US5595732A
(en)
*
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
WO1994004193A1
(en)
*
|
1992-08-21 |
1994-03-03 |
Enzon, Inc. |
Novel attachment of polyalkylene oxides to bio-effecting substances
|
US5382657A
(en)
*
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
NZ250375A
(en)
*
|
1992-12-09 |
1995-07-26 |
Ortho Pharma Corp |
Peg hydrazone and peg oxime linkage forming reagents and protein derivatives
|
US5359030A
(en)
*
|
1993-05-10 |
1994-10-25 |
Protein Delivery, Inc. |
Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
|
US5478860A
(en)
*
|
1993-06-04 |
1995-12-26 |
Inex Pharmaceuticals Corp. |
Stable microemulsions for hydrophobic compound delivery
|
CA2174350A1
(en)
*
|
1993-10-20 |
1995-04-27 |
Richard B. Greenwald |
2'- and/or 7- substituted taxoids
|
US5880131A
(en)
*
|
1993-10-20 |
1999-03-09 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
US5965566A
(en)
*
|
1993-10-20 |
1999-10-12 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
US5919455A
(en)
*
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
US5643575A
(en)
*
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
EP0730470B1
(en)
*
|
1993-11-10 |
2002-03-27 |
Enzon, Inc. |
Improved interferon polymer conjugates
|
US5951974A
(en)
*
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
US5730990A
(en)
*
|
1994-06-24 |
1998-03-24 |
Enzon, Inc. |
Non-antigenic amine derived polymers and polymer conjugates
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
US5738846A
(en)
*
|
1994-11-10 |
1998-04-14 |
Enzon, Inc. |
Interferon polymer conjugates and process for preparing the same
|
US7008624B1
(en)
*
|
1995-02-22 |
2006-03-07 |
Immunex Corporation |
Antagonists of interleukin-15
|
DE19512484A1
(de)
*
|
1995-04-04 |
1996-10-17 |
Bayer Ag |
Kohlenhydratmodifizierte Cytostatika
|
DE19514087A1
(de)
*
|
1995-04-13 |
1996-10-17 |
Deutsches Krebsforsch |
Konjugat aus einem Wirkstoff, einem Polyether und ggfs. einem nicht als körperfremd angesehenen, nativen Protein
|
EP0741187A2
(en)
*
|
1995-05-05 |
1996-11-06 |
F. Hoffmann-La Roche Ag |
Recombinant obese (Ob) proteins
|
ZA963530B
(en)
*
|
1995-05-05 |
1996-11-05 |
Hoffmann La Roche |
Recombinant obese (ob) proteins
|
DK0858343T3
(da)
|
1995-11-02 |
2004-05-10 |
Schering Corp |
Kontinuerlig lavdosis cytokininfusionsterapi
|
US5908621A
(en)
*
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
US6025324A
(en)
*
|
1996-05-15 |
2000-02-15 |
Hoffmann-La Roche Inc. |
Pegylated obese (ob) protein compositions
|
TW517067B
(en)
*
|
1996-05-31 |
2003-01-11 |
Hoffmann La Roche |
Interferon conjugates
|
ATE200030T1
(de)
*
|
1997-01-29 |
2001-04-15 |
Polymasc Pharmaceuticals Plc |
Pegylationsverfahren
|
AU6326198A
(en)
|
1997-02-13 |
1998-09-08 |
Lxr Biotechnology Inc. |
Organ preservation solution
|
DK0968291T3
(da)
|
1997-02-21 |
2004-06-07 |
Genentech Inc |
Antistoffragment-polymerkonjugater
|
US7122636B1
(en)
*
|
1997-02-21 |
2006-10-17 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and uses of same
|
US5985263A
(en)
*
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
US5981709A
(en)
*
|
1997-12-19 |
1999-11-09 |
Enzon, Inc. |
α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
|
US7005504B2
(en)
*
|
1998-01-22 |
2006-02-28 |
Genentech, Inc. |
Antibody fragment-peg conjugates
|
US6468532B1
(en)
|
1998-01-22 |
2002-10-22 |
Genentech, Inc. |
Methods of treating inflammatory diseases with anti-IL-8 antibody fragment-polymer conjugates
|
US6458355B1
(en)
|
1998-01-22 |
2002-10-01 |
Genentech, Inc. |
Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates
|
FR2774687B1
(fr)
*
|
1998-02-06 |
2002-03-22 |
Inst Nat Sante Rech Med |
Lipopeptides contenant un fragment de l'interferon gamma, et leur utilisation dans des compositions pharmaceutiques
