ZA954940B - Enzyme inhibitors - Google Patents

Enzyme inhibitors

Info

Publication number
ZA954940B
ZA954940B ZA954940A ZA954940A ZA954940B ZA 954940 B ZA954940 B ZA 954940B ZA 954940 A ZA954940 A ZA 954940A ZA 954940 A ZA954940 A ZA 954940A ZA 954940 B ZA954940 B ZA 954940B
Authority
ZA
South Africa
Prior art keywords
enzyme inhibitors
protecting group
amidino
intermediates
chem
Prior art date
Application number
ZA954940A
Other languages
English (en)
Inventor
Harold Francis Hodson
David Alan Sawyer
Karl Witold Franzmann
Steven Smith
Helen Alice Rebecca Clark
Richard Michael John Palmer
Richard Graham Knowles
Martin James Drysdale
Patricia Ifeyinwa Davies
Barry George Shearer
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9509774.7A external-priority patent/GB9509774D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of ZA954940B publication Critical patent/ZA954940B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA954940A 1994-06-15 1995-06-14 Enzyme inhibitors ZA954940B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94304314 1994-06-15
GBGB9509774.7A GB9509774D0 (en) 1995-05-15 1995-05-15 Enzyme inhibitors

Publications (1)

Publication Number Publication Date
ZA954940B true ZA954940B (en) 1996-12-17

Family

ID=26137155

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA954940A ZA954940B (en) 1994-06-15 1995-06-14 Enzyme inhibitors

Country Status (29)

Country Link
US (2) USRE39576E1 (de)
EP (2) EP0957087B1 (de)
JP (2) JP2989010B2 (de)
KR (1) KR100430207B1 (de)
CN (1) CN1070849C (de)
AT (2) ATE229001T1 (de)
AU (1) AU692892B2 (de)
BR (1) BR9507995A (de)
CA (1) CA2192668A1 (de)
CY (2) CY2238B1 (de)
DE (2) DE69529101T2 (de)
DK (2) DK0765308T3 (de)
ES (2) ES2189322T3 (de)
FI (1) FI965019A0 (de)
GR (1) GR3033746T3 (de)
HK (1) HK1003935A1 (de)
HU (1) HUT77407A (de)
IL (2) IL114142A (de)
IS (1) IS4384A (de)
MX (1) MX9606136A (de)
MY (1) MY115437A (de)
NO (1) NO308655B1 (de)
NZ (1) NZ289157A (de)
PT (2) PT957087E (de)
RU (1) RU2162841C2 (de)
SI (2) SI0765308T1 (de)
TW (1) TW442453B (de)
WO (1) WO1995034534A1 (de)
ZA (1) ZA954940B (de)

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DE10111052A1 (de) * 2001-03-06 2002-09-12 Beiersdorf Ag Verwendung von Substanzen, die verhindern, daß die NO-Synthase des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen zur Steigerung der Ceramidbiosynthese
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Also Published As

Publication number Publication date
SI0957087T1 (en) 2003-04-30
DK0765308T3 (da) 2000-09-11
GR3033746T3 (en) 2000-10-31
ATE191470T1 (de) 2000-04-15
BR9507995A (pt) 1997-08-05
NO965379L (no) 1996-12-13
ES2145282T3 (es) 2000-07-01
DE69529101T2 (de) 2003-11-13
US5889056A (en) 1999-03-30
IS4384A (is) 1996-11-13
AU2891795A (en) 1996-01-05
ATE229001T1 (de) 2002-12-15
WO1995034534A1 (en) 1995-12-21
EP0765308A1 (de) 1997-04-02
IL128717A0 (en) 2000-01-31
MX9606136A (es) 1998-06-30
FI965019A (fi) 1996-12-13
PT957087E (pt) 2003-04-30
HK1003935A1 (en) 1998-11-13
KR100430207B1 (ko) 2004-07-19
RU2162841C2 (ru) 2001-02-10
EP0957087B1 (de) 2002-12-04
NO308655B1 (no) 2000-10-09
USRE39576E1 (en) 2007-04-17
IL114142A0 (en) 1995-10-31
NZ289157A (en) 1998-03-25
ES2189322T3 (es) 2003-07-01
JP2000026402A (ja) 2000-01-25
DK0957087T3 (da) 2003-03-24
DE69516141D1 (de) 2000-05-11
IL114142A (en) 2000-02-17
JP2989010B2 (ja) 1999-12-13
NO965379D0 (no) 1996-12-13
DE69529101D1 (de) 2003-01-16
CN1070849C (zh) 2001-09-12
CY2238B1 (en) 2003-07-04
EP0957087A2 (de) 1999-11-17
EP0765308B1 (de) 2000-04-05
HUT77407A (hu) 1998-04-28
TW442453B (en) 2001-06-23
DE69516141T2 (de) 2000-10-19
EP0957087A3 (de) 2000-12-20
SI0765308T1 (en) 2000-08-31
MY115437A (en) 2003-06-30
CY2455B1 (en) 2005-06-03
AU692892B2 (en) 1998-06-18
PT765308E (pt) 2000-09-29
CA2192668A1 (en) 1995-12-21
FI965019A0 (fi) 1996-12-13
JP3614711B2 (ja) 2005-01-26
JPH10506371A (ja) 1998-06-23
HU9603454D0 (en) 1997-02-28
CN1155276A (zh) 1997-07-23

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