AP762A - Substituted 6,5-hetero-bicyclic derivatives. - Google Patents
Substituted 6,5-hetero-bicyclic derivatives. Download PDFInfo
- Publication number
- AP762A AP762A APAP/P/1997/001077A AP9701077A AP762A AP 762 A AP762 A AP 762A AP 9701077 A AP9701077 A AP 9701077A AP 762 A AP762 A AP 762A
- Authority
- AP
- ARIPO
- Prior art keywords
- alkyl
- phenyl
- trimethyl
- methyl
- ethyl
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims abstract description 201
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- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- FVZVCSNXTFCBQU-UHFFFAOYSA-N phosphanyl Chemical group [PH2] FVZVCSNXTFCBQU-UHFFFAOYSA-N 0.000 description 1
- CYQAYERJWZKYML-UHFFFAOYSA-N phosphorus pentasulfide Chemical compound S1P(S2)(=S)SP3(=S)SP1(=S)SP2(=S)S3 CYQAYERJWZKYML-UHFFFAOYSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 1
- NTTOTNSKUYCDAV-UHFFFAOYSA-N potassium hydride Chemical compound [KH] NTTOTNSKUYCDAV-UHFFFAOYSA-N 0.000 description 1
- 229910000105 potassium hydride Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000006268 reductive amination reaction Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
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- YHOBGCSGTGDMLF-UHFFFAOYSA-N sodium;di(propan-2-yl)azanide Chemical compound [Na+].CC(C)[N-]C(C)C YHOBGCSGTGDMLF-UHFFFAOYSA-N 0.000 description 1
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- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- ZWZVWGITAAIFPS-UHFFFAOYSA-N thiophosgene Chemical compound ClC(Cl)=S ZWZVWGITAAIFPS-UHFFFAOYSA-N 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
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Classifications
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Hematology (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2503996P | 1996-08-28 | 1996-08-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP9701077A0 AP9701077A0 (en) | 1997-10-31 |
| AP762A true AP762A (en) | 1999-09-13 |
Family
ID=21823717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1997/001077A AP762A (en) | 1996-08-28 | 1997-08-21 | Substituted 6,5-hetero-bicyclic derivatives. |
Country Status (36)
| Country | Link |
|---|---|
| EP (1) | EP0923582B1 (fr) |
| JP (2) | JP3621706B2 (fr) |
| KR (1) | KR20000035934A (fr) |
| CN (1) | CN1227554A (fr) |
| AP (1) | AP762A (fr) |
| AR (1) | AR015103A1 (fr) |
| AT (1) | ATE340176T1 (fr) |
| AU (1) | AU735401B2 (fr) |
| BG (1) | BG103189A (fr) |
| BR (1) | BR9711970A (fr) |
| CA (1) | CA2263566C (fr) |
| CO (1) | CO4600634A1 (fr) |
| CZ (1) | CZ68199A3 (fr) |
| DE (1) | DE69736711T2 (fr) |
| DZ (1) | DZ2300A1 (fr) |
| EA (1) | EA002769B1 (fr) |
| ES (1) | ES2273369T3 (fr) |
| GT (1) | GT199700095A (fr) |
| HR (1) | HRP970454B1 (fr) |
| HU (1) | HUP9903965A3 (fr) |
| ID (1) | ID18249A (fr) |
| IL (1) | IL127566A0 (fr) |
| IS (1) | IS4963A (fr) |
| MA (1) | MA26438A1 (fr) |
| NO (1) | NO313636B1 (fr) |
| NZ (1) | NZ333302A (fr) |
| OA (1) | OA10977A (fr) |
| PA (1) | PA8436201A1 (fr) |
| PE (1) | PE108898A1 (fr) |
| PL (1) | PL332040A1 (fr) |
| SK (1) | SK23399A3 (fr) |
| TN (1) | TNSN97145A1 (fr) |
| TR (1) | TR199900389T2 (fr) |
| TW (1) | TW575573B (fr) |
| WO (1) | WO1998008847A1 (fr) |
