DE602006015963D1 - Immunstimulatorisches verfahren - Google Patents
Immunstimulatorisches verfahrenInfo
- Publication number
- DE602006015963D1 DE602006015963D1 DE602006015963T DE602006015963T DE602006015963D1 DE 602006015963 D1 DE602006015963 D1 DE 602006015963D1 DE 602006015963 T DE602006015963 T DE 602006015963T DE 602006015963 T DE602006015963 T DE 602006015963T DE 602006015963 D1 DE602006015963 D1 DE 602006015963D1
- Authority
- DE
- Germany
- Prior art keywords
- immunostimulative
- procedure
- oligonucleotide
- steroid
- pharmaceuticals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69617305P | 2005-07-01 | 2005-07-01 | |
PCT/SE2006/050229 WO2007004977A1 (en) | 2005-07-01 | 2006-06-29 | Immunostimulatory method |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006015963D1 true DE602006015963D1 (de) | 2010-09-16 |
Family
ID=37604739
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006015963T Active DE602006015963D1 (de) | 2005-07-01 | 2006-06-29 | Immunstimulatorisches verfahren |
Country Status (14)
Country | Link |
---|---|
US (2) | US8258107B2 (de) |
EP (3) | EP2380584B1 (de) |
JP (3) | JP5074392B2 (de) |
AT (1) | ATE476193T1 (de) |
AU (1) | AU2006266503B2 (de) |
CA (1) | CA2612162C (de) |
CY (1) | CY1114965T1 (de) |
DE (1) | DE602006015963D1 (de) |
DK (2) | DK2269622T3 (de) |
ES (3) | ES2349617T3 (de) |
PL (2) | PL2269622T3 (de) |
PT (1) | PT2269622E (de) |
SI (2) | SI2380584T1 (de) |
WO (1) | WO2007004977A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2435531T3 (es) * | 2005-07-01 | 2013-12-20 | Index Pharmaceuticals Ab | Modulación de la capacidad de respuesta a los esteroides |
PT2269622E (pt) * | 2005-07-01 | 2014-03-20 | Index Pharmaceuticals Ab | Oligonucleotídeos cpg utilizados para aumentar a actividade dos esteróides num doente dependente de esteróides |
EP1940472A1 (de) * | 2005-10-28 | 2008-07-09 | Index Pharmaceuticals AB | Zusammensetzung und verfahren zur prävention, behandlung und/oder linderung einer entzündlichen erkrankung |
CN101820908A (zh) * | 2007-10-09 | 2010-09-01 | 科利制药公司 | 包含改性糖部分的免疫刺激寡核苷酸类似物 |
US8574834B2 (en) | 2007-12-14 | 2013-11-05 | Index Pharmaceuticals Ab | Method for predicting the response to a therapy |
CA2728276A1 (en) * | 2008-06-18 | 2009-12-23 | Index Pharmaceuticals Ab | Combination therapies against cancer |
ES2560782T3 (es) * | 2008-11-04 | 2016-02-22 | Index Pharmaceuticals Ab | Compuestos y métodos para el tratamiento de enfermedades inflamatorias del SNC |
US9920317B2 (en) | 2010-11-12 | 2018-03-20 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
AU2011325956B2 (en) | 2010-11-12 | 2016-07-14 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
EP2596806A1 (de) | 2011-11-25 | 2013-05-29 | Index Pharmaceuticals AB | Verfahren zur Vorbeugung einer Dickdarmresektion |
EA201492116A1 (ru) | 2012-05-16 | 2015-05-29 | Рана Терапьютикс, Инк. | Композиции и способы для модулирования экспрессии mecp2 |
CN104583398A (zh) | 2012-05-16 | 2015-04-29 | Rana医疗有限公司 | 用于调节基因表达的组合物和方法 |
US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
CA2966044A1 (en) | 2014-10-30 | 2016-05-06 | The General Hospital Corporation | Methods for modulating atrx-dependent gene repression |
US10900036B2 (en) | 2015-03-17 | 2021-01-26 | The General Hospital Corporation | RNA interactome of polycomb repressive complex 1 (PRC1) |
CA3043768A1 (en) | 2016-11-29 | 2018-06-07 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
GB201707503D0 (en) * | 2017-05-10 | 2017-06-21 | Index Pharmaceuticals Ab | New Therapy 3 |
GB201707500D0 (en) * | 2017-05-10 | 2017-06-21 | Index Pharmaceuticals Ab | New therapy |
GB201707501D0 (en) * | 2017-05-10 | 2017-06-21 | Index Pharmaceuticals Ab | New therapy 2 |
GB201807312D0 (en) * | 2018-05-03 | 2018-06-20 | Index Pharmaceuticals Ab | Formulation |
