AR032892A1 - Derivados de benzofurano o de benzotiofeno, su utilizacion, su procedimiento de preparacion y medicamentos y composiciones farmaceuticas o veterinarias que los contienen - Google Patents
Derivados de benzofurano o de benzotiofeno, su utilizacion, su procedimiento de preparacion y medicamentos y composiciones farmaceuticas o veterinarias que los contienenInfo
- Publication number
- AR032892A1 AR032892A1 ARP010104023A ARP010104023A AR032892A1 AR 032892 A1 AR032892 A1 AR 032892A1 AR P010104023 A ARP010104023 A AR P010104023A AR P010104023 A ARP010104023 A AR P010104023A AR 032892 A1 AR032892 A1 AR 032892A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- general formula
- linear
- alkyl
- branched
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Derivados de benzofurano o de benzotiofeno de formula general (1) así como sus sales farmacéuticamente aceptables, en la cual: A representa alquileno C1-5, eventualmente sustituido por hidroxilo, o A representa la formula general (2) donde R19 y R20, idénticos o diferentes, representan cada uno, alquileno C1-4, R30 y R31, tomados juntos, representan carbonilo con el carbono sobre el cual están fijos, o representan la formula general (3), en la cual R29 representa un grupo alquileno C1-4, T representa hidrogeno o un radical alquilo C1-4, R representa: ciano, hidroximetilo, formilo o tetrazolilo, un grupo éster de formula general (4), donde R4 representa alquilo C1-6, o cicloalquilo C3-6, un grupo carboxilo de formula general (5), donde R5, representa hidrogeno o un átomo de metal alcalino, un grupo amida de formula general (6) donde R6 y R7, idénticos o diferentes, representan hidrogeno o alquilo C1-4, o R6 y R7, cuando se toman, representan una cadena alquileno C2-6, un grupo cetona de formula general (7) donde R8 representa alquilo C1-4, un grupo oxima de formula general (8) donde R9 representa hidrogeno o alquilo C1-4, un grupo carboxilo de formula general (9) donde R10 representa un grupo alquileno C1-4, R11 representa hidrogeno o un radical alquilo C1-4, R12 representa un radical alquilo C1-4 o R11 y R12, cuando se toman en forma conjunta, representan una cadena alquileno C2-6, un grupo de la formula general (10), en la cual R32 y R33, idénticos o diferentes, representan un grupo alquilo C1-4, lineal o ramificado, R1 representa hidrogeno, un grupo alquilo C1-6 lineal o ramificado, cicloalquilo C3-6, bencilo o fenilo eventualmente sustituido por uno o varios sustituyentes seleccionados entre átomos de halogeno, grupos alquilo C1-4 o grupos alcoxi C1-4 o grupos alcoxi C1-4, o R1 representa un grupo de formula general (11) en la cual R21 representa un grupo alquileno C1-4, lineal o ramificado, y R22 representa un grupo alquilo C1-4, lineal o ramificado o R1 representa un grupo de formula general (12) en la cual R23 representa un grupo alquileno C1-6, lineal o ramificado, R2 y R3 idénticos o diferentes, representan hidrogeno, un grupo alquilo C1-6, lineal o ramificado, eventualmente sustituido por uno o varios átomos de halogeno o por un grupo pirrolidinilo, un grupo cicloalquilo C3-6 un grupo de formula general (13) en la cual R24 representa un grupo alquileno C1-4, lineal o ramificado y R25 representa un grupo alquilo C1-4, lineal o ramificado, o R2 y R3 cuando se toman en forma conjunta, representan un grupo alquileno C3-10, lineal o ramificado, o representan con el átomo de nitrogeno sobre el cual están fijos, un grupo de formula general (14) en la cual R26, R27 y R28, idénticos o diferentes, representan hidrogeno o un grupo alquilo C1-4, lineal o ramificado, o R26 representa hidrogeno o un grupo alquilo C1-4, lineal o ramificado, y R27 y R28, cuando se toman en forma conjunta, representan un grupo alquileno C1-4, lineal o ramificado, W, W' y Z son tales que: cuando W y W', idénticos representan CH, Z representa ûO- o ûS-, cuando W representa CH y W' representa C-R13, Z representa ûCH=C-R14, R13 y R14 son idénticos o diferentes y representan hidrogeno, un átomo de halogeno, un radical alquilo C1-4, o un radical alcoxi C1-4, X representa ûO- o ûS-, esos derivados de benzofurano o de benzotiofeno se encuentran en forma de isomeros individuales o de mezclas de éstos. Son utiles como medicamentos en particular en el tratamiento de síndromes patologicos del sistema cardiovascular.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0010834A FR2813306B1 (fr) | 2000-08-23 | 2000-08-23 | Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR032892A1 true AR032892A1 (es) | 2003-12-03 |
Family
ID=8853674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010104023A AR032892A1 (es) | 2000-08-23 | 2001-08-23 | Derivados de benzofurano o de benzotiofeno, su utilizacion, su procedimiento de preparacion y medicamentos y composiciones farmaceuticas o veterinarias que los contienen |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US6949583B2 (es) |
| EP (1) | EP1315709B1 (es) |
| JP (2) | JP5081363B2 (es) |
| KR (1) | KR100911280B1 (es) |
| CN (1) | CN1246315C (es) |
| AR (1) | AR032892A1 (es) |
| AT (1) | ATE469138T1 (es) |
| AU (2) | AU2001284149B2 (es) |
| BG (1) | BG66240B1 (es) |
| BR (1) | BR0113425B1 (es) |
| CA (1) | CA2415847C (es) |
| CY (1) | CY1110738T1 (es) |
| CZ (1) | CZ304003B6 (es) |
| DE (1) | DE60142240D1 (es) |
| DK (1) | DK1315709T3 (es) |
| EA (1) | EA006237B1 (es) |
| ES (1) | ES2346291T3 (es) |
| FR (1) | FR2813306B1 (es) |
| HK (1) | HK1053113A1 (es) |
| HU (1) | HU229456B1 (es) |
| IL (2) | IL153632A0 (es) |
| IS (1) | IS2821B (es) |
| MA (1) | MA26943A1 (es) |
| ME (2) | MEP23008A (es) |
| MX (1) | MXPA03001463A (es) |
| NO (1) | NO328138B1 (es) |
| NZ (1) | NZ523446A (es) |
| OA (1) | OA12359A (es) |
| PL (1) | PL219848B1 (es) |
| PT (1) | PT1315709E (es) |
| RS (1) | RS51603B (es) |
| SI (1) | SI1315709T1 (es) |
| SK (1) | SK288126B6 (es) |
| TW (1) | TWI290920B (es) |
| WO (1) | WO2002016339A1 (es) |
| ZA (1) | ZA200300744B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7401072B2 (en) * | 2003-06-10 | 2008-07-15 | Google Inc. | Named URL entry |
| RU2409352C2 (ru) * | 2005-05-05 | 2011-01-20 | САНОФИ-АВЕНТИС Ю.Эс. ЭлЭлСи | Стабильные составы наночастиц |
| FR2893616B1 (fr) * | 2005-11-23 | 2008-01-04 | Sanofi Aventis Sa | Nouveaux derives d'indolizine, leur procede de preparation et les compositions therapeutiques les comprenant |
| CN1946120B (zh) * | 2006-10-20 | 2010-05-12 | 华为技术有限公司 | 实现话单关联的方法及系统 |
| EP2308488A1 (en) | 2009-10-09 | 2011-04-13 | Sanofi-Aventis | Use of celivarone for the preparation of a medicament for use in the prevention of implantable cardioverter defibrillator interventions or death |
| US20110207811A1 (en) * | 2010-02-19 | 2011-08-25 | Sanofi-Aventis | Use of celivarone for reducing occurrences of cardiovascular hospitalization |
| FR2958290B1 (fr) | 2010-03-30 | 2012-10-19 | Sanofi Aventis | Procede de preparation de derives de sulfonamido-benzofurane |
| HUP1000330A2 (en) | 2010-06-18 | 2011-12-28 | Sanofi Sa | Process for the preparation of dronedarone and the novel intermediates |
| AU2011202542A1 (en) | 2010-07-14 | 2012-02-02 | Indian Institute Of Science | Benzothiophene carboxamide compounds, composition and applications thereof |
| FR2963006B1 (fr) | 2010-07-21 | 2013-03-15 | Sanofi Aventis | Procede de preparation de derives de nitro-benzofurane |
| FR2967067A1 (fr) | 2010-11-10 | 2012-05-11 | Sanofi Aventis | Composition pharmaceutique et forme galenique a base de dronedarone et son procede de preparation |
| HUP1100167A2 (en) | 2011-03-29 | 2012-11-28 | Sanofi Sa | Process for preparation of dronedarone by mesylation |
| HUP1100165A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Process for preparation of dronedarone by n-butylation |
| CN102757444B (zh) * | 2011-04-29 | 2016-02-10 | 南京信诺泰医药有限公司 | 具有一氧化氮供体性质的苯并呋喃类化合物 |
| FR2983198B1 (fr) | 2011-11-29 | 2013-11-15 | Sanofi Sa | Procede de preparation de derives de 5-amino-benzoyl-benzofurane |
| EP2617718A1 (en) | 2012-01-20 | 2013-07-24 | Sanofi | Process for preparation of dronedarone by the use of dibutylaminopropanol reagent |
| WO2013121235A2 (en) | 2012-02-13 | 2013-08-22 | Sanofi | Process for preparation of dronedarone by removal of hydroxyl group |
| WO2013121234A1 (en) | 2012-02-14 | 2013-08-22 | Sanofi | Process for the preparation of dronedarone by oxidation of a sulphenyl group |
| US9382223B2 (en) | 2012-02-22 | 2016-07-05 | Sanofi | Process for preparation of dronedarone by oxidation of a hydroxyl group |
| US9238636B2 (en) | 2012-05-31 | 2016-01-19 | Sanofi | Process for preparation of dronedarone by Grignard reaction |
| CN105315245B (zh) * | 2014-06-16 | 2018-10-12 | 华润赛科药业有限责任公司 | 苯并呋喃类衍生物、其制备方法和应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3248401A (en) | 1966-04-26 | Diethylaminoe hoxybenzoyl benzofurans | ||
| GB1345872A (en) * | 1970-09-03 | 1974-02-06 | Wyeth John & Brother Ltd | Amino-and acylamino-pyridine and hydropyridine derivatives |
| US4806663A (en) | 1987-04-06 | 1989-02-21 | The University Of Tennessee Research Corporation | Certain 3-substituted 2-alkyl benzofuran derivatives |
| US4851554A (en) | 1987-04-06 | 1989-07-25 | University Of Tennessee Research Corporation | Certain 3-substituted 2-alkyl benzofuran derivatives |
| US4831054A (en) * | 1988-04-18 | 1989-05-16 | Taro Pharmaceuticals, Ltd. | 2-Alkyl-3-benzoylbenzofurans useful for treating cardiac arrhythmia |
| AT391316B (de) | 1988-09-15 | 1990-09-25 | Ebewe Arzneimittel | Neue thienyloxy-alkylamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| FR2665444B1 (fr) * | 1990-08-06 | 1992-11-27 | Sanofi Sa | Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. |
| JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
| US5482949A (en) * | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
| US5364880A (en) | 1993-06-16 | 1994-11-15 | Advanced Therapies, Inc. | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use |
| US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| US5482950A (en) * | 1993-10-15 | 1996-01-09 | Eli Lilly And Company | Methods for lowering serum cholesterol |
