HK1003935A1 - Enzyme inhibitors - Google Patents

Enzyme inhibitors

Info

Publication number
HK1003935A1
HK1003935A1 HK98103253A HK98103253A HK1003935A1 HK 1003935 A1 HK1003935 A1 HK 1003935A1 HK 98103253 A HK98103253 A HK 98103253A HK 98103253 A HK98103253 A HK 98103253A HK 1003935 A1 HK1003935 A1 HK 1003935A1
Authority
HK
Hong Kong
Prior art keywords
enzyme inhibitors
protecting group
amidino
intermediates
chem
Prior art date
Application number
HK98103253A
Other languages
English (en)
Inventor
Francis Harold Hodson
Richard M J Palmer
Alan David Sawyer
Graham Richard Knowles
Witold Karl Franzmann
James Martin Drysdale
Steven Smith
Ifeyinwa Patricia Davies
Helen Alice Rebecca Clark
George Barry Shearer
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9509774.7A external-priority patent/GB9509774D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of HK1003935A1 publication Critical patent/HK1003935A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
HK98103253A 1994-06-15 1998-04-17 Enzyme inhibitors HK1003935A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94304314 1994-06-15
GBGB9509774.7A GB9509774D0 (en) 1995-05-15 1995-05-15 Enzyme inhibitors
PCT/GB1995/001378 WO1995034534A1 (en) 1994-06-15 1995-06-14 Enzyme inhibitors

Publications (1)

Publication Number Publication Date
HK1003935A1 true HK1003935A1 (en) 1998-11-13

Family

ID=26137155

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98103253A HK1003935A1 (en) 1994-06-15 1998-04-17 Enzyme inhibitors

Country Status (29)

Country Link
US (2) USRE39576E1 (xx)
EP (2) EP0765308B1 (xx)
JP (2) JP2989010B2 (xx)
KR (1) KR100430207B1 (xx)
CN (1) CN1070849C (xx)
AT (2) ATE229001T1 (xx)
AU (1) AU692892B2 (xx)
BR (1) BR9507995A (xx)
CA (1) CA2192668A1 (xx)
CY (2) CY2238B1 (xx)
DE (2) DE69516141T2 (xx)
DK (2) DK0957087T3 (xx)
ES (2) ES2189322T3 (xx)
FI (1) FI965019A (xx)
GR (1) GR3033746T3 (xx)
HK (1) HK1003935A1 (xx)
HU (1) HUT77407A (xx)
IL (2) IL114142A (xx)
IS (1) IS4384A (xx)
MX (1) MX9606136A (xx)
MY (1) MY115437A (xx)
NO (1) NO308655B1 (xx)
NZ (1) NZ289157A (xx)
PT (2) PT957087E (xx)
RU (1) RU2162841C2 (xx)
SI (2) SI0765308T1 (xx)
TW (1) TW442453B (xx)
WO (1) WO1995034534A1 (xx)
ZA (1) ZA954940B (xx)

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US6534503B1 (en) 1998-04-28 2003-03-18 Lion Bioscience Ag Melanocortin receptor-3 ligands to treat sexual dysfunction
AU3768799A (en) 1998-04-28 1999-11-16 Trega Biosciences, Inc. Isoquinoline compound melanocortin receptor ligands and methods of using same
US6284735B1 (en) * 1998-04-28 2001-09-04 Lion Bioscience Ag HP-3228 and related peptides to treat sexual dysfunction
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JP2012520686A (ja) 2009-03-19 2012-09-10 メルク・シャープ・エンド・ドーム・コーポレイション 低分子干渉核酸（ｓｉＮＡ）を用いたシグナル伝達性転写因子６（ＳＴＡＴ６）遺伝子発現のＲＮＡ干渉媒介性阻害
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Also Published As

Publication number Publication date
FI965019A0 (fi) 1996-12-13
WO1995034534A1 (en) 1995-12-21
ATE191470T1 (de) 2000-04-15
DE69529101T2 (de) 2003-11-13
AU692892B2 (en) 1998-06-18
DE69516141D1 (de) 2000-05-11
CY2455B1 (en) 2005-06-03
IL114142A (en) 2000-02-17
MY115437A (en) 2003-06-30
NO965379D0 (no) 1996-12-13
BR9507995A (pt) 1997-08-05
SI0957087T1 (en) 2003-04-30
JP2989010B2 (ja) 1999-12-13
CN1155276A (zh) 1997-07-23
NZ289157A (en) 1998-03-25
JP3614711B2 (ja) 2005-01-26
USRE39576E1 (en) 2007-04-17
PT765308E (pt) 2000-09-29
MX9606136A (es) 1998-06-30
EP0957087B1 (en) 2002-12-04
EP0957087A3 (en) 2000-12-20
IS4384A (is) 1996-11-13
RU2162841C2 (ru) 2001-02-10
CA2192668A1 (en) 1995-12-21
JPH10506371A (ja) 1998-06-23
DK0957087T3 (da) 2003-03-24
FI965019A (fi) 1996-12-13
ATE229001T1 (de) 2002-12-15
NO308655B1 (no) 2000-10-09
IL114142A0 (en) 1995-10-31
GR3033746T3 (en) 2000-10-31
AU2891795A (en) 1996-01-05
ZA954940B (en) 1996-12-17
TW442453B (en) 2001-06-23
CN1070849C (zh) 2001-09-12
DE69529101D1 (de) 2003-01-16
PT957087E (pt) 2003-04-30
SI0765308T1 (en) 2000-08-31
NO965379L (no) 1996-12-13
ES2189322T3 (es) 2003-07-01
IL128717A0 (en) 2000-01-31
ES2145282T3 (es) 2000-07-01
JP2000026402A (ja) 2000-01-25
DE69516141T2 (de) 2000-10-19
KR100430207B1 (ko) 2004-07-19
EP0765308A1 (en) 1997-04-02
HU9603454D0 (en) 1997-02-28
HUT77407A (hu) 1998-04-28
CY2238B1 (en) 2003-07-04
EP0765308B1 (en) 2000-04-05
EP0957087A2 (en) 1999-11-17
DK0765308T3 (da) 2000-09-11
US5889056A (en) 1999-03-30

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Legal Events

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PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20090614