|
US6180096B1
(en)
*
|
1998-03-26 |
2001-01-30 |
Schering Corporation |
Formulations for protection of peg-interferon alpha conjugates
|
SK286654B6
(sk)
*
|
1998-04-28 |
2009-03-05 |
Laboratoires Serono Sa |
Spôsob postupného pripájania polyetylénglykolových častí a použitie PEG-polypeptidových konjugátov vyrobených týmto spôsobom
|
EP1213029A1
(en)
|
1998-05-15 |
2002-06-12 |
Schering Corporation |
Combination therapy for eradicating detectable HCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection
|
CA2334267C
(en)
*
|
1998-06-08 |
2009-02-17 |
F. Hoffmann-La Roche Ag |
Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c
|
US6703381B1
(en)
|
1998-08-14 |
2004-03-09 |
Nobex Corporation |
Methods for delivery therapeutic compounds across the blood-brain barrier
|
PT1121382E
(pt)
*
|
1998-10-16 |
2006-10-31 |
Biogen Idec Inc |
Proteinas de fusao do interferao beta e as respectivas utilizacoes
|
EP2599503B1
(en)
|
1998-10-16 |
2017-05-17 |
Biogen MA Inc. |
Polymer conjugates of interferon beta-1A and uses thereof
|
PL219605B1
(pl)
|
1998-10-23 |
2015-06-30 |
Kirin Amgen Inc |
Dimeryczne mimetyki peptydów trombopoetynowych wiążące się z receptorem MP1 i wykazujące aktywność trombopoetyczną
|
TWI292320B
(en)
|
1999-04-08 |
2008-01-11 |
Schering Corp |
Melanoma therapy
|
US6923966B2
(en)
|
1999-04-08 |
2005-08-02 |
Schering Corporation |
Melanoma therapy
|
US6362162B1
(en)
|
1999-04-08 |
2002-03-26 |
Schering Corporation |
CML Therapy
|
US6605273B2
(en)
|
1999-04-08 |
2003-08-12 |
Schering Corporation |
Renal cell carcinoma treatment
|
PE20010288A1
(es)
|
1999-07-02 |
2001-03-07 |
Hoffmann La Roche |
Derivados de eritropoyetina
|
WO2001005819A1
(en)
*
|
1999-07-15 |
2001-01-25 |
Kuhnil Pharm. Co., Ltd. |
Novel water soluble-cyclosporine conjugated compounds
|
US7230081B1
(en)
|
1999-11-12 |
2007-06-12 |
Maxygen Holdings, Ltd. |
Interferon gamma conjugates
|
MXPA02004671A
(es)
|
1999-11-12 |
2004-09-10 |
Maxygen Holdings Ltd |
Conjugados de interferon gamma.
|
BR0107561A
(pt)
|
2000-01-10 |
2002-11-19 |
Maxygen Holdings Ltd |
Polipeptìdios ou conjugados entre polipeptìdios que exibem atividade (g-csf), métodos de preparação dos mesmos e seus usos
|
EP1982732A3
(en)
|
2000-02-11 |
2011-06-08 |
Bayer HealthCare LLC |
Factor VII or VIIA-like conjugates
|
US7109303B2
(en)
*
|
2000-02-15 |
2006-09-19 |
Fondazione Centro San Raffaele Del Monte Tabor |
Modified cytokines for use in cancer therapy
|
US7309694B2
(en)
*
|
2000-02-15 |
2007-12-18 |
Fondazione Centro San Raffaele Del Monte Tabor |
Modified cytokines for use in cancer therapy
|
IT1317835B1
(it)
*
|
2000-02-15 |
2003-07-15 |
San Raffaele Centro Fond |
Citochine modificate per uso nella terapia del cancro.
|
US6586398B1
(en)
*
|
2000-04-07 |
2003-07-01 |
Amgen, Inc. |
Chemically modified novel erythropoietin stimulating protein compositions and methods
|
SG98393A1
(en)
|
2000-05-19 |
2003-09-19 |
Inst Materials Research & Eng |
Injectable drug delivery systems with cyclodextrin-polymer based hydrogels
|
US7208167B2
(en)
*
|
2000-08-07 |
2007-04-24 |
Sciclone Pharmaceuticals, Inc. |
Treatment of hepatitis C with thymosin and peptide combination therapy
|
US7118737B2
(en)
*
|
2000-09-08 |
2006-10-10 |
Amylin Pharmaceuticals, Inc. |
Polymer-modified synthetic proteins
|
JP2004508338A
(ja)
*
|
2000-09-08 |
2004-03-18 |
グリフォン セラピューティクス,インコーポレーテッド |
ポリマー修飾合成タンパク質
|
US20020065397A1
(en)
*
|
2000-10-12 |
2002-05-30 |
Joseph Roberts |
Protecting therapeutic compositions from host-mediated inactivation
|
IL156059A0
(en)
|
2001-02-27 |
2003-12-23 |
Maxygen Aps |
NEW INTERFERON beta-LIKE MOLECULES
|
US7038015B2
(en)
*
|
2001-04-06 |
2006-05-02 |
Maxygen Holdings, Ltd. |
