CY1112971T1 - Σουλφοναμιδια 2-(υποκατεστημενο-αμινο)-βενζοθειαζολης ως αναστολεις της πρωτεασης ηiv - Google Patents

Σουλφοναμιδια 2-(υποκατεστημενο-αμινο)-βενζοθειαζολης ως αναστολεις της πρωτεασης ηiv

Info

Publication number
CY1112971T1
CY1112971T1 CY20121100429T CY121100429T CY1112971T1 CY 1112971 T1 CY1112971 T1 CY 1112971T1 CY 20121100429 T CY20121100429 T CY 20121100429T CY 121100429 T CY121100429 T CY 121100429T CY 1112971 T1 CY1112971 T1 CY 1112971T1
Authority
CY
Cyprus
Prior art keywords
amino
substituted
inhibitors
present
benzothiothiazole
Prior art date
Application number
CY20121100429T
Other languages
English (en)
Inventor
Kock Herman De
Tim Hugo Maria Jonckers
Paul Jozef Gabriel Maria Boonants
Stefaan Julien Last
Inge Dierynck
Judith Eva Baumeister
Klooster Gerben Albert Eleutherius Van´T
Original Assignee
Tibotec Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharmaceuticals filed Critical Tibotec Pharmaceuticals
Publication of CY1112971T1 publication Critical patent/CY1112971T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Η παρούσα εφεύρεση αφορά στις ενώσεις και στα παράγωγα σουλφοναμιδίου 2-(υποκατεστημένο-αμινο)-βενζοθειαζόλης, στη χρήση τους ως αναστολείς της πρωτεάσης, ιδίως ως αναστολείς της πρωτεάσης ΗIV ευρέος φάσματος, στις διαδικασίες για την παρασκευή τους, καθώς και σε φαρμακευτικές συνθέσεις και διαγνωστικά κιτ που τις περιλαμβάνουν. Η παρούσα εφεύρεση αφορά επίσης στους συνδυασμούς των παρουσών ενώσεων και παραγώγων σουλφοναμιδίου 2-(υποκατεστημένο-αμινο)-βενζοθειαζόλης με έναν άλλον αντι-ρετροϊικό παράγοντα. Αφορά περαιτέρω στη χρήση τους σε δοκιμασίες, ως ενώσεις αναφοράς ή ως αντιδραστήρια.
CY20121100429T 2006-06-23 2012-05-08 Σουλφοναμιδια 2-(υποκατεστημενο-αμινο)-βενζοθειαζολης ως αναστολεις της πρωτεασης ηiv CY1112971T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06116003 2006-06-23
EP07765554A EP2035432B1 (en) 2006-06-23 2007-06-22 2-(Substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors

Publications (1)

Publication Number Publication Date
CY1112971T1 true CY1112971T1 (el) 2016-04-13

Family

ID=37596252

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100429T CY1112971T1 (el) 2006-06-23 2012-05-08 Σουλφοναμιδια 2-(υποκατεστημενο-αμινο)-βενζοθειαζολης ως αναστολεις της πρωτεασης ηiv

Country Status (31)

