IS4384A - Ensím latar - Google Patents

Ensím latar

Info

Publication number
IS4384A
IS4384A IS4384A IS4384A IS4384A IS 4384 A IS4384 A IS 4384A IS 4384 A IS4384 A IS 4384A IS 4384 A IS4384 A IS 4384A IS 4384 A IS4384 A IS 4384A
Authority
IS
Iceland
Prior art keywords
protecting group
lazy
enzymes
amidino
intermediates
Prior art date
Application number
IS4384A
Other languages
English (en)
Inventor
Francis Hodson Harold
Martin John Palmer Richard
Alan Sawyer David
Graham Knowles Richard
Witold Franzmann Karl
James Drysdale Martin
Ifeyinwa Davies Patricia
Alicia Rebecca Clark Helen
George Shearer Barry
Smith Steven
Original Assignee
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9509774.7A external-priority patent/GB9509774D0/en
Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited
Publication of IS4384A publication Critical patent/IS4384A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
IS4384A 1994-06-15 1996-11-13 Ensím latar IS4384A (is)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94304314 1994-06-15
GBGB9509774.7A GB9509774D0 (en) 1995-05-15 1995-05-15 Enzyme inhibitors
PCT/GB1995/001378 WO1995034534A1 (en) 1994-06-15 1995-06-14 Enzyme inhibitors

Publications (1)

Publication Number Publication Date
IS4384A true IS4384A (is) 1996-11-13

Family

ID=26137155

Family Applications (1)

Application Number Title Priority Date Filing Date
IS4384A IS4384A (is) 1994-06-15 1996-11-13 Ensím latar

Country Status (29)

Country Link
US (2) USRE39576E1 (is)
EP (2) EP0957087B1 (is)
JP (2) JP2989010B2 (is)
KR (1) KR100430207B1 (is)
CN (1) CN1070849C (is)
AT (2) ATE191470T1 (is)
AU (1) AU692892B2 (is)
BR (1) BR9507995A (is)
CA (1) CA2192668A1 (is)
CY (2) CY2238B1 (is)
DE (2) DE69516141T2 (is)
DK (2) DK0957087T3 (is)
ES (2) ES2145282T3 (is)
FI (1) FI965019A (is)
GR (1) GR3033746T3 (is)
HK (1) HK1003935A1 (is)
HU (1) HUT77407A (is)
IL (2) IL114142A (is)
IS (1) IS4384A (is)
MX (1) MX9606136A (is)
MY (1) MY115437A (is)
NO (1) NO308655B1 (is)
NZ (1) NZ289157A (is)
PT (2) PT957087E (is)
RU (1) RU2162841C2 (is)
SI (2) SI0765308T1 (is)
TW (1) TW442453B (is)
WO (1) WO1995034534A1 (is)
ZA (1) ZA954940B (is)

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US6369272B1 (en) 1997-01-13 2002-04-09 Glaxosmithkline Nitric oxide synthase inhibitors
US6620848B2 (en) 1997-01-13 2003-09-16 Smithkline Beecham Corporation Nitric oxide synthase inhibitors
WO1998033379A1 (en) * 1997-02-04 1998-08-06 The General Hospital Corporation A novel method for treating epidermal or dermal conditions
AU8647198A (en) * 1997-08-12 1999-03-01 Chugai Seiyaku Kabushiki Kaisha Remedies for diseases associated with bone resorption
HUP0101467A3 (en) * 1998-03-11 2003-03-28 G D Searle & Co Skokie Halogenated amidino amino acid derivatives useful as nitric monoxide synthase inhibitors
US6284735B1 (en) * 1998-04-28 2001-09-04 Lion Bioscience Ag HP-3228 and related peptides to treat sexual dysfunction
US6534503B1 (en) 1998-04-28 2003-03-18 Lion Bioscience Ag Melanocortin receptor-3 ligands to treat sexual dysfunction
WO1999055679A1 (en) 1998-04-28 1999-11-04 Trega Biosciences, Inc. Isoquinoline compound melanocortin receptor ligands and methods of using same
GB9811599D0 (en) 1998-05-30 1998-07-29 Glaxo Group Ltd Nitric oxide synthase inhibitors
AU6605800A (en) * 1999-07-16 2001-02-05 Trega Biosciences, Inc. Melanocortin receptor-3 ligands to treat sexual dysfunction
US6403830B2 (en) * 2000-03-24 2002-06-11 Pharmacia Corporation Amidino compound and salts thereof useful as nitric oxide synthase inhibitors
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GB0031179D0 (en) * 2000-12-21 2001-01-31 Glaxo Group Ltd Nitric oxide synthase inhibitors
DE10111050A1 (de) * 2001-03-06 2002-09-12 Beiersdorf Ag Verwendung von Substanzen, die verhindern, daß die NO-Synthase des warmblütigenOrganismus ihre Wirkung entfaltet, zur Herstellung von kosmetischewn oder dermatologischen Zubereitungen zur Behandlung und/oder Prophylaxe unerwünschter Hautpigmentierung
DE10111049A1 (de) * 2001-03-06 2002-09-12 Beiersdorf Ag Verwendung von Substanzen, die verhindern, daß die NO-Synthese des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen, zur Prophylaxe und Behandlung von entzündlichen Hautzuständen und/oder zum Hautschutz bei empfindlich determinierter trockener Haut
DE10111054A1 (de) * 2001-03-06 2002-09-12 Beiersdorf Ag Verwendung von Substanzen, die verhindern, daß die NO-Synthese des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen zur Stärkung der Barrierefunktion der Haut
DE10111052A1 (de) * 2001-03-06 2002-09-12 Beiersdorf Ag Verwendung von Substanzen, die verhindern, daß die NO-Synthase des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen zur Steigerung der Ceramidbiosynthese
US7012098B2 (en) * 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
BR0310061A (pt) * 2002-05-16 2005-03-01 Pharmacia Corp Métodos para o tratamento de doenças e condições respiratórias com um inibidor seletivo da inos e um inibidor da pde e suas composições
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KR20090003349A (ko) 2006-04-20 2009-01-09 글락소 그룹 리미티드 화합물
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WO2010122088A1 (en) 2009-04-24 2010-10-28 Glaxo Group Limited Pyrazole and triazole carboxamides as crac channel inhibitors
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JP5890312B2 (ja) * 2009-10-09 2016-03-22 ザフゲン，インコーポレイテッド 肥満治療に用いられるスルホン化合物
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JP2013512878A (ja) 2009-12-03 2013-04-18 グラクソ グループ リミテッド 新規化合物
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ES2602972T3 (es) 2010-09-08 2017-02-23 Glaxosmithkline Intellectual Property Development Limited Derivados de indazol para su uso en el tratamiento de infección por virus de la gripe
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Family Cites Families (4)

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Also Published As

Publication number Publication date
JP2000026402A (ja) 2000-01-25
EP0957087A2 (en) 1999-11-17
CN1155276A (zh) 1997-07-23
IL128717A0 (en) 2000-01-31
HU9603454D0 (en) 1997-02-28
CY2238B1 (en) 2003-07-04
FI965019A0 (fi) 1996-12-13
RU2162841C2 (ru) 2001-02-10
FI965019A (fi) 1996-12-13
MY115437A (en) 2003-06-30
EP0765308B1 (en) 2000-04-05
IL114142A0 (en) 1995-10-31
WO1995034534A1 (en) 1995-12-21
DE69529101D1 (de) 2003-01-16
SI0765308T1 (en) 2000-08-31
ZA954940B (en) 1996-12-17
TW442453B (en) 2001-06-23
US5889056A (en) 1999-03-30
DE69529101T2 (de) 2003-11-13
DE69516141D1 (de) 2000-05-11
PT765308E (pt) 2000-09-29
ATE229001T1 (de) 2002-12-15
MX9606136A (es) 1998-06-30
KR100430207B1 (ko) 2004-07-19
CY2455B1 (en) 2005-06-03
SI0957087T1 (en) 2003-04-30
CA2192668A1 (en) 1995-12-21
JP2989010B2 (ja) 1999-12-13
HUT77407A (hu) 1998-04-28
DK0765308T3 (da) 2000-09-11
AU692892B2 (en) 1998-06-18
ES2189322T3 (es) 2003-07-01
DK0957087T3 (da) 2003-03-24
DE69516141T2 (de) 2000-10-19
JP3614711B2 (ja) 2005-01-26
CN1070849C (zh) 2001-09-12
NZ289157A (en) 1998-03-25
USRE39576E1 (en) 2007-04-17
EP0957087B1 (en) 2002-12-04
ATE191470T1 (de) 2000-04-15
IL114142A (en) 2000-02-17
HK1003935A1 (en) 1998-11-13
JPH10506371A (ja) 1998-06-23
EP0957087A3 (en) 2000-12-20
NO308655B1 (no) 2000-10-09
NO965379L (no) 1996-12-13
EP0765308A1 (en) 1997-04-02
GR3033746T3 (en) 2000-10-31
NO965379D0 (no) 1996-12-13
ES2145282T3 (es) 2000-07-01
PT957087E (pt) 2003-04-30
AU2891795A (en) 1996-01-05
BR9507995A (pt) 1997-08-05

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