ZA947622B - Piperidines and piperazines - Google Patents

Piperidines and piperazines

Info

Publication number
ZA947622B
ZA947622B ZA947622A ZA947622A ZA947622B ZA 947622 B ZA947622 B ZA 947622B ZA 947622 A ZA947622 A ZA 947622A ZA 947622 A ZA947622 A ZA 947622A ZA 947622 B ZA947622 B ZA 947622B
Authority
ZA
South Africa
Prior art keywords
chromen
chroman
hal
cor
unsubstituted
Prior art date
Application number
ZA947622A
Other languages
English (en)
Inventor
Henning Boettcher
Christoph Seyfried
Gerd Bartoszyk
Hartmut Greiner
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA947622B publication Critical patent/ZA947622B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
ZA947622A 1993-09-30 1994-09-29 Piperidines and piperazines ZA947622B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4333254A DE4333254A1 (de) 1993-09-30 1993-09-30 Piperidine und Piperazine

Publications (1)

Publication Number Publication Date
ZA947622B true ZA947622B (en) 1995-05-16

Family

ID=6499013

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA947622A ZA947622B (en) 1993-09-30 1994-09-29 Piperidines and piperazines

Country Status (21)

Country Link
US (1) US5532241A (xx)
EP (1) EP0648767B1 (xx)
JP (2) JP4065034B2 (xx)
KR (1) KR100341190B1 (xx)
CN (1) CN1056610C (xx)
AT (1) ATE153663T1 (xx)
AU (1) AU679774B2 (xx)
CA (1) CA2133152C (xx)
CZ (1) CZ293558B6 (xx)
DE (2) DE4333254A1 (xx)
DK (1) DK0648767T3 (xx)
ES (1) ES2105454T3 (xx)
GR (1) GR3024551T3 (xx)
HU (1) HU218918B (xx)
NO (1) NO306948B1 (xx)
PL (1) PL178137B1 (xx)
RU (1) RU2132848C1 (xx)
SK (1) SK281793B6 (xx)
TW (1) TW313569B (xx)
UA (1) UA34449C2 (xx)
ZA (1) ZA947622B (xx)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4333254A1 (de) * 1993-09-30 1995-04-06 Merck Patent Gmbh Piperidine und Piperazine
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
FR2712591B1 (fr) * 1993-11-19 1996-02-09 Pf Medicament Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique.
GB9501865D0 (en) * 1995-01-31 1995-03-22 Merck Sharp & Dohme Therapeutic agents
DE19514567A1 (de) * 1995-04-20 1996-10-24 Merck Patent Gmbh Benzofurane
US6436940B2 (en) * 1996-12-20 2002-08-20 H. Lundbeck A/S Indane or dihydroindole derivatives
DE19730989A1 (de) * 1997-07-18 1999-01-21 Merck Patent Gmbh Piperazin-Derivate
CA2297825C (en) * 1997-07-25 2006-03-14 H. Lundbeck A/S Indole and 2,3-dihydroindole derivatives, their preparation and use
US6004982A (en) * 1997-09-15 1999-12-21 Hoechst Marion Roussel, Inc. 4-piperidinyl) H-2-benzopyran derivatives useful as antipsychotic agents
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6303627B1 (en) * 1998-06-19 2001-10-16 Eli Lilly And Company Inhibitors of serotonin reuptake
DE19858340A1 (de) * 1998-12-17 2000-06-21 Merck Patent Gmbh Verfahren zur Herstellung von 3-Alkanoyl- und 3-Alkylindolen
IL146309A (en) * 1999-05-21 2008-03-20 Scios Inc Derivatives of the indole type and pharmaceutical preparations containing them as inhibitors of kinase p38
US20120077825A1 (en) * 1999-05-27 2012-03-29 Merck Patentgesellschaft Novel use of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and its physiologically acceptable salts
TW518218B (en) * 1999-05-27 2003-01-21 Merck Patent Gmbh Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders
DE19932314A1 (de) 1999-07-10 2001-01-11 Merck Patent Gmbh Benzofuranderivate
RU2246494C2 (ru) * 1999-08-23 2005-02-20 Солвей Фармасьютикалс Б.В. Новые фенилпиперазины
KR20030059244A (ko) * 2000-11-14 2003-07-07 메르크 파텐트 게엠베하 조합된 5-ht1a 작용제 및 세로토닌 재흡수 저해제의신규한 용도
UA76130C2 (en) * 2000-11-20 2006-07-17 Merck Patent Gmbh Use of compounds combining properties of selective inhibitors of serotonin re-uptake and agonists of 5-ht1a receptor for treatment of irritable bowel syndrome