| ZA (1) | ZA977687B (fr) |
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| RS56034B1 (sr) | 2013-06-11 | 2017-09-29 | Bayer Pharma AG | Derivati prolekova supstituisanih triazolopiridina |
| BR112015032546B1 (pt) | 2013-06-27 | 2022-05-17 | Janssen Sciences Ireland Uc | Derivados de pirrolo[3,2-d]pirimidina e composição farmacêutica que os compreende para o tratamento de infecções virais e outras doenças |
| KR102322425B1 (ko) | 2013-07-30 | 2021-11-05 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염의 치료를 위한 티에노[3,2-d]피리미딘 유도체 |
| EP2940022B1 (fr) * | 2014-04-30 | 2020-09-02 | Masarykova Univerzita | Furopyridines comme inhibiteurs de protèines kinases |
| MX386419B (es) | 2015-01-06 | 2025-03-18 | Arena Pharm Inc | Metodos de condiciones de tratamiento relacionadas con el receptor s1p1. |
| EP3939965A1 (fr) | 2015-06-22 | 2022-01-19 | Arena Pharmaceuticals, Inc. | Sel l-arginine cristallin d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclo-penta[b]indol-3-yl)acétique pour une utilisation dans des troubles associés au récepteur de s1p1 |
| RU2699568C2 (ru) * | 2015-12-21 | 2019-09-06 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" | Лиганды транслокаторного белка TSPO, обладающие антидепрессивной и ноотропной активностью |
| AU2017289418B2 (en) | 2016-07-01 | 2021-06-03 | Janssen Sciences Ireland Unlimited Company | Dihydropyranopyrimidines for the treatment of viral infections |
| JP7274415B2 (ja) | 2016-09-29 | 2023-05-16 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | ウイルス感染症および他の疾患を処置するためのピリミジンプロドラッグ |
| CN118845788A (zh) | 2017-08-14 | 2024-10-29 | 云杉生物科学公司 | 促肾上腺皮质激素释放因子受体拮抗剂 |
| TW202415645A (zh) | 2018-03-01 | 2024-04-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | ２，４－二胺基喹唑啉衍生物及其醫學用途 |
| EP4438124A3 (fr) | 2018-04-27 | 2024-12-18 | Spruce Biosciences, Inc. | Méthodes de traitement de tumeurs de repos surrénales testiculaires et ovariennes |
| ES2987794T3 (es) | 2018-06-06 | 2024-11-18 | Arena Pharm Inc | Procedimientos de tratamiento de afecciones relacionadas con el receptor S1P1 |
| CN108812546A (zh) * | 2018-09-07 | 2018-11-16 | 四川省草原科学研究院 | 适于青藏高原地区牦牛运输减少应激的药物及使用方法 |
| BR112023002497A2 (pt) | 2020-08-12 | 2023-05-02 | Spruce Biosciences Inc | Métodos e composições para tratamento da síndrome dos ovários policísticos |
| US11708372B2 (en) | 2021-11-19 | 2023-07-25 | Spruce Biosciences, Inc. | Crystalline composition of tildacerfont and methods of use and preparation thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995033750A1 (fr) * | 1994-06-08 | 1995-12-14 | Pfizer Inc. | Antagonistes du facteur liberant la corticotrophine |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6020492A (en) * | 1995-05-12 | 2000-02-01 | Neurogen Corporation | Deazapurine derivatives; a new class of CRF1 specific ligands |
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- 1997-08-27 MA MA24779A patent/MA26438A1/fr unknown
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- 1997-08-27 DZ DZ970150A patent/DZ2300A1/fr active
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995033750A1 (fr) * | 1994-06-08 | 1995-12-14 | Pfizer Inc. | Antagonistes du facteur liberant la corticotrophine |
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