ZA80962B - Antihypercholesteraemic agent,monacolin k,and its preparation - Google Patents

Antihypercholesteraemic agent,monacolin k,and its preparation

Info

Publication number
ZA80962B
ZA80962B ZA00800962A ZA80962A ZA80962B ZA 80962 B ZA80962 B ZA 80962B ZA 00800962 A ZA00800962 A ZA 00800962A ZA 80962 A ZA80962 A ZA 80962A ZA 80962 B ZA80962 B ZA 80962B
Authority
ZA
South Africa
Prior art keywords
antihypercholesteraemic
monacolin
agent
preparation
antihypercholesteraemic agent
Prior art date
Application number
ZA00800962A
Other languages
English (en)
Inventor
Akira Endo
Endo Akira
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of ZA80962B publication Critical patent/ZA80962B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ZA00800962A 1979-02-20 1980-02-20 Antihypercholesteraemic agent,monacolin k,and its preparation ZA80962B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54017856A JPS5925599B2 (ja) 1979-02-20 1979-02-20 新生理活性物質モナコリンｋおよびその製造法

Publications (1)

Publication Number Publication Date
ZA80962B true ZA80962B (en) 1981-03-25

Family

ID=11955290

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00800962A ZA80962B (en) 1979-02-20 1980-02-20 Antihypercholesteraemic agent,monacolin k,and its preparation

Country Status (27)

Country Link
JP (1) JPS5925599B2 (nl)
KR (1) KR830002801B1 (nl)
AT (1) AT373915B (nl)
AU (1) AU532626B2 (nl)
BE (1) BE881825A (nl)
CA (1) CA1129794A (nl)
CH (1) CH645890A5 (nl)
DD (1) DD154494A5 (nl)
DE (2) DE3006216C2 (nl)
DK (2) DK149095C (nl)
ES (1) ES8103171A1 (nl)
FI (1) FI66427C (nl)
FR (1) FR2449685B1 (nl)
GB (1) GB2046737B (nl)
HU (1) HU182069B (nl)
IE (1) IE49743B1 (nl)
IT (1) IT1175260B (nl)
MX (1) MX6314E (nl)
NL (1) NL191540C (nl)
NO (1) NO153974C (nl)
NZ (1) NZ192919A (nl)
PH (1) PH15145A (nl)
PL (1) PL124304B1 (nl)
SE (1) SE453301B (nl)
SG (1) SG6784G (nl)
SU (2) SU1158048A3 (nl)
ZA (1) ZA80962B (nl)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
JPS5621594A (en) * 1979-07-27 1981-02-28 Sankyo Co Ltd Mb-530b carboxylic acid metal salt and its preparation
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
JPS56142236A (en) 1980-04-08 1981-11-06 Sankyo Co Ltd Ml-236a and mb-530a derivative
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
JPS5835144A (ja) * 1981-08-27 1983-03-01 Sankyo Co Ltd Ｍｂ−５３０ｂ誘導体およびその製造法
US4782084A (en) * 1987-06-29 1988-11-01 Merck & Co., Inc. HMG-COA reductase inhibitors
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
CA2062023A1 (en) * 1992-02-10 1993-08-11 Jagroop S. Dahiya Novel fungal strains and use thereof in antibiotic production
WO1993017991A1 (en) * 1992-03-04 1993-09-16 Fujisawa Pharmaceutical Co., Ltd. TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS
ZA933359B (en) 1992-05-15 1993-12-08 Sankyo Co Octahydronaphthalene oxime derivatives for cholesterol biosynthesis inhibition, their preparation and use
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
US6812007B1 (en) * 1992-11-04 2004-11-02 Keri Vilmos Process for the isolation and purification of mevinolin
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) * 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
US6046022A (en) 1996-09-30 2000-04-04 Peking University Methods and compositions employing red rice fermentation products
JP2001527424A (ja) 1998-03-20 2001-12-25 ビオガル・ジョージィセルジャール・エル・テー ロバスタチンヒドロキシ酸を製造するための代謝コントロール発酵操作
CZ20022779A3 (cs) 2000-02-24 2003-02-12 Biogal Gyogyszergyar Rt. Způsob purifikace fermentačního bujónu
AU4183301A (en) 2000-03-03 2001-09-17 Biogal Gyogyszergyar A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities
KR20010095780A (ko) * 2000-04-12 2001-11-07 나가오카 마사시 배아 홍국
IN192861B (nl) 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
AU2002235885A1 (en) 2001-02-09 2002-08-28 Unilever N.V. Process for the preparation of one or more statins by fermentation
KR100379075B1 (en) 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
KR20020093147A (ko) * 2002-05-30 2002-12-13 지니스생명공학 주식회사 성인병 예방 및 치료 보조제
KR100710500B1 (ko) 2005-05-18 2007-04-24 고려대학교 산학협력단 홍국균을 이용한 모나콜린 ｋ 생산방법
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
SI2373609T1 (sl) 2008-12-19 2013-12-31 Krka, D.D., Novo Mesto Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov
RO128803A0 (ro) 2012-10-12 2013-09-30 Ion Gigel Fulga Compoziţie pentru tratamentul sau prevenirea dislipidemiilor
CN110331151A (zh) * 2019-04-11 2019-10-15 北京工商大学 紫色红曲菌mokH基因过表达菌株的构建方法
CN111297938A (zh) * 2020-03-11 2020-06-19 北京康立生医药技术开发有限公司 一种辅助降血脂组合物中洛伐他汀的检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (nl) * 1974-06-07 1981-03-18
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
AU535944B2 (en) * 1979-06-15 1984-04-12 Merck & Co., Inc. Hypocholestermic fermentation products from aspergillus

