CY1112971T1 (el)
DK (1) DK2035432T3 (el)
EA (1) EA016387B1 (el)
ES (1) ES2381129T3 (el)
HK (1) HK1125633A1 (el)
IL (1) IL195381A (el)
JO (1) JO2841B1 (el)
MX (1) MX2009000160A (el)
MY (1) MY146805A (el)
NZ (1) NZ573286A (el)
PE (1) PE20080342A1 (el)
PL (1) PL2035432T3 (el)
PT (1) PT2035432E (el)
SI (1) SI2035432T1 (el)
TW (1) TWI415851B (el)
UA (1) UA96445C2 (el)
UY (1) UY30416A1 (el)
WO (1) WO2007147884A1 (el)
ZA (1) ZA200810350B (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3090B1 (ar) * 2009-12-11 2017-03-15 Janssen Sciences Ireland Uc 5- امينو-4- هيدروكسي-بنتويل اميدات
AP2013006707A0 (en) 2010-07-02 2013-02-28 Gilead Sciences Inc 2-Quinolinyl-acetic acid derivatives as HIV antiviral compounds
UY33480A (es) 2010-07-02 2012-02-29 Gilead Sciences Inc Compuestos terapeuticos, composicion farmaceutica que lo comprende, metodo de tratamiento y su uso para la manufactura de un medicamento.
US9024038B2 (en) * 2010-12-27 2015-05-05 Purdue Research Foundation Compunds and methods for treating HIV
ES2615734T3 (es) * 2011-04-21 2017-06-08 Gilead Sciences, Inc. Compuestos de benzotiazol y su uso farmacéutico
WO2013103738A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. Napthalene acetic acid derivatives against hiv infection
WO2013103724A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids
US9096586B2 (en) 2012-04-20 2015-08-04 Gilead Sciences, Inc. Therapeutic compounds
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2438304C (en) * 2001-02-14 2011-04-12 Dominique Louis Nestor Ghislain Surleraux Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors
TWI286476B (en) * 2001-12-12 2007-09-11 Tibotec Pharm Ltd Combination of cytochrome P450 dependent protease inhibitors
EA008594B1 (ru) * 2002-08-02 2007-06-29 Тиботек Фармасьютикалз Лтд. 2-аминобензотиазолсульфонамидные ингибиторы протеазы вич широкого спектра действия
ES2297467T3 (es) * 2003-09-30 2008-05-01 Tibotec Pharmaceuticals Ltd. Sulfonamidas de inhibicion de vhc.

Also Published As

Publication number Publication date
KR20090024257A (ko) 2009-03-06
EA016387B1 (ru) 2012-04-30
CL2007001826A1 (es) 2008-01-18
UA96445C2 (ru) 2011-11-10
JO2841B1 (en) 2014-09-15
CN101479275A (zh) 2009-07-08
EP2035432B1 (en) 2012-02-08
ES2381129T3 (es) 2012-05-23
MX2009000160A (es) 2009-01-23
AU2007262943B2 (en) 2012-04-12
ZA200810350B (en) 2010-05-26
UY30416A1 (es) 2008-01-31
DK2035432T3 (da) 2012-05-14
TW200817416A (en) 2008-04-16
IL195381A (en) 2013-01-31
MY146805A (en) 2012-09-28
BRPI0713487B1 (pt) 2022-07-26
CA2653233A1 (en) 2007-12-27
CN101479275B (zh) 2012-03-07
EP2035432A1 (en) 2009-03-18
CA2653233C (en) 2015-09-29
PL2035432T3 (pl) 2012-07-31
ATE544769T1 (de) 2012-02-15
AU2007262943A1 (en) 2007-12-27
AR061619A1 (es) 2008-09-10
BRPI0713487A8 (pt) 2018-01-02
KR101419320B1 (ko) 2014-07-14
AP2008004679A0 (en) 2008-12-31
EA200970052A1 (ru) 2009-04-28
PT2035432E (pt) 2012-04-24
NZ573286A (en) 2011-09-30
BRPI0713487A2 (el) 2012-11-13
WO2007147884A1 (en) 2007-12-27
HK1125633A1 (el) 2009-08-14
TWI415851B (zh) 2013-11-21
JP2009541272A (ja) 2009-11-26
US20090209583A1 (en) 2009-08-20
SI2035432T1 (sl) 2012-06-29
JP5232776B2 (ja) 2013-07-10
US8202887B2 (en) 2012-06-19
IL195381A0 (en) 2009-08-03
PE20080342A1 (es) 2008-04-25
AP2069A (en) 2009-12-08

Similar Documents

Publication Publication Date Title
CY1112971T1 (el) Σουλφοναμιδια 2-(υποκατεστημενο-αμινο)-βενζοθειαζολης ως αναστολεις της πρωτεασης ηiv
ATE544870T1 (de) Profilierung einer rezeptorfamilie
UY31806A (es) Compuestos de tiazole y oxazole de sulfonamida de benceno
CL2008000862A1 (es) Compuestos derivados de triazolonas, inhibidores no nucleosidos de transcriptasa inversa; composicion farmaceutica que contiene a dichos compuestos; y uso del compuesto para tratar la infeccion del vih-1.
CR8824A (es) Derivados de 2-carbamida-4-feniltiazol, su preparacion y su aplicacion en terapeutica
NO20045152L (no) Ikke-nukleosid-reverstranskriptaseinhibitorer
TR200201187T2 (tr) Ters transkriptazın inhibitörleri olarak benzofenonlar
BRPI0815920A2 (pt) Composto, composição farmacêutica, e, uso do composto.
ATE553104T1 (de) Substituierte 1h-benzimidazol-4-carboxamide als potente parp-hemmer
BRPI0510665A (pt) 3-(4-heteroarilcicloexilamino) ciclopentano-carboxiamidas como moduladores de receptores de quimiocinas
CY1113102T1 (el) Ενωσεις φαινυλπροπιοναμιδιου και η χρηση αυτων
CL2008002430A1 (es) Compuestos derivados de bencenosulfonamida, inhibidores de catepsina c; composicion farmaceutica que los comprende; y su uso para el tratamiento de la epoc.
EA201000948A1 (ru) Ингибиторы вирусной полимеразы
UY30048A1 (es) Derivados sustituidos de la n,2-(1h-benzimidazol-1-il) acetamida, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones
ATE511500T1 (de) Sulfonamide als orexin-antagonisten
EA200602281A1 (ru) Гетероарилсульфоны и сульфонамиды и их терапевтические применения
FR2924118B1 (fr) Fragments d'anticorps inhibiteurs de la proteine nef du vih.
EA200801476A1 (ru) Замещенные аминофенилсульфонамидные соединения в качестве ингибиторов протеазы вич
BRPI0820838B8 (pt) derivados de arilamida substituídos por tetrazol, composição farmacêutica que os compreende e seu uso como antagonistas do receptor purinérgico p2x3 e/ou p2x2/3
BRPI0915878A2 (pt) sais ou hidratos de compostos inibidores de hiv, seu uso e composição farmacêutica que os compreende
BR0306927A (pt) Compostos tricìclicos de 2-pirimidona úteis como inibidores de transcriptase reversa de hiv
TW200710091A (en) (1,10B-dihydro-2-(aminoalkyl-phenyl)-5H-pyrazolo [1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors
BRPI0510612A (pt) derivados de (1,10b-diidro-2-(aminocarbonil-fenil)-5h-pirazol[1,5-c][ 1,3]-benzoxazin-5-il)fenil metanona como inibidores de replicação viral do hiv
BR0208987A (pt) Composto tricìclicos úteis como inibidores de transcriptase reserva de hiv
UY30552A1 (es) Combinaciones farmacologiicas en base a derivados sustituidos de la n-(5-{2-[1,1-dimetil-propilamino]-1-hidroxi-metil}-2-hidroxi-fenil)-metansulfonamida y aplicaciones