CY1108963T1 - Λιπαρα οξεα μεσης-αλυσου, γλυκεριδια και αναλογα ως διεγερτες ερυθροποιησης - Google Patents
Λιπαρα οξεα μεσης-αλυσου, γλυκεριδια και αναλογα ως διεγερτες ερυθροποιησηςInfo
- Publication number
- CY1108963T1 CY1108963T1 CY20091100397T CY091100397T CY1108963T1 CY 1108963 T1 CY1108963 T1 CY 1108963T1 CY 20091100397 T CY20091100397 T CY 20091100397T CY 091100397 T CY091100397 T CY 091100397T CY 1108963 T1 CY1108963 T1 CY 1108963T1
- Authority
- CY
- Cyprus
- Prior art keywords
- glycerides
- analogs
- oil fat
- chain oil
- fat acids
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Abstract
Χρήση μιας σύνθεσης που περιλαμβάνει μια ένωση οποιουδήποτε των τύπων I, II, IIa, III και IIIa ή συνδυασμό αυτών, όπου έκαστο R1 ανεξαρτήτως είναι C7-11 αλκύλ, τα Α και Β ανεξαρτήτως είναι Η ή CO R1, το R2 είναι Η ή C1-4 αλκύλ, το Μ είναι μονοκατιόν μετάλλου (k = 1) ή δικατιόν (k = 2), το Υ είναι Ο ή ΝΗ και το Ζ είναι Ο, ΝΗ, CH2O ή ένας δεσμός για τη βιομηχανική κατασκευή ενός φαρμάκου για διέγερση ερυθροποίησης. Κατά προτίμηση, η σύνθεση περαιτέρω περιλαμβάνει ανθρώπινη ερυθροποιητίνη.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44545403P | 2003-02-07 | 2003-02-07 | |
| EP04708802A EP1592416B1 (en) | 2003-02-07 | 2004-02-06 | Medium-chain length fatty acids, glycerides and analogues as stimulators of erythropoiesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1108963T1 true CY1108963T1 (el) | 2014-07-02 |
Family
ID=32850990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091100397T CY1108963T1 (el) | 2003-02-07 | 2009-04-06 | Λιπαρα οξεα μεσης-αλυσου, γλυκεριδια και αναλογα ως διεγερτες ερυθροποιησης |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US9682054B2 (el) |
| EP (1) | EP1592416B1 (el) |
| JP (1) | JP5390070B2 (el) |
| KR (1) | KR101120775B1 (el) |
| CN (1) | CN100427081C (el) |
| AP (1) | AP2005003367A0 (el) |
| AR (1) | AR043120A1 (el) |
| AT (1) | ATE419846T1 (el) |
| AU (1) | AU2004210193B2 (el) |
| BR (1) | BRPI0407276A (el) |
| CA (1) | CA2515160C (el) |
| CY (1) | CY1108963T1 (el) |
| DE (2) | DE04708802T1 (el) |
| DK (1) | DK1592416T3 (el) |
| EA (1) | EA009939B1 (el) |
| ES (1) | ES2255467T3 (el) |
| IL (1) | IL170057A (el) |
| JO (1) | JO2705B1 (el) |
| MA (1) | MA27664A1 (el) |
| MX (1) | MXPA05008382A (el) |
| MY (1) | MY140913A (el) |
| NO (1) | NO334085B1 (el) |
| NZ (1) | NZ541593A (el) |
| PT (1) | PT1592416E (el) |
| SI (1) | SI1592416T1 (el) |
| TN (1) | TNSN05189A1 (el) |
| WO (1) | WO2004069237A1 (el) |
| ZA (1) | ZA200506246B (el) |
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| EA007322B1 (ru) | 2001-04-18 | 2006-08-25 | Прометик Байосайенсиз, Инк. | Жирные кислоты со средней длиной цепи, глицериды и аналоги как факторы, способствующие выживанию и активации нейтрофилов |
| US20070219131A1 (en) * | 2004-04-15 | 2007-09-20 | Ben-Sasson Shmuel A | Compositions capable of facilitating penetration across a biological barrier |