Also Published As

Publication number Publication date
NZ192919A (en) 1984-07-06
DK73080A (da) 1980-08-21
FI66427B (fi) 1984-06-29
CH645890A5 (de) 1984-10-31
PH15145A (en) 1982-08-24
CA1129794A (en) 1982-08-17
AT373915B (de) 1984-03-12
JPS5925599B2 (ja) 1984-06-19
DK21889D0 (da) 1989-01-18
SG6784G (en) 1985-02-08
NO800451L (no) 1980-08-21
IE800321L (en) 1980-08-20
SU969702A1 (ru) 1982-10-30
DD154494A5 (de) 1982-03-24
BE881825A (fr) 1980-08-20
SE453301B (sv) 1988-01-25
HU182069B (en) 1983-12-28
AU5567380A (en) 1980-08-28
ATA92980A (de) 1983-07-15
IE49743B1 (en) 1985-12-11
DE3006216A1 (de) 1980-09-04
KR830002030A (ko) 1983-05-21
FR2449685B1 (fr) 1985-06-28
AU532626B2 (en) 1983-10-06
GB2046737A (en) 1980-11-19
SE8001339L (sv) 1980-08-21
NO153974B (no) 1986-03-17
PL124304B1 (en) 1983-01-31
NL8001041A (nl) 1980-08-22
JPS55111790A (en) 1980-08-28
NL191540B (nl) 1995-05-01
ES488796A0 (es) 1981-02-16
DE3006216C2 (de) 1985-10-31
NO153974C (no) 1986-06-25
GB2046737B (en) 1983-01-12
ES8103171A1 (es) 1981-02-16
IT1175260B (it) 1987-07-01
MX6314E (es) 1985-04-01
DK149095C (da) 1986-06-16
DK21889A (da) 1989-01-18
IT8067262A0 (it) 1980-02-20
PL222120A1 (nl) 1980-10-20
DK149095B (da) 1986-01-20
NL191540C (nl) 1995-09-04
FI800506A (fi) 1980-08-21
KR830002801B1 (ko) 1983-12-16
DE3051175C2 (nl) 1989-12-21
SU1158048A3 (ru) 1985-05-23
FI66427C (fi) 1984-10-10
FR2449685A1 (fr) 1980-09-19

Similar Documents

Publication Publication Date Title
ZA80962B (en) Antihypercholesteraemic agent,monacolin k,and its preparation
IL56774A0 (en) Arylsulfamates,their preparation and their use as hermicid
IL60065A0 (en) Dietetic agent and its preparation
ZA806626B (en) Absorbent products,processes and compositions
DE3061392D1 (en) Demolition agent, its preparation and its use
IL60138A (en) 7-(-2-aminothiazolyl-2-methoxy-imino acetamido)-3-thiovinyl-cephalosporins,their preparation and compositions containing them
DE3061010D1 (en) Substituted acetophenones, preparations containing them and processes for their preparation
JPS55133376A (en) 55substituted pyranone compound and its use as medicine
JPS565207A (en) Tireeliner and its preparation
IL56882A0 (en) Acylated1-azolyl-2-hydroxy-butane derivatives,their preparation and their use asfungicides
GB2061306B (en) 1,3-glucanpolyol its preparation and composition comprising it
NZ193324A (en) Preparation of n2-phenyl-2,6-diaminonebularines
IL58525A (en) 24,24-difluoro-25-hydroxychole-calciferol and its preparation
AU528732B2 (en) Preparation of 4-hydroxy-5-alkyl and 2, 5-dialkyl-3-oxo-2h-furans
DE3067996D1 (en) Microbial polysaccharide, its preparation and use
DE2960021D1 (en) Acyloxy-2-butenes, their preparation and their use for the preparation of 4-acetoxytiglinaldehyde
DE2961268D1 (en) Bicyclo-compounds, processes for their preparation and their application
JPS55133375A (en) 66substituted pyranone compound and its use as medicine
IL54275A0 (en) Substituted bis-benzimidazolyl compounds, preparation and use thereof
DE2967095D1 (en) Phenyliminomethyl-3-pyridine derivatives, their preparation and use
DE2966446D1 (en) Beta-lactam compounds, their preparation and use
DE3064789D1 (en) New 25-hydroxy-24-oxocholestane derivatives and preparation thereof
DE3071198D1 (en) Acridinones, their preparation and use; intermediates and their preparation
GB2123421B (en) 2,6,6-trimethyl-cyclohex-3-en-1-one and preparation of b-damascenone therefrom
GB2030977B (en) 2,1-benzisothiazoles and preparation thereof