AR049771A1 - Derivados de pirimidina para uso como ligandos del receptor vaniloide y su empleo en tratamientos - Google Patents
Derivados de pirimidina para uso como ligandos del receptor vaniloide y su empleo en tratamientosInfo
- Publication number
- AR049771A1 AR049771A1 ARP050100490A ARP050100490A AR049771A1 AR 049771 A1 AR049771 A1 AR 049771A1 AR P050100490 A ARP050100490 A AR P050100490A AR P050100490 A ARP050100490 A AR P050100490A AR 049771 A1 AR049771 A1 AR 049771A1
- Authority
- AR
- Argentina
- Prior art keywords
- nrara
- alkyl
- orb
- disorders
- inflammatory
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 230000002757 inflammatory effect Effects 0.000 abstract 5
- 208000004454 Hyperalgesia Diseases 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000035475 disorder Diseases 0.000 abstract 3
- 208000004296 neuralgia Diseases 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 230000002792 vascular Effects 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
- 206010019233 Headaches Diseases 0.000 abstract 2
- 208000035154 Hyperesthesia Diseases 0.000 abstract 2
- 206010065390 Inflammatory pain Diseases 0.000 abstract 2
- 208000002193 Pain Diseases 0.000 abstract 2
- 206010053552 allodynia Diseases 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 230000002496 gastric effect Effects 0.000 abstract 2
- 231100000869 headache Toxicity 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 208000021722 neuropathic pain Diseases 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- 230000036407 pain Effects 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 208000011580 syndromic disease Diseases 0.000 abstract 2
- 208000014181 Bronchial disease Diseases 0.000 abstract 1
- 208000001387 Causalgia Diseases 0.000 abstract 1
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 abstract 1
- 206010012434 Dermatitis allergic Diseases 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 208000009889 Herpes Simplex Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000003251 Pruritus Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- -1 Pyrimidine ethers Chemical class 0.000 abstract 1
- 208000025747 Rheumatic disease Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 206010040830 Skin discomfort Diseases 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- 206010043269 Tension headache Diseases 0.000 abstract 1
- 208000008548 Tension-Type Headache Diseases 0.000 abstract 1
- 206010047642 Vitiligo Diseases 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 208000014439 complex regional pain syndrome type 2 Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000000718 duodenal ulcer Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 210000000981 epithelium Anatomy 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 208000030533 eye disease Diseases 0.000 abstract 1
- 208000020694 gallbladder disease Diseases 0.000 abstract 1
- 230000003779 hair growth Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000004899 motility Effects 0.000 abstract 1
- 230000002956 necrotizing effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000002889 sympathetic effect Effects 0.000 abstract 1
- 230000001457 vasomotor Effects 0.000 abstract 1
- 208000001319 vasomotor rhinitis Diseases 0.000 abstract 1
- 230000009278 visceral effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Nutrition Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54389604P | 2004-02-11 | 2004-02-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR049771A1 true AR049771A1 (es) | 2006-09-06 |
Family
ID=34860474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050100490A AR049771A1 (es) | 2004-02-11 | 2005-02-11 | Derivados de pirimidina para uso como ligandos del receptor vaniloide y su empleo en tratamientos |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7511044B2 (https=) |
| EP (1) | EP1720868B1 (https=) |
| JP (1) | JP2007522235A (https=) |
| KR (1) | KR100813093B1 (https=) |
| CN (1) | CN1953976A (https=) |
| AR (1) | AR049771A1 (https=) |
| AT (1) | ATE447570T1 (https=) |
| AU (1) | AU2005212517B2 (https=) |
| BR (1) | BRPI0507927A (https=) |
| CA (1) | CA2555685A1 (https=) |
| DE (1) | DE602005017468D1 (https=) |
| EA (1) | EA010265B1 (https=) |
| ES (1) | ES2333973T3 (https=) |
| IL (1) | IL177369A0 (https=) |
| MY (1) | MY139645A (https=) |
| NO (1) | NO20064055L (https=) |
| TW (1) | TWI295670B (https=) |
| WO (1) | WO2005077944A1 (https=) |
| ZA (1) | ZA200607518B (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006006740A1 (ja) * | 2004-07-14 | 2006-01-19 | Japan Tobacco Inc. | ３−アミノベンズアミド化合物及びバニロイド受容体１型(ｖｒ１)活性阻害剤 |
| MX2007000480A (es) | 2004-07-15 | 2007-03-29 | Japan Tobacco Inc | Compuesto de benzamida fusionado e inhibidor de actividad de receptor de vainilloide 1. |
| US7301022B2 (en) | 2005-02-15 | 2007-11-27 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| EP1967519B1 (en) * | 2005-12-28 | 2012-09-05 | Japan Tobacco Inc. | 3,4-dihydrobenzoxazine compound and inhibitor of vanilloid receptor type 1 (vr1) activity |