| AU2005329255B2 (en) * | 2004-04-15 | 2010-09-30 | Chiasma, Inc. | Compositions capable of facilitating penetration across a biological barrier |
| DK2332977T3 (en) | 2004-07-23 | 2016-02-29 | Acceleron Pharma Inc | ActRII receptor polypeptides |
| WO2006024174A1 (en) * | 2004-09-03 | 2006-03-09 | Prometic Biosciences Inc. | Substituted purinyl derivatives with immunomodulator and chemoprotective activity and use alone or with medium-chain length fatty acids or glycerides |
| MX2007003967A (es) * | 2004-10-01 | 2008-03-04 | Prometic Biosciences Inc | Alcoholes grasos con longitud de cadena media como estimuladores de hematopoyesis. |
| US8071580B2 (en) * | 2004-10-01 | 2011-12-06 | Prometic Biosciences Inc. | Medium-chain length fatty alcohols as stimulators of hematopoiesis |
| CA3045808C (en) | 2005-11-23 | 2022-08-16 | Acceleron Pharma, Inc. | Activin-actriia antagonists and uses for promoting bone growth |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| ES2415666T3 (es) | 2007-02-01 | 2013-07-26 | Acceleron Pharma, Inc. | Composiciones farmacéuticas que comprenden antagonistas de Activina-ActRIIa para uso en la prevención o el tratamiento de metástasis de cáncer de mama o pérdida ósea relacionada con el cáncer de mama |
| TW201907946A (zh) | 2007-02-02 | 2019-03-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
| EP2484372A1 (en) | 2007-02-09 | 2012-08-08 | Acceleron Pharma, Inc. | Activin-ActRIIa Antagonists and Uses for Promoting Bone Growth in Cancer Patients |
| CA2699936A1 (en) | 2007-09-18 | 2009-03-26 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
| MX338513B (es) * | 2007-11-02 | 2016-04-20 | Prometic Pharma Smt Ltd | Acidos grasos de longitud de cadena mediana y gliceridos como agentes de nefroprotección. |
| ES2414617T3 (es) * | 2007-12-19 | 2013-07-22 | Prometic Biosciences Inc. | Ácidos grasos de cadena de longitud media, sales y triglicéridos en combinación con gemcitabina para el tratamiento del cáncer pancreático |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| HRP20230761T1 (hr) | 2008-08-14 | 2023-10-13 | Acceleron Pharma Inc. | Gdf zamke |
| JP5623406B2 (ja) | 2008-09-17 | 2014-11-12 | キアズマ インコーポレイテッド | 医薬組成物および関連する送達方法 |
| AU2010258931B2 (en) | 2009-06-08 | 2015-04-23 | Acceleron Pharma Inc. | Methods for increasing thermogenic adipocytes |
| US8293881B2 (en) | 2009-06-12 | 2012-10-23 | Acceleron Pharma Inc. | Isolated nucleic acid encoding a truncated ActRIIB fusion protein |
| IL287990B (en) * | 2009-08-13 | 2022-07-01 | Acceleron Pharma Inc | Combined use of gdf traps and erythropoietin receptor activators to increase red blood cell levels |
| ES2658292T3 (es) | 2009-11-17 | 2018-03-09 | Acceleron Pharma, Inc. | Proteínas ActRIIB y variantes y usos de las mismas con respecto a la inducción de la utrofina para el tratamiento de la distrofia muscular |
| EP2638065A4 (en) | 2010-11-08 | 2014-04-09 | Acceleron Pharma Inc | ACTRIIA BINDING AGENTS AND USES THEREOF |
| TWI572352B (zh) * | 2012-03-01 | 2017-03-01 | 波麥堤克藥學Ｓｍｔ有限公司 | 用於製備具中鏈長度之脂肪酸的三酸甘油酯之方法 |
