SI0675110T1 - 1H-Indole-3-glyoxylamide sPLA2 inhibitors - Google Patents

1H-Indole-3-glyoxylamide sPLA2 inhibitors

Info

Publication number
SI0675110T1
SI0675110T1 SI9530616T SI9530616T SI0675110T1 SI 0675110 T1 SI0675110 T1 SI 0675110T1 SI 9530616 T SI9530616 T SI 9530616T SI 9530616 T SI9530616 T SI 9530616T SI 0675110 T1 SI0675110 T1 SI 0675110T1
Authority
SI
Slovenia
Prior art keywords
indole
spla2 inhibitors
glyoxylamide spla2
glyoxylamide
sub
Prior art date
Application number
SI9530616T
Other languages
English (en)
Slovenian (sl)
Inventor
Nicholas James Bach
Robert Delane Dillard
Susan Elizabeth Draheim
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of SI0675110T1 publication Critical patent/SI0675110T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
SI9530616T 1994-04-01 1995-03-31 1H-Indole-3-glyoxylamide sPLA2 inhibitors SI0675110T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22191694A 1994-04-01 1994-04-01
EP95302166A EP0675110B1 (en) 1994-04-01 1995-03-31 1H-Indole-3-glyoxylamide sPLA2 inhibitors

Publications (1)

Publication Number Publication Date
SI0675110T1 true SI0675110T1 (en) 2002-12-31

Family

ID=22829963

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9530616T SI0675110T1 (en) 1994-04-01 1995-03-31 1H-Indole-3-glyoxylamide sPLA2 inhibitors

Country Status (29)