| US7906508B2 (en) * | 2005-12-28 | 2011-03-15 | Japan Tobacco Inc. | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity |
| BRPI0818003A2 (pt) * | 2007-10-18 | 2019-09-24 | Novartis Ag | inibidores de csf-1r, composições e métodos de uso |
| US7905954B2 (en) * | 2008-03-07 | 2011-03-15 | Xerox Corporation | Nanosized particles of benzimidazolone pigments |
| US8025723B2 (en) | 2008-03-07 | 2011-09-27 | Xerox Corporation | Nonpolar liquid and solid phase change ink compositions comprising nanosized particles of benzimidazolone pigments |
| US7985290B2 (en) | 2008-03-07 | 2011-07-26 | Xerox Corporation | Nonpolar liquid and solid phase change ink compositions comprising nanosized particles of benzimidazolone pigments |
| US7938903B2 (en) * | 2008-03-07 | 2011-05-10 | Xerox Corporation | Nanosized particles of benzimidazolone pigments |
| US7857901B2 (en) * | 2008-03-07 | 2010-12-28 | Xerox Corporation | Nonpolar liquid and solid phase change ink compositions comprising nanosized particles of benzimidazolone pigments |
| US8012254B2 (en) | 2008-03-07 | 2011-09-06 | Xerox Corporation | Nanosized particles of benzimidazolone pigments |
| US7883574B2 (en) | 2008-03-07 | 2011-02-08 | Xerox Corporation | Methods of making nanosized particles of benzimidazolone pigments |
| HRP20131069T1 (hr) | 2008-06-16 | 2013-12-20 | Merck Patent Gmbh | Derivati kinoksalindiona |
| EP2416766B1 (en) | 2009-04-09 | 2014-04-09 | Symrise AG | Compositions comprising trans-tert-butyl cyclohexanol as skin irritation-reducing agent |
| US8362270B2 (en) | 2010-05-11 | 2013-01-29 | Xerox Corporation | Self-assembled nanostructures |
| US8703988B2 (en) | 2010-06-22 | 2014-04-22 | Xerox Corporation | Self-assembled nanostructures |
| EP2322512B1 (en) | 2009-10-19 | 2015-10-21 | Xerox Corporation | Alkylated benzimidazolone compounds and self-assembled nanostructures generated therefrom |
| KR102678074B1 (ko) * | 2012-05-17 | 2024-06-26 | 제넨테크, 인크. | 무정형 형태의 akt 저해성 피리미디닐 - 사이클로펜탄 화합물, 조성물 및 이들의 방법 |
| CN103923033B (zh) * | 2013-01-14 | 2015-11-18 | 天津药物研究院 | 具有抗胃溃疡作用的哌嗪类衍生物 |
| US10537552B2 (en) | 2015-05-05 | 2020-01-21 | Carafe Drug Innovation, Llc | Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers |
| CN111393380A (zh) * | 2018-07-09 | 2020-07-10 | 湖南博隽生物医药有限公司 | 一种用于治疗慢性炎性痛的辣椒素受体拮抗剂 |
| PY2311120A (es) * | 2022-03-01 | 2023-09-14 | Syngenta Crop Protection Ag | Compuestos herbicidas |
| CN120398870A (zh) * | 2024-01-31 | 2025-08-01 | 深圳晶蛋生物医药科技有限公司 | 一种苯并吗啉类化合物及其应用 |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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-
2005
- 2005-02-08 MY MYPI20050501A patent/MY139645A/en unknown
- 2005-02-11 DE DE602005017468T patent/DE602005017468D1/de not_active Expired - Fee Related
- 2005-02-11 JP JP2006553265A patent/JP2007522235A/ja not_active Withdrawn
- 2005-02-11 CA CA002555685A patent/CA2555685A1/en not_active Abandoned
- 2005-02-11 AR ARP050100490A patent/AR049771A1/es not_active Application Discontinuation
- 2005-02-11 CN CNA200580008675XA patent/CN1953976A/zh active Pending
- 2005-02-11 WO PCT/US2005/004378 patent/WO2005077944A1/en not_active Ceased
- 2005-02-11 EP EP05722962A patent/EP1720868B1/en not_active Expired - Lifetime
- 2005-02-11 ES ES05722962T patent/ES2333973T3/es not_active Expired - Lifetime
- 2005-02-11 AT AT05722962T patent/ATE447570T1/de not_active IP Right Cessation
- 2005-02-11 AU AU2005212517A patent/AU2005212517B2/en not_active Ceased
- 2005-02-11 BR BRPI0507927-6A patent/BRPI0507927A/pt not_active IP Right Cessation
- 2005-02-11 KR KR1020067018172A patent/KR100813093B1/ko not_active Expired - Fee Related
- 2005-02-11 EA EA200601426A patent/EA010265B1/ru not_active IP Right Cessation
- 2005-02-11 US US11/056,568 patent/US7511044B2/en not_active Expired - Fee Related
- 2005-02-14 TW TW094104222A patent/TWI295670B/zh active
-
2006
- 2006-08-08 IL IL177369A patent/IL177369A0/en unknown
- 2006-09-08 ZA ZA200607518A patent/ZA200607518B/en unknown
- 2006-09-08 NO NO20064055A patent/NO20064055L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005212517B2 (en) | 2009-05-21 |
| TWI295670B (en) | 2008-04-11 |
| AU2005212517A1 (en) | 2005-08-25 |
| US7511044B2 (en) | 2009-03-31 |
| CA2555685A1 (en) | 2005-08-25 |
| ATE447570T1 (de) | 2009-11-15 |
| IL177369A0 (en) | 2006-12-10 |
| EA010265B1 (ru) | 2008-06-30 |
| US20050176726A1 (en) | 2005-08-11 |
| KR20070033325A (ko) | 2007-03-26 |
| EP1720868B1 (en) | 2009-11-04 |
| ES2333973T3 (es) | 2010-03-03 |
| TW200534858A (en) | 2005-11-01 |
| CN1953976A (zh) | 2007-04-25 |
| EP1720868A1 (en) | 2006-11-15 |
| EA200601426A1 (ru) | 2007-02-27 |
| MY139645A (en) | 2009-10-30 |
| DE602005017468D1 (de) | 2009-12-17 |
| WO2005077944A1 (en) | 2005-08-25 |
| JP2007522235A (ja) | 2007-08-09 |
| ZA200607518B (en) | 2008-07-30 |
| KR100813093B1 (ko) | 2008-03-17 |
| NO20064055L (no) | 2006-10-24 |
| BRPI0507927A (pt) | 2007-07-17 |
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