Interferon gamma polypeptide variants
|
US6958388B2
(en)
|
2001-04-06 |
2005-10-25 |
Maxygen, Aps |
Interferon gamma polypeptide variants
|
US6828297B2
(en)
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
US6828305B2
(en)
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
US7713932B2
(en)
|
2001-06-04 |
2010-05-11 |
Biocon Limited |
Calcitonin drug-oligomer conjugates, and uses thereof
|
US6858580B2
(en)
*
|
2001-06-04 |
2005-02-22 |
Nobex Corporation |
Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
US6835802B2
(en)
*
|
2001-06-04 |
2004-12-28 |
Nobex Corporation |
Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
|
US6713452B2
(en)
*
|
2001-06-04 |
2004-03-30 |
Nobex Corporation |
Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
WO2003018665A1
(en)
|
2001-08-22 |
2003-03-06 |
Bioartificial Gel Technologies Inc. |
Process for the preparation of activated polyethylene glycols
|
US7166571B2
(en)
|
2001-09-07 |
2007-01-23 |
Biocon Limited |
Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
US6913903B2
(en)
|
2001-09-07 |
2005-07-05 |
Nobex Corporation |
Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
US7030082B2
(en)
*
|
2001-09-07 |
2006-04-18 |
Nobex Corporation |
Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
|
US6770625B2
(en)
|
2001-09-07 |
2004-08-03 |
Nobex Corporation |
Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
|
US7312192B2
(en)
|
2001-09-07 |
2007-12-25 |
Biocon Limited |
Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
UA78726C2
(en)
|
2001-11-01 |
2007-04-25 |
Sciclone Pharmaceuticals Inc |
Pharmaceutical composition of thymosin alpha 1 conjugated with polyethylene glycol, method for production, and method for treatment
|
US20040058865A1
(en)
*
|
2001-11-26 |
2004-03-25 |
Danishefsky Samuel J |
Homing peptide multimers, their preparation and uses
|
KR100488351B1
(ko)
*
|
2001-12-11 |
2005-05-11 |
선바이오(주) |
신규한 폴리에틸렌글리콜-프로피온알데히드 유도체
|
US6916962B2
(en)
*
|
2001-12-11 |
2005-07-12 |
Sun Bio, Inc. |
Monofunctional polyethylene glycol aldehydes
|
US7041855B2
(en)
*
|
2001-12-11 |
2006-05-09 |
Sun Bio, Inc. |
Monofunctional polyethylene glycol aldehydes
|
US6956135B2
(en)
*
|
2001-12-11 |
2005-10-18 |
Sun Bio, Inc. |
Monofunctional polyethylene glycol aldehydes
|
KR100888371B1
(ko)
|
2002-01-17 |
2009-03-13 |
동아제약주식회사 |
가지 달린 고분자 유도체와 인터페론 결합체를 포함하는 항바이러스제
|
RS55578B1
(sr)
|
2002-01-18 |
2017-06-30 |
Biogen Ma Inc |
Polimerna jedinjenja polialkilena i njihova upotreba
|
US20030191056A1
(en)
|
2002-04-04 |
2003-10-09 |
Kenneth Walker |
Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
|
GB0209893D0
(en)
*
|
2002-04-30 |
2002-06-05 |
Molmed Spa |
Conjugate
|
GB0209896D0
(en)
*
|
2002-04-30 |
2002-06-05 |
Molmed Spa |
Conjugate
|
US20040002451A1
(en)
*
|
2002-06-20 |
2004-01-01 |
Bruce Kerwin |
Compositions of pegylated soluble tumor necrosis factor receptors and methods of preparing
|
RU2362807C2
(ru)
|
2002-06-21 |
2009-07-27 |
Ново Нордиск Хелт Кэр Аг |
Конъюгат полипептида фактора vii, способ его получения, его применение и содержащая его фармацевтическая композиция
|
CN103319554A
(zh)
|
2002-06-28 |
2013-09-25 |
埃迪尼克斯医药公司 |
用于治疗黄病毒感染的修饰的2’和3’-核苷前药
|
AU2003239774A1
(en)
*
|
2002-07-03 |
2004-01-23 |
Maxygen Holdings Ltd. |
Full-length interferon gamma polypeptide variants
|
EP1382352A1
(de)
|
2002-07-19 |
2004-01-21 |
GBF Gesellschaft für Biotechnologische Forschung mbH |
Bisacyloxypropylcystein-Konjugate und deren Verwendung
|
US7297348B2
(en)
|
2002-07-19 |
2007-11-20 |
Omeros Corporation |
Biodegradable triblock copolymers, synthesis methods therefore, and hydrogels and biomaterials made there from
|
MXPA05000796A
(es)
|
2002-07-24 |
2005-04-19 |
Hoffmann La Roche |
Aditivos de acidos polialquilenglicolicos.