Country Link
US (6) US5654326A (ja)
EP (5) EP2341045A1 (ja)
JP (1) JP3109974B2 (ja)
KR (1) KR100368707B1 (ja)
CN (1) CN1067054C (ja)
AT (2) ATE220394T1 (ja)
AU (1) AU688458B2 (ja)
BR (1) BR9501404A (ja)
CA (1) CA2146097C (ja)
CO (1) CO4370099A1 (ja)
CZ (1) CZ82295A3 (ja)
DE (1) DE69527322T2 (ja)
DK (2) DK1950200T3 (ja)
ES (2) ES2179088T3 (ja)
FI (1) FI114793B (ja)
HU (1) HUT72048A (ja)
IL (1) IL113210A (ja)
MX (1) MX9501608A (ja)
MY (1) MY112897A (ja)
NO (1) NO304186B1 (ja)
NZ (1) NZ270848A (ja)
PE (1) PE18696A1 (ja)
PL (1) PL180523B1 (ja)
PT (1) PT675110E (ja)
RU (1) RU2128169C1 (ja)
SI (1) SI0675110T1 (ja)
TW (1) TW383302B (ja)
UA (1) UA47387C2 (ja)
ZA (1) ZA952693B (ja)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT675110E (pt) * 1994-04-01 2002-11-29 Lilly Co Eli 1h-indole-3-glioxilamidas inibidoras da spla2
JPH08193074A (ja) * 1994-11-18 1996-07-30 Nippon Bayeragrochem Kk 除草性１−シクロプロピルテトラゾリノン類
EP0751126A4 (en) * 1995-01-06 1998-05-13 Toray Industries BENZOCONDENSE HETEROCYCLIC DERIVATIVE AND ITS USE
US6630496B1 (en) 1996-08-26 2003-10-07 Genetics Institute Llc Inhibitors of phospholipase enzymes
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
US5919774A (en) * 1996-12-10 1999-07-06 Eli Lilly And Company Pyrroles as sPLA2 inhibitors
AU6229298A (en) * 1997-02-20 1998-09-09 Shionogi & Co., Ltd. Indole dicarboxylic acid derivatives
US5972988A (en) * 1997-03-26 1999-10-26 Eli Lilly And Company Method for treatment of chronic bronchitis using indole compounds
WO1998047507A1 (en) * 1997-04-24 1998-10-29 Shionogi & Co., Ltd. Method for the treatment of stroke using n-heterocyclic glyoxylamide compounds
TW455581B (en) * 1997-06-26 2001-09-21 Lilly Co Eli Process for preparing 4-substituted-1H-indole-3-glyoxamides
AU9123198A (en) * 1997-08-28 1999-03-16 Eli Lilly And Company Method for treatment of non-rheumatoid athritis
WO1999021545A1 (en) * 1997-10-27 1999-05-06 Eli Lilly And Company ISOPROPYL ESTER PRODRUGS OF INDOLE sPLA2 INHIBITORS
AU1279899A (en) * 1997-10-27 1999-05-17 Eli Lilly And Company N,n-diethylglycolamido ester prodrugs of indole spla2 inhibitors
WO1999021559A1 (en) 1997-10-27 1999-05-06 Eli Lilly And Company MORPHOLINO-N-ETHYL ESTER PRODRUGS OF INDOLE sPLA2 INHIBITORS
WO1999024033A1 (en) * 1997-11-12 1999-05-20 Shionogi & Co., Ltd. Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds
AU1405899A (en) * 1997-11-14 1999-06-07 Eli Lilly And Company Treatment for alzheimer's disease
EP1043991A4 (en) * 1997-11-14 2005-02-02 Lilly Co Eli TREATMENT OF ALZHEIMER DISEASE
US6828344B1 (en) 1998-02-25 2004-12-07 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6916841B2 (en) * 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
PL343007A1 (en) * 1998-02-25 2001-07-30 Genetics Inst Inhibitors of phospholipase enzymes
US6500853B1 (en) 1998-02-28 2002-12-31 Genetics Institute, Llc Inhibitors of phospholipase enzymes
JP2002505282A (ja) * 1998-03-03 2002-02-19 塩野義製薬株式会社 ホスホリパーゼ阻害剤の［［３−（２−アミノ−１，２−ジオキソエチル）−２−エチル−１−フェニルメチル）−１ｈ−インドール−４−イル］オキシ］酢酸ナトリウムを含む薬学的組成物
KR20010042307A (ko) 1998-03-31 2001-05-25 시오노 요시히코 피롤로[1,2-ａ]피라진 ｓＰＬＡ2 억제제
CZ302588B6 (cs) * 1998-04-02 2011-07-27 Ziopharm Oncology, Inc. Použití N-substituovaného indol-3-glyoxylamidu pro výrobu léciva
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DZ2770A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4.
JP2002512222A (ja) * 1998-04-17 2002-04-23 イーライ・リリー・アンド・カンパニー ４−ヒドロキシインドール、インダゾール、及び、カルバゾール化合物の製造方法
US6407261B1 (en) 1998-04-17 2002-06-18 Eli Lilly And Company Process for preparing 4-hdyroxy indole, indazole and carbazole compounds
SK16332000A3 (sk) * 1998-05-01 2001-06-11 Eli Lilly And Company Ester ako inhibítor spla2
WO1999057100A1 (en) * 1998-05-01 1999-11-11 Eli Lilly And Company Spla2 inhibitor compounds for treatment of disease
CA2332528A1 (en) 1998-05-21 1999-11-25 Shionogi & Co., Ltd. Pyrrolo[1,2-b]pyridazine spla2 inhibitory
EP1100493A4 (en) 1998-08-03 2001-10-24 Lilly Co Eli SPLA 2 INHIBITORS? OF THE INDOLTYPS
CA2338855A1 (en) * 1998-08-03 2000-02-17 Eli Lilly And Company Indole spla2 inhibitors
US6325991B1 (en) 1998-08-24 2001-12-04 Susan E. Draheim Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase A2
US6576654B1 (en) 1998-09-23 2003-06-10 Eli Lilly And Company Method for the treatment of cystic fibrosis
DZ2771A1 (fr) * 1998-10-09 2003-12-01 Lilly Co Eli Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4.
DE69931963D1 (de) * 1998-10-14 2006-07-27 Shionogi & Co Spla2-inhibitoren zur behandlung von ischämischen reperfusionsschäden
US20030149000A1 (en) * 1998-11-10 2003-08-07 Shionogi & Co., Ltd. Method for the treatment of disorders associated with apoptosis using N-heterocyclic glyoxylamide compounds
JP2002542148A (ja) * 1998-12-21 2002-12-10 イーライ・リリー・アンド・カンパニー 敗血症の処置のための組み合わせ療法
JP2002532571A (ja) * 1998-12-22 2002-10-02 イーライ・リリー・アンド・カンパニー 新規ｓＰＬＡ２インヒビター
CA2356162A1 (en) 1998-12-22 2000-06-29 Eli Lilly And Company Substituted tricyclics
US6380397B1 (en) 1999-04-15 2002-04-30 Eli Lilly And Company Process for preparing 4-substituted-1H-indole-3-glyoxamides
