ZA952693B - 1H-indole-3-Glyoxylamide sPLA2 inhibitors - Google Patents

1H-indole-3-Glyoxylamide sPLA2 inhibitors

Info

Publication number
ZA952693B
ZA952693B ZA952693A ZA952693A ZA952693B ZA 952693 B ZA952693 B ZA 952693B ZA 952693 A ZA952693 A ZA 952693A ZA 952693 A ZA952693 A ZA 952693A ZA 952693 B ZA952693 B ZA 952693B
Authority
ZA
South Africa
Prior art keywords
indole
spla2 inhibitors
glyoxylamide spla2
glyoxylamide
sub
Prior art date
Application number
ZA952693A
Other languages
English (en)
Inventor
Nicholas James Bach
Robert Delane Dillard
Susan Elizabeth Draheim
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA952693B publication Critical patent/ZA952693B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
ZA952693A 1994-04-01 1995-03-31 1H-indole-3-Glyoxylamide sPLA2 inhibitors ZA952693B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22191694A 1994-04-01 1994-04-01

Publications (1)

Publication Number Publication Date
ZA952693B true ZA952693B (en) 1996-09-30

Family

ID=22829963

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA952693A ZA952693B (en) 1994-04-01 1995-03-31 1H-indole-3-Glyoxylamide sPLA2 inhibitors

Country Status (29)

Country Link
US (6) US5654326A (ja)
EP (5) EP0675110B1 (ja)
JP (1) JP3109974B2 (ja)
KR (1) KR100368707B1 (ja)
CN (1) CN1067054C (ja)
AT (2) ATE220394T1 (ja)
AU (1) AU688458B2 (ja)
BR (1) BR9501404A (ja)
CA (1) CA2146097C (ja)
CO (1) CO4370099A1 (ja)
CZ (1) CZ82295A3 (ja)
DE (1) DE69527322T2 (ja)
DK (2) DK0675110T3 (ja)
ES (2) ES2179088T3 (ja)
FI (1) FI114793B (ja)
HU (1) HUT72048A (ja)
IL (1) IL113210A (ja)
MX (1) MX9501608A (ja)
MY (1) MY112897A (ja)
NO (1) NO304186B1 (ja)
NZ (1) NZ270848A (ja)
PE (1) PE18696A1 (ja)
PL (1) PL180523B1 (ja)
PT (1) PT675110E (ja)
RU (1) RU2128169C1 (ja)
SI (1) SI0675110T1 (ja)
TW (1) TW383302B (ja)
UA (1) UA47387C2 (ja)
ZA (1) ZA952693B (ja)

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EP1039911B1 (en) * 1997-10-27 2005-05-25 Eli Lilly And Company MORPHOLINO-N-ETHYL ESTER PRODRUGS OF INDOLE sPLA 2 INHIBITORS
AU1200799A (en) * 1997-10-27 1999-05-17 Eli Lilly And Company Isopropyl ester prodrugs of indole spla2 inhibitors
WO1999024033A1 (en) * 1997-11-12 1999-05-20 Shionogi & Co., Ltd. Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds
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US6916841B2 (en) * 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
CN1310706A (zh) * 1998-02-25 2001-08-29 遗传研究所有限公司 磷脂酶抑制剂
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Also Published As

Publication number Publication date
PL180523B1 (pl) 2001-02-28
DK1950200T3 (da) 2012-04-10
DE69527322T2 (de) 2003-02-27
PT675110E (pt) 2002-11-29
BR9501404A (pt) 1996-03-05
JPH07285933A (ja) 1995-10-31
FI951553A (fi) 1995-10-02
UA47387C2 (uk) 2002-07-15
CA2146097C (en) 2000-03-21
AU688458B2 (en) 1998-03-12
ES2377223T3 (es) 2012-03-23
DE69527322D1 (de) 2002-08-14
US5919943A (en) 1999-07-06
IL113210A0 (en) 1995-06-29
EP1081135A2 (en) 2001-03-07
CO4370099A1 (es) 1996-10-07
US5919810A (en) 1999-07-06
KR950032117A (ko) 1995-12-20
US5654326A (en) 1997-08-05
US6433001B1 (en) 2002-08-13
SI0675110T1 (en) 2002-12-31
EP0675110A1 (en) 1995-10-04
ATE540923T1 (de) 2012-01-15
EP1197484A2 (en) 2002-04-17
IL113210A (en) 2001-01-28
CN1067054C (zh) 2001-06-13
HU9500957D0 (en) 1995-05-29
RU2128169C1 (ru) 1999-03-27
FI114793B (fi) 2004-12-31
HUT72048A (en) 1996-03-28
FI951553A0 (fi) 1995-03-31
NZ270848A (en) 1997-05-26
US5733923A (en) 1998-03-31
CN1114310A (zh) 1996-01-03
KR100368707B1 (ko) 2003-06-02
EP2341045A1 (en) 2011-07-06
RU95104885A (ru) 1997-04-27
US6175021B1 (en) 2001-01-16
ATE220394T1 (de) 2002-07-15
PL307951A1 (en) 1995-10-02
JP3109974B2 (ja) 2000-11-20
TW383302B (en) 2000-03-01
CA2146097A1 (en) 1995-10-02
NO951252L (no) 1995-10-02
EP0675110B1 (en) 2002-07-10
MX9501608A (es) 1997-02-28
NO951252D0 (no) 1995-03-31
EP1081135A3 (en) 2003-11-05
PE18696A1 (es) 1996-05-30
EP1950200A1 (en) 2008-07-30
MY112897A (en) 2001-10-31
AU1621795A (en) 1995-10-12
NO304186B1 (no) 1998-11-09
DK0675110T3 (da) 2002-10-07
ES2179088T3 (es) 2003-01-16
EP1950200B1 (en) 2012-01-11
CZ82295A3 (en) 1995-12-13

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