BRPI0113477B8 - proteína de fusão para distribuição de um peptídeo, proteína, glicoproteína ou oligonucleotídeo em uma célula - Google Patents
proteína de fusão para distribuição de um peptídeo, proteína, glicoproteína ou oligonucleotídeo em uma célulaInfo
- Publication number
- BRPI0113477B8 BRPI0113477B8 BRPI0113477A BRPI0113477B8 BR PI0113477 B8 BRPI0113477 B8 BR PI0113477B8 BR PI0113477 A BRPI0113477 A BR PI0113477A BR PI0113477 B8 BRPI0113477 B8 BR PI0113477B8
- Authority
- BR
- Brazil
- Prior art keywords
- delivering
- protein
- membrane
- glycoprotein
- oligonucleotide
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 102000003886 Glycoproteins Human genes 0.000 title 1
- 108090000288 Glycoproteins Proteins 0.000 title 1
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000012528 membrane Substances 0.000 abstract 2
- 239000000969 carrier Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000149 penetrating effect Effects 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22764700P | 2000-08-25 | 2000-08-25 | |
GBGB0103110.3A GB0103110D0 (en) | 2000-08-25 | 2001-02-07 | A membrane penetrating peptide encoded by a nuclear localization sequence from human period 1 |
PCT/US2001/026421 WO2002018572A2 (en) | 2000-08-25 | 2001-08-23 | Membrane penetrating peptides and uses thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
BR0113477A BR0113477A (pt) | 2004-04-20 |
BRPI0113477B1 BRPI0113477B1 (pt) | 2019-10-22 |
BRPI0113477B8 true BRPI0113477B8 (pt) | 2021-05-25 |
Family
ID=22853919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0113477 BRPI0113477B8 (pt) | 2000-08-25 | 2001-08-23 | proteína de fusão para distribuição de um peptídeo, proteína, glicoproteína ou oligonucleotídeo em uma célula |
Country Status (10)
Country | Link |
---|---|
US (2) | US20030229202A1 (pt) |
JP (1) | JP4896356B2 (pt) |
KR (1) | KR100810927B1 (pt) |
AR (1) | AR033834A1 (pt) |
BR (1) | BRPI0113477B8 (pt) |
DE (1) | DE60133585T2 (pt) |
GB (1) | GB0103110D0 (pt) |
IL (1) | IL154589A (pt) |
TW (1) | TWI317737B (pt) |
ZA (1) | ZA200301476B (pt) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8128922B2 (en) * | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
KR20030062788A (ko) * | 2002-01-19 | 2003-07-28 | 포휴먼텍(주) | 생체분자 전달 펩타이드 mph1-btm 및 이것을포함하는 생명공학제품 |
WO2003086273A2 (en) * | 2002-04-08 | 2003-10-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Histone conjugates and uses thereof |
WO2005111058A1 (en) * | 2004-04-13 | 2005-11-24 | Medtronic Sofamor Danek, Inc | Intracellular delivery of osteoinductive proteins and peptides |
WO2004098526A2 (en) | 2003-05-05 | 2004-11-18 | Johns Hopkins University | Anti-cancer dna vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein |
CA2839032A1 (en) * | 2003-05-19 | 2005-01-06 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for treating and preventing heart tissue degeneration, and uses thereof |
CA2660661A1 (en) * | 2005-09-26 | 2007-04-05 | The Trustees Of Columbia University In The City Of New York | Side population cells in cardiac repair |
DE602006016468D1 (de) * | 2005-11-04 | 2010-10-07 | Forhumantech Co Ltd | Verfahren zur abgabe von fusionspolypeptid in eine zelle |
CN101490080A (zh) * | 2006-07-24 | 2009-07-22 | 为人技术株式会社 | 用于缓解和治疗缺血性病症的药物组合物及其输送方法 |
KR100843634B1 (ko) * | 2006-08-03 | 2008-07-03 | 연세대학교 산학협력단 | 세포막투과 전달 펩타이드 및 이를 포함하는 생물제제 |