GB2370270A (en) * 2000-12-20 2002-06-26 Lilly Co Eli Pharmaceutical compounds
AR032712A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
DE10112151A1 (de) 2001-03-14 2002-09-19 Merck Patent Gmbh Substituierte Benzofuran-2-carbonsäureamide
US6656950B2 (en) * 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
UA76758C2 (uk) * 2001-06-19 2006-09-15 Мерк Патент Гмбх Поліморфні форми гідрохлориду 1-'4-(5-ціаноіндол-3-іл)бутил-4-(2-карбамоїлбензофуран-5-іл)піперазину
DE10217006A1 (de) * 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
DE10259244A1 (de) * 2002-12-17 2004-07-01 Merck Patent Gmbh N-(Indolethyl-)cycloamin-Verbindungen
JP4897221B2 (ja) * 2002-12-20 2012-03-14 チバ ホールディング インコーポレーテッド アミン類の合成及びその合成のための中間体
DE10305739A1 (de) * 2003-02-11 2004-08-19 Merck Patent Gmbh Benzofuranderivate
DE10306941A1 (de) * 2003-02-18 2004-08-26 Merck Patent Gmbh Benzofuranoxyethylamine
DE10315285A1 (de) * 2003-04-04 2004-10-14 Merck Patent Gmbh Chromenonindole
DE10326940A1 (de) * 2003-06-16 2005-01-05 Merck Patent Gmbh Indol-Derivate
DE10326939A1 (de) * 2003-06-16 2005-01-05 Merck Patent Gmbh Indol-Derivate
DE102004063797A1 (de) * 2004-12-30 2006-07-13 Schwarz Pharma Ag Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide
DE102005019670A1 (de) * 2005-04-26 2006-11-02 Merck Patent Gmbh Verfahren zur Herstellung von (5-(4-[4-(5-Cyano-3-indolyl)-butyl)-1-piperazinyl)-benzofuran-2-carboxamid
EP2110374A1 (en) * 2008-04-18 2009-10-21 Merck Sante Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators
TWI477497B (zh) 2009-03-10 2015-03-21 Takeda Pharmaceutical 苯并呋喃衍生物
US8877778B2 (en) * 2010-12-15 2014-11-04 Hoffmann-La Roche Inc. Benzofurane compounds
EP2688884A1 (en) 2011-03-20 2014-01-29 Cadila Healthcare Limited Amorphous form of vilazodone hydrochloride and process for its preparation
CN102219783B (zh) * 2011-05-05 2013-07-03 天津市汉康医药生物技术有限公司 盐酸维拉佐酮及其组合物
CN102267985B (zh) * 2011-06-15 2015-12-09 上海医药工业研究院 维拉佐酮或其盐酸盐的制备方法
CN102267932A (zh) * 2011-06-15 2011-12-07 上海医药工业研究院 4-(5-氰基-1h-吲哚-3-基)丁基取代磺酸酯类化合物及其应用
CN102949364A (zh) * 2011-08-30 2013-03-06 天津药物研究院 一种含有效成分盐酸维拉佐酮的缓释片
US9505744B2 (en) 2011-11-23 2016-11-29 Assia Chemical Industries Ltd. Solid state forms of vilazodone and vilazodone hydrochloride
WO2013088373A1 (en) 2011-12-12 2013-06-20 Ranbaxy Laboratories Limited Amorphous vilazodone hydrochloride, a process for its preparation and pharmaceutical compositions thereof
ITMI20120531A1 (it) 2012-04-02 2013-10-03 Erregierre Spa Procedimento per la preparazione di vilazodone cloridrato
WO2013153492A2 (en) * 2012-04-12 2013-10-17 Alembic Pharmaceuticals Limited Process for the preparation of vilazodone hydrochloride and its amorphous form
WO2013156935A1 (en) 2012-04-16 2013-10-24 Ranbaxy Laboratories Limited Process for the preparation of crystalline vilazodone hydrochloride
WO2013164794A1 (en) 2012-05-04 2013-11-07 Ranbaxy Laboratories Limited Crystalline forms of vilazodone hydrochloride
CN102659660B (zh) * 2012-05-11 2014-07-02 杭州和泽医药科技有限公司 3-(4-氯丁基)-1h-吲哚-5-氰基的制备方法及其应用
WO2013175361A1 (en) 2012-05-24 2013-11-28 Ranbaxy Laboratories Limited Process for the preparation of vilazodone hydrochloride
US8835635B2 (en) 2012-06-05 2014-09-16 Symed Labs Limited Amorphous form of vilazodone hydrochloride substantially free of crystalline forms
WO2013182946A2 (en) * 2012-06-06 2013-12-12 Ranbaxy Laboratories Limited Process for the preparation of vilazodone hydrochloride
EP2861586A4 (en) 2012-06-13 2015-11-11 Apotex Inc FORMS OF VILAZODONE AND METHODS OF PREPARATION THEREOF
US8815870B2 (en) * 2012-06-29 2014-08-26 Forest Laboratories Holdings Ltd. 4-(2-(6-substituted-hexylidene) hydrazinyl)benzonitrile and preparation thereof
US9399630B2 (en) 2012-07-02 2016-07-26 Symed Labs Limited Process for preparing benzofuran-2-carboxamide derivatives