Family Cites Families (68)
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US5149797A (en) | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
EP0468520A3 (en) | 1990-07-27 | 1992-07-01 | Mitsui Toatsu Chemicals, Inc. | Immunostimulatory remedies containing palindromic dna sequences |
US6346614B1 (en) | 1992-07-23 | 2002-02-12 | Hybridon, Inc. | Hybrid oligonucleotide phosphorothioates |
TW244371B (de) | 1992-07-23 | 1995-04-01 | Tri Clover Inc | |
US5652355A (en) * | 1992-07-23 | 1997-07-29 | Worcester Foundation For Experimental Biology | Hybrid oligonucleotide phosphorothioates |
CA2105595A1 (en) * | 1992-09-23 | 1994-03-24 | Ramaswamy Narayanan | Antisense polynucleotides |
US5849719A (en) * | 1993-08-26 | 1998-12-15 | The Regents Of The University Of California | Method for treating allergic lung disease |
CA2194761C (en) | 1994-07-15 | 2006-12-19 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6429199B1 (en) * | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
US20030078223A1 (en) * | 1996-01-30 | 2003-04-24 | Eyal Raz | Compositions and methods for modulating an immune response |
EP0879284B1 (de) | 1996-01-30 | 2009-07-29 | The Regents of The University of California | Expressionsvektoren, die eine antigen-spezifische immunantwort induzieren, und methoden für ihre verwendung. |
SE9602300D0 (sv) * | 1996-06-11 | 1996-06-11 | Karolinska Innovations Ab | New composition and methods |
ATE292980T1 (de) | 1996-10-11 | 2005-04-15 | Univ California | Immunostimulierende oligonucleotidekonjugate |
WO1998037919A1 (en) | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
ATE441432T1 (de) | 1997-03-10 | 2009-09-15 | Ottawa Hospital Res Inst | Verwendung von nicht-methyliertem cpg dinukleotid in kombination mit aluminium als adjuvantien |
US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
US6426334B1 (en) | 1997-04-30 | 2002-07-30 | Hybridon, Inc. | Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal |
EP1003531B1 (de) | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Verfahren zur Herstellung von Nukleinsäurekonstrukten |
US6589940B1 (en) * | 1997-06-06 | 2003-07-08 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
US6133246A (en) * | 1997-08-13 | 2000-10-17 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide compositions and methods for the modulation of JNK proteins |
ES2284247T3 (es) * | 1998-04-03 | 2007-11-01 | University Of Iowa Research Foundation | Metodos y productos para estimular el sistema inmunitario usando oligonucleotidos y citoquinas inmunoterapeuticos. |
AU3884199A (en) | 1998-05-06 | 1999-11-23 | Ottawa Health Research Institute | Methods for the prevention and treatment of parasitic infections and related diseases using cpg oligonucleotides |
IL139646A0 (en) * | 1998-05-14 | 2002-02-10 | Coley Pharm Group Inc | Methods for regulating hematopoiesis using cpg-oligonucleotides |
EP1733735B1 (de) * | 1998-05-22 | 2017-03-22 | Ottawa Hospital Research Institute | Verfahren und Produkte zur Induktion von mukosaler Immunität |
US6562798B1 (en) | 1998-06-05 | 2003-05-13 | Dynavax Technologies Corp. | Immunostimulatory oligonucleotides with modified bases and methods of use thereof |
WO2000006588A1 (en) | 1998-07-27 | 2000-02-10 | University Of Iowa Research Foundation | STEREOISOMERS OF CpG OLIGONUCLEOTIDES AND RELATED METHODS |
AP1775A (en) * | 1999-09-25 | 2007-08-28 | Univ Iowa Res Found | Immunostimulatory nucleic acids. |
US6949520B1 (en) * | 1999-09-27 | 2005-09-27 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
MXPA02003059A (es) | 1999-09-27 | 2002-09-30 | Univ Iowa Res Found | Metodos relacionados con interferon inducido por acido nucleico inmunoestabilizador. |
EP1688147A1 (de) | 1999-09-27 | 2006-08-09 | Coley Pharmaceutical Group, Inc. | Verfahren mittels durch Nukleinsäuren induziertes immunstimulatorisches Interferon |
