ZA898858B - New quinuclidines,their use as medicaments and processes for their preparation - Google Patents

New quinuclidines,their use as medicaments and processes for their preparation

Info

Publication number
ZA898858B
ZA898858B ZA898858A ZA898858A ZA898858B ZA 898858 B ZA898858 B ZA 898858B ZA 898858 A ZA898858 A ZA 898858A ZA 898858 A ZA898858 A ZA 898858A ZA 898858 B ZA898858 B ZA 898858B
Authority
ZA
South Africa
Prior art keywords
quinuclidines
medicaments
processes
preparation
new
Prior art date
Application number
ZA898858A
Other languages
English (en)
Inventor
Gerhard Walther
Walther Gerhard
Karl-Heinz Weber
Weber Karl-Heinz
Werner Stransky
Stransky Werner
Franz Josef Kuhn
Josef Kuhn Franz
Enzio Mueller
Mueller Enzio
Helmut Ensinger
Ensinger Helmut
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ZA898858B publication Critical patent/ZA898858B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA898858A 1988-11-22 1989-11-21 New quinuclidines,their use as medicaments and processes for their preparation ZA898858B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3839385A DE3839385A1 (de) 1988-11-22 1988-11-22 Neue quinuclidine, ihre herstellung als arzneimittel und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ZA898858B true ZA898858B (en) 1991-07-31

Family

ID=6367625

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA898858A ZA898858B (en) 1988-11-22 1989-11-21 New quinuclidines,their use as medicaments and processes for their preparation

Country Status (18)

Country Link
US (2) US5451587A (fi)
EP (1) EP0370415B1 (fi)
JP (1) JPH0686449B2 (fi)
KR (1) KR0165667B1 (fi)
AU (1) AU628884B2 (fi)
BG (1) BG61859B2 (fi)
CA (1) CA2003422C (fi)
DE (3) DE3839385A1 (fi)
DK (1) DK170167B1 (fi)
ES (1) ES2054988T3 (fi)
FI (1) FI91637C (fi)
HU (1) HU202527B (fi)
IE (1) IE62328B1 (fi)
IL (1) IL92377A (fi)
NO (1) NO172801C (fi)
NZ (1) NZ231445A (fi)
PT (1) PT92368B (fi)
ZA (1) ZA898858B (fi)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1307790C (en) * 1987-08-04 1992-09-22 Ian Anthony Cliffe Ethers
YU84791A (sh) * 1990-05-19 1994-06-10 Boehringer Ingelheim Kg. Biciklicni 1-aza-cikloalkalni
EP0492904A1 (en) * 1990-12-21 1992-07-01 MERCK SHARP & DOHME LTD. Substituted benzene derivatives for use in the treatment of glaucoma
EP0492903A1 (en) * 1990-12-21 1992-07-01 MERCK SHARP & DOHME LTD. Substituted pyrazines, pyrimidines and pyridazines for use in the treatment of glaucoma
EP0492902A1 (en) * 1990-12-21 1992-07-01 MERCK SHARP & DOHME LTD. Substituted pyridine derivatives for use in the treatment of glaucoma
ZA92278B (en) * 1991-02-01 1992-10-28 Akzo Nv 3-quinuclidine derivatives
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
GB9127279D0 (en) * 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
CA2093778A1 (en) * 1992-04-10 1993-10-11 George R. Brown Heterocyclic compounds
GB9211796D0 (en) * 1992-06-04 1992-07-15 Ici Plc Heterocyclic derivatives
GB9216721D0 (en) * 1992-08-06 1992-09-23 Ici Plc Therapeutic heterocyclic derivatives
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
DE4236331A1 (de) * 1992-10-28 1994-05-05 Boehringer Ingelheim Kg Synergistische Kombination
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
US5998404A (en) * 1994-10-24 1999-12-07 Eli Lilly And Company Heterocyclic compounds and their use
US5512574A (en) * 1994-12-21 1996-04-30 American Home Products Corporation Quinuclidine and azabicyclo 2.2.1! heptane pyrazinyl ethers as muscarinic agonists
DE59605542D1 (de) 1996-01-19 2000-08-10 Lonza Ag Verfahren zur Herstellung von optisch aktivem 3-Chinuclidinol
SE9600683D0 (sv) * 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
CZ54498A3 (cs) * 1997-03-07 1998-11-11 Lonza Ag Katalyzátorová směs na bázi amorfního částečně dehydratovaného hydroxidu zirkoničitého a způsob její výroby a použití
AU6896098A (en) * 1997-04-11 1998-11-11 Eli Lilly And Company Method for treating schizophrenia
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
DE10106971A1 (de) * 2001-02-15 2002-08-29 Boehringer Ingelheim Pharma Arzneimittelformulierung die einen muskarinischen Agonisten enthält
KR100448002B1 (ko) * 2002-02-01 2004-09-13 한국과학기술연구원 신규한 퀴누클리딘 화합물 및 그 제조방법
KR20030083289A (ko) * 2002-04-20 2003-10-30 한승호 다공질 화분
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
PE20060437A1 (es) 2004-06-18 2006-06-08 Novartis Ag COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
US7678363B2 (en) * 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2020117637A1 (en) * 2018-12-05 2020-06-11 Presbyopia Therapies Llc Prodrugs of quinuclidine ring-containing muscarinic agonists and compositions and methods thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2014831A1 (en) * 1968-08-01 1970-04-24 Sogeras Quinuclidinyl and quinuclidinylalkyl ethers with cholino - lytic, antihistaminic and neurosedative activity
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use

Also Published As

Publication number Publication date
BG61859B2 (bg) 1998-07-31
KR900007837A (ko) 1990-06-02
DE58904567D1 (de) 1993-07-08
DK170167B1 (da) 1995-06-06
FI91637C (fi) 1994-07-25
AU4540389A (en) 1990-05-31
FI895531A0 (fi) 1989-11-21
EP0370415A1 (de) 1990-05-30
NO172801C (no) 1993-09-08
EP0370415B1 (de) 1993-06-02
IE62328B1 (en) 1995-01-25
NO172801B (no) 1993-06-01
JPH02243688A (ja) 1990-09-27
CA2003422A1 (en) 1990-05-22
DE8817121U1 (de) 1993-02-04
JPH0686449B2 (ja) 1994-11-02
AU628884B2 (en) 1992-09-24
PT92368B (pt) 1995-07-18
NZ231445A (en) 1991-08-27
IL92377A (en) 1995-01-24
PT92368A (pt) 1990-05-31
DK584089A (da) 1990-05-23
FI91637B (fi) 1994-04-15
HU202527B (en) 1991-03-28
DE3839385A1 (de) 1990-05-23
ES2054988T3 (es) 1994-08-16
HU896032D0 (en) 1990-02-28
KR0165667B1 (ko) 1999-01-15
CA2003422C (en) 1999-12-21
US5451587A (en) 1995-09-19
NO894630L (no) 1990-05-23
US5508405A (en) 1996-04-16
HUT53102A (en) 1990-09-28
IE893712L (en) 1990-05-22
NO894630D0 (no) 1989-11-21
IL92377A0 (en) 1990-07-26
DK584089D0 (da) 1989-11-21

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