FR2924118B1 - Fragments d'anticorps inhibiteurs de la proteine nef du vih. - Google Patents

Fragments d'anticorps inhibiteurs de la proteine nef du vih.

Info

Publication number
FR2924118B1
FR2924118B1 FR0708189A FR0708189A FR2924118B1 FR 2924118 B1 FR2924118 B1 FR 2924118B1 FR 0708189 A FR0708189 A FR 0708189A FR 0708189 A FR0708189 A FR 0708189A FR 2924118 B1 FR2924118 B1 FR 2924118B1
Authority
FR
France
Prior art keywords
hiv
nef protein
inhibitor fragments
fragments
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0708189A
Other languages
English (en)
Other versions
FR2924118A1 (fr
Inventor
Daniel Baty
Martine Jeanne Pierrette Chartier
Patrick Chames
Serge Salomon Benichou
Stephane Eric Basmaciogullari
Jerome Christophe Marie Abel Bouchet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR0708189A priority Critical patent/FR2924118B1/fr
Priority to EP08852180A priority patent/EP2212353A1/fr
Priority to PCT/IB2008/054832 priority patent/WO2009066241A1/fr
Priority to US12/734,773 priority patent/US9512203B2/en
Publication of FR2924118A1 publication Critical patent/FR2924118A1/fr
Application granted granted Critical
Publication of FR2924118B1 publication Critical patent/FR2924118B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FR0708189A 2007-11-22 2007-11-22 Fragments d'anticorps inhibiteurs de la proteine nef du vih. Expired - Fee Related FR2924118B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR0708189A FR2924118B1 (fr) 2007-11-22 2007-11-22 Fragments d'anticorps inhibiteurs de la proteine nef du vih.
EP08852180A EP2212353A1 (fr) 2007-11-22 2008-11-18 Fragments d'anticorps inhibiteurs de la proteine nef du vih
PCT/IB2008/054832 WO2009066241A1 (fr) 2007-11-22 2008-11-18 Fragments d'anticorps inhibiteurs de la proteine nef du vih
US12/734,773 US9512203B2 (en) 2007-11-22 2008-11-18 Single-domain antibodies that bind to HIV-1 Nef with high affinity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0708189A FR2924118B1 (fr) 2007-11-22 2007-11-22 Fragments d'anticorps inhibiteurs de la proteine nef du vih.

Publications (2)

Publication Number Publication Date
FR2924118A1 FR2924118A1 (fr) 2009-05-29
FR2924118B1 true FR2924118B1 (fr) 2015-02-13

Family

ID=39284209

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0708189A Expired - Fee Related FR2924118B1 (fr) 2007-11-22 2007-11-22 Fragments d'anticorps inhibiteurs de la proteine nef du vih.

Country Status (4)

Country Link
US (1) US9512203B2 (fr)
EP (1) EP2212353A1 (fr)
FR (1) FR2924118B1 (fr)
WO (1) WO2009066241A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013000603A2 (pt) * 2010-07-09 2016-07-05 Jv Bio Srl anticorpos conjugados com lipídios
US20150158934A1 (en) * 2011-09-09 2015-06-11 Ucl Business Plc Broadly neutralizing vhh against hiv-1
WO2013041901A1 (fr) 2011-09-20 2013-03-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de préparation de microréseau d'adn à anticorps à domaine unique
EP2857415A1 (fr) 2013-10-02 2015-04-08 Institut National De La Sante Et De La Recherche Medicale (Inserm) Structure cristallographique du complexe Nef/sdAb19/HckSH3 et son utilisation
CN103866401B (zh) * 2014-03-28 2014-11-26 中国农业科学院油料作物研究所 一种黄曲霉毒素纳米抗体基因库、构建方法、用途及黄曲霉毒素b1纳米抗体2014afb-g15
US11299751B2 (en) 2016-04-29 2022-04-12 Voyager Therapeutics, Inc. Compositions for the treatment of disease
EP3448874A4 (fr) 2016-04-29 2020-04-22 Voyager Therapeutics, Inc. Compositions pour le traitement de maladies
CN110759996B (zh) * 2018-07-27 2022-09-06 深圳康体生命科技有限公司 一种gfp抗体
CN109678953A (zh) * 2018-12-24 2019-04-26 西北农林科技大学 一种抗pedv n蛋白的vhh噬菌体展示文库的构建方法及用途
CN110256562B (zh) * 2019-07-05 2022-10-25 石河子大学 Pd-1纳米抗体、制备方法及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2668488A1 (fr) * 1990-10-26 1992-04-30 Pasteur Institut Peptides inducteurs d'anticorps inhibant des retrovirus du type hiv et anticorps diriges contre ces peptides.
US6139843A (en) * 1991-04-02 2000-10-31 Albert Einstein College Of Medicine Of Yeshiva University Peptide compositions for the treatment of HIV
EP1844073A1 (fr) * 2005-01-31 2007-10-17 Ablynx N.V. Procede de generation de sequences a domaine variable d'anticorps a chaine lourde

Also Published As

Publication number Publication date
WO2009066241A1 (fr) 2009-05-28
US20130330342A1 (en) 2013-12-12
EP2212353A1 (fr) 2010-08-04
FR2924118A1 (fr) 2009-05-29
US9512203B2 (en) 2016-12-06

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