US20080132450A1 (en) * | 2006-08-29 | 2008-06-05 | Forhumantech. Co., Ltd. | Pharmaceutical composition for suppression of apoptosis and method for delivering the same |
US7981446B2 (en) * | 2007-11-26 | 2011-07-19 | Forhumantech. Co., Ltd. | Pharmaceutical compositions and methods for delivering nucleic acids into cells |
JP4573143B2 (ja) * | 2008-01-25 | 2010-11-04 | 東亞合成株式会社 | 人工ペプチド及びその利用 |
CA2713872A1 (en) | 2008-02-21 | 2009-08-27 | Burnham Institute For Medical Research | Methods and compositions related to peptides and proteins with c-terminal elements |
JP5709013B2 (ja) | 2009-04-10 | 2015-04-30 | 東亞合成株式会社 | 神経分化誘導ペプチド及びその利用 |
WO2010129033A2 (en) * | 2009-04-29 | 2010-11-11 | Calmune Corporation | Modified antibodies for passive immunotherapy |
CN102869384B (zh) | 2009-06-22 | 2016-01-13 | 伯纳姆医学研究所 | 使用带有c-端元件的肽和蛋白质的方法和组合物 |
US20120149053A1 (en) * | 2009-07-29 | 2012-06-14 | Toagosei Co. Ltd. | Carrier peptide fragment and use thereof |
WO2011013700A1 (ja) | 2009-07-29 | 2011-02-03 | 東亞合成株式会社 | キャリアペプチドフラグメント及びその利用 |
WO2011013698A1 (ja) * | 2009-07-29 | 2011-02-03 | 東亞合成株式会社 | キャリアペプチドフラグメント及びその利用 |
JP5792625B2 (ja) | 2009-11-02 | 2015-10-14 | 東亞合成株式会社 | 細胞増殖促進ペプチド及びその利用 |
JP5808082B2 (ja) * | 2010-04-30 | 2015-11-10 | 株式会社Adeka | 細胞への水溶性高分子量物質の導入方法及び導入剤 |
JP6044032B2 (ja) * | 2010-05-25 | 2016-12-14 | 国立大学法人 熊本大学 | 物質導入用プラズマ照射装置を用いた物質導入方法 |
US9238796B2 (en) | 2010-06-04 | 2016-01-19 | Toagosei Co. Ltd. | Cell growth-promoting peptide and use thereof |
WO2011152524A1 (ja) | 2010-06-04 | 2011-12-08 | 東亞合成株式会社 | 細胞増殖促進ペプチド及びその利用 |
JP6202707B2 (ja) * | 2011-10-13 | 2017-09-27 | 国立大学法人鳥取大学 | 新規細胞膜透過ペプチド |
JP6066222B2 (ja) | 2012-05-28 | 2017-01-25 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
US20150104873A1 (en) * | 2012-07-11 | 2015-04-16 | University of Nevada, Las Vegas | Genome Surgery with Paired, Permeant Endonuclease Construct |
WO2014061749A1 (ja) | 2012-10-18 | 2014-04-24 | 東亞合成株式会社 | 2型tnf受容体の発現を抑制する合成ペプチド及びその利用 |
EP2945964A2 (en) * | 2013-01-18 | 2015-11-25 | Glycotope GmbH | Fusion peptides for enhancing protein expression |
BR112016013516A8 (pt) | 2013-12-12 | 2020-05-19 | Life Technologies Corp | complexo de transfecção e seu uso para aumentar transporte de molécula de carga em células e para o tratamento de câncer e terapia gênica, bem como método in vitro para fornecer um poliânion a uma célula |
US10456475B2 (en) | 2015-02-03 | 2019-10-29 | Kennsaw State University Research and Service Foundation, Inc. | Cell penetrating protein adaptor molecules and their application in research and medicine |
US10793603B2 (en) | 2015-02-27 | 2020-10-06 | Josho Gakuen Educational Foundation | Polysaccharide derivative having membrane-permeable peptide chain |
EP3263582B1 (en) | 2015-02-27 | 2019-08-14 | Josho Gakuen Educational Foundation | Polymer compound which has membrane-permeable peptide in side chain |
US10435446B2 (en) | 2015-06-03 | 2019-10-08 | Kennesaw State University Research and Service Foundation Inc. | Cell penetrating protein adaptor molecules and their application in research and medicine |
EP3411387A4 (en) | 2016-02-03 | 2019-12-04 | Kennesaw State University Research And Services Foundation Inc. | SIGNAL MOLECULES USEFUL AS CELL PENETRATION AGENTS |
SG10202110500TA (en) | 2017-06-22 | 2021-11-29 | Catalyst Biosciences Inc | Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use |
WO2019157089A1 (en) * | 2018-02-06 | 2019-08-15 | University Of Maryland, Baltimore | Tlr9 inhibitors to suppress inflammatory response to pathogens |
KR102386498B1 (ko) * | 2018-12-27 | 2022-04-15 | 한양대학교 산학협력단 | Crispr-cas를 기반으로 하는 유전자 교정용 조성물 |
US20220009968A1 (en) * | 2018-12-27 | 2022-01-13 | Industry-University Cooperation Foundation Hanyang University | Crispr-cas-based composition for gene correction |
MX2021007843A (es) | 2018-12-28 | 2021-08-11 | Vertex Pharma | Polipeptidos de activador de plasminogeno, tipo urocinasa, modificados y metodos de uso. |
US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
CN110441156A (zh) * | 2019-07-20 | 2019-11-12 | 大连理工大学 | 一种基于土体稳定状态特性测量三轴试样膜嵌入量的方法 |
CN114716569B (zh) * | 2022-04-13 | 2023-11-10 | 浙江大学 | 一种携带目标蛋白自主进入真核细胞的重组蛋白、重组表达载体和重组菌及应用 |
CN116120400A (zh) * | 2022-12-20 | 2023-05-16 | 浙江大学杭州国际科创中心 | 一种细胞穿膜肽及其应用 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6316003B1 (en) * | 1989-12-21 | 2001-11-13 | Whitehead Institute For Biomedical Research | Tat-derived transport polypeptides |
US5804604A (en) | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
US5747641A (en) | 1989-12-21 | 1998-05-05 | Biogen Inc | Tat-derived transport polypeptide conjugates |
US6197925B1 (en) * | 1991-08-22 | 2001-03-06 | Sara Lee Corporation | NF-AT polypeptides and polynucleotides |
US5843643A (en) * | 1992-02-21 | 1998-12-01 | Ratner; Paul L. | Site-specific transfection of eukaryotic cells using polypeptide-linked recombinant nucleic acid |
US5766903A (en) | 1995-08-23 | 1998-06-16 | University Technology Corporation | Circular RNA and uses thereof |
ATE308611T1 (de) * | 1996-08-09 | 2005-11-15 | Dnavec Research Inc | Phage verbunden an ein nukleus lokalisierungssignal |
US5962415A (en) | 1996-09-20 | 1999-10-05 | Bristol-Myers Squibb Co. | Compositions comprising a peptide inhibitor of nuclear protein translocation and an immunosuppressant and methods of use thereof |
US5877282A (en) | 1996-09-20 | 1999-03-02 | Bristol-Myers Squibb Company | Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof |
US5929042A (en) * | 1997-03-03 | 1999-07-27 | The Trustees Of Columbia University In The City Of New York | Antisense compounds which prevent cell death and uses thereof |
WO1998049325A1 (en) | 1997-04-28 | 1998-11-05 | Mcgill University | Reporter fusion proteins, expression vectors and transfected cell lines thereof for the analysis of nuclear transport |
FR2767323B1 (fr) | 1997-08-12 | 2001-01-05 | Synt Em | Peptides lineaires derives de peptides antibiotiques, leur preparation et leur utilisation pour vectoriser des substances actives |
US6258774B1 (en) * | 1998-03-19 | 2001-07-10 | University Of Medicine And Dentistry Of New Jersey | Carrier for in vivo delivery of a therapeutic agent |
SE9801055D0 (sv) * | 1998-03-25 | 1998-03-25 | Inst Of Molecul & Cell Biology | Use of growth hormone binding protein (GHBP) |
US6248558B1 (en) | 1998-03-31 | 2001-06-19 | Vanderbilt University | Sequence and method for genetic engineering of proteins with cell membrane translocating activity |
US6436628B1 (en) * | 1998-06-19 | 2002-08-20 | The Rockefeller University | Methods of identifying an agent which modulates period and doubletime protein interaction |
JP2002520435A (ja) * | 1998-07-13 | 2002-07-09 | エクスプレション・ジェネティックス・インコーポレーテッド | 可溶性、生物分解性な遺伝子輸送キャリアーとしてのポリ−l−リジンのポリエステル類似体 |
US6246558B1 (en) * | 1998-08-24 | 2001-06-12 | Leviton Manufacturing Company | Circuit interrupting device with reverse wiring protection |
FR2786397B1 (fr) | 1998-11-30 | 2003-01-10 | Synt Em | Vecteurs peptidiques de substances a travers la barriere hematoencephalique pour etre utilises dans le diagnostic ou la therapie d'une affection du snc |
FR2786398B1 (fr) | 1998-11-30 | 2002-12-27 | Synt Em | Composition pharmaceutique anti-cancereuse et anti-chimioresistance comprenant un agent anticancereux et au moins un peptide |
WO2000075669A1 (en) * | 1999-06-08 | 2000-12-14 | Aventis Pharmaceuticals Inc. | Screening methods for altering circadian rhythm proteins |
WO2001038547A2 (en) | 1999-11-24 | 2001-05-31 | Mcs Micro Carrier Systems Gmbh | Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells |
JP3908425B2 (ja) * | 1999-12-24 | 2007-04-25 | アルパイン株式会社 | ナビゲーション装置 |
JP2003535832A (ja) | 2000-06-09 | 2003-12-02 | ブリカス,テニ | ポリヌクレオチドおよび薬物の標的化リポソームへのカプセル化 |
JP3686961B2 (ja) * | 2000-08-04 | 2005-08-24 | シャープ株式会社 | 液晶表示装置及びそれを用いた電子機器 |
JP2002304088A (ja) * | 2001-04-09 | 2002-10-18 | Ricoh Co Ltd | 画像形成装置 |
US20040002455A1 (en) * | 2002-01-29 | 2004-01-01 | Aventis Pasteur, Ltd. | Targeted immunogens |
US6877262B2 (en) * | 2003-07-10 | 2005-04-12 | Ronald Bianco | Perpetual calendar |
DE10341112A1 (de) * | 2003-09-05 | 2005-03-31 | Li-Li Yehhsu | Behälter mit separaten Speicherkammern |
EP1699492A2 (en) * | 2003-12-31 | 2006-09-13 | Sanofi Pasteur Inc. | Targeted immunogens |
-
2001
- 2001-02-07 GB GBGB0103110.3A patent/GB0103110D0/en not_active Ceased
- 2001-08-21 US US09/933,780 patent/US20030229202A1/en not_active Abandoned
- 2001-08-23 BR BRPI0113477 patent/BRPI0113477B8/pt not_active IP Right Cessation
- 2001-08-23 JP JP2002524075A patent/JP4896356B2/ja not_active Expired - Lifetime
- 2001-08-23 KR KR1020037002754A patent/KR100810927B1/ko active IP Right Grant
- 2001-08-23 DE DE60133585T patent/DE60133585T2/de not_active Expired - Fee Related
- 2001-08-24 AR ARP010104056A patent/AR033834A1/es not_active Application Discontinuation
- 2001-08-24 TW TW090120788A patent/TWI317737B/zh not_active IP Right Cessation
-
2003
- 2003-02-23 IL IL154589A patent/IL154589A/en active IP Right Grant
- 2003-02-24 ZA ZA200301476A patent/ZA200301476B/en unknown
-
2005
- 2005-10-17 US US11/251,734 patent/US7754678B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20030229202A1 (en) | 2003-12-11 |
JP4896356B2 (ja) | 2012-03-14 |
JP2004512275A (ja) | 2004-04-22 |
DE60133585D1 (de) | 2008-05-21 |
KR100810927B1 (ko) | 2008-03-10 |
BR0113477A (pt) | 2004-04-20 |
IL154589A (en) | 2011-08-31 |
GB0103110D0 (en) | 2001-03-28 |
TWI317737B (en) | 2009-12-01 |
US7754678B2 (en) | 2010-07-13 |
AR033834A1 (es) | 2004-01-07 |
BRPI0113477B1 (pt) | 2019-10-22 |
DE60133585T2 (de) | 2009-06-04 |
KR20030034156A (ko) | 2003-05-01 |
US20060100134A1 (en) | 2006-05-11 |
ZA200301476B (en) | 2004-06-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0113477B8 (pt) | proteína de fusão para distribuição de um peptídeo, proteína, glicoproteína ou oligonucleotídeo em uma célula | |
AU8524901A (en) | Membrane penetrating peptides and uses thereof | |
BR0109266A (pt) | Composto, composição farmacêutica, método de tratamento de um mamìfero afetado com um câncer, método de liberação de um composto nas células de um mamìfero afetado com um câncer e uso do composto | |
DE69832706D1 (de) | Immunschützendes influenzaantigen und dessen verwendung zur impfung | |
DE69734605D1 (de) | Abgeschwächter salmonellenstamm, gebraucht als vehikel zur oralen immunisierung | |
ATE368054T1 (de) | Verbindungen und methoden zur modulierung von occludin-abhängiger gewebepermeabilität | |
BRPI0416044A (pt) | sistema e método para distribuição transdérmica | |
WO2001091728A3 (en) | Nanoemulsion formulations | |
DE69329903D1 (de) | Bioabbaubare polymere zur zelltransplantation | |
PE20110236A1 (es) | Proteccion y mejoramiento de celulas, tejidos y organos que responden a la eritropoyetina | |
NZ591261A (en) | Improvements in the absorption of therapeutic agents across mucosal membranes or the skin | |
DE69730218D1 (de) | Fusogene liposomen | |
BR0207775A (pt) | Lipossomos anfotéricos métodos para carregamento dos mesmos com ingredientes ativos e sua utilização | |
EA200500644A1 (ru) | Высокоэффективные способные к слиянию везикулы, способ их получения и фармацевтическая композиция, их содержащая | |
WO1996036314A3 (en) | Method for drug delivery to the pulmonary system | |
EP2583976A3 (en) | Peptide vaccines with SEQ ID NO: 210, 196, 202, 213, 214, 214 or 223 for cancers expressing tumor-associated antigens | |
MX2007008980A (es) | Acidos nucleicos para apoptosis de celulas cancerigenas. | |
ES2190799T3 (es) | Inmunogenos peptidicos para vacunacion y tratamiento de la alergia. | |
BRPI0815578B8 (pt) | peptídeos, agentes farmacêuticos compreendendo os mesmos, métodos in vitro para induzir uma célula apresentadora de antígeno, usos dos referidos peptídeos, e vacina | |
BR9811094A (pt) | Agente terapêutico para tumores linfáticos | |
BR9812553A (pt) | Formulação medicamentosa com liberação de substância ativa controlada | |
CY1112867T1 (el) | Πεπτιδια επιτοπων που προερχονται απο τον υποδοχεα 1 του αγγειακου ενδοθηλιακου αυξητικου παραγοντα και εμβολια περιεχοντας αυτα τα πεπτιδια | |
BRPI0410562A (pt) | molécula recombinante e veìculo para expressão, liberação e purificação de polipeptìdeos alvo | |
BR0009472A (pt) | Antagonistas de lhrh com propriedades desolubilidade aperfeiçoadas | |
Hur et al. | Effect of oligoarginine conjugation on the antiwrinkle activity and transdermal delivery of GHK peptide |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: HMR PHARMA, INC. (US) Free format text: TRANSFERIDO DE :AVENTIS PHARMCEUTICALS, INC. |
|
B25A | Requested transfer of rights approved |
Owner name: AVENTIS HOLDINGS INC. (US) Free format text: TRANSFERIDO DE : HMR PHARMA , INC. |
|
B25L | Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled |
Owner name: AVENTIS PHARMACEUTICALS, INC. (US) Free format text: ANULADA AS PUBLICACOES: COD. DO DESPACHO (25.1) PUBLICADA NAS RPI 2051 DE 27/04/2010 E 2053 DE 11/05/2010 RESPECTIVAMENTE, PARA A LEGALIZACAO DO PROCESSO. |
|
B25G | Requested change of headquarter approved |
Owner name: AVENTIS PHARMACEUTICALS, INC. (US) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070165509/RJ DE 23/11/2007. |
|
B25A | Requested transfer of rights approved |
Owner name: HMR PHARMA, INC. (US) Free format text: TRANSFERIDO DE: AVENTIS PHARMACEUTICALS, INC. |
|
B25A | Requested transfer of rights approved |
Owner name: AVENTIS HOLDINGS INC. (US) Free format text: TRANSFERIDO DE: HMR PHARMA, INC. |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: C12N 15/00 Ipc: C07K 19/00 (2006.01), C07K 14/47 (2006.01), A61K 3 |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/10/2019, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/08/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 23/08/2021 |