AR027509A1 - Conjugados g-csf - Google Patents
Conjugados g-csfInfo
- Publication number
- AR027509A1 AR027509A1 ARP010100090A ARP010100090A AR027509A1 AR 027509 A1 AR027509 A1 AR 027509A1 AR P010100090 A ARP010100090 A AR P010100090A AR P010100090 A ARP010100090 A AR P010100090A AR 027509 A1 AR027509 A1 AR 027509A1
- Authority
- AR
- Argentina
- Prior art keywords
- polypeptide
- amino acid
- binding group
- csf
- acid sequence
- Prior art date
Links
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 title abstract 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 150000001413 amino acids Chemical group 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 abstract 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 abstract 1
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- 235000018977 lysine Nutrition 0.000 abstract 1
- 229920001542 oligosaccharide Polymers 0.000 abstract 1
- 150000002482 oligosaccharides Chemical class 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200000024 | 2000-01-10 | ||
| DKPA200000341 | 2000-03-02 | ||
| DKPA200000943 | 2000-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR027509A1 true AR027509A1 (es) | 2003-04-02 |
Family
ID=27222334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010100090A AR027509A1 (es) | 2000-01-10 | 2001-01-09 | Conjugados g-csf |
Country Status (20)
| Country | Link |
|---|---|
| EP (2) | EP2133098A1 (https=) |
| JP (1) | JP2003519478A (https=) |
| KR (1) | KR100773323B1 (https=) |
| CN (1) | CN1188172C (https=) |
| AR (1) | AR027509A1 (https=) |
| AT (1) | ATE435033T1 (https=) |
| AU (2) | AU782580B2 (https=) |
| BR (1) | BR0107561A (https=) |
| CA (1) | CA2395713C (https=) |
| CZ (1) | CZ20022727A3 (https=) |
| DE (1) | DE60139110D1 (https=) |
| DK (1) | DK1250154T3 (https=) |
| ES (1) | ES2327606T3 (https=) |
| HU (1) | HUP0203751A3 (https=) |
| IL (2) | IL150153A0 (https=) |
| MX (1) | MXPA02006795A (https=) |
| NO (1) | NO20023315L (https=) |
| NZ (1) | NZ520261A (https=) |
| SK (1) | SK11672002A3 (https=) |
| WO (1) | WO2001051510A2 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100773323B1 (ko) * | 2000-01-10 | 2007-11-05 | 맥시겐 홀딩스 리미티드 | 지-씨에스에프 접합체 |
| US6831158B2 (en) | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
| GB0022877D0 (en) * | 2000-09-18 | 2000-11-01 | Isis Innovation | Analogues |
| EP1425304B9 (en) | 2001-07-11 | 2010-09-08 | Maxygen, Inc. | G-csf conjugates |
| US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| ES2411007T3 (es) * | 2001-10-10 | 2013-07-04 | Novo Nordisk A/S | Remodelación y glicoconjugación de péptidos |
| GB0130720D0 (en) * | 2001-12-21 | 2002-02-06 | Serono Internat S A | Proteins |
| KR100508358B1 (ko) * | 2002-03-20 | 2005-08-17 | 주식회사 바이오폴리메드 | 생체적합성 고분자가 시스테인 잔기에 화학양론적으로 결합된 ｇ-ｃｓｆ의 제조 방법 |
| KR100521309B1 (ko) * | 2002-08-31 | 2005-10-14 | 씨제이 주식회사 | 당쇄화된 인간 과립구 형성인자 |
| US7553930B2 (en) | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof |
| NZ542094A (en) | 2003-03-14 | 2008-12-24 | Neose Technologies Inc | Branched polymer conjugates comprising a peptide and water-soluble polymer chains |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| PL1615945T3 (pl) | 2003-04-09 | 2012-03-30 | Ratiopharm Gmbh | Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami |
| KR20060018851A (ko) * | 2003-05-16 | 2006-03-02 | 교와 핫꼬 고교 가부시끼가이샤 | 조직 파괴를 수반하는 질환의 예방 및/또는 치료제 |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| US7220407B2 (en) | 2003-10-27 | 2007-05-22 | Amgen Inc. | G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| NZ548123A (en) * | 2004-01-08 | 2010-05-28 | Novo Nordisk As | O-linked glycosylation of peptides |
| US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
| WO2006031811A2 (en) | 2004-09-10 | 2006-03-23 | Neose Technologies, Inc. | Glycopegylated interferon alpha |
| WO2006050247A2 (en) | 2004-10-29 | 2006-05-11 | Neose Technologies, Inc. | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
| AU2005306894B2 (en) | 2004-11-05 | 2011-11-24 | Northwestern University | Use of SCF and G-CSF in the treatment of cerebral ischemia and neurological disorders |
| JP2006137678A (ja) * | 2004-11-10 | 2006-06-01 | Shionogi & Co Ltd | インターロイキン−２組成物 |
| US9029331B2 (en) | 2005-01-10 | 2015-05-12 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| WO2006094530A1 (en) * | 2005-03-11 | 2006-09-14 | Siegfried Ltd. | Di-polymer protein conjugates and processes for their preparation |
| WO2006121569A2 (en) | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| EP2975135A1 (en) | 2005-05-25 | 2016-01-20 | Novo Nordisk A/S | Glycopegylated factor IX |
| KR20080027291A (ko) | 2005-06-01 | 2008-03-26 | 맥시겐 홀딩스 엘티디 | 피이지화된 지-씨에스에프 폴리펩타이드 및 그 제조방법 |
| KR100694994B1 (ko) | 2005-06-13 | 2007-03-14 | 씨제이 주식회사 | 사람 과립구 콜로니 형성인자 동종체 |
| KR100735784B1 (ko) | 2005-07-20 | 2007-07-06 | 재단법인 목암생명공학연구소 | 인간 과립구콜로니자극인자 변이체 및 이의 화학적 접합물 |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| EP2049144B8 (en) | 2006-07-21 | 2015-02-18 | ratiopharm GmbH | Glycosylation of peptides via o-linked glycosylation sequences |
| EP2054521A4 (en) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | PROCESS FOR CLEANING POLYPEPTIDE CONJUGATES |
| HRP20130382T1 (hr) | 2007-04-03 | 2013-05-31 | Biogenerix Ag | Postupci lijeäśenja pomoä†u glikopegiliranog g-csf |
| WO2008147534A1 (en) * | 2007-05-22 | 2008-12-04 | Maxygen Holdings Ltd. | Method for the treatment of neutropenia by administration of a multi-pegylated granulocyte colony stimulating factor (g-csf) variant |
| CA2690611C (en) | 2007-06-12 | 2015-12-08 | Novo Nordisk A/S | Improved process for the production of nucleotide sugars |
| MX2010002448A (es) | 2007-08-27 | 2010-10-04 | Biogenerix Ag | Formulacion liquida del g-csf conjugado. |
| US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
| JP5225393B2 (ja) | 2008-02-18 | 2013-07-03 | ジエンス ヘンルイ メデイシンカンパニー リミテッド | 水溶性高分子修飾ｇ−ｃｓｆ複合体 |
| PL2257311T3 (pl) | 2008-02-27 | 2014-09-30 | Novo Nordisk As | Koniugaty cząsteczek czynnika VIII |
| US20110137011A1 (en) | 2008-04-21 | 2011-06-09 | Novo Nordisk A/S | Hyperglycosylated human coagulation factor ix |
| WO2010001414A1 (en) * | 2008-07-03 | 2010-01-07 | Lupin Limited | Expression of heterologous proteins in bacterial system using a gm-csf fusion tag |
| CN102164955B (zh) * | 2008-10-02 | 2015-05-13 | 奥克塔法马股份有限公司 | 重组人g-csf的改进的加工 |