|
US7563507B2
(en)
*
|
2002-08-16 |
2009-07-21 |
University Of Massachusetts |
Pyridine and related ligand compounds, functionalized nanoparticulate composites and methods of preparation
|
US7314613B2
(en)
|
2002-11-18 |
2008-01-01 |
Maxygen, Inc. |
Interferon-alpha polypeptides and conjugates
|
US7217845B2
(en)
*
|
2002-11-25 |
2007-05-15 |
Sun Bio, Inc. |
Bifunctional polyethylene glycol derivatives
|
BR0317742A
(pt)
*
|
2002-12-26 |
2005-11-22 |
Mountain View Pharmaceuticals |
Conjugados poliméricos de interferon-beta com potência biológica aumentada
|
PL396711A1
(pl)
*
|
2002-12-26 |
2011-12-19 |
Mountain View Pharmaceuticals, Inc. |
Koniugaty polimerów z cytokinami, chemokinami, czynnikami wzrostu, hormonami polipeptydowymi i ich antagonistami, kompozycja farmaceutyczna i sposób zapobiegania, diagnozowania lub leczenia
|
US20040176655A1
(en)
*
|
2003-02-05 |
2004-09-09 |
Ayoub Paul Marie |
Methods of preparing branched alkyl aromatic hydrocarbons
|
WO2004084949A2
(en)
*
|
2003-03-20 |
2004-10-07 |
Xencor |
Generating protein pro-drugs using reversible ppg linkages
|
CA2458085A1
(en)
|
2003-03-21 |
2004-09-21 |
F. Hoffmann-La Roche Ag |
Transcriptional activity assay
|
EP2345659A1
(en)
|
2003-05-30 |
2011-07-20 |
Pharmasset, Inc. |
Modified fluorinated nucleoside analogues
|
GB0320638D0
(en)
|
2003-09-03 |
2003-10-01 |
Novartis Ag |
Organic compounds
|
JP4890253B2
(ja)
*
|
2003-10-09 |
2012-03-07 |
アンブレツクス・インコーポレイテツド |
アジドまたはアセチレン末端水溶性ポリマー
|
CN1867581B
(zh)
|
2003-10-10 |
2012-02-01 |
诺沃挪第克公司 |
Il-21衍生物
|
ES2428358T3
(es)
|
2003-10-17 |
2013-11-07 |
Novo Nordisk A/S |
Terapia de combinación
|
ZA200606225B
(en)
*
|
2004-02-02 |
2007-11-28 |
Ambrx Inc |
Modified human four helical bundle polypeptides and their uses
|
US8778880B2
(en)
|
2004-02-02 |
2014-07-15 |
Ambrx, Inc. |
Human growth hormone modified at position 35
|
US7351787B2
(en)
*
|
2004-03-05 |
2008-04-01 |
Bioartificial Gel Technologies, Inc. |
Process for the preparation of activated polyethylene glycols
|
RU2006145020A
(ru)
|
2004-05-19 |
2008-06-27 |
Максиджен, Инк. (Us) |
Полипептиды и конъюгаты интерферона-альфа
|
US20060194726A1
(en)
*
|
2004-05-25 |
2006-08-31 |
Rueger David C |
Methods of treating cartilage defects
|
WO2005123113A2
(en)
*
|
2004-06-14 |
2005-12-29 |
Intermune, Inc. |
Interferon compositions and methods of use thereof
|
NZ551335A
(en)
*
|
2004-06-18 |
2010-03-26 |
Ambrx Inc |
Antibodies and fragments thereof comprising an non naturally encoded amino acid coupled to a linker
|
AU2005260763B2
(en)
*
|
2004-06-30 |
2011-12-22 |
Nektar Therapeutics |
Polymer-factor IX moiety conjugates
|
EP1773400A2
(en)
*
|
2004-07-08 |
2007-04-18 |
Amgen Inc. |
Therapeutic peptides
|
RU2393168C2
(ru)
|
2004-07-19 |
2010-06-27 |
Биокон Лимитед |
Инсулин-олигомерные конъюгаты, их препараты и применения
|
BRPI0512396A
(pt)
*
|
2004-07-21 |
2008-03-11 |
Ambrx Inc |
polipeptìdeos biossintéticos utilizando aminoácidos codificados não naturalmente
|
CN101023094B
(zh)
|
2004-07-21 |
2011-05-18 |
法莫赛特股份有限公司 |
烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
|
BRPI0513332A
(pt)
*
|
2004-08-12 |
2008-05-06 |
Schering Corp |
formulação de interferon peguilado estável
|
EP1809301B1
(en)
*
|
2004-09-14 |
2019-11-06 |
Gilead Pharmasset LLC |
2-fluoro-2-alkyl-substituted d-ribonolactone intermediates
|
AU2005319518B2
(en)
*
|
2004-12-22 |
2010-09-09 |
Ambrx, Inc. |
Compositions of aminoacyl-tRNA synthetase and uses thereof
|
WO2006073846A2
(en)
*
|
2004-12-22 |
2006-07-13 |
Ambrx, Inc. |
Methods for expression and purification of recombinant human growth hormone
|
NZ584597A
(en)
|
2004-12-22 |
2011-09-30 |
Ambrx Inc |
Modified human growth hormone
|
CN103520735B
(zh)
|
2004-12-22 |
2015-11-25 |
Ambrx公司 |
包含非天然编码的氨基酸的人生长激素配方
|
JP5022231B2
(ja)
|
2004-12-27 |
2012-09-12 |
バクスター・インターナショナル・インコーポレイテッド |
ポリマー−フォンビルブラント因子結合体
|
AU2005326226B2
(en)
|
2005-01-31 |
2010-11-11 |
Eci, Inc. |
Immunopotentiating agent
|
WO2007044083A2
(en)
|
2005-05-18 |
2007-04-19 |
Maxygen, Inc. |
Evolved interferon-alpha polypeptides
|
US20070015701A1
(en)
*
|
2005-06-01 |
2007-01-18 |
Samuel Zalipsky |
Macromolecular conjugates of bone morphogenetic protein-7
|
MX2007015058A
(es)
*
|
2005-06-03 |
2008-01-28 |
Ambrx Inc |
Moleculas de interferon humano mejoradas y sus usos.
