NO301638B1 - 4- (4-fluorophenylmethyl) piperidines with sigma and D2 receptor affinity and their use - Google Patents

4- (4-fluorophenylmethyl) piperidines with sigma and D2 receptor affinity and their use

Info

Publication number
NO301638B1
NO301638B1 NO950062A NO950062A NO301638B1 NO 301638 B1 NO301638 B1 NO 301638B1 NO 950062 A NO950062 A NO 950062A NO 950062 A NO950062 A NO 950062A NO 301638 B1 NO301638 B1 NO 301638B1
Authority
NO
Norway
Prior art keywords
fluorophenylmethyl
piperidines
sigma
receptor affinity
affinity
Prior art date
Application number
NO950062A
Other languages
Norwegian (no)
Other versions
NO950062L (en
NO950062D0 (en
Inventor
Rafael Foguet
Jordi Bolos
Aurelio Sacristan
Jose Ortiz
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of NO950062L publication Critical patent/NO950062L/en
Publication of NO950062D0 publication Critical patent/NO950062D0/en
Publication of NO301638B1 publication Critical patent/NO301638B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO950062A 1993-05-18 1995-01-06 4- (4-fluorophenylmethyl) piperidines with sigma and D2 receptor affinity and their use NO301638B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES09301062A ES2066721B1 (en) 1993-05-18 1993-05-18 NEW COMPOUNDS DERIVED FROM PIRIDINE 1,4-DISSTITUTED.
PCT/EP1994/001594 WO1994026712A1 (en) 1993-05-18 1994-05-17 4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity

Publications (3)

Publication Number Publication Date
NO950062L NO950062L (en) 1995-01-06
NO950062D0 NO950062D0 (en) 1995-01-06
NO301638B1 true NO301638B1 (en) 1997-11-24

Family

ID=8281846

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950062A NO301638B1 (en) 1993-05-18 1995-01-06 4- (4-fluorophenylmethyl) piperidines with sigma and D2 receptor affinity and their use

Country Status (12)

Country Link
EP (1) EP0651744A1 (en)
JP (1) JPH07509255A (en)
KR (1) KR950702535A (en)
AU (1) AU675332B2 (en)
CA (1) CA2140260A1 (en)
ES (1) ES2066721B1 (en)
FI (1) FI950197A0 (en)
NO (1) NO301638B1 (en)
NZ (1) NZ267100A (en)
TW (1) TW252975B (en)
WO (1) WO1994026712A1 (en)
ZA (1) ZA943036B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1999000149A (en) 1998-09-09 2000-01-12 Pfizer Prod Inc DERIVATIVES OF 4,4-BIARILPIPERIDINA

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3576810A (en) * 1968-06-20 1971-04-27 Robins Co Inc A H 1-substituted-3-(-4)-aroylpiperidines
SE7409245L (en) * 1973-07-19 1975-01-20 Robins Co Inc A H
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
DK623586A (en) * 1985-12-27 1987-06-28 Eisai Co Ltd PIPERIDE INGREDIENTS OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS
FR2681319B1 (en) * 1991-09-12 1995-02-17 Synthelabo 1- (PHENOXYALKYL) PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.
ES2060547B1 (en) * 1992-06-04 1995-06-16 Ferrer Int IMPROVEMENTS IN THE PURPOSE OF THE INVENTION PATENT N / 9201158 THAT REFERS TO "PROCEDURE FOR OBTAINING NEW DERIVATIVES OF 4-BENCILPIPERIDINE".

Also Published As

Publication number Publication date
JPH07509255A (en) 1995-10-12
ES2066721B1 (en) 1996-02-16
ZA943036B (en) 1995-05-02
FI950197A (en) 1995-01-17
AU6928494A (en) 1994-12-12
CA2140260A1 (en) 1994-11-24
AU675332B2 (en) 1997-01-30
NO950062L (en) 1995-01-06
KR950702535A (en) 1995-07-29
WO1994026712A1 (en) 1994-11-24
EP0651744A1 (en) 1995-05-10
ES2066721A1 (en) 1995-03-01
FI950197A0 (en) 1995-01-17
TW252975B (en) 1995-08-01
NZ267100A (en) 1996-09-25
NO950062D0 (en) 1995-01-06

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