AP704A - Process for the diastereoselective synthesis of nucleoside analogues. - Google Patents

Process for the diastereoselective synthesis of nucleoside analogues. Download PDF

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Publication number
AP704A
AP704A APAP/P/1996/000871A AP9600871A AP704A AP 704 A AP704 A AP 704A AP 9600871 A AP9600871 A AP 9600871A AP 704 A AP704 A AP 704A
Authority
AP
ARIPO
Prior art keywords
formula
isomers
mixture
cis
alcohols
Prior art date
Application number
APAP/P/1996/000871A
Other languages
English (en)
Other versions
AP9600871A0 (en
Inventor
Malcolm Leithead Hill
Andrew Jonathan Whitehead
Roy Hornby
Peter Hallett
Michael David Goodyear
P Owen Dwyer
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27267157&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP704(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB9408103A external-priority patent/GB9408103D0/en
Priority claimed from GB9408091A external-priority patent/GB9408091D0/en
Priority claimed from GB9408112A external-priority patent/GB9408112D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AP9600871A0 publication Critical patent/AP9600871A0/xx
Application granted granted Critical
Publication of AP704A publication Critical patent/AP704A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Treatment Of Water By Oxidation Or Reduction (AREA)
APAP/P/1996/000871A 1994-04-23 1995-04-21 Process for the diastereoselective synthesis of nucleoside analogues. AP704A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9408103A GB9408103D0 (en) 1994-04-23 1994-04-23 Chemical compounds
GB9408091A GB9408091D0 (en) 1994-04-23 1994-04-23 Process
GB9408112A GB9408112D0 (en) 1994-04-23 1994-04-23 Process
PCT/EP1995/001503 WO1995029174A1 (en) 1994-04-23 1995-04-21 Process for the diastereoselective synthesis of nucleoside analogues

Publications (2)

Publication Number Publication Date
AP9600871A0 AP9600871A0 (en) 1996-10-31
AP704A true AP704A (en) 1998-12-04

Family

ID=27267157

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1996/000871A AP704A (en) 1994-04-23 1995-04-21 Process for the diastereoselective synthesis of nucleoside analogues.

Country Status (30)

Country Link
US (2) US6051709A (et)
EP (1) EP0757684B1 (et)
JP (2) JP4056558B2 (et)
KR (1) KR100241842B1 (et)
CN (2) CN1151146C (et)
AP (1) AP704A (et)
AT (1) ATE181326T1 (et)
AU (1) AU696612B2 (et)
BG (1) BG62810B1 (et)
BR (1) BR9507499A (et)
CZ (1) CZ293827B6 (et)
DE (1) DE69510347T2 (et)
DK (1) DK0757684T3 (et)
EE (1) EE03442B1 (et)
ES (1) ES2133769T3 (et)
FI (1) FI120401B (et)
GR (1) GR3031043T3 (et)
HK (1) HK1004221A1 (et)
HU (1) HU218044B (et)
IL (1) IL113432A (et)
IS (1) IS1844B (et)
NO (2) NO307179B1 (et)
NZ (1) NZ285396A (et)
PL (1) PL180090B1 (et)
RO (2) RO117916B1 (et)
RU (1) RU2158736C2 (et)
SK (1) SK281327B6 (et)
TW (1) TW487704B (et)
UA (1) UA43362C2 (et)
WO (1) WO1995029174A1 (et)