|
JP5335422B2
(ja)
|
2005-06-17 |
2013-11-06 |
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト |
少なくとも1つの非天然のシステインを含んでいる操作されたタンパク質の選択的な還元および誘導体化
|
ATE524183T1
(de)
|
2005-06-17 |
2011-09-15 |
Novartis Ag |
Verwendung von sanglifehrin bei der hcv-therapie
|
WO2007002362A2
(en)
*
|
2005-06-24 |
2007-01-04 |
Duke University |
A direct drug delivery system based on thermally responsive biopolymers
|
DK1937824T3
(da)
|
2005-08-18 |
2013-04-02 |
Ambrx Inc |
Sammensætninger af tRNA og anvendelser deraf
|
US20070123646A1
(en)
*
|
2005-09-13 |
2007-05-31 |
Lele Bhalchandra S |
Protein-polymer conjugates and synthesis thereof
|
EP1776963A1
(en)
|
2005-10-19 |
2007-04-25 |
Gbf-Gesellschaft Für Biotechnologische Forschung Mbh |
Hexosylceramides as adjuvants and their uses in pharmaceutical compositions
|
WO2007056448A2
(en)
*
|
2005-11-08 |
2007-05-18 |
Ambrx, Inc. |
Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides
|
ES2547554T3
(es)
|
2005-11-16 |
2015-10-07 |
Ambrx, Inc. |
Métodos y composiciones que comprenden aminoácidos no naturales
|
ES2529065T3
(es)
*
|
2005-12-14 |
2015-02-16 |
Ambrx, Inc. |
Composiciones que contienen, procedimientos que implican y usos de aminoácidos no naturales y polipéptidos
|
ES2779992T3
(es)
|
2005-12-20 |
2020-08-21 |
Univ Duke |
Métodos y composiciones para suministrar agentes activos con propiedades farmacológicas potenciadas
|
US8841255B2
(en)
|
2005-12-20 |
2014-09-23 |
Duke University |
Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
|
US20130172274A1
(en)
|
2005-12-20 |
2013-07-04 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
AU2007205545B9
(en)
|
2006-01-12 |
2012-10-18 |
Hokusan Co. Ltd. |
Oral composition containing interferon-alpha
|
EP1991577A2
(en)
|
2006-01-31 |
2008-11-19 |
Parkinson, John F. |
Modulation of mdl-1 activity for treatment of inflammatory disease
|
EP1818392B1
(en)
*
|
2006-02-14 |
2010-08-25 |
Genetix Limited |
Cell culture medium
|
EP2010222A1
(en)
*
|
2006-03-31 |
2009-01-07 |
Baxter International Inc. |
Pegylated factor viii
|
US7645860B2
(en)
|
2006-03-31 |
2010-01-12 |
Baxter Healthcare S.A. |
Factor VIII polymer conjugates
|
MX2008013119A
(es)
|
2006-04-11 |
2008-10-21 |
Novartis Ag |
Inhibidores de hcv/vih y sus usos.