| US5523309A (en) * | 1995-03-10 | 1996-06-04 | Eli Lilly And Company | Benzofuran pharmaceutical compounds |
| CA2217373A1 (en) | 1996-10-10 | 1998-04-10 | Michael John Martin | Benzo¬b|thiophene compounds, intermediates, formulations, and methods |
-
2000
- 2000-08-23 FR FR0010834A patent/FR2813306B1/fr not_active Expired - Fee Related
-
2001
- 2001-08-21 AU AU2001284149A patent/AU2001284149B2/en not_active Ceased
- 2001-08-21 OA OA1200300035A patent/OA12359A/fr unknown
- 2001-08-21 ME MEP-230/08A patent/MEP23008A/xx unknown
- 2001-08-21 WO PCT/FR2001/002640 patent/WO2002016339A1/fr active IP Right Grant
- 2001-08-21 ME MEP-2008-230A patent/ME00106B/me unknown
- 2001-08-21 JP JP2002521440A patent/JP5081363B2/ja not_active Expired - Fee Related
- 2001-08-21 IL IL15363201A patent/IL153632A0/xx active IP Right Grant
- 2001-08-21 CZ CZ20030521A patent/CZ304003B6/cs not_active IP Right Cessation
- 2001-08-21 SI SI200130974T patent/SI1315709T1/sl unknown
- 2001-08-21 SK SK216-2003A patent/SK288126B6/sk not_active IP Right Cessation
- 2001-08-21 HU HU0302968A patent/HU229456B1/hu not_active IP Right Cessation
- 2001-08-21 AT AT01963113T patent/ATE469138T1/de active
- 2001-08-21 DE DE60142240T patent/DE60142240D1/de not_active Expired - Lifetime
- 2001-08-21 US US10/362,324 patent/US6949583B2/en not_active Expired - Lifetime
- 2001-08-21 BR BRPI0113425-6A patent/BR0113425B1/pt not_active IP Right Cessation
- 2001-08-21 EP EP01963113A patent/EP1315709B1/fr not_active Expired - Lifetime
- 2001-08-21 RS YU12903A patent/RS51603B/sr unknown
- 2001-08-21 CN CNB018177670A patent/CN1246315C/zh not_active Expired - Fee Related
- 2001-08-21 ES ES01963113T patent/ES2346291T3/es not_active Expired - Lifetime
- 2001-08-21 AU AU8414901A patent/AU8414901A/xx active Pending
- 2001-08-21 MX MXPA03001463A patent/MXPA03001463A/es active IP Right Grant
- 2001-08-21 EA EA200300062A patent/EA006237B1/ru not_active IP Right Cessation
- 2001-08-21 DK DK01963113.4T patent/DK1315709T3/da active
- 2001-08-21 NZ NZ523446A patent/NZ523446A/xx not_active IP Right Cessation
- 2001-08-21 KR KR1020037002618A patent/KR100911280B1/ko active IP Right Grant
- 2001-08-21 CA CA2415847A patent/CA2415847C/fr not_active Expired - Fee Related
- 2001-08-21 PL PL362119A patent/PL219848B1/pl unknown
- 2001-08-21 PT PT01963113T patent/PT1315709E/pt unknown
- 2001-08-22 TW TW090120633A patent/TWI290920B/zh not_active IP Right Cessation
- 2001-08-23 AR ARP010104023A patent/AR032892A1/es not_active Application Discontinuation
-
2002
- 2002-12-24 IL IL153632A patent/IL153632A/en not_active IP Right Cessation
-
2003
- 2003-01-13 IS IS6677A patent/IS2821B/is unknown
- 2003-01-28 ZA ZA200300744A patent/ZA200300744B/xx unknown
- 2003-02-05 BG BG107527A patent/BG66240B1/bg unknown
- 2003-02-17 MA MA27042A patent/MA26943A1/fr unknown
- 2003-02-20 NO NO20030800A patent/NO328138B1/no not_active IP Right Cessation
- 2003-07-25 HK HK03105391.1A patent/HK1053113A1/xx not_active IP Right Cessation
-
2010
- 2010-08-17 CY CY20101100763T patent/CY1110738T1/el unknown
-
2011
- 2011-12-14 JP JP2011273790A patent/JP5603849B2/ja not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR032892A1 (es) | Derivados de benzofurano o de benzotiofeno, su utilizacion, su procedimiento de preparacion y medicamentos y composiciones farmaceuticas o veterinarias que los contienen | |
