CN102659660B - 3-(4-氯丁基)-1h-吲哚-5-氰基的制备方法及其应用 - Google Patents
3-(4-氯丁基)-1h-吲哚-5-氰基的制备方法及其应用 Download PDFInfo
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CN102659660B true CN102659660B (zh) | 2014-07-02 |
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Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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US9533949B2 (en) | 2012-09-12 | 2017-01-03 | Apotex Pharmachem Inc. | Processes for the preparation of 3-alkyl indoles |
CN102964287B (zh) * | 2012-11-13 | 2014-04-09 | 苏州永健生物医药有限公司 | 一种3-(4-氯丁基)-5-氰基吲哚的合成方法 |
CN103058912A (zh) * | 2012-12-28 | 2013-04-24 | 山东邹平大展新材料有限公司 | 一种3-(4-氯丁基)吲哚-5-甲腈的制备方法 |
CN103304466A (zh) * | 2013-05-18 | 2013-09-18 | 嘉兴中科化学有限公司 | 一种3-烷基取代吲哚类化合物的合成方法 |
CN104230903A (zh) * | 2013-06-15 | 2014-12-24 | 广东东阳光药业有限公司 | 抗抑郁症药物维拉唑酮的制备方法 |
CN103467357B (zh) * | 2013-09-13 | 2016-02-10 | 陕西步长高新制药有限公司 | 一种制备维拉唑酮中间体3-(4-氯丁基)-1h-吲哚-5-氰基的方法 |
CN104592087B (zh) * | 2013-11-01 | 2016-06-15 | 北京英科博雅科技有限公司 | 一种盐酸维拉佐酮中间体3-(4-氯丁基)-1h-5-氰基吲哚的制备方法 |
CN107501159B (zh) * | 2017-08-14 | 2020-11-24 | 连云港恒运药业有限公司 | 维拉佐酮中间体3-(4-氯丁基)-5-氰基吲哚合成方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1106811A (zh) * | 1993-09-30 | 1995-08-16 | 默克专利股份有限公司 | 哌啶和哌嗪衍生物 |
CN1330635A (zh) * | 1998-12-17 | 2002-01-09 | 默克专利股份公司 | 3-链烷酰基-和3-烷基吲哚的制备方法 |
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- 2012-05-11 CN CN201210144271.5A patent/CN102659660B/zh active Active
Patent Citations (2)
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CN1106811A (zh) * | 1993-09-30 | 1995-08-16 | 默克专利股份有限公司 | 哌啶和哌嗪衍生物 |
CN1330635A (zh) * | 1998-12-17 | 2002-01-09 | 默克专利股份公司 | 3-链烷酰基-和3-烷基吲哚的制备方法 |
Non-Patent Citations (2)
Title |
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Synthesis and Structure-Activity Relationship in a Class of Indolebutylpiperazines as Dual 5-HT1A Receptor Agonists and Serotonin Reuptake Inhibitors;Timo Heinrich et al;《Journal of Medicinal Chemistry》;20040810;第47卷(第19期);4684-4692 * |
Timo Heinrich et al.Synthesis and Structure-Activity Relationship in a Class of Indolebutylpiperazines as Dual 5-HT1A Receptor Agonists and Serotonin Reuptake Inhibitors.《Journal of Medicinal Chemistry》.2004,第47卷(第19期),4684-4692. |
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Address after: Room 4, building 101, No. 1, No. 310018, Hangzhou economic and Technological Development Zone, Zhejiang, China Patentee after: Hangzhou HEZE Pharmaceutical Technology Co., Ltd. Address before: Hangzhou City, Zhejiang province 310018 Hangzhou economic and Technological Development Zone No. 6 No. 452 Street (Hangzhou City high-tech business incubator incubator building, No. 1, room 3A13, 1B08) Patentee before: Hangzhou HEZE Pharmaceutical Technology Co., Ltd. |
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Address after: 201, room 4, building 101, No. 1, 310018 Avenue, Hangzhou economic and Technological Development Zone, Zhejiang, China Patentee after: Zhejiang Heze Pharmaceutical Technology Co., Ltd Address before: 201, room 4, building 101, No. 1, 310018 Avenue, Hangzhou economic and Technological Development Zone, Zhejiang, China Patentee before: HANGZHOU HEZE PHARMACEUTICAL TECHNOLOGY Co.,Ltd. |
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