|
JO3324B1
(ar)
|
2006-04-21 |
2019-03-13 |
Amgen Inc |
مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية
|
EP2029738A2
(en)
|
2006-05-24 |
2009-03-04 |
Novo Nordisk Health Care AG |
Factor ix analogues having prolonged in vivo half life
|
EP1897557A1
(en)
*
|
2006-09-07 |
2008-03-12 |
Helmholtz-Zentrum für Infektionsforschung GmbH |
Use of glycolipids as adjuvants
|
PT2061878E
(pt)
*
|
2006-09-08 |
2014-04-22 |
Ambrx Inc |
Supressor híbrido arnt para células de vertebrados
|
EP2069396B1
(en)
|
2006-09-08 |
2015-10-21 |
Ambrx, Inc. |
Modified human plasma polypeptide or fc scaffolds and their uses
|
US8420792B2
(en)
*
|
2006-09-08 |
2013-04-16 |
Ambrx, Inc. |
Suppressor tRNA transcription in vertebrate cells
|
AU2008232937B2
(en)
|
2007-03-30 |
2012-09-27 |
Ambrx, Inc. |
Modified FGF-21 polypeptides and their uses
|
US7964580B2
(en)
|
2007-03-30 |
2011-06-21 |
Pharmasset, Inc. |
Nucleoside phosphoramidate prodrugs
|
EP2076533B1
(en)
|
2007-05-02 |
2014-10-08 |
Ambrx, Inc. |
Modified interferon beta polypeptides and their uses
|
NZ585135A
(en)
|
2007-10-16 |
2012-08-31 |
Biocon Ltd |
An orally administerable solid pharmaceutical composition comprising in-105 and a process thereof
|
JP5547083B2
(ja)
|
2007-11-20 |
2014-07-09 |
アンブルックス,インコーポレイテッド |
修飾されたインスリンポリペプチドおよびそれらの使用
|
NZ602170A
(en)
|
2008-02-08 |
2014-03-28 |
Ambrx Inc |
Modified leptin polypeptides and their uses
|
TW200946541A
(en)
*
|
2008-03-27 |
2009-11-16 |
Idenix Pharmaceuticals Inc |
Solid forms of an anti-HIV phosphoindole compound
|
TWI573806B
(zh)
|
2008-04-17 |
2017-03-11 |
巴克斯歐塔公司 |
生物活性胜肽
|
US8173621B2
(en)
|
2008-06-11 |
2012-05-08 |
Gilead Pharmasset Llc |
Nucleoside cyclicphosphates
|
EP2926825A1
(en)
|
2008-06-27 |
2015-10-07 |
Duke University |
Therapeutic agents comprising elastin-like peptides
|
NZ600382A
(en)
|
2008-07-23 |
2013-11-29 |
Ambrx Inc |
Modified bovine G-CSF polypeptides and their uses
|
CN101671390B
(zh)
*
|
2008-09-10 |
2012-10-03 |
海南四环心脑血管药物研究院有限公司 |
人干扰素α衍生物及其聚乙二醇化修饰物的制备和用途
|
MX348657B
(es)
|
2008-09-26 |
2017-06-21 |
Ambrx Inc |
Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.
|
AU2009296397B2
(en)
|
2008-09-26 |
2012-11-08 |
Ambrx Inc. |
Modified animal erythropoietin polypeptides and their uses
|
SG194404A1
(en)
|
2008-12-23 |
2013-11-29 |
Gilead Pharmasset Llc |
Synthesis of purine nucleosides
|
US8716262B2
(en)
|
2008-12-23 |
2014-05-06 |
Gilead Pharmasset Llc |
Nucleoside phosphoramidates
|
US8551973B2
(en)
|
2008-12-23 |
2013-10-08 |
Gilead Pharmasset Llc |
Nucleoside analogs
|
US8512690B2
(en)
|
2009-04-10 |
2013-08-20 |
Novartis Ag |
Derivatised proline containing peptide compounds as protease inhibitors
|
US20110182850A1
(en)
|
2009-04-10 |
2011-07-28 |
Trixi Brandl |
Organic compounds and their uses
|
CN101870728A
(zh)
|
2009-04-23 |
2010-10-27 |
派格生物医药(苏州)有限公司 |
新型Exendin变体及其缀合物
|
US8618076B2
(en)
|
2009-05-20 |
2013-12-31 |
Gilead Pharmasset Llc |
Nucleoside phosphoramidates
|
TWI576352B
(zh)
*
|
2009-05-20 |
2017-04-01 |
基利法瑪席特有限責任公司 |
核苷磷醯胺
|
US9220746B2
(en)
*
|
2009-06-04 |
2015-12-29 |
The University Of North Carolina At Chapel Hill |
Compounds and methods for treating bone disorders and controlling weight
|
US20110097302A1
(en)
*
|
2009-07-16 |
2011-04-28 |
Ta Tung Yuan |
Il-1ra-polymer conjugates
|
US20110027229A1
(en)
|
2009-07-31 |
2011-02-03 |
Medtronic, Inc. |
Continuous subcutaneous administration of interferon-alpha to hepatitis c infected patients
|
CA2804755C
(en)
|
2009-08-14 |
2018-06-05 |
Phasebio Pharmaceuticals, Inc. |
Modified vasoactive intestinal peptides
|
US8475652B2
(en)
|
2009-10-19 |
2013-07-02 |
Jan A. K. Paul |
Method for purification of uncatalyzed natural fuels from metal ions by means of at least one hemeprotein and use of the at least on hemeprotein
|
AU2010313497B2
(en)
|
2009-10-30 |
2013-08-01 |
Boehringer Ingelheim International Gmbh |
Dosage regimens for HCV combination therapy comprising BI201335, interferon alpha and ribavirin
|
CN102753573A
(zh)
|
2009-12-21 |
2012-10-24 |
Ambrx公司 |
经过修饰的牛促生长素多肽和其用途
|
SG181769A1
(en)
|
2009-12-21 |
2012-07-30 |
Ambrx Inc |
Modified porcine somatotropin polypeptides and their uses
|
EP2542569B1
(en)
|
2010-03-05 |
2020-09-16 |
Omeros Corporation |
Chimeric inhibitor molecules of complement activation
|
CN104017020B
(zh)
|
2010-03-31 |
2017-04-12 |
吉利德制药有限责任公司 |
核苷氨基磷酸酯
|
PL3290428T3
(pl)
|
2010-03-31 |
2022-02-07 |
Gilead Pharmasset Llc |
Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
|
JP2013528374A
(ja)
|
2010-05-10 |
2013-07-11 |
パーシード セラピューティクス リミテッド ライアビリティ カンパニー |
Vla4のポリペプチド阻害剤
|
EP2585065A1
(en)
|
2010-06-24 |
2013-05-01 |
Panmed Ltd. |
Treatment of hepatitis c virus related diseases using hydroxychloroquine or a combination of hydroxychloroquine and an anti-viral agent
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
AU2011291943B2
(en)
|
2010-08-17 |
2015-01-22 |
Ambrx, Inc. |
Modified relaxin polypeptides and their uses
|
SG188324A1
(en)
|
2010-09-03 |
2013-04-30 |
Academia Sinica |
Anti-c-met antibody and methods of use thereof
|
AR083006A1
(es)
|
2010-09-23 |
2013-01-23 |
Lilly Co Eli |
Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
|
WO2012045704A1
(en)
|
2010-10-05 |
2012-04-12 |
Novartis Ag |
New treatments of hepatitis c virus infection
|
KR20130120481A
(ko)
|
2010-10-08 |
2013-11-04 |
노파르티스 아게 |
술파미드 ns3 억제제의 비타민 e 제제
|
IL295201A
(en)
|
2010-11-12 |
2022-10-01 |
Nektar Therapeutics |
Conjugations of a part of il-2 and a polymer, preparations containing them and their uses
|
CN103221053A
(zh)
|
2010-11-30 |
2013-07-24 |
诺华有限公司 |
丙型肝炎病毒感染的新疗法
|
WO2012075140A1
(en)
|
2010-11-30 |
2012-06-07 |
Pharmasset, Inc. |
Compounds
|
US8440309B2
(en)
|
2011-01-31 |
2013-05-14 |
Confluent Surgical, Inc. |
Crosslinked polymers with the crosslinker as therapeutic for sustained release
|
CN103476409A
(zh)
|
2011-03-31 |
2013-12-25 |
诺华股份有限公司 |
治疗丙肝病毒感染的阿拉泊韦
|
CA2831675A1
(en)
|
2011-04-01 |
2012-10-04 |
Novartis Ag |
Treatment for infection with hepatitis b virus alone or in combination with hepatitis delta virus and associated liver diseases
|
AU2012241859A1
(en)
|
2011-04-13 |
2013-10-10 |
Debiopharm International Sa |
Treatment of Hepatitis C virus infection with alisporivir
|
CA2873553C
(en)
|
2011-06-06 |
2020-01-28 |
Phasebio Pharmaceuticals, Inc. |
Use of modified vasoactive intestinal peptides in the treatment of hypertension
|
SI2717898T1
(sl)
|
2011-06-10 |
2019-07-31 |
Bioverativ Therapeutics Inc. |
Spojine prokoagulantov in metode za njihovo uporabo
|
EP2726502A1
(en)
|
2011-07-01 |
2014-05-07 |
Bayer Intellectual Property GmbH |
Relaxin fusion polypeptides and uses thereof
|
RU2014116988A
(ru)
|
2011-09-27 |
2015-11-10 |
Новартис Аг |
Алиспоривир для лечения инфекции, вызванной вирусом гепатита с
|
US8767214B2
(en)
|
2011-10-06 |
2014-07-01 |
Nordson Corporation |
Powder flow detection
|
US8889159B2
(en)
|
2011-11-29 |
2014-11-18 |
Gilead Pharmasset Llc |
Compositions and methods for treating hepatitis C virus
|
JP2015509980A
(ja)
|
2012-03-14 |
2015-04-02 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Hcv−hiv同時感染患者集団のhcv感染症を治療するための併用療法
|
JP2015512900A
(ja)
|
2012-03-28 |
2015-04-30 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
特別な患者の遺伝子亜型分集団のhcv感染症を治療するための併用療法
|
CA2871579A1
(en)
*
|
2012-04-25 |
2013-10-31 |
Daiichi Sankyo Company, Limited |
Use of a c-type natriuretic peptide as a bone repair promoter
|
CN104583235B
(zh)
|
2012-06-08 |
2019-03-01 |
苏特罗生物制药公司 |
含位点特异非天然氨基酸残基的抗体、其制备和使用方法
|
ES2611788T3
(es)
|
2012-06-26 |
2017-05-10 |
Sutro Biopharma, Inc. |
Proteínas de Fc modificadas que comprenden residuos de aminoácidos no naturales específicos del sitio, conjugados de las mismas, métodos para su preparación y métodos para su uso
|
KR102165464B1
(ko)
|
2012-07-19 |
2020-10-14 |
레드우드 바이오사이언스 인코포레이티드 |
Cd22에 대해 특이적인 항체 및 이들의 사용 방법
|
NZ730763A
(en)
|
2012-08-16 |
2018-06-29 |
Ipierian Inc |
Methods of treating a tauopathy
|
SG11201501464TA
(en)
|
2012-08-31 |
2015-03-30 |
Sutro Biopharma Inc |
Modified amino acids comprising an azido group
|
AU2013334229B2
(en)
|
2012-10-25 |
2018-02-15 |
Bioverativ Usa Inc. |
Anti-complement C1s antibodies and uses thereof
|
CA2889197A1
(en)
|
2012-11-02 |
2014-05-08 |
True North Therapeutics, Inc. |
Anti-complement c1s antibodies and uses thereof
|
WO2014080350A1
(en)
|
2012-11-21 |
2014-05-30 |
The Governors Of The University Of Alberta |
Immunomodulatory peptides and methods of use thereof
|
US20140205566A1
(en)
|
2012-11-30 |
2014-07-24 |
Novartis Ag |
Cyclic nucleuoside derivatives and uses thereof
|
PL3007726T3
(pl)
|
2013-06-10 |
2021-01-11 |
Ipierian, Inc. |
Metody leczenia tauopatii
|
ES2865473T3
(es)
|
2013-07-10 |
2021-10-15 |
Sutro Biopharma Inc |
Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso
|
NZ716840A
(en)
|
2013-08-27 |
2017-06-30 |
Gilead Pharmasset Llc |
Combination formulation of two antiviral compounds
|
WO2015054658A1
(en)
|
2013-10-11 |
2015-04-16 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
WO2015070014A1
(en)
|
2013-11-08 |
2015-05-14 |
Biogen Idec Ma Inc. |
Procoagulant fusion compound
|
CN111569063A
(zh)
|
2013-11-27 |
2020-08-25 |
伊皮埃里安股份有限公司 |
治疗tau病变的方法
|
CA2947982C
(en)
|
2014-05-08 |
2022-11-29 |
Phasebio Pharmaceuticals, Inc. |
Methods and compositions for treating cystic fibrosis
|
LT3183264T
(lt)
|
2014-08-19 |
2021-01-11 |
Biogen Ma Inc. |
Pegilinimo būdas
|
JP6702962B2
(ja)
|
2014-10-24 |
2020-06-03 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
改変fgf−21ポリペプチドおよびその使用
|
CN114652817A
(zh)
|
2015-02-09 |
2022-06-24 |
费斯生物制药公司 |
用于治疗肌肉疾病和病症的方法和组合物
|
CN108699145A
(zh)
|
2015-09-02 |
2018-10-23 |
伊缪泰普有限公司 |
抗lag-3抗体
|
CN108135979A
(zh)
|
2015-11-03 |
2018-06-08 |
豪夫迈·罗氏有限公司 |
Hbv衣壳组装抑制剂和干扰素的组合疗法
|
US10934347B2
(en)
|
2016-04-04 |
2021-03-02 |
Genzyme Corporation |
Anti-complement factor BB antibodies and uses thereof
|
WO2018087345A1
(en)
|
2016-11-14 |
2018-05-17 |
F. Hoffmann-La Roche Ag |
COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON
|
MY193457A
(en)
|
2017-02-08 |
2022-10-14 |
Bristol Myers Squibb Co |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
EP3652316A4
(en)
|
2017-07-11 |
2021-04-07 |
Synthorx, Inc. |
INTEGRATION OF NON-NATURAL NUCLEOTIDES AND METHOD FOR THEREFORE
|
MX2020001332A
(es)
|
2017-08-03 |
2020-09-09 |
Synthorx Inc |
Conjugados de citoquina para el tratamiento de enfermedades proliferativas e infecciosas.
|
CN116948006A
(zh)
|
2018-09-11 |
2023-10-27 |
北京泰德制药股份有限公司 |
白介素-2多肽偶联物及其用途
|
AU2019361206A1
(en)
|
2018-10-19 |
2021-06-03 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
|
KR20210123299A
(ko)
|
2019-02-06 |
2021-10-13 |
신톡스, 인크. |
Il-2 콘쥬게이트 및 이의 사용 방법
|
KR20210136014A
(ko)
|
2019-02-12 |
2021-11-16 |
암브룩스, 인코포레이티드 |
항체-tlr 작용제 콘쥬게이트를 함유하는 조성물, 방법 및 이의 용도
|
AU2021233909A1
(en)
|
2020-03-11 |
2022-09-29 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and methods of use thereof
|
AU2021327396A1
(en)
|
2020-08-20 |
2023-03-23 |
Ambrx, Inc. |
Antibody-TLR agonist conjugates, methods and uses thereof
|
KR20240004342A
(ko)
|
2021-04-03 |
2024-01-11 |
암브룩스, 인코포레이티드 |
항-her2 항체-약물 접합체 및 이의 용도
|