| WO2014071158A1 (en) | 2012-11-02 | 2014-05-08 | Celgene Corporation | Activin-actrii antagonists and uses for treating bone and other disorders |
| CN102973922B (zh) * | 2012-12-18 | 2016-02-03 | 华东理工大学 | 一种融合蛋白的应用 |
| CA2951926C (en) | 2014-06-13 | 2023-01-10 | Acceleron Pharma, Inc. | Methods and compositions for treating ulcers |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| ES2946160T3 (es) | 2014-12-03 | 2023-07-13 | Celgene Corp | Antagonistas de activina-ActRII y usos para tratar síndrome mielodisplásico |
| AU2016215350B2 (en) | 2015-02-03 | 2021-11-25 | Amryt Endo, Inc. | Method of treating diseases |
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| US8071580B2 (en) | 2004-10-01 | 2011-12-06 | Prometic Biosciences Inc. | Medium-chain length fatty alcohols as stimulators of hematopoiesis |
-
2004
- 2004-02-06 ZA ZA200506246A patent/ZA200506246B/en unknown
- 2004-02-06 AP AP2005003367A patent/AP2005003367A0/xx unknown
- 2004-02-06 SI SI200431064T patent/SI1592416T1/sl unknown
- 2004-02-06 AU AU2004210193A patent/AU2004210193B2/en not_active Ceased
- 2004-02-06 DK DK04708802T patent/DK1592416T3/da active
- 2004-02-06 PT PT04708802T patent/PT1592416E/pt unknown
- 2004-02-06 BR BR0407276-6A patent/BRPI0407276A/pt not_active Application Discontinuation
- 2004-02-06 KR KR1020057014499A patent/KR101120775B1/ko active IP Right Grant
- 2004-02-06 DE DE04708802T patent/DE04708802T1/de active Pending
- 2004-02-06 EP EP04708802A patent/EP1592416B1/en not_active Expired - Lifetime
- 2004-02-06 CN CNB200480004978XA patent/CN100427081C/zh not_active Expired - Fee Related
- 2004-02-06 AT AT04708802T patent/ATE419846T1/de active
- 2004-02-06 CA CA2515160A patent/CA2515160C/en not_active Expired - Fee Related
- 2004-02-06 EA EA200501267A patent/EA009939B1/ru not_active IP Right Cessation
- 2004-02-06 ES ES04708802T patent/ES2255467T3/es not_active Expired - Lifetime
- 2004-02-06 MX MXPA05008382A patent/MXPA05008382A/es active IP Right Grant
- 2004-02-06 JP JP2006502243A patent/JP5390070B2/ja not_active Expired - Fee Related
- 2004-02-06 US US10/544,350 patent/US9682054B2/en active Active
- 2004-02-06 DE DE602004018902T patent/DE602004018902D1/de not_active Expired - Lifetime
- 2004-02-06 AR ARP040100385A patent/AR043120A1/es not_active Application Discontinuation
- 2004-02-06 WO PCT/GB2004/000457 patent/WO2004069237A1/en active IP Right Grant
- 2004-02-06 NZ NZ541593A patent/NZ541593A/xx not_active IP Right Cessation
- 2004-02-07 MY MYPI20040371A patent/MY140913A/en unknown
- 2004-02-24 JO JOP/2004/0017A patent/JO2705B1/ar active
-
2005
- 2005-08-03 TN TNP2005000189A patent/TNSN05189A1/en unknown
- 2005-08-03 IL IL170057A patent/IL170057A/en active IP Right Grant
- 2005-08-26 NO NO20053994A patent/NO334085B1/no not_active IP Right Cessation
- 2005-09-05 MA MA28479A patent/MA27664A1/fr unknown
-
2009
- 2009-04-06 CY CY20091100397T patent/CY1108963T1/el unknown
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