| AR038843A1 (es) | Derivados de fenetanolamina para el tratamiento de enfermedades respiratorias | |
| AR048282A1 (es) | Indol- o - glucosidos sustituidos | |
| AR106945A2 (es) | Compuestos de isoindolina y composiciones farmacéuticas de los mismos | |
| AR062677A1 (es) | Derivados de biaril-sulfonamida, procesos de produccion y composiciones farmaceuticas que los comprenden | |
| ES2183782T3 (es) | Material de sutura para heridas a base de metilideno malonato. | |
| AR035617A1 (es) | Compuestos derivados de fenetanolamina, combinaciones y formulaciones farmaceuticas de los mismos, proceso para su preparacion, su uso en la preparacion de medicamentos para el tratamiento o profilaxis de una condicion clinica para la cual se indica un agonista beta2 adreno-receptor e intermediarios | |
| AR056875A1 (es) | Ligandos del receptor vaniloide y su aplicacion para la fabricacion de medicamentos | |
| AR083070A1 (es) | Analogos de nucleotidos sustituidos con heterociclos nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos para tratar enfermedades virales, en particular infecciones por vhc | |
| AR048039A1 (es) | Profarmacos de piperazina y agentes antivirales de piperidina sustituidos | |
| CY1108963T1 (el) | Λιπαρα οξεα μεσης-αλυσου, γλυκεριδια και αναλογα ως διεγερτες ερυθροποιησης | |
| AR082391A1 (es) | Inhibidores biciclicos de acetil-coa y usos de los mismos | |
| GT200300268A (es) | Nuevos derivados fluoroglucosidos heterociclicos, medicamentos que contienen estos compuestos y el uso de los mismos | |
| AR035933A1 (es) | Un compuesto derivado de fosfonato nucleosido aciclico, uso del mismo, un proceso para su preparacion y un compuesto de fosfonato. | |
| AR053149A1 (es) | Uso de compuestos de diosmetina para la obtencion de composiciones farmaceuticas destinadas a la prevencion y/o tratamiento de patologias tromboticas y patologias que conlleven el riesgo de producir trombosis | |
| PE20060430A1 (es) | Derivados de pirrolopiridina como moduladores de los receptores cannabinoides | |
| AR055568A1 (es) | Compuestos de bifenilo como antagonistas de receptores muscarinicos. procesos de obtencion y composiciones farmaceuticas. | |
| AR045155A1 (es) | Derivados de 6-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos | |
| CY1108797T1 (el) | Α-κρυσταλλικη μορφη του ρανελικου στροντιου, μεθοδος παρασκευης της και φαρμακευτικες συνθεσεις που την περιεχουν | |
| ATE370982T1 (de) | Polypropylen-blasfolie | |
| AR039601A1 (es) | Derivados de nitrosodifenilamina y composiciones farmaceuticas que los comprenden como medicamentos que se pueden utilizar en el tratamiento de patologias que se caracterizan por estres oxidativo | |
| AR040126A1 (es) | Compuesto de fenilsulfonilo, composicion farmaceutica que lo comprende y su uso para la elaboracion de un medicamento | |
| AR045156A1 (es) | Derivados de 5-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos | |
| AR048826A1 (es) | Composiciones antitranspirantes | |
| AR057651A1 (es) | Derivados n-amida de 8-azabiciclo[3.2.1]oct-3-ilo como antagonistas de ccr1, una composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades relacionadas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed, e.g., due to non-payment of fee |