FR2924118B1 - INHIBITOR FRAGMENTS OF THE NEF PROTEIN OF HIV. - Google Patents

INHIBITOR FRAGMENTS OF THE NEF PROTEIN OF HIV.

Info

Publication number
FR2924118B1
FR2924118B1 FR0708189A FR0708189A FR2924118B1 FR 2924118 B1 FR2924118 B1 FR 2924118B1 FR 0708189 A FR0708189 A FR 0708189A FR 0708189 A FR0708189 A FR 0708189A FR 2924118 B1 FR2924118 B1 FR 2924118B1
Authority
FR
France
Prior art keywords
hiv
nef protein
inhibitor fragments
fragments
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0708189A
Other languages
French (fr)
Other versions
FR2924118A1 (en
Inventor
Daniel Baty
Martine Jeanne Pierrette Chartier
Patrick Chames
Serge Salomon Benichou
Stephane Eric Basmaciogullari
Jerome Christophe Marie Abel Bouchet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR0708189A priority Critical patent/FR2924118B1/en
Priority to US12/734,773 priority patent/US9512203B2/en
Priority to PCT/IB2008/054832 priority patent/WO2009066241A1/en
Priority to EP08852180A priority patent/EP2212353A1/en
Publication of FR2924118A1 publication Critical patent/FR2924118A1/en
Application granted granted Critical
Publication of FR2924118B1 publication Critical patent/FR2924118B1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
FR0708189A 2007-11-22 2007-11-22 INHIBITOR FRAGMENTS OF THE NEF PROTEIN OF HIV. Expired - Fee Related FR2924118B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR0708189A FR2924118B1 (en) 2007-11-22 2007-11-22 INHIBITOR FRAGMENTS OF THE NEF PROTEIN OF HIV.
US12/734,773 US9512203B2 (en) 2007-11-22 2008-11-18 Single-domain antibodies that bind to HIV-1 Nef with high affinity
PCT/IB2008/054832 WO2009066241A1 (en) 2007-11-22 2008-11-18 Antibody fragments inhibiting hiv nef protein
EP08852180A EP2212353A1 (en) 2007-11-22 2008-11-18 Antibody fragments inhibiting hiv nef protein

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0708189A FR2924118B1 (en) 2007-11-22 2007-11-22 INHIBITOR FRAGMENTS OF THE NEF PROTEIN OF HIV.

Publications (2)

Publication Number Publication Date
FR2924118A1 FR2924118A1 (en) 2009-05-29
FR2924118B1 true FR2924118B1 (en) 2015-02-13

Family

ID=39284209

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0708189A Expired - Fee Related FR2924118B1 (en) 2007-11-22 2007-11-22 INHIBITOR FRAGMENTS OF THE NEF PROTEIN OF HIV.

Country Status (4)

Country Link
US (1) US9512203B2 (en)
EP (1) EP2212353A1 (en)
FR (1) FR2924118B1 (en)
WO (1) WO2009066241A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013000603A2 (en) * 2010-07-09 2016-07-05 Jv Bio Srl lipid conjugated antibodies
EP2753644A1 (en) * 2011-09-09 2014-07-16 Universiteit Utrecht Holding B.V. Broadly neutralizing vhh against hiv-1
US20140235492A1 (en) 2011-09-20 2014-08-21 Institut National De La Sante Et De La Recherche Medicate (Inserm) Methods for preparing single domain antibody microarrays
EP2857415A1 (en) 2013-10-02 2015-04-08 Institut National De La Sante Et De La Recherche Medicale (Inserm) Crystal structure of a Nef/sdAb19/HckSH3 complex and uses thereof
CN103866401B (en) * 2014-03-28 2014-11-26 中国农业科学院油料作物研究所 Aflatoxin nano antibody gene pool, construction method and application of aflatoxin nano antibody gene pool as well as aflatoxin B1 nano antibody 2014AFB-G15
US11299751B2 (en) 2016-04-29 2022-04-12 Voyager Therapeutics, Inc. Compositions for the treatment of disease
EP3448874A4 (en) 2016-04-29 2020-04-22 Voyager Therapeutics, Inc. Compositions for the treatment of disease
CN110759996B (en) * 2018-07-27 2022-09-06 深圳康体生命科技有限公司 GFP antibody
CN109678953A (en) * 2018-12-24 2019-04-26 西北农林科技大学 A kind of construction method and purposes of the VHH phage display library of anti-PEDV N protein
CN110256562B (en) * 2019-07-05 2022-10-25 石河子大学 PD-1 nano antibody, preparation method and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2668488A1 (en) * 1990-10-26 1992-04-30 Pasteur Institut New peptide(s) common to mycoplasm adhesion molecule and HIV proteins
US6139843A (en) * 1991-04-02 2000-10-31 Albert Einstein College Of Medicine Of Yeshiva University Peptide compositions for the treatment of HIV
AU2005325801A1 (en) * 2005-01-31 2006-08-03 Ablynx N.V. Method for generating variable domain sequences of heavy chain antibodies

Also Published As

Publication number Publication date
US20130330342A1 (en) 2013-12-12
FR2924118A1 (en) 2009-05-29
EP2212353A1 (en) 2010-08-04
US9512203B2 (en) 2016-12-06
WO2009066241A1 (en) 2009-05-28

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