US7223398B1 (en) * | 1999-11-15 | 2007-05-29 | Dynavax Technologies Corporation | Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof |
US7585847B2 (en) * | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
US20020156033A1 (en) * | 2000-03-03 | 2002-10-24 | Bratzler Robert L. | Immunostimulatory nucleic acids and cancer medicament combination therapy for the treatment of cancer |
US20040131628A1 (en) * | 2000-03-08 | 2004-07-08 | Bratzler Robert L. | Nucleic acids for the treatment of disorders associated with microorganisms |
US20020107212A1 (en) | 2000-03-10 | 2002-08-08 | Nest Gary Van | Methods of reducing papillomavirus infection using immunomodulatory polynucleotide sequences |
US6649341B1 (en) * | 2000-04-19 | 2003-11-18 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Human glucocorticoid receptor 1A promoter and splice variants |
WO2001097843A2 (en) | 2000-06-22 | 2001-12-27 | University Of Iowa Research Foundation | Methods for enhancing antibody-induced cell lysis and treating cancer |
US20020198165A1 (en) * | 2000-08-01 | 2002-12-26 | Bratzler Robert L. | Nucleic acids for the prevention and treatment of gastric ulcers |
WO2002022809A2 (en) | 2000-09-15 | 2002-03-21 | Coley Pharmaceutical Gmbh | PROCESS FOR HIGH THROUGHPUT SCREENING OF CpG-BASED IMMUNO-AGONIST/ANTAGONIST |
US6294382B1 (en) * | 2000-11-27 | 2001-09-25 | Isis Pharmaceuticals, Inc. | Antisense modulation of SRC-1 expression |
AU2002248185A1 (en) * | 2000-12-14 | 2002-07-16 | Coley Pharmaceutical Group, Inc. | Inhibition of angiogenesis by nucleic acids |
JP2002257827A (ja) * | 2001-03-01 | 2002-09-11 | Jenokkusu Soyaku Kenkyusho:Kk | ステロイド応答性の検査方法 |
US20030050268A1 (en) * | 2001-03-29 | 2003-03-13 | Krieg Arthur M. | Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases |
WO2002085308A2 (en) * | 2001-04-24 | 2002-10-31 | Epigenesis Pharmaceuticals, Inc. | Antisense and anti-inflammatory based compositions to treat respiratory disorders |
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EP1434602B1 (de) * | 2001-10-06 | 2014-12-17 | Merial Limited | CpG plus Öl in Wasser Emulsionen als Adjuvantsystem fuer trunkiertes bovines Herpesvirus-1 Glykoprotein D |
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EP3006043B1 (de) * | 2002-04-04 | 2019-05-29 | Zoetis Belgium S.A. | Immunostimulatorische g,u-haltige oligoribonucleotide |
US20060257851A1 (en) * | 2002-11-26 | 2006-11-16 | Itzhak Bentwich | Bioinformatically detectable group of novel viral regulatory genes and uses thereof |
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WO2004064782A2 (en) * | 2003-01-16 | 2004-08-05 | Hybridon, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides |
ZA200507562B (en) * | 2003-03-26 | 2006-11-29 | Cytos Biotechnology Ag | HIV-peptide-carrier-conjugates |
AU2004226605A1 (en) | 2003-04-02 | 2004-10-14 | Coley Pharmaceutical Group, Ltd. | Immunostimulatory nucleic acid oil-in-water formulations for topical application |
MXPA05012421A (es) | 2003-05-16 | 2006-02-22 | Hybridon Inc | Tratamiento sinergistico de cancer usando inmunomeros junto con agentes quimioterapeuticos. |
US20050175630A1 (en) * | 2003-12-23 | 2005-08-11 | Eyal Raz | Immunogenic compositions and methods of use thereof |
WO2005065678A1 (en) * | 2003-12-30 | 2005-07-21 | 3M Innovative Properties Company | Immunomodulatory combinations |
DK1716234T3 (da) | 2004-02-20 | 2014-01-20 | Mologen Ag | Substitueret, ikke-kodende nukleinsyremolekyle til terapeutisk og profylaktisk immunstimulering i mennesker og højerestående dyr |
SE0400399D0 (sv) | 2004-02-20 | 2004-02-20 | Index Pharmaceuticals Ab | Methods and compositions for the treatment or prevention of secondary ischemic injury |