US6274578B1 (en) 1999-04-20 2001-08-14 Eli Lilly And Company sPLA2 inhibitor ester
US6140327A (en) * 1999-05-12 2000-10-31 Eli Lilly And Company Morpholino-n-ethyl ester derivative of an indole sPLA2 inhibitor
CA2379208A1 (en) * 1999-07-19 2001-01-25 Eli Lilly & Company Spla2 inhibitors
US6706752B1 (en) 1999-07-19 2004-03-16 Eli Lilly And Company sPLA2 inhibitors
WO2001005789A1 (fr) 1999-07-19 2001-01-25 Shionogi & Co., Ltd. Composes tricycliques a action inhibitrice a l'encontre de spla¿2?
AU6023200A (en) 1999-08-02 2001-02-19 Shionogi & Co., Ltd. Tricyclic compounds having spla2-inhibitory activities
WO2001014378A1 (fr) 1999-08-23 2001-03-01 Shionogi & Co., Ltd. DERIVES DE PYRROLOTRIAZINE A ACTIVITES INHIBANT sPLA¿2?
JP2003509491A (ja) * 1999-09-20 2003-03-11 イーライ・リリー・アンド・カンパニー 新規なｓＰＬＡ２インヒビター
US6831095B1 (en) 1999-09-20 2004-12-14 Eli Lilly And Company Hydroxyfunctional amide 1h-indole derivatives active as sPLA2 inhibitors
WO2001026653A1 (fr) * 1999-10-15 2001-04-19 Shionogi & Co., Ltd. Inhibiteurs spla2 du type v et/ou du type x
US6756376B1 (en) 1999-11-15 2004-06-29 Shionogi & Co., Ltd. Tricyclic azaindolizine derivatives having an sPLA2-inhibitory activities
AU2050001A (en) * 1999-12-16 2001-06-25 Eli Lilly And Company Synthesis of indole-containing spla2 inhibitors
WO2001044185A1 (en) * 1999-12-16 2001-06-21 Eli Lilly And Company Carbon monoxide-based synthesis of spla2 inhibitors
DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
JP2003519198A (ja) * 2000-01-06 2003-06-17 イーライ・リリー・アンド・カンパニー 炎症性疾患および呼吸器疾患の処置のための併用療法
AU4599601A (en) * 2000-01-07 2001-07-16 Eli Lilly And Company Substituted tricyclics
US20030096854A1 (en) * 2002-06-12 2003-05-22 Ho-Shen Lin Substituted tricyclics
AU2001229252A1 (en) * 2000-03-09 2001-09-17 Eli Lilly And Company Method for the treatment of renal dysfunction with spla2 inhibitors
BR0002188A (pt) * 2000-03-30 2001-11-13 Brasil Compressores Sa Processo de formação do pacote de lâminasmetálicas de estator de motor elétrico e pacotede lâminas metálicas
AU2001252922A1 (en) * 2000-04-19 2001-11-07 Eli Lilly And Company Azide cyclization-based synthesis and intermediates for spla2 inhibitors
US6967200B2 (en) 2000-06-29 2005-11-22 Shionogi & Co., Ltd. Remedies for cirrhosis
WO2002000257A1 (fr) * 2000-06-29 2002-01-03 Shionogi & Co., Ltd. Remedes a la maladie d'alzheimer
TW583000B (en) * 2000-06-29 2004-04-11 Shionogi & Co X-type sPLA2 inhibitor as a cancer therapeutical agent
JPWO2002000621A1 (ja) * 2000-06-29 2004-04-22 塩野義製薬株式会社 Ｘ型ｓＰＬＡ２阻害作用を有する化合物
CA2413582A1 (en) * 2000-07-14 2002-01-24 Eli Lilly And Company Use of a spla2 inhibitor for the treatment of sepsis
WO2002012249A2 (en) * 2000-08-04 2002-02-14 Eli Lilly And Company Substituted pyrrole compounds and their use as spla2 inhibitors
EP1358156B1 (en) * 2000-12-18 2007-02-21 Eli Lilly And Company Benz(g) indoles and their use as spla2 inhibitors
TWI314457B (ja) * 2001-03-19 2009-09-11 Shionogi & Co
US6730694B1 (en) 2001-07-20 2004-05-04 Eli Lilly And Company sPLA2 inhibitors
TWI323658B (en) 2001-12-06 2010-04-21 Nat Health Research Institutes Novel compounds of indol-3-yl-2-oxyacetylamide derivatives, pharmaceutical composition thereof, and method for manufacturing the same
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
DE10348022A1 (de) * 2003-10-15 2005-05-25 Imtm Gmbh Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
US20050244367A1 (en) * 2004-05-03 2005-11-03 Ilypsa, Inc. Phospholipase inhibitors localized in the gastrointestinal lumen
AU2006311766A1 (en) * 2005-11-03 2007-05-18 Ilypsa, Inc. Indole compounds having C4-acidic substituents and use thereof as phospholipase-A2 inhibitors
MX2008005666A (es) * 2005-11-03 2009-03-02 Ilypsa Inc Compuestos multivalentes de indol y uso de los mismos como inhibidores de fosfolipasa-a2.
CA2627349A1 (en) * 2005-11-03 2007-05-18 Ilypsa, Inc. Azaindole compounds and use thereof as phospholipase-a2 inhibitors
MX2008005660A (es) * 2005-11-03 2008-12-15 Ilypsa Inc Compuestos de indol que tienen sustituyentes c4-amida y uso de los mismos como inhibidores de la fosfolipasa a2.
US8048880B2 (en) * 2007-05-03 2011-11-01 Anthera Pharmaceuticals, Inc. Treatment of cardiovascular disease and dyslipidemia using secretory phospholipase A2 (SPLA2) inhibitors and SPLA2 inhibitor combination therapies
CA2722102C (en) * 2008-04-28 2013-06-11 Asahi Kasei Pharma Corporation Phenylpropionic acid derivative and use thereof
CA2749534A1 (en) * 2009-01-08 2010-07-15 Anthera Pharmaceuticals, Inc. Secretory phospholipase a2 (spla2) inhibitor and niacin drug compositions and methods for treating cardiovascular disease and dyslipidemia
NZ720946A (en) 2009-04-29 2017-09-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
CN101838232B (zh) * 2009-07-07 2012-02-22 爱斯医药科技(南京)有限公司 Varespladib的制备方法
MA40998A (fr) * 2014-11-21 2017-09-26 Ophirex Inc Thérapies contre une envenimation, ainsi que compositions, systèmes et kits pharmaceutiques associés
CA2996464A1 (en) * 2015-08-31 2017-03-09 Diaccurate Use of indole compounds to stimulate the immune system

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2825734A (en) 1955-04-11 1958-03-04 Upjohn Co Reduction of carbonylic radicals in indolyl-3 compounds
US2825743A (en) 1955-08-30 1958-03-04 Celanese Corp Catalytic hydrogenation of unsaturated aldehydes and ketones
US3242163A (en) * 1961-03-13 1966-03-22 Merck & Co Inc Indolyl aliphatic acids
US3259622A (en) * 1962-09-07 1966-07-05 Merck & Co Inc 1-benzyl-3-indolyl-alpha-haloalkyl and alkylidenyl acetic acids
GB1089071A (en) 1964-02-28 1967-11-01 Merck & Co Inc Indole derivatives
NL287416A (ja) 1964-04-25
US3449363A (en) 1966-12-22 1969-06-10 American Cyanamid Co 3-substituted 4-trifluoromethyl indoles
IT1036004B (it) * 1968-05-21 1979-10-30 Abc Ist Biolog Chem Spa Acidt 3 indolil adetoidrossamici
US3691194A (en) * 1970-07-30 1972-09-12 Little Inc A 3-indole-glyoxamides
US3686213A (en) 1970-08-28 1972-08-22 American Cyanamid Co Substituted aminoethyl indoles
US4012513A (en) * 1971-11-03 1977-03-15 Imperial Chemical Industries Limited Indole derivatives for providing analgesic and anti-inflammatory effects
US4397850A (en) 1981-10-07 1983-08-09 Sandoz, Inc. Isoxazolyl indolamines
US4552876A (en) * 1984-07-09 1985-11-12 Usv Pharmaceutical Corp. Bisbenzoxazines and pharmaceutical use
US4792555A (en) * 1987-03-20 1988-12-20 American Home Products Corporation Phospholipase A2 inhibitors
NZ234883A (en) * 1989-08-22 1995-01-27 Merck Frosst Canada Inc Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof
US5420289A (en) * 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
US5192770A (en) * 1990-12-07 1993-03-09 Syntex (U.S.A.) Inc. Serotonergic alpha-oxoacetamides
US5334719A (en) * 1992-06-17 1994-08-02 Merck Frosst Canada, Inc. Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
PT675110E (pt) 1994-04-01 2002-11-29 Lilly Co Eli 1h-indole-3-glioxilamidas inibidoras da spla2
US5639780A (en) * 1995-05-22 1997-06-17 Merck Frosst Canada, Inc. N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors
HUP9902121A3 (en) 1995-12-14 2001-05-28 Merck & Co Inc Indole derivatives as antagonists of gonadotropin releasing hormone and pharmaceutical compositions containing them
EA000992B1 (ru) * 1995-12-14 2000-08-28 Мерк Энд Ко., Инк. Антагонисты гормона, высвобождающего гонадотропин
AU1279899A (en) * 1997-10-27 1999-05-17 Eli Lilly And Company N,n-diethylglycolamido ester prodrugs of indole spla2 inhibitors