CN102796037B (zh) * 2012-08-09 2013-11-06 成都苑东药业有限公司 一种3-(4-(4-取代哌嗪)-1-丁酰基)吲哚-5-甲腈及其用途
WO2014028473A1 (en) 2012-08-13 2014-02-20 Assia Chemical Industries Ltd. New salts of vilazodone and solid state forms thereof
CA2884676A1 (en) 2012-09-12 2014-03-20 Apotex Pharmachem Inc. Processes for the preparation of 3-alkyl indoles
WO2014049609A2 (en) 2012-09-26 2014-04-03 Cadila Healthcare Limited Novel salts of vilazodone
WO2014061000A1 (en) 2012-10-19 2014-04-24 Ranbaxy Laboratories Limited Process for the preparation of vilazodone or pharmaceutically acceptable salt thereof
WO2014061004A2 (en) 2012-10-19 2014-04-24 Ranbaxy Laboratories Limited Process for the preparation of vilazodone or pharmaceutically acceptable salt thereof
WO2014064715A2 (en) 2012-10-22 2014-05-01 Cadila Healthcare Limited Amorphous form of vilazodone hydrochloride and process for preparing thereof
CN102977083A (zh) * 2012-12-17 2013-03-20 南京海纳医药科技有限公司 1-[4-(5-氰基吲哚-3-基)丁基]-4-(2-氨甲酰-苯并呋喃-5-基)-哌嗪盐酸盐的新晶型xⅶ及其制备方法
CN102993186B (zh) * 2012-12-20 2015-11-18 北京海步国际医药科技发展有限公司 一种新型的哌嗪衍生物
ITMI20130392A1 (it) 2013-03-15 2014-09-16 Dipharma Francis Srl Sintesi di un inibitore della ricaptazione della serotonina
CN104098552A (zh) * 2013-04-02 2014-10-15 上海医药工业研究院 维拉佐酮的制备方法
WO2014178013A1 (en) 2013-04-30 2014-11-06 Ranbaxy Laboratories Limited Vilazodone impurities, process for their preparation, and their use as reference standards
IN2013MU02001A (xx) 2013-06-12 2015-05-29 Lupin Ltd
EP2824104A1 (en) 2013-07-12 2015-01-14 Sandoz AG Process for the preparation of form III of Vilazodone hydrochloride
CN103360373B (zh) * 2013-07-12 2016-06-15 苏州永健生物医药有限公司 维拉唑酮中间体及其盐的合成方法
US9598401B2 (en) 2013-07-29 2017-03-21 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
WO2015019237A1 (en) 2013-08-06 2015-02-12 Ranbaxy Laboratories Limited Pharmaceutical composition of vilazodone
WO2015019256A1 (en) 2013-08-06 2015-02-12 Ranbaxy Laboratories Limited Pharmaceutical composition of vilazodone and processes of preparation thereof
WO2015090235A1 (en) 2013-12-20 2015-06-25 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use thereof
CN103709089B (zh) * 2013-12-31 2015-08-19 南通恒盛精细化工有限公司 一种制备3-(4’-氯丁基)-5-氰基吲哚的方法
WO2016128987A1 (en) * 2015-02-13 2016-08-18 Harman Finochem Limited A process for preparation of 2-benzofurancarboxamide, 5-[4-[4-(5cyano-1h-indol-3-yl)butyl]-1-piperazinyl] free base and its hydrochloride salt
WO2016142952A1 (en) * 2015-03-10 2016-09-15 Nosch Labs Private Limited Process for preparation of vilazodone and its novel intermediates
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
CN109922807A (zh) 2016-11-02 2019-06-21 广东东阳光药业有限公司 维拉佐酮包合物及其组合物和制备方法
TR201702103A2 (tr) 2017-02-13 2018-08-27 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Vilazodon hi̇droklorürün tablet formlari
TR201702104A2 (tr) 2017-02-13 2018-08-27 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Vi̇lazodon hi̇droklorür farmasöti̇k bi̇leşi̇mleri̇
WO2019062662A1 (en) 2017-09-29 2019-04-04 Sunshine Lake Pharma Co., Ltd. SUBSTITUTED PYRIMIDINE PIPERAZINE COMPOUND AND USE THEREOF
CN111454250B (zh) * 2019-01-21 2021-05-07 华东理工大学 多靶点活性化合物及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1075156A (en) * 1963-08-27 1967-07-12 Luso Farmaco Inst Substituted piperazines
US3468882A (en) * 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
JPH0465034A (ja) * 1990-07-02 1992-03-02 Mitsubishi Electric Corp 酸化物超電導線材の製造方法
FR2670491B1 (fr) 1990-12-14 1993-02-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
DE4127849A1 (de) 1991-08-22 1993-02-25 Merck Patent Gmbh Benzodioxanderivate
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
DE4333254A1 (de) * 1993-09-30 1995-04-06 Merck Patent Gmbh Piperidine und Piperazine