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US6175008B1 (en) * 1988-04-11 2001-01-16 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
IL113432A (en) * 1994-04-23 2000-11-21 Glaxo Group Ltd Process for the diastereoselective synthesis of nucleoside analogues
WO1996012716A1 (en) * 1994-10-22 1996-05-02 Chong Kun Dang Corp. Nucleoside derivatives and process for preparing thereof
GB9506644D0 (en) * 1995-03-31 1995-05-24 Wellcome Found Preparation of nucleoside analogues
US6113920A (en) * 1996-10-31 2000-09-05 Glaxo Wellcome Inc. Pharmaceutical compositions
ES2232169T3 (es) * 1998-08-12 2005-05-16 Gilead Sciences, Inc. Procedimiento de fabricacion de nucleosidos de 1,3-oxatiolano.
GB9820417D0 (en) * 1998-09-18 1998-11-11 Glaxo Group Ltd Antiviral combinations
US6432966B2 (en) 1999-10-29 2002-08-13 Smithkline Beecham Corporation Antiviral combinations
CA2788498C (en) * 2001-03-01 2016-02-16 Gilead Sciences, Inc. Polymorphic and other crystalline forms of cis-ftc
US6600044B2 (en) 2001-06-18 2003-07-29 Brantford Chemicals Inc. Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers
WO2003027106A1 (en) * 2001-09-25 2003-04-03 Cadila Healthcar Limited Process for the preparation of crystalline polymorph ii of lamivudine
ITMI20030578A1 (it) * 2003-03-24 2004-09-25 Clariant Lsm Italia Spa Processo ed intermedi per la preparazione di emtricitabina
US20050187913A1 (en) 2003-05-06 2005-08-25 Yoram Nelken Web-based customer service interface
CN101307048B (zh) 2007-05-18 2011-03-23 上海迪赛诺医药发展有限公司 立体选择性制备拉米夫定的方法
WO2009037538A2 (en) * 2007-09-17 2009-03-26 Aurobindo Pharma Ltd Process for the preparation of lamivudine form i
EP2048151A1 (en) * 2007-10-10 2009-04-15 Cilag AG Method for producing nucleosides by direct glycosylation of the nucleoside base
WO2009069011A1 (en) 2007-11-29 2009-06-04 Ranbaxy Laboratories Limited Process for the preparation of substituted 1,3-oxathiolanes
AU2008331167A1 (en) * 2007-11-29 2009-06-04 Ranbaxy Laboratories Limited Process and intermediates for the preparation of substituted 1, 3-oxathiolanes, especially lamivudine
CN101918393A (zh) * 2007-11-29 2010-12-15 兰贝克赛实验室有限公司 拉米夫定的晶形i及其制备方法
US8350030B2 (en) * 2007-12-07 2013-01-08 Matrix Laboratories Limited Process for producing 5-fluoro-1-(2R, 5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
CN101362752B (zh) * 2008-09-18 2011-12-28 浙江教育学院 一种拉米夫定中间体的合成方法
CN101391997B (zh) * 2008-09-18 2010-12-22 江苏科本医药化学有限公司 一种恩曲他滨中间体的合成方法
US20110282046A1 (en) 2009-01-19 2011-11-17 Rama Shankar Process for preparation of cis-nucleoside derivative
KR101474570B1 (ko) 2009-04-13 2014-12-19 주식회사 대희화학 라미부딘의 신규한 중간체 및 이의 제조방법
CN101544632B (zh) * 2009-04-24 2011-09-07 湖南千金湘江药业股份有限公司 拉米夫定非对映选择合成方法
DK2488516T3 (en) 2009-10-14 2015-05-26 Mylan Lab Ltd Method of producing lamivudine and novel salts in the preparation thereof
DK3494972T3 (da) 2010-01-27 2024-01-29 Viiv Healthcare Co Kombinationer af dolutegravir og lamivudin til behandling af HIV-infektion
US20120295930A1 (en) 2010-02-03 2012-11-22 Shankar Rama Novel process for the preparation of cis-nucleoside derivative
CN102167696B (zh) * 2010-02-25 2013-09-18 南京正大天晴制药有限公司 拉米夫定草酸盐及其制备方法
PL2542551T3 (pl) 2010-03-04 2015-01-30 Ranbaxy Laboratories Ltd Sposób stereoselektywnego otrzymywania 5-fluoro-1-(2R,SS)-[2-(hydroksymetylo)-1,3-oksatiolan--5-ylo]cytozyny
CN101830893A (zh) * 2010-05-31 2010-09-15 安徽一帆香料有限公司 一种拉米夫定中间体hdms的合成制备工艺
CN102399213A (zh) * 2010-09-08 2012-04-04 重庆医药工业研究院有限责任公司 拉米夫定单邻苯二甲酸盐及其合成方法
CN103221037A (zh) 2010-11-12 2013-07-24 葛兰素惠尔康制造业私人有限公司 新药物组合物
CN103282369A (zh) 2011-04-08 2013-09-04 劳乐斯实验室私营有限公司 抗逆转录病毒化合物与抗氧化酸的固体形式、其制备方法以及其药物组合物
CN102796088B (zh) * 2012-05-21 2015-06-10 湖南千金湘江药业股份有限公司 一种拉米夫定的制备方法
CN103450166A (zh) * 2012-05-31 2013-12-18 上海迪赛诺药业有限公司 制备核苷化合物的方法
CN103864835A (zh) * 2013-03-26 2014-06-18 安徽贝克联合制药有限公司 一种提高拉米夫定中间体立体选择性制备方法
CN103288806A (zh) * 2013-07-02 2013-09-11 山东大学 一种曲沙他滨的合成方法
CN103694231A (zh) * 2013-11-28 2014-04-02 安徽一帆香料有限公司 一种拉米夫定中间体hdms的合成制备方法
US9571109B2 (en) * 2015-03-27 2017-02-14 International Business Machines Corporation Voltage controlled oscillator runaway prevention
CN106146481A (zh) * 2015-04-07 2016-11-23 江苏普信制药有限公司 一种核苷类似物的制备方法
CN105037340B (zh) * 2015-07-14 2018-08-10 福建广生堂药业股份有限公司 一种拉米夫定关键中间体手性异构体杂质的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017159A1 (en) * 1990-05-02 1991-11-14 Iaf Biochem International Inc. 1,3-oxathiolane nucleoside analogues
EP0515157A1 (en) * 1991-05-21 1992-11-25 Biochem Pharma Inc. Processes for the diastereoselective synthesis of nucleosides
WO1994014802A1 (en) * 1989-02-08 1994-07-07 Biochem Pharma Inc. Process for preparing substituted 1,3-oxathiolanes with antiviral properties