Also Published As

Publication number Publication date
KR950032117A (ko) 1995-12-20
NO951252L (no) 1995-10-02
US5733923A (en) 1998-03-31
UA47387C2 (uk) 2002-07-15
EP1950200A1 (en) 2008-07-30
EP1197484A2 (en) 2002-04-17
BR9501404A (pt) 1996-03-05
PL180523B1 (pl) 2001-02-28
MX9501608A (es) 1997-02-28
ATE220394T1 (de) 2002-07-15
IL113210A0 (en) 1995-06-29
NZ270848A (en) 1997-05-26
FI114793B (fi) 2004-12-31
ZA952693B (en) 1996-09-30
JP3109974B2 (ja) 2000-11-20
EP1081135A2 (en) 2001-03-07
CN1114310A (zh) 1996-01-03
RU95104885A (ru) 1997-04-27
FI951553A (fi) 1995-10-02
NO304186B1 (no) 1998-11-09
JPH07285933A (ja) 1995-10-31
US5654326A (en) 1997-08-05
DE69527322D1 (de) 2002-08-14
IL113210A (en) 2001-01-28
EP1950200B1 (en) 2012-01-11
NO951252D0 (no) 1995-03-31
US5919943A (en) 1999-07-06
US6433001B1 (en) 2002-08-13
TW383302B (en) 2000-03-01
DK1950200T3 (da) 2012-04-10
ES2377223T3 (es) 2012-03-23
HUT72048A (en) 1996-03-28
CA2146097C (en) 2000-03-21
HU9500957D0 (en) 1995-05-29
CA2146097A1 (en) 1995-10-02
KR100368707B1 (ko) 2003-06-02
PE18696A1 (es) 1996-05-30
MY112897A (en) 2001-10-31
DE69527322T2 (de) 2003-02-27
RU2128169C1 (ru) 1999-03-27
AU688458B2 (en) 1998-03-12
US5919810A (en) 1999-07-06
EP0675110A1 (en) 1995-10-04
FI951553A0 (fi) 1995-03-31
PT675110E (pt) 2002-11-29
EP1081135A3 (en) 2003-11-05
ATE540923T1 (de) 2012-01-15
PL307951A1 (en) 1995-10-02
EP0675110B1 (en) 2002-07-10
AU1621795A (en) 1995-10-12
CO4370099A1 (es) 1996-10-07
EP2341045A1 (en) 2011-07-06
CZ82295A3 (en) 1995-12-13
DK0675110T3 (da) 2002-10-07
CN1067054C (zh) 2001-06-13
US6175021B1 (en) 2001-01-16
ES2179088T3 (es) 2003-01-16

Similar Documents

Publication Publication Date Title
HU9500957D0 (en) 1h-indole-3-glyoxylamide spla2 inhibitors
IL130338A0 (en) Pyrroles as sPLA2 inhibitors
HU9401060D0 (en) 1-h-indole-3-acetamide spla2 inhibitors
MX9700511A (es) Inhibidores de spla2 de indolizina.
MX9804751A (es) Naftil acetamidas como inhibidores de la spla2.
EP1100492A4 (en) SPLA 2 INHIBITORS? INDOLE TYPE
IL130201A0 (en) Phenyl glyoxamides as spla2 inhibitors
MX9804750A (es) Naftil glioxamidas como inhibidores de la spla2.
AU5873400A (en) spla2 inhibitors
ATE247119T1 (de) Substituierte pyrroloindole
AU7053700A (en) Novel spla2 inhibitors