Country Link
US (1) US8202887B2 (el)
EP (1) EP2035432B1 (el)
JP (1) JP5232776B2 (el)
KR (1) KR101419320B1 (el)
CN (1) CN101479275B (el)
AP (1) AP2069A (el)
AR (1) AR061619A1 (el)
AT (1) ATE544769T1 (el)
AU (1) AU2007262943B2 (el)
BR (1) BRPI0713487B1 (el)
CA (1) CA2653233C (el)
CL (1) CL2007001826A1 (el)
CY (1) CY1112971T1 (el)
DK (1) DK2035432T3 (el)
EA (1) EA016387B1 (el)
ES (1) ES2381129T3 (el)
HK (1) HK1125633A1 (el)
IL (1) IL195381A (el)
JO (1) JO2841B1 (el)
MX (1) MX2009000160A (el)
MY (1) MY146805A (el)
NZ (1) NZ573286A (el)
PE (1) PE20080342A1 (el)
PL (1) PL2035432T3 (el)
PT (1) PT2035432E (el)
SI (1) SI2035432T1 (el)
TW (1) TWI415851B (el)
UA (1) UA96445C2 (el)
UY (1) UY30416A1 (el)
WO (1) WO2007147884A1 (el)
ZA (1) ZA200810350B (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3090B1 (ar) * 2009-12-11 2017-03-15 Janssen Sciences Ireland Uc 5- امينو-4- هيدروكسي-بنتويل اميدات
US9102614B2 (en) 2010-07-02 2015-08-11 Gilead Sciences, Inc. Naphth-2-ylacetic acid derivatives to treat AIDS
AU2011274323B2 (en) 2010-07-02 2015-08-06 Gilead Sciences, Inc. 2 -quinolinyl- acetic acid derivatives as HIV antiviral compounds
US9024038B2 (en) * 2010-12-27 2015-05-05 Purdue Research Foundation Compunds and methods for treating HIV
AP2015008931A0 (en) 2011-04-21 2015-12-31 Gilead Sciences Inc Benzothiazole compounds and their pharmaceutical use
WO2013103738A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. Napthalene acetic acid derivatives against hiv infection
WO2013103724A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids
CA2850881C (en) 2012-04-20 2021-02-16 Gilead Sciences, Inc. Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2275866T3 (es) * 2001-02-14 2007-06-16 Tibotec Pharmaceuticals Ltd. 2-(aminosustituido)-benzotiazol-sulfonamidas de amplio esprecto inhibidoras de la proteasa de vih.
AR037797A1 (es) * 2001-12-12 2004-12-01 Tibotec Pharm Ltd Combinacion de inhibidores de proteasa dependientes del citocromo p450
NZ538488A (en) * 2002-08-02 2007-10-26 Tibotec Pharm Ltd Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors
JP2007507469A (ja) * 2003-09-30 2007-03-29 テイボテク・フアーマシユーチカルズ・リミテツド Ｈｃｖ阻害性スルホンアミド

Also Published As

Publication number Publication date
AP2008004679A0 (en) 2008-12-31
IL195381A0 (en) 2009-08-03
CN101479275B (zh) 2012-03-07
KR101419320B1 (ko) 2014-07-14
HK1125633A1 (el) 2009-08-14
MX2009000160A (es) 2009-01-23
TW200817416A (en) 2008-04-16
WO2007147884A1 (en) 2007-12-27
AU2007262943B2 (en) 2012-04-12
CN101479275A (zh) 2009-07-08
NZ573286A (en) 2011-09-30
CL2007001826A1 (es) 2008-01-18
AU2007262943A1 (en) 2007-12-27
DK2035432T3 (da) 2012-05-14
AP2069A (en) 2009-12-08
SI2035432T1 (sl) 2012-06-29
EA200970052A1 (ru) 2009-04-28
US8202887B2 (en) 2012-06-19
AR061619A1 (es) 2008-09-10
ATE544769T1 (de) 2012-02-15
ES2381129T3 (es) 2012-05-23
PE20080342A1 (es) 2008-04-25
JP5232776B2 (ja) 2013-07-10
EA016387B1 (ru) 2012-04-30
TWI415851B (zh) 2013-11-21
ZA200810350B (en) 2010-05-26
MY146805A (en) 2012-09-28
BRPI0713487A8 (pt) 2018-01-02
BRPI0713487A2 (el) 2012-11-13
CA2653233C (en) 2015-09-29
UY30416A1 (es) 2008-01-31
EP2035432A1 (en) 2009-03-18
IL195381A (en) 2013-01-31
PL2035432T3 (pl) 2012-07-31
PT2035432E (pt) 2012-04-24
CA2653233A1 (en) 2007-12-27
UA96445C2 (ru) 2011-11-10
KR20090024257A (ko) 2009-03-06
JP2009541272A (ja) 2009-11-26
JO2841B1 (en) 2014-09-15
BRPI0713487B1 (pt) 2022-07-26
US20090209583A1 (en) 2009-08-20
EP2035432B1 (en) 2012-02-08

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