US20050222072A1 (en) | 2004-02-20 | 2005-10-06 | Hybridon, Inc. | Potent mucosal immune response induced by modified immunomodulatory oligonucleotides |
AU2005257938B2 (en) | 2004-06-15 | 2010-11-11 | Idera Pharmaceuticals, Inc. | Immunostimulatory oligonucleotide multimers |
WO2006015560A1 (de) | 2004-08-09 | 2006-02-16 | Mologen Ag | Immunmodulierendes mittel in verbindung mit chemotherapeutischen massnahmen |
PL1794174T3 (pl) | 2004-09-01 | 2012-11-30 | Dynavax Tech Corp | Sposoby i kompozycje do hamowania wrodzonych odpowiedzi immunologicznych i autoodporności |
JP2008535859A (ja) | 2005-04-08 | 2008-09-04 | コーリー ファーマシューティカル グループ,インコーポレイテッド | 感染症によって悪化した喘息を治療するための方法 |
ES2435531T3 (es) * | 2005-07-01 | 2013-12-20 | Index Pharmaceuticals Ab | Modulación de la capacidad de respuesta a los esteroides |
PT2269622E (pt) * | 2005-07-01 | 2014-03-20 | Index Pharmaceuticals Ab | Oligonucleotídeos cpg utilizados para aumentar a actividade dos esteróides num doente dependente de esteróides |
-
2006
- 2006-06-29 PT PT101629897T patent/PT2269622E/pt unknown
- 2006-06-29 AU AU2006266503A patent/AU2006266503B2/en not_active Ceased
- 2006-06-29 EP EP11166835.6A patent/EP2380584B1/de active Active
- 2006-06-29 AT AT06748068T patent/ATE476193T1/de not_active IP Right Cessation
- 2006-06-29 ES ES06748068T patent/ES2349617T3/es active Active
- 2006-06-29 US US11/917,482 patent/US8258107B2/en active Active
- 2006-06-29 SI SI200631723T patent/SI2380584T1/sl unknown
- 2006-06-29 WO PCT/SE2006/050229 patent/WO2007004977A1/en active Application Filing
- 2006-06-29 EP EP06748068A patent/EP1901759B1/de not_active Not-in-force
- 2006-06-29 PL PL10162989T patent/PL2269622T3/pl unknown
- 2006-06-29 ES ES11166835.6T patent/ES2442090T3/es active Active
- 2006-06-29 SI SI200631755T patent/SI2269622T1/sl unknown
- 2006-06-29 DK DK10162989.7T patent/DK2269622T3/en active
- 2006-06-29 JP JP2008519234A patent/JP5074392B2/ja not_active Expired - Fee Related
- 2006-06-29 ES ES10162989.7T patent/ES2450593T3/es active Active
- 2006-06-29 DK DK11166835.6T patent/DK2380584T3/da active
- 2006-06-29 CA CA2612162A patent/CA2612162C/en not_active Expired - Fee Related
- 2006-06-29 PL PL11166835T patent/PL2380584T3/pl unknown
- 2006-06-29 DE DE602006015963T patent/DE602006015963D1/de active Active
- 2006-06-29 EP EP10162989.7A patent/EP2269622B1/de active Active
-
2012
- 2012-07-03 JP JP2012149378A patent/JP5945176B2/ja not_active Expired - Fee Related
- 2012-07-03 JP JP2012149379A patent/JP2012232989A/ja not_active Withdrawn
- 2012-07-09 US US13/544,353 patent/US8592390B2/en active Active
-
2014
- 2014-03-07 CY CY20141100187T patent/CY1114965T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2612162A1 (en) | 2007-01-11 |
ES2349617T3 (es) | 2011-01-07 |
WO2007004977A1 (en) | 2007-01-11 |
EP2380584A1 (de) | 2011-10-26 |
US20120277293A1 (en) | 2012-11-01 |
ES2450593T3 (es) | 2014-03-25 |
ES2442090T3 (es) | 2014-02-10 |
DK2380584T3 (da) | 2014-01-20 |
EP2269622A1 (de) | 2011-01-05 |
US8258107B2 (en) | 2012-09-04 |
PT2269622E (pt) | 2014-03-20 |
US8592390B2 (en) | 2013-11-26 |
US20100234449A1 (en) | 2010-09-16 |
EP2380584B1 (de) | 2013-10-16 |
AU2006266503A1 (en) | 2007-01-11 |
PL2380584T3 (pl) | 2014-03-31 |
JP2012232988A (ja) | 2012-11-29 |
JP5945176B2 (ja) | 2016-07-05 |
DK2269622T3 (en) | 2014-03-24 |
EP1901759A1 (de) | 2008-03-26 |
ATE476193T1 (de) | 2010-08-15 |
SI2269622T1 (sl) | 2014-05-30 |
JP2008544983A (ja) | 2008-12-11 |
PL2269622T3 (pl) | 2014-05-30 |
JP5074392B2 (ja) | 2012-11-14 |
CA2612162C (en) | 2016-05-17 |
EP2269622B1 (de) | 2013-12-25 |
SI2380584T1 (sl) | 2014-04-30 |
EP1901759B1 (de) | 2010-08-04 |
AU2006266503B2 (en) | 2011-12-08 |
CY1114965T1 (el) | 2016-12-14 |
JP2012232989A (ja) | 2012-11-29 |
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