| SG11201406455YA (en) * | 2012-04-17 | 2014-11-27 | Univ Aarhus | SorCS1 FOR USE IN THE TREATMENT OF OBESITY AND OVERWEIGHT |
| KR101623906B1 (ko) | 2014-07-23 | 2016-05-24 | 주식회사 이큐스앤자루 | 과립구 콜로니 자극인자 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물 |
| CN107916257B (zh) * | 2018-01-09 | 2020-07-28 | 华南理工大学 | T1脂肪酶突变体和应用 |
| EP4041760A4 (en) * | 2019-10-08 | 2023-10-11 | Zymeworks BC Inc. | Modified extracellular domain of granulocyte colony-stimulating factor receptor (g-csfr) and cytokines binding same |
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- 2001-01-09 NZ NZ520261A patent/NZ520261A/en not_active IP Right Cessation
- 2001-01-09 CN CNB018035906A patent/CN1188172C/zh not_active Expired - Fee Related
- 2001-01-09 CZ CZ20022727A patent/CZ20022727A3/cs unknown
- 2001-01-09 ES ES01900105T patent/ES2327606T3/es not_active Expired - Lifetime
- 2001-01-09 AR ARP010100090A patent/AR027509A1/es active IP Right Grant
- 2001-01-09 WO PCT/DK2001/000011 patent/WO2001051510A2/en not_active Ceased
- 2001-01-09 AU AU23533/01A patent/AU782580B2/en not_active Ceased
- 2001-01-09 IL IL15015301A patent/IL150153A0/xx unknown
- 2001-01-09 EP EP09075142A patent/EP2133098A1/en not_active Withdrawn
- 2001-01-09 BR BR0107561-6A patent/BR0107561A/pt not_active IP Right Cessation
- 2001-01-09 MX MXPA02006795A patent/MXPA02006795A/es active IP Right Grant
- 2001-01-09 HU HU0203751A patent/HUP0203751A3/hu unknown
- 2001-01-09 CA CA2395713A patent/CA2395713C/en not_active Expired - Fee Related
- 2001-01-09 EP EP01900105A patent/EP1250154B1/en not_active Expired - Lifetime
- 2001-01-09 DE DE60139110T patent/DE60139110D1/de not_active Expired - Lifetime
- 2001-01-09 JP JP2001551094A patent/JP2003519478A/ja active Pending
- 2001-01-09 SK SK1167-2002A patent/SK11672002A3/sk not_active Application Discontinuation
- 2001-01-09 AT AT01900105T patent/ATE435033T1/de not_active IP Right Cessation
- 2001-01-09 DK DK01900105T patent/DK1250154T3/da active
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Also Published As
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|---|---|
| NO20023315L (no) | 2002-09-05 |
| CA2395713C (en) | 2012-04-10 |
| IL150153A (en) | 2009-12-24 |
| AU2353301A (en) | 2001-07-24 |
| HK1051964A1 (en) | 2003-08-29 |
| BR0107561A (pt) | 2002-11-19 |
| EP2133098A1 (en) | 2009-12-16 |
| KR100773323B1 (ko) | 2007-11-05 |
| WO2001051510A2 (en) | 2001-07-19 |
| AU782580B2 (en) | 2005-08-11 |
| AU2005222524B2 (en) | 2008-12-11 |
| CN1404401A (zh) | 2003-03-19 |
| MXPA02006795A (es) | 2005-04-19 |
| CA2395713A1 (en) | 2001-07-19 |
| NO20023315D0 (no) | 2002-07-09 |
| SK11672002A3 (sk) | 2002-12-03 |
| JP2003519478A (ja) | 2003-06-24 |
| WO2001051510A3 (en) | 2002-03-21 |
| HUP0203751A2 (hu) | 2003-07-28 |
| EP1250154A2 (en) | 2002-10-23 |
| HUP0203751A3 (en) | 2005-01-28 |
| NZ520261A (en) | 2003-10-31 |
| ATE435033T1 (de) | 2009-07-15 |
| IL150153A0 (en) | 2002-12-01 |
| EP1250154B1 (en) | 2009-07-01 |
| KR20020079778A (ko) | 2002-10-19 |
| DE60139110D1 (de) | 2009-08-13 |
| CN1188172C (zh) | 2005-02-09 |
| AU2005222524A1 (en) | 2005-11-10 |
| CZ20022727A3 (cs) | 2002-11-13 |
| ES2327606T3 (es) | 2009-11-02 |
| DK1250154T3 (da) | 2009-08-17 |
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