ZA200705071B - Heterocyclic aspartyl protease inhibitors - Google Patents

Heterocyclic aspartyl protease inhibitors

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Publication number
ZA200705071B
ZA200705071B ZA200705071A ZA200705071A ZA200705071B ZA 200705071 B ZA200705071 B ZA 200705071B ZA 200705071 A ZA200705071 A ZA 200705071A ZA 200705071 A ZA200705071 A ZA 200705071A ZA 200705071 B ZA200705071 B ZA 200705071B
Authority
ZA
South Africa
Prior art keywords
protease inhibitors
aspartyl protease
heterocyclic aspartyl
heterocyclic
inhibitors
Prior art date
Application number
ZