AR008807A1 - Utilizacion de lipidos complejos como aditivos estabilizadores a preparados farmaceuticos de mezclas de enzimas digestivas - Google Patents
Utilizacion de lipidos complejos como aditivos estabilizadores a preparados farmaceuticos de mezclas de enzimas digestivasInfo
- Publication number
- AR008807A1 AR008807A1 ARP970103511A ARP970103511A AR008807A1 AR 008807 A1 AR008807 A1 AR 008807A1 AR P970103511 A ARP970103511 A AR P970103511A AR P970103511 A ARP970103511 A AR P970103511A AR 008807 A1 AR008807 A1 AR 008807A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical preparations
- complex lipids
- digestive enzyme
- stabilizing additives
- enzyme mixtures
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Se describe la utilizacion de lípidos complejos, especialmente de lecitina, como aditivos que estabilizan contra una disminucion de actividadlipolítica bajo la influencia de la humedad, en preparados farmacéuticos solubles en aguade mezclas de enzimas digestivas que contienen lipasas yproteasas, especialmente mezclas de enzimas digestivas que contiene pancreatina los cuales son apropiados para la preparacion de soluciones acuosas para suintroduccion continua en el tractogastro ntestinal mediante una sonda.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19634752 | 1996-08-28 | ||
DE19724845A DE19724845A1 (de) | 1996-08-28 | 1997-06-12 | Verwendung von komplexen Lipiden als stabilisierende Zusätze zu pharmazeutischen Zubereitungen von Verdauungsenzymgemischen |
Publications (1)
Publication Number | Publication Date |
---|---|
AR008807A1 true AR008807A1 (es) | 2000-02-23 |
Family
ID=26028823
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970103511A AR008807A1 (es) | 1996-08-28 | 1997-08-01 | Utilizacion de lipidos complejos como aditivos estabilizadores a preparados farmaceuticos de mezclas de enzimas digestivas |
Country Status (22)
Country | Link |
---|---|
US (1) | US5993806A (es) |
EP (1) | EP0826375B1 (es) |
JP (1) | JP4593697B2 (es) |
CN (1) | CN1199694C (es) |
AR (1) | AR008807A1 (es) |
AT (1) | ATE284225T1 (es) |
AU (1) | AU722151B2 (es) |
BR (1) | BR9704554B1 (es) |
CA (1) | CA2213151C (es) |
CZ (1) | CZ295329B6 (es) |
DE (2) | DE19724845A1 (es) |
DK (1) | DK0826375T3 (es) |
EE (1) | EE04179B1 (es) |
ES (1) | ES2235206T3 (es) |
HK (1) | HK1005224A1 (es) |
HU (1) | HUP9701437A3 (es) |
NO (1) | NO973940L (es) |
NZ (1) | NZ328616A (es) |
PL (1) | PL190140B1 (es) |
PT (1) | PT826375E (es) |
SK (1) | SK284639B6 (es) |
TR (1) | TR199700872A3 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6074689A (en) * | 1998-03-10 | 2000-06-13 | Immucell Corporation | Colonic delivery of protein or peptide compositions |
KR100367659B1 (ko) * | 2000-05-08 | 2003-01-14 | 주식회사 바이넥스 | 선택적 안정화제의 첨가에 따른 자가분해(autolysis)를 통한 고역가 판크레아틴의 제조방법 |
GB0019118D0 (en) * | 2000-08-03 | 2000-09-27 | Danisco | Solid phase glycerolysis |
ATE295737T1 (de) * | 2000-11-02 | 2005-06-15 | Cilian Ag | Verwendung von aus ciliaten gewonnenen enzymen als verdauungsfördernde arzneimittel |
US20030099626A1 (en) * | 2001-11-20 | 2003-05-29 | Health Education Corporation | Nutrient absorption enhancing compositions and methods |
BRPI0509148B8 (pt) * | 2004-03-22 | 2021-05-25 | Abbott Products Gmbh | composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina contendo tensoativos, seus usos e respectivos processos de fabricação |
US7153504B2 (en) * | 2004-07-30 | 2006-12-26 | Can Technologies, Inc. | Stabilized pancreas product |
WO2007012069A2 (en) * | 2005-07-20 | 2007-01-25 | Brophy James S | Modification of particle morphology to improve product functionality |
JP5140586B2 (ja) | 2005-07-29 | 2013-02-06 | アボット プロダクツ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 滅菌パンクレアチン粉末の製法 |
US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
US20110183050A1 (en) * | 2006-07-20 | 2011-07-28 | Brophy James S | Modification of particle morphology to improve product functionality |
US8444967B2 (en) | 2010-07-09 | 2013-05-21 | Master Supplements, Inc. | Treatment including prebiotic composition for use with probiotics |
US20090130063A1 (en) * | 2007-11-15 | 2009-05-21 | Solvay Pharmaceuticals Gmbh | Process for separating and determining the viral load in a pancreatin sample |
DE102009006594A1 (de) | 2009-01-29 | 2010-08-05 | Nordmark Arzneimittel Gmbh & Co. Kg | Pharmazeutisches Präparat |
