AR058067A1 - Azepinas inhibidoras de quinasas janus - Google Patents
Azepinas inhibidoras de quinasas janusInfo
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- AR058067A1 AR058067A1 ARP060104186A ARP060104186A AR058067A1 AR 058067 A1 AR058067 A1 AR 058067A1 AR P060104186 A ARP060104186 A AR P060104186A AR P060104186 A ARP060104186 A AR P060104186A AR 058067 A1 AR058067 A1 AR 058067A1
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- alkyl
- alkynyl
- alkenyl
- nrcrd
- cycloalkyl
- Prior art date
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- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- A61P19/00—Drugs for skeletal disorders
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- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
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- C07—ORGANIC CHEMISTRY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
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Abstract
Los compuestos de la presente son utiles en el tratamiento de enfermedades relacionadas con la actividad de las quinasa Janus, entre las que se incluyen, por ejemplo, enfermedades relacionadas con el sistema inmune, trastornos dermatologicos, trastornos proliferativos mieloides, cáncer y otras enfermedades. Reivindicacion 1: un compuesto caracterizado porque responde a la formula (1a), (1b), o (1c); o sus sales aceptables para uso farmacéutico o prodrogas de los mismos, en donde: D1, D2, D3, D4, D5, D6 y D7 son, en forma independiente, CR1 o N; E es O, S, SO, SO2, o NR2a; G es N o CR2b; Q1 y Q2 son cada uno, en forma independiente, N o CR2; W1 está ausente, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, O, S, NR3, CO, COO, CONR3, SO, SO2, SONR3, SO2NR, o NR3CONR4, en donde dicho alquilo C1-6, alquenilo C2-6 o alquinilo C2-6 está opcionalmente sustituido con 1, 2 o 3 sustituyentes seleccionados en forma independiente entre halo, OH, alcoxi C1-4, haloalcoxi C1-4, amino, alquilamino C1-4, y dialquilamino C2-8; W2 está ausente, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo o heterocicloalquilo, en donde dicho alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo o heterocicloalquilo está opcionalmente sustituido con 1, 2 o 3 sustituyentes seleccionados en forma independiente entre halo, CN, NO2, OH, =NH, =NOH, =NO-(alquilo C1-4), -NR3C(O)O-(alquilo C1-4), -NR3C(O)-(alquilo C1-4), -C(O)O-(alquilo C1-4), haloalquilo C1-4, cianoalquilo C1-4, pentahalosulfanilo, hidroxialquilo C1-4, alquiltio C1-4,haloalquiltio C1-4, alcoxi C1-4, haloalcoxi C1-4, amino, alquilamino C1-4, y dialquilamino C2-8; W3 está ausente, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, O, S, NR3, =N-, =N-O-, =N-O-(alquil C1-4)-, -O-(alquilo C1-4), S-(alquilo C1-4), NR3-(alquilo C1-4), (alquil C1-4)-O-(alquilo C1-4), (alquil C1-4)-S-(alquilo C1-4), (alquil C1-4)-NR3-(alquilo C1-4), CO, COO, C(O)- (alquilo C1-4), C(O)O-(alquilo C1-4), C(O)- (alquil C1-4)-C(O), NR3C(O)O-(alquilo C1-4), -C(O)NR3-(alquilo C1-4),NR3C(O)O-(alquilo C1-4), NR3C(O)O, CONR3, SO, SO2, SONR3, SO2NR3, o NR3CONR4, en donde dicho alquilo C1-6, alquenilo C2-6 o alquinilo C2-6 está opcionalmente sustituido con 1, 2 o 3 sustituyentes seleccionados en forma independiente entre halo, OH, CN, alcoxi C1-4, haloalcoxi C1-4, amino, alquilamino C1-4, y dialquilamino C2-8; W4 es H, NR3R4, CN, alquilo C1-6, alquenilo C2-6, alquinilo C2- 6, arilo, cicloalquilo, heteroarilo o heterocicloalquilo, en donde cada uno de dichos alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo o heterocicloalquilo está opcionalmente sustituido con 1, 2, 3, 4 o 5 sustituyentes seleccionados en forma independiente entre halo, OH, alcoxi C1-4, =NH, =NOH, =NO-(alquilo C1-4), haloalquilo C1-4, haloalcoxi C1-4, pentahalosulfanilo, COOH, CONH2, COO-(alquilo C1-4), amino, alquilamino C1-4, y dialquilamino C2-8; R1 es, en forma independiente, H, halo, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, haloalquilo C1-4, arilo, cicloalquilo, heteroarilo, heterocicloalquilo, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, NRc(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, NRcS(O)NRcRd, pentahalosulfanilo, S(O)2Rb, o S(O)2NRcRd; R2a es H, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, OH, alcoxi C1-4, C(O)Rb, C(O)NRcRd, S(O)Rb, S(O)NRcRd, S(O)2Rb, o S(O)2NRcRd; R2b y R2c son cada uno, en forma