ES2066721A1 - Nuevos compuestos derivados de la piridina 1,4-disustituida. - Google Patents
Nuevos compuestos derivados de la piridina 1,4-disustituida.Info
- Publication number
- ES2066721A1 ES2066721A1 ES09301062A ES9301062A ES2066721A1 ES 2066721 A1 ES2066721 A1 ES 2066721A1 ES 09301062 A ES09301062 A ES 09301062A ES 9301062 A ES9301062 A ES 9301062A ES 2066721 A1 ES2066721 A1 ES 2066721A1
- Authority
- ES
- Spain
- Prior art keywords
- fluorophenylmethyl
- piperidines
- sigma
- receptor affinity
- methoxymethylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NUEVOS COMPUESTOS DERIVADOS DE LA PIPERIDINA 1,4-DISUSTITUIDA. CONSISTE EN LOS NUEVOS COMPUESTOS DERIVADOS DE LA PIPERIDINA 1,4-DISUSTITUIDA, DE FORMULA GENERAL (I): *FIG* DONDE X ES HIDROXIMETILEN O METOXIMETILEN, Y ES UNA SECUENCIA METILENICA DE TRES MIEMBROS Y R ES UN RESTO P-FLUOROFENIL, ASI COMO SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES. ESTOS COMPUESTOS SON DE USO POTENCIAL PARA TRATAR ENFERMEDADES DEL SISTEMA NERVIOSO SOMETIDAS A CONTROL DE LOS RECEPTORES {SI.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09301062A ES2066721B1 (es) | 1993-05-18 | 1993-05-18 | Nuevos compuestos derivados de la piridina 1,4-disustituida. |
TW083103579A TW252975B (es) | 1993-05-18 | 1994-04-22 | |
ZA943036A ZA943036B (en) | 1993-05-18 | 1994-05-03 | 1,4-disubstituted piperidine derivative compounds |
PCT/EP1994/001594 WO1994026712A1 (en) | 1993-05-18 | 1994-05-17 | 4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity |
KR1019950700196A KR950702535A (ko) | 1993-05-18 | 1994-05-17 | 시그마 및 d₂-수용체 친화성을 가진 4-(4-플루오로페닐메틸)-피페리딘(4-(4-fluorophenylmethyl)-piperidines having sigma and d2-peceptor affinity) |
AU69284/94A AU675332B2 (en) | 1993-05-18 | 1994-05-17 | 4-(4-fluorophenylmethyl)-piperidines having sigma and D2-receptor affinity |
EP94917641A EP0651744A1 (en) | 1993-05-18 | 1994-05-17 | 4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity |
CA002140260A CA2140260A1 (en) | 1993-05-18 | 1994-05-17 | 4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity |
NZ267100A NZ267100A (en) | 1993-05-18 | 1994-05-17 | 4-[4-fluorophenyl({hydroxy or methoxy} methyl)]-1-(4-fluorophenyloxypropyl) piperidine, and pharmaceutical compositions |
JP6524990A JPH07509255A (ja) | 1993-05-18 | 1994-05-17 | シグマレセプター及びd↓2レセプター親和性を有する4−(4−フルオロフェニルメチル)−ピペリジン |
NO950062A NO301638B1 (no) | 1993-05-18 | 1995-01-06 | 4-(4-fluorfenylmetyl)-piperidiner med sigma- og D2-reseptoraffinitet og deres anvendelse |
FI950197A FI950197A0 (fi) | 1993-05-18 | 1995-01-17 | 4-(4-fluorofenyylimetyyli)-piperidiini, jolla on sigma ja D2-reseptori affiniteetti |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09301062A ES2066721B1 (es) | 1993-05-18 | 1993-05-18 | Nuevos compuestos derivados de la piridina 1,4-disustituida. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2066721A1 true ES2066721A1 (es) | 1995-03-01 |
ES2066721B1 ES2066721B1 (es) | 1996-02-16 |
Family
ID=8281846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09301062A Expired - Fee Related ES2066721B1 (es) | 1993-05-18 | 1993-05-18 | Nuevos compuestos derivados de la piridina 1,4-disustituida. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0651744A1 (es) |
JP (1) | JPH07509255A (es) |
KR (1) | KR950702535A (es) |
AU (1) | AU675332B2 (es) |
CA (1) | CA2140260A1 (es) |
ES (1) | ES2066721B1 (es) |
FI (1) | FI950197A0 (es) |
NO (1) | NO301638B1 (es) |
NZ (1) | NZ267100A (es) |
TW (1) | TW252975B (es) |
WO (1) | WO1994026712A1 (es) |
ZA (1) | ZA943036B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HN1999000149A (es) | 1998-09-09 | 2000-01-12 | Pfizer Prod Inc | Derivados de 4,4-biarilpiperidina |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2237633A1 (es) * | 1973-07-19 | 1975-02-14 | Robins Co Inc A H | |
US3956296A (en) * | 1974-12-11 | 1976-05-11 | A. H. Robins Company, Incorporated | 1-Substituted-4-benzylpiperidines |
EP0229391A1 (en) * | 1985-12-27 | 1987-07-22 | Eisai Co., Ltd. | Piperidine derivate, its use and pharmaceutical composition containing it |
FR2681319A1 (fr) * | 1991-09-12 | 1993-03-19 | Synthelabo | Derives de 1-(phenoxyalkyl)piperidine, leur preparation et leur application en therapeutique. |
EP0572952A1 (en) * | 1992-06-04 | 1993-12-08 | Ferrer Internacional, S.A. | 4-Benzylpiperidine derivatives, a process for preparing them and pharmaceutical compositions containing them |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3576810A (en) * | 1968-06-20 | 1971-04-27 | Robins Co Inc A H | 1-substituted-3-(-4)-aroylpiperidines |
-
1993
- 1993-05-18 ES ES09301062A patent/ES2066721B1/es not_active Expired - Fee Related
-
1994
- 1994-04-22 TW TW083103579A patent/TW252975B/zh active
- 1994-05-03 ZA ZA943036A patent/ZA943036B/xx unknown
- 1994-05-17 AU AU69284/94A patent/AU675332B2/en not_active Ceased
- 1994-05-17 EP EP94917641A patent/EP0651744A1/en not_active Withdrawn
- 1994-05-17 NZ NZ267100A patent/NZ267100A/en unknown
- 1994-05-17 CA CA002140260A patent/CA2140260A1/en not_active Abandoned
- 1994-05-17 JP JP6524990A patent/JPH07509255A/ja active Pending
- 1994-05-17 WO PCT/EP1994/001594 patent/WO1994026712A1/en not_active Application Discontinuation
- 1994-05-17 KR KR1019950700196A patent/KR950702535A/ko not_active Application Discontinuation
-
1995
- 1995-01-06 NO NO950062A patent/NO301638B1/no unknown
- 1995-01-17 FI FI950197A patent/FI950197A0/fi not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2237633A1 (es) * | 1973-07-19 | 1975-02-14 | Robins Co Inc A H | |
US3956296A (en) * | 1974-12-11 | 1976-05-11 | A. H. Robins Company, Incorporated | 1-Substituted-4-benzylpiperidines |
EP0229391A1 (en) * | 1985-12-27 | 1987-07-22 | Eisai Co., Ltd. | Piperidine derivate, its use and pharmaceutical composition containing it |
FR2681319A1 (fr) * | 1991-09-12 | 1993-03-19 | Synthelabo | Derives de 1-(phenoxyalkyl)piperidine, leur preparation et leur application en therapeutique. |
EP0572952A1 (en) * | 1992-06-04 | 1993-12-08 | Ferrer Internacional, S.A. | 4-Benzylpiperidine derivatives, a process for preparing them and pharmaceutical compositions containing them |
Also Published As
Publication number | Publication date |
---|---|
WO1994026712A1 (en) | 1994-11-24 |
NZ267100A (en) | 1996-09-25 |
AU675332B2 (en) | 1997-01-30 |
FI950197A (fi) | 1995-01-17 |
ES2066721B1 (es) | 1996-02-16 |
TW252975B (es) | 1995-08-01 |
AU6928494A (en) | 1994-12-12 |
CA2140260A1 (en) | 1994-11-24 |
FI950197A0 (fi) | 1995-01-17 |
NO950062L (no) | 1995-01-06 |
KR950702535A (ko) | 1995-07-29 |
EP0651744A1 (en) | 1995-05-10 |
ZA943036B (en) | 1995-05-02 |
NO301638B1 (no) | 1997-11-24 |
NO950062D0 (no) | 1995-01-06 |
JPH07509255A (ja) | 1995-10-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000201 |