WO1994026712A1 - 4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity - Google Patents
4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity Download PDFInfo
- Publication number
- WO1994026712A1 WO1994026712A1 PCT/EP1994/001594 EP9401594W WO9426712A1 WO 1994026712 A1 WO1994026712 A1 WO 1994026712A1 EP 9401594 W EP9401594 W EP 9401594W WO 9426712 A1 WO9426712 A1 WO 9426712A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- formula
- compounds
- fluorophenyl
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Definitions
- No. 4929734 describes the preparation of N-substituted 1- (1,2,3,6-tetrahydro-3-piridinyl)oximes and N-substituted 1-(1,2,3,6-tetrahydro-4-piridinyl)oximes and their use in treating depression, psychosis and/or inflammatory diseases.
- US Patent No. 5061728 describes the use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in treating psychosis and inflammation and their use as immunosupressants.
- Irwin test It consists in a package of tests intended to find out the properties of a compound as well as the magnitude of such properties which are completely unknown.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU69284/94A AU675332B2 (en) | 1993-05-18 | 1994-05-17 | 4-(4-fluorophenylmethyl)-piperidines having sigma and D2-receptor affinity |
JP6524990A JPH07509255A (en) | 1993-05-18 | 1994-05-17 | 4-(4-fluorophenylmethyl)-piperidine with sigma receptor and D↓2 receptor affinity |
KR1019950700196A KR950702535A (en) | 1993-05-18 | 1994-05-17 | 4- (4-FLUOROPHENYLMETHYL) -PIPERIDINES HAVING SIGMA AND D2-PECEPTOR AFFINITY |
EP94917641A EP0651744A1 (en) | 1993-05-18 | 1994-05-17 | 4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity |
NO950062A NO301638B1 (en) | 1993-05-18 | 1995-01-06 | 4- (4-fluorophenylmethyl) piperidines with sigma and D2 receptor affinity and their use |
FI950197A FI950197A (en) | 1993-05-18 | 1995-01-17 | 4- (4-fluorophenylmethyl) -piperidine with sigma and D2 receptor affinity |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ESP9301062 | 1993-05-18 | ||
ES09301062A ES2066721B1 (en) | 1993-05-18 | 1993-05-18 | NEW COMPOUNDS DERIVED FROM PIRIDINE 1,4-DISSTITUTED. |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994026712A1 true WO1994026712A1 (en) | 1994-11-24 |
Family
ID=8281846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1994/001594 WO1994026712A1 (en) | 1993-05-18 | 1994-05-17 | 4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0651744A1 (en) |
JP (1) | JPH07509255A (en) |
KR (1) | KR950702535A (en) |
AU (1) | AU675332B2 (en) |
CA (1) | CA2140260A1 (en) |
ES (1) | ES2066721B1 (en) |
FI (1) | FI950197A (en) |
NO (1) | NO301638B1 (en) |
NZ (1) | NZ267100A (en) |
TW (1) | TW252975B (en) |
WO (1) | WO1994026712A1 (en) |
ZA (1) | ZA943036B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000014066A1 (en) * | 1998-09-09 | 2000-03-16 | Pfizer Products Inc. | 4,4-biarylpiperidine derivatives with opioid receptor activity |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3576810A (en) * | 1968-06-20 | 1971-04-27 | Robins Co Inc A H | 1-substituted-3-(-4)-aroylpiperidines |
EP0229391A1 (en) * | 1985-12-27 | 1987-07-22 | Eisai Co., Ltd. | Piperidine derivate, its use and pharmaceutical composition containing it |
FR2681319A1 (en) * | 1991-09-12 | 1993-03-19 | Synthelabo | 1-(Phenoxyalkyl)piperidine derivatives, their preparation and their application in therapeutics |
EP0572952A1 (en) * | 1992-06-04 | 1993-12-08 | Ferrer Internacional, S.A. | 4-Benzylpiperidine derivatives, a process for preparing them and pharmaceutical compositions containing them |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7409245L (en) * | 1973-07-19 | 1975-01-20 | Robins Co Inc A H | |
US3956296A (en) * | 1974-12-11 | 1976-05-11 | A. H. Robins Company, Incorporated | 1-Substituted-4-benzylpiperidines |
-
1993
- 1993-05-18 ES ES09301062A patent/ES2066721B1/en not_active Expired - Fee Related
-
1994
- 1994-04-22 TW TW083103579A patent/TW252975B/zh active
- 1994-05-03 ZA ZA943036A patent/ZA943036B/en unknown
- 1994-05-17 KR KR1019950700196A patent/KR950702535A/en not_active Application Discontinuation
- 1994-05-17 WO PCT/EP1994/001594 patent/WO1994026712A1/en not_active Application Discontinuation
- 1994-05-17 NZ NZ267100A patent/NZ267100A/en unknown
- 1994-05-17 EP EP94917641A patent/EP0651744A1/en not_active Withdrawn
- 1994-05-17 JP JP6524990A patent/JPH07509255A/en active Pending
- 1994-05-17 CA CA002140260A patent/CA2140260A1/en not_active Abandoned
- 1994-05-17 AU AU69284/94A patent/AU675332B2/en not_active Ceased
-
1995
- 1995-01-06 NO NO950062A patent/NO301638B1/en unknown
- 1995-01-17 FI FI950197A patent/FI950197A/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3576810A (en) * | 1968-06-20 | 1971-04-27 | Robins Co Inc A H | 1-substituted-3-(-4)-aroylpiperidines |
EP0229391A1 (en) * | 1985-12-27 | 1987-07-22 | Eisai Co., Ltd. | Piperidine derivate, its use and pharmaceutical composition containing it |
FR2681319A1 (en) * | 1991-09-12 | 1993-03-19 | Synthelabo | 1-(Phenoxyalkyl)piperidine derivatives, their preparation and their application in therapeutics |
EP0572952A1 (en) * | 1992-06-04 | 1993-12-08 | Ferrer Internacional, S.A. | 4-Benzylpiperidine derivatives, a process for preparing them and pharmaceutical compositions containing them |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000014066A1 (en) * | 1998-09-09 | 2000-03-16 | Pfizer Products Inc. | 4,4-biarylpiperidine derivatives with opioid receptor activity |
US6720336B2 (en) | 1998-09-09 | 2004-04-13 | Pfizer, Inc. | 4,4-biarylpiperidine derivatives |
Also Published As
Publication number | Publication date |
---|---|
AU675332B2 (en) | 1997-01-30 |
AU6928494A (en) | 1994-12-12 |
NZ267100A (en) | 1996-09-25 |
TW252975B (en) | 1995-08-01 |
EP0651744A1 (en) | 1995-05-10 |
ZA943036B (en) | 1995-05-02 |
NO950062D0 (en) | 1995-01-06 |
ES2066721B1 (en) | 1996-02-16 |
FI950197A0 (en) | 1995-01-17 |
ES2066721A1 (en) | 1995-03-01 |
FI950197A (en) | 1995-01-17 |
NO301638B1 (en) | 1997-11-24 |
CA2140260A1 (en) | 1994-11-24 |
KR950702535A (en) | 1995-07-29 |
NO950062L (en) | 1995-01-06 |
JPH07509255A (en) | 1995-10-12 |
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