CN102231988A (zh) * | 2009-01-29 | 2011-11-02 | 诺尔玛克药物有限责任及股份两合公司 | 细菌脂肪酶药物制剂 |
MX348118B (es) | 2010-10-01 | 2017-05-26 | Aptalis Pharma Ltd | Formulaciones de pancrelipasa con recubrimiento enterico de baja potencia. |
EP3030257B1 (en) | 2013-08-09 | 2020-02-19 | Allergan Pharmaceuticals International Limited | Digestive enzyme composition suitable for enteral administration |
EP3003360B1 (en) * | 2013-11-05 | 2020-10-07 | Allergan Pharmaceuticals International Limited | High potency pancreatin pharmaceutical compositions |
JP2014193909A (ja) * | 2014-06-04 | 2014-10-09 | Nordmark Arzneimittel Gmbh & Co Kg | 医薬調製物 |
TR201704471T1 (tr) * | 2014-11-05 | 2018-04-24 | Abbott Gmbh & Co Kg | Pankreatin İhtiva Eden İyileştirilmiş Güvenlik Profiline Sahip Bileşimlerin Üretilmesi İçin Prosesler Ve Farmasötik Kullanıma Uygun Bileşimler |
US20180028454A1 (en) | 2015-02-04 | 2018-02-01 | Abbvie Inc. | Pharmaceutical compositions and methods of use thereof to treat pancreatic enzyme insufficiency |
DE102015114862A1 (de) * | 2015-09-04 | 2017-03-09 | Nordmark Arzneimittel Gmbh & Co. Kg | Pharmazeutische Zusammensetzung, enthaltend eine bakterielle Lipase |
DE102015114857A1 (de) | 2015-09-04 | 2017-03-09 | Nordmark Arzneimittel Gmbh & Co. Kg | Getränk, enthaltend eine pharmazeutische Zusammensetzung |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3956483A (en) * | 1968-10-24 | 1976-05-11 | Wilson Pharmaceutical & Chemical Corporation | Preparing pancreatin |
US3991180A (en) * | 1972-03-06 | 1976-11-09 | Rohm And Haas Company | Stabilization of internally administered pancreatic lipase |
DE2512746C3 (de) * | 1975-03-22 | 1980-04-24 | Kali-Chemie Pharma Gmbh, 3000 Hannover | Verfahren zur Herstellung von keimarmem, faserfreiem Pankreatin |
GB1603640A (en) * | 1977-07-20 | 1981-11-25 | Gist Brocades Nv | Enzyme particles |
JPS58148814A (ja) * | 1982-03-01 | 1983-09-05 | Fujimoto Seiyaku Kk | 消化酵素軟カプセル剤 |
JPS59169491A (ja) * | 1983-03-15 | 1984-09-25 | Duskin Franchise Co Ltd | 酵素の安定化法 |
JPH0229950A (ja) * | 1988-07-18 | 1990-01-31 | Nec Corp | 光ディスク |
JP2679852B2 (ja) * | 1989-11-29 | 1997-11-19 | 株式会社サム研究所 | 経口及び局所投与用生物活性蛋白組成物 |
GB9007052D0 (en) * | 1990-03-29 | 1990-05-30 | Skua Investments Ltd | Pharmaceutical formulations |
ZA92452B (en) * | 1991-01-24 | 1992-10-28 | Martek Corp | Microbial oil mixtures and uses thereof |
DE4200002A1 (de) * | 1992-01-02 | 1993-07-08 | Rudolf V Dipl Chem Dr Noronha | Reinigungstablette fuer die zahnprothesen |
CA2168870A1 (en) * | 1993-09-15 | 1995-03-23 | Anthony Vincent Rawlings | Skin care method and composition |
JPH09125096A (ja) * | 1995-10-30 | 1997-05-13 | Koei Sangyo:Kk | 液状天然油脂洗剤 |
-
1997
- 1997-06-12 DE DE19724845A patent/DE19724845A1/de not_active Withdrawn
- 1997-07-09 CZ CZ19972184A patent/CZ295329B6/cs not_active IP Right Cessation
- 1997-08-01 AR ARP970103511A patent/AR008807A1/es unknown
- 1997-08-18 CA CA002213151A patent/CA2213151C/en not_active Expired - Fee Related
- 1997-08-20 EP EP97114330A patent/EP0826375B1/de not_active Expired - Lifetime
- 1997-08-20 DE DE1997512108 patent/DE59712108D1/de not_active Expired - Lifetime
- 1997-08-20 ES ES97114330T patent/ES2235206T3/es not_active Expired - Lifetime
- 1997-08-20 PT PT97114330T patent/PT826375E/pt unknown
- 1997-08-20 DK DK97114330T patent/DK0826375T3/da active
- 1997-08-20 AT AT97114330T patent/ATE284225T1/de not_active IP Right Cessation
- 1997-08-22 SK SK1159-97A patent/SK284639B6/sk unknown
- 1997-08-22 US US08/916,325 patent/US5993806A/en not_active Expired - Lifetime
- 1997-08-25 HU HU9701437A patent/HUP9701437A3/hu unknown
- 1997-08-25 JP JP22800897A patent/JP4593697B2/ja not_active Expired - Lifetime
- 1997-08-27 PL PL97321825A patent/PL190140B1/pl unknown
- 1997-08-27 CN CNB971177007A patent/CN1199694C/zh not_active Expired - Fee Related
- 1997-08-27 NO NO973940A patent/NO973940L/no not_active Application Discontinuation
- 1997-08-27 NZ NZ328616A patent/NZ328616A/xx unknown
- 1997-08-27 AU AU35309/97A patent/AU722151B2/en not_active Ceased
- 1997-08-28 EE EE9700249A patent/EE04179B1/xx not_active IP Right Cessation
- 1997-08-28 TR TR97/00872A patent/TR199700872A3/tr unknown
- 1997-08-28 BR BRPI9704554-3A patent/BR9704554B1/pt not_active IP Right Cessation
-
1998
- 1998-04-30 HK HK98103695A patent/HK1005224A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |