MX9606136A - Inhibidores de enzimas. - Google Patents
Inhibidores de enzimas.Info
- Publication number
- MX9606136A MX9606136A MX9606136A MX9606136A MX9606136A MX 9606136 A MX9606136 A MX 9606136A MX 9606136 A MX9606136 A MX 9606136A MX 9606136 A MX9606136 A MX 9606136A MX 9606136 A MX9606136 A MX 9606136A
- Authority
- MX
- Mexico
- Prior art keywords
- hydrogen
- group
- alkyl
- 6alkyl
- independently selected
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Un compuesto de la formula (I): en donde R1 es un grupo alquilo de 1 a 6átomos de carbono de cadena recta o ramificada, un grupo alquenilo de 2 a 6átomos de carbono, un grupo alquinilo de 2 a 6 átomos de carbono, un grupo cicloalquilo de 3 a 6 átomos de carbono, o un grupo cicloalquilo de 3 a 6 átomos de carbono-alquilo de 1 a 6 átomos de carbono, cada uno opcionalmente sustituido por uno a tres grupos independientemente seleccionados de: -CN; -NO2; un grupo -COR2 en donde R2 es hidrogeno, alquilo de 1 a 6 átomos de carbono, -Or3 en donde R3 es hidrogeno o alquilo de 1 a 6 átomos de carbono. o NR4R5 en donde R4 y R5 son independientemente seleccionados de hidrogeno o alquilo de 1 a 6 átomos de carbono; un grupo -S(O)mR6 en donde m es 0.1 o 2, R6 es hidrogeno, alquilo de 1 a 6 átomos de carbono. hidroxi o NR7R8 en donde R7 y R8 son independientemente hidrogeno o alquilo de 1 a 6 átomos de carbono; un grupo PO(OR9)2 en donde R9 es hidrogeno o alquilo de 1 a 6 átomos de carbono; un grupo CR10R11 en donde R10 y R11 son independientemente seleccionados de hidrogeno, alquilo de 1 a 6 átomos de carbono, -COR12 en donde R12 es hidrogeno o alquilo de 1 a 6 átomos de carbono , o -S(O)m'R13 en donde m' es 0, 1 o " y R13 es hidrogeno o alquilo de 1 a 6 átomos de carbono; o un grupo -OR14 en donde R14 es hidrogeno, alquilo de 1 a 6 átomos de carbono opcionalmente sustituido por uno a tres átomo halo, arilo de 6 a 10 átomos de carbono o -COR15 en donde R15 es hidrogeno o alquilo de 1 a 6 átomos de carbono; p es 2 o 3, q es 1 o 2 y n es 0 o 1 y todas las sales, ésteres, amidas y profármacos fisiologicamente aceptables del mismo; se describen usos farmacéuticos y formulaciones para los mismos; y procedimientos para su preparacion.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94304314 | 1994-06-15 | ||
GBGB9509774.7A GB9509774D0 (en) | 1995-05-15 | 1995-05-15 | Enzyme inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9606136A true MX9606136A (es) | 1998-06-30 |
Family
ID=26137155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9606136A MX9606136A (es) | 1994-06-15 | 1996-12-05 | Inhibidores de enzimas. |
Country Status (29)
Country | Link |
---|---|
US (2) | USRE39576E1 (es) |
EP (2) | EP0957087B1 (es) |
JP (2) | JP2989010B2 (es) |
KR (1) | KR100430207B1 (es) |
CN (1) | CN1070849C (es) |
AT (2) | ATE229001T1 (es) |
AU (1) | AU692892B2 (es) |
BR (1) | BR9507995A (es) |
CA (1) | CA2192668A1 (es) |
CY (2) | CY2238B1 (es) |
DE (2) | DE69529101T2 (es) |
DK (2) | DK0765308T3 (es) |
ES (2) | ES2189322T3 (es) |
FI (1) | FI965019A0 (es) |
GR (1) | GR3033746T3 (es) |
HK (1) | HK1003935A1 (es) |
HU (1) | HUT77407A (es) |
IL (2) | IL114142A (es) |
IS (1) | IS4384A (es) |
MX (1) | MX9606136A (es) |
MY (1) | MY115437A (es) |
NO (1) | NO308655B1 (es) |
NZ (1) | NZ289157A (es) |
PT (2) | PT957087E (es) |
RU (1) | RU2162841C2 (es) |
SI (2) | SI0765308T1 (es) |
TW (1) | TW442453B (es) |
WO (1) | WO1995034534A1 (es) |
ZA (1) | ZA954940B (es) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2740339B1 (fr) * | 1995-10-26 | 1997-12-05 | Oreal | Utilisation d'au moins un inhibiteur de no-synthase dans le traitement des peaux sensibles |
US6369272B1 (en) | 1997-01-13 | 2002-04-09 | Glaxosmithkline | Nitric oxide synthase inhibitors |
US6620848B2 (en) | 1997-01-13 | 2003-09-16 | Smithkline Beecham Corporation | Nitric oxide synthase inhibitors |
JP2001511151A (ja) * | 1997-02-04 | 2001-08-07 | ザ ジェネラル ホスピタル コーポレイション | 表皮又は皮膚疾患部の処理方法と形質転換動物 |
AU8647198A (en) * | 1997-08-12 | 1999-03-01 | Chugai Seiyaku Kabushiki Kaisha | Remedies for diseases associated with bone resorption |
NZ506721A (en) * | 1998-03-11 | 2003-07-25 | G | Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors |
AU3768799A (en) | 1998-04-28 | 1999-11-16 | Trega Biosciences, Inc. | Isoquinoline compound melanocortin receptor ligands and methods of using same |
US6284735B1 (en) * | 1998-04-28 | 2001-09-04 | Lion Bioscience Ag | HP-3228 and related peptides to treat sexual dysfunction |
US6534503B1 (en) | 1998-04-28 | 2003-03-18 | Lion Bioscience Ag | Melanocortin receptor-3 ligands to treat sexual dysfunction |
GB9811599D0 (en) | 1998-05-30 | 1998-07-29 | Glaxo Group Ltd | Nitric oxide synthase inhibitors |
WO2001005401A1 (en) * | 1999-07-16 | 2001-01-25 | Trega Biosciences, Inc. | Melanocortin receptor-3 ligands to treat sexual dysfunction |
NZ520813A (en) * | 2000-03-24 | 2004-05-28 | Pharmacia Corp | Amidino compounds useful as nitric oxide synthase inhibitors |
AR034120A1 (es) * | 2000-04-13 | 2004-02-04 | Pharmacia Corp | Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico |
GB0031179D0 (en) * | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Nitric oxide synthase inhibitors |
DE10111050A1 (de) * | 2001-03-06 | 2002-09-12 | Beiersdorf Ag | Verwendung von Substanzen, die verhindern, daß die NO-Synthase des warmblütigenOrganismus ihre Wirkung entfaltet, zur Herstellung von kosmetischewn oder dermatologischen Zubereitungen zur Behandlung und/oder Prophylaxe unerwünschter Hautpigmentierung |
DE10111049A1 (de) * | 2001-03-06 | 2002-09-12 | Beiersdorf Ag | Verwendung von Substanzen, die verhindern, daß die NO-Synthese des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen, zur Prophylaxe und Behandlung von entzündlichen Hautzuständen und/oder zum Hautschutz bei empfindlich determinierter trockener Haut |
DE10111054A1 (de) * | 2001-03-06 | 2002-09-12 | Beiersdorf Ag | Verwendung von Substanzen, die verhindern, daß die NO-Synthese des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen zur Stärkung der Barrierefunktion der Haut |
DE10111052A1 (de) * | 2001-03-06 | 2002-09-12 | Beiersdorf Ag | Verwendung von Substanzen, die verhindern, daß die NO-Synthase des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen zur Steigerung der Ceramidbiosynthese |
US7012098B2 (en) * | 2001-03-23 | 2006-03-14 | Pharmacia Corporation | Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers |
EP1505972A2 (en) * | 2002-05-16 | 2005-02-16 | Pharmacia Corporation | A selective inos inhibitor and a pde inhibitor in combination for the treatment of respiratory diseases |
GB0214147D0 (en) * | 2002-06-19 | 2002-07-31 | Glaxo Group Ltd | Formulations |
PL1603872T3 (pl) * | 2003-03-11 | 2011-09-30 | Pharmacia Corp | Krystaliczna sól chlorowodorku maleinianu S-[2-[(1-iminoetylo)amino]etylo]-2-metylo-L-cysteiny |
TWI328009B (en) | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
GB0316290D0 (en) | 2003-07-11 | 2003-08-13 | Glaxo Group Ltd | Novel compounds |
PE20060272A1 (es) | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
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ATE517908T1 (de) | 2005-01-10 | 2011-08-15 | Glaxo Group Ltd | Androstan-17-alpha-carbonat-derivate zur verwendung bei der behandlung allergischer und entzündlicher zustände |
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GB0611587D0 (en) | 2006-06-12 | 2006-07-19 | Glaxo Group Ltd | Novel compounds |
PL2046787T3 (pl) | 2006-08-01 | 2011-10-31 | Glaxo Group Ltd | Związki pirazolo[3,4-b]pirydynowe i ich zastosowanie jako inhibitory PDE4 |
US20080114021A1 (en) * | 2006-11-09 | 2008-05-15 | University Of Maryland Baltimore | Use Of 5,6-Dimethylxanthenone-4-Acetic Acid as an Antimicrobial Agent |
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JP2012520845A (ja) | 2009-03-17 | 2012-09-10 | グラクソ グループ リミテッド | Itk阻害剤として使用されるピリミジン誘導体 |
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JP2012521760A (ja) | 2009-03-27 | 2012-09-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸(siNA)を用いたアポトーシスシグナル調節キナーゼ1(ASK1)遺伝子発現のRNA干渉媒介性阻害 |
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US20120022143A1 (en) | 2009-03-27 | 2012-01-26 | Merck Sharp & Dohme Corp | RNA Interference Mediated Inhibition of the Thymic Stromal Lymphopoietin (TSLP) Gene Expression Using Short Interfering Nucliec Acid (siNA) |
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US20120035237A1 (en) | 2009-04-24 | 2012-02-09 | Diane Mary Coe | Pyrazole and triazole carboxamides as crac chann el inhibitors |
WO2010122089A1 (en) | 2009-04-24 | 2010-10-28 | Glaxo Group Limited | N-pyrazolyl carboxamides as crac channel inhibitors |
EA021056B1 (ru) | 2009-04-30 | 2015-03-31 | Глаксо Груп Лимитед | Оксазолзамещенные индазолы в качестве ингибиторов pi3-киназ, содержащая их фармацевтическая композиция и их применение в лечении расстройств, опосредованных ненадлежащей активностью pi3-киназ |
JP5890312B2 (ja) * | 2009-10-09 | 2016-03-22 | ザフゲン,インコーポレイテッド | 肥満治療に用いられるスルホン化合物 |
WO2011067365A1 (en) | 2009-12-03 | 2011-06-09 | Glaxo Group Limited | Benzpyrazole derivatives as inhibitors of p13 kinases |
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EP3020393B1 (en) | 2009-12-16 | 2020-10-07 | 3M Innovative Properties Company | Formulations and methods for controlling mdi particle size delivery |
WO2011110575A1 (en) | 2010-03-11 | 2011-09-15 | Glaxo Group Limited | Derivatives of 2-[2-(benzo- or pyrido-) thiazolylamino]-6-aminopyridine, useful in the treatment of respiratoric, allergic or inflammatory diseases |
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GB201512635D0 (en) | 2015-07-17 | 2015-08-26 | Ucl Business Plc | Uses of therapeutic compounds |
JP2018527362A (ja) | 2015-09-11 | 2018-09-20 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドSunshine Lake Pharma Co.,Ltd. | 置換されたヘテロアリール化合物および使用方法 |
EP3710006A4 (en) | 2017-11-19 | 2021-09-01 | Sunshine Lake Pharma Co., Ltd. | SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR METHODS OF USE |
CA3083040A1 (en) | 2018-01-20 | 2019-07-25 | Sunshine Lake Pharma Co., Ltd. | Substituted aminopyrimidine compounds and methods of use |
CA3173172A1 (en) | 2020-03-26 | 2021-09-30 | Christopher D. Kane | Cathepsin inhibitors for preventing or treating viral infections |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3514450A1 (de) * | 1985-04-22 | 1986-10-23 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von imidaten sowie neue arylsubstituierte imidate |
GB9127376D0 (en) | 1991-12-24 | 1992-02-19 | Wellcome Found | Amidino derivatives |
DE4310202A1 (de) * | 1992-03-30 | 1993-10-07 | Ciba Geigy | µ-Ketoimidoester als Stabilisatoren für chlorhaltige Polymerisate |
FR2727111B1 (fr) * | 1994-11-21 | 1997-01-17 | Hoechst Lab | Nouveaux analogues soufres d'aminoacides, leur procede de preparation et leurs applications comme medicaments |
-
1995
- 1995-06-14 NZ NZ289157A patent/NZ289157A/en not_active IP Right Cessation
- 1995-06-14 WO PCT/GB1995/001378 patent/WO1995034534A1/en active IP Right Grant
- 1995-06-14 CA CA002192668A patent/CA2192668A1/en not_active Abandoned
- 1995-06-14 KR KR1019960707192A patent/KR100430207B1/ko not_active IP Right Cessation
- 1995-06-14 PT PT99116304T patent/PT957087E/pt unknown
- 1995-06-14 ES ES99116304T patent/ES2189322T3/es not_active Expired - Lifetime
- 1995-06-14 EP EP99116304A patent/EP0957087B1/en not_active Expired - Lifetime
- 1995-06-14 AU AU28917/95A patent/AU692892B2/en not_active Ceased
- 1995-06-14 US US10/407,204 patent/USRE39576E1/en not_active Expired - Lifetime
- 1995-06-14 IL IL11414295A patent/IL114142A/xx not_active IP Right Cessation
- 1995-06-14 AT AT99116304T patent/ATE229001T1/de not_active IP Right Cessation
- 1995-06-14 HU HU9603454A patent/HUT77407A/hu unknown
- 1995-06-14 DK DK95924405T patent/DK0765308T3/da active
- 1995-06-14 DK DK99116304T patent/DK0957087T3/da active
- 1995-06-14 DE DE69529101T patent/DE69529101T2/de not_active Expired - Lifetime
- 1995-06-14 DE DE69516141T patent/DE69516141T2/de not_active Expired - Fee Related
- 1995-06-14 PT PT95924405T patent/PT765308E/pt unknown
- 1995-06-14 EP EP95924405A patent/EP0765308B1/en not_active Expired - Lifetime
- 1995-06-14 ZA ZA954940A patent/ZA954940B/xx unknown
- 1995-06-14 AT AT95924405T patent/ATE191470T1/de not_active IP Right Cessation
- 1995-06-14 JP JP8501803A patent/JP2989010B2/ja not_active Expired - Lifetime
- 1995-06-14 SI SI9530412T patent/SI0765308T1/xx unknown
- 1995-06-14 US US08/750,679 patent/US5889056A/en not_active Ceased
- 1995-06-14 ES ES95924405T patent/ES2145282T3/es not_active Expired - Lifetime
- 1995-06-14 SI SI9530645T patent/SI0957087T1/xx unknown
- 1995-06-14 CN CN95194518A patent/CN1070849C/zh not_active Expired - Fee Related
- 1995-06-14 RU RU97100747/04A patent/RU2162841C2/ru not_active IP Right Cessation
- 1995-06-14 BR BR9507995A patent/BR9507995A/pt not_active IP Right Cessation
- 1995-06-15 MY MYPI95001621A patent/MY115437A/en unknown
- 1995-07-15 TW TW084107349A patent/TW442453B/zh not_active IP Right Cessation
-
1996
- 1996-11-13 IS IS4384A patent/IS4384A/is unknown
- 1996-12-05 MX MX9606136A patent/MX9606136A/es not_active IP Right Cessation
- 1996-12-13 FI FI965019A patent/FI965019A0/fi not_active Application Discontinuation
- 1996-12-13 NO NO965379A patent/NO308655B1/no unknown
-
1998
- 1998-04-17 HK HK98103253A patent/HK1003935A1/xx not_active IP Right Cessation
-
1999
- 1999-02-25 IL IL12871799A patent/IL128717A0/xx not_active IP Right Cessation
- 1999-06-07 JP JP16019399A patent/JP3614711B2/ja not_active Expired - Fee Related
-
2000
- 2000-06-22 GR GR20000401441T patent/GR3033746T3/el not_active IP Right Cessation
-
2001
- 2001-09-07 CY CY0100026A patent/CY2238B1/xx unknown
-
2004
- 2004-06-03 CY CY0400042A patent/CY2455B1/xx unknown
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