Also Published As

Publication number Publication date
HUT71833A (en) 1996-02-28
JP4065034B2 (ja) 2008-03-19
HU218918B (hu) 2000-12-28
RU2132848C1 (ru) 1999-07-10
DE4333254A1 (de) 1995-04-06
JP4700017B2 (ja) 2011-06-15
KR100341190B1 (ko) 2002-11-13
TW313569B (xx) 1997-08-21
KR950008510A (ko) 1995-04-17
CA2133152C (en) 2005-08-30
NO306948B1 (no) 2000-01-17
CZ237094A3 (en) 1995-04-12
SK118494A3 (en) 1995-05-10
AU679774B2 (en) 1997-07-10
ATE153663T1 (de) 1997-06-15
EP0648767B1 (de) 1997-05-28
RU94035660A (ru) 1996-07-20
US5532241A (en) 1996-07-02
CZ293558B6 (cs) 2004-06-16
CN1056610C (zh) 2000-09-20
PL305216A1 (en) 1995-04-03
DK0648767T3 (da) 1997-12-22
UA34449C2 (uk) 2001-03-15
AU7424494A (en) 1995-04-13
JP2007119502A (ja) 2007-05-17
DE59402902D1 (de) 1997-07-03
NO943616D0 (no) 1994-09-29
SK281793B6 (sk) 2001-08-06
JPH07149762A (ja) 1995-06-13
HU9402806D0 (en) 1995-01-30
ES2105454T3 (es) 1997-10-16
GR3024551T3 (en) 1997-12-31
PL178137B1 (pl) 2000-03-31
CN1106811A (zh) 1995-08-16
EP0648767A1 (de) 1995-04-19
CA2133152A1 (en) 1995-03-31
NO943616L (no) 1995-03-31

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