independiente, H, halo, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, haloalquilo C1-4, arilo, cicloalquilo, heteroarilo, heterocicloalquilo, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcC(O)NRcRd, NRcRd, NRcC(O)Rd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, NRcS(O)NRcRd, S(O)2Rb, o S(O)2NRcRd; R3 y R4 son cada uno, en forma independiente H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, arilalquilo, cicloalquilo COORa', CORb', SORb', o SO2Rb' en donde cada uno de dichos alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, arilalquilo, o cicloalquilalquilo está opcionalmente sustituido con 1, 2 o 3 sustituyentes seleccionados entre halo, alquilo C1-4, haloalquilo C1-4, OH, alcoxi C1- 4, haloalcoxi C1-4, amino, alquilamino C1-4, dialquilamino C2-8, aminocarbonilo, alquilaminocarbonilo C1-4, dialquilaminocarbonilo C2-8, CN y NO2; o R3 y R4 junto con el átomo de N al cual están unidos forman un grupo heterocicloalquilo opcionalmente sustituido con 1, 2 o 3 sustituyentes seleccionados entre halo, alquilo C1-4, haloalquilo C1-4, OH, alcoxi C1-4, haloalcoxi C1-4, amino, alquilamino C1-4, dialquilamino C2-8, aminocarbonilo, alquilaminocarbonilo C1-4 y dialquilaminocarbonilo C2-8; Ra y Ra' son cada uno, en forma independiente H, alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo o heterocicloalquilo; Rb y Rb' son cada uno, en forma independiente, H, alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo o heterocicloalquilo, y Rc y Rd son cada uno, en forma independiente H, alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, arilalquilo, o cicloalquilalquilo; o Rc y Rd junto con el átomo de N al cual están unidos forman un grupo heterocicloalquilo de 4, 5, 6 o 7 miembros; con la salvedad de que cuando D7 es N, E es O o S, y G es N; entonces -W1-W2-W3-W4 es distinto de H.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US71946205P | 2005-09-22 | 2005-09-22 | |
US81049006P | 2006-06-02 | 2006-06-02 |
Publications (1)
Publication Number | Publication Date |
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AR058067A1 true AR058067A1 (es) | 2008-01-23 |
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ID=37747347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060104186A AR058067A1 (es) | 2005-09-22 | 2006-09-25 | Azepinas inhibidoras de quinasas janus |
Country Status (7)
Country | Link |
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US (4) | US20070149506A1 (es) |
EP (2) | EP1926735A1 (es) |
JP (1) | JP5119154B2 (es) |
AR (1) | AR058067A1 (es) |
CA (1) | CA2621261C (es) |
TW (1) | TWI406865B (es) |
WO (1) | WO2007038215A1 (es) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005105814A1 (en) * | 2004-04-28 | 2005-11-10 | Incyte Corporation | Tetracyclic inhibitors of janus kinases |
EP1926735A1 (en) | 2005-09-22 | 2008-06-04 | Incyte Corporation | Tetracyclic inhibitors of janus kinases |
PT1951684T (pt) * | 2005-11-01 | 2016-10-13 | Targegen Inc | Inibidores de cinases de tipo biaril-meta-pirimidina |
US8133900B2 (en) * | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
US8604042B2 (en) * | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
CN103214483B (zh) | 2005-12-13 | 2014-12-17 | 因塞特公司 | 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]嘧啶 |
US20070248961A1 (en) * | 2006-04-20 | 2007-10-25 | Maher Albitar | Methods for detecting mutations in JAK2 nucleic acid |
AU2007322033B2 (en) | 2006-11-20 | 2013-07-11 | President And Fellows Of Harvard College | Methods, compositions, and kits for treating pain and pruritis |
EP2121692B1 (en) | 2006-12-22 | 2013-04-10 | Incyte Corporation | Substituted heterocycles as janus kinase inhibitors |
KR101549876B1 (ko) | 2007-06-13 | 2015-09-03 | 인사이트 코포레이션 | 야누스 키나제 억제제(R)―3―(4―(7H―피롤로[2,3-d]피리미딘―4―일)―1H―피라졸―1―일)―3―사이클로펜틸프로판니트릴의 염 |
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US20090197869A1 (en) | 2009-08-06 |
EP2270014A1 (en) | 2011-01-05 |
JP2009508968A (ja) | 2009-03-05 |
US8563541B2 (en) | 2013-10-22 |
US8835423B2 (en) | 2014-09-16 |
TWI406865B (zh) | 2013-09-01 |
US20070149506A1 (en) | 2007-06-28 |
EP1926735A1 (en) | 2008-06-04 |
US20140031344A1 (en) | 2014-01-30 |
TW200804391A (en) | 2008-01-16 |
CA2621261A1 (en) | 2007-04-05 |
CA2621261C (en) | 2014-05-20 |
JP5119154B2 (ja) | 2013-01-16 |
US20120329782A1 (en) | 2012-12-27 |
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