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
US5466806A (en) * 1989-02-08 1995-11-14 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
US6175008B1 (en) * 1988-04-11 2001-01-16 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5587480A (en) * 1990-11-13 1996-12-24 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
IL100502A (en) * 1991-01-03 1995-12-08 Iaf Biochem Int PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (-
AU1787492A (en) 1991-05-16 1992-12-30 Glaxo Group Limited Antiviral combinations containing nucleoside analogs
GB9110874D0 (en) * 1991-05-20 1991-07-10 Iaf Biochem Int Medicaments
GB9116601D0 (en) * 1991-08-01 1991-09-18 Iaf Biochem Int 1,3-oxathiolane nucleoside analogues
IL113432A (en) * 1994-04-23 2000-11-21 Glaxo Group Ltd Process for the diastereoselective synthesis of nucleoside analogues

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014802A1 (en) * 1989-02-08 1994-07-07 Biochem Pharma Inc. Process for preparing substituted 1,3-oxathiolanes with antiviral properties
WO1991017159A1 (en) * 1990-05-02 1991-11-14 Iaf Biochem International Inc. 1,3-oxathiolane nucleoside analogues
EP0515157A1 (en) * 1991-05-21 1992-11-25 Biochem Pharma Inc. Processes for the diastereoselective synthesis of nucleosides

Also Published As

Publication number Publication date
BG100916A (en) 1997-07-31
NO313096B1 (no) 2002-08-12
GR3031043T3 (en) 1999-12-31
WO1995029174A1 (en) 1995-11-02
SK281327B6 (sk) 2001-02-12
AU2447195A (en) 1995-11-16
PL180090B1 (pl) 2000-12-29
HU218044B (hu) 2000-05-28
EE03442B1 (et) 2001-06-15
HUT76296A (en) 1997-07-28
IS4366A (is) 1996-09-27
NO964487L (no) 1996-12-17
TW487704B (en) 2002-05-21
SK135596A3 (en) 1997-07-09
AU696612B2 (en) 1998-09-17
NO995646D0 (no) 1999-11-17
US6051709A (en) 2000-04-18
KR100241842B1 (ko) 2000-03-02
IL113432A0 (en) 1995-07-31
RO118714B1 (ro) 2003-09-30
CN1151146C (zh) 2004-05-26
NZ285396A (en) 1998-10-28
EE9600134A (et) 1997-04-15
FI964251A (fi) 1996-10-22
IS1844B (is) 2003-01-30
CN1149871A (zh) 1997-05-14
BR9507499A (pt) 1997-09-23
PL316904A1 (en) 1997-02-17
NO995646L (no) 1999-11-17
CN1290841C (zh) 2006-12-20
EP0757684A1 (en) 1997-02-12
JP4056558B2 (ja) 2008-03-05
IL113432A (en) 2000-11-21
FI120401B (fi) 2009-10-15
JPH10502615A (ja) 1998-03-10
UA43362C2 (uk) 2001-12-17
JP2007217425A (ja) 2007-08-30
CZ293827B6 (cs) 2004-08-18
EP0757684B1 (en) 1999-06-16
HK1004221A1 (en) 1998-11-20
AP9600871A0 (en) 1996-10-31
NO307179B1 (no) 2000-02-21
ATE181326T1 (de) 1999-07-15
RO117916B1 (ro) 2002-09-30
HU9602925D0 (en) 1996-12-30
NO964487D0 (no) 1996-10-22
DE69510347D1 (de) 1999-07-22
CN1500782A (zh) 2004-06-02
CZ309696A3 (en) 1997-04-16
RU2158736C2 (ru) 2000-11-10
DE69510347T2 (de) 1999-11-18
BG62810B1 (bg) 2000-08-31
FI964251A0 (fi) 1996-10-22
DK0757684T3 (da) 2000-01-17
ES2133769T3 (es) 1999-09-16
US6329522B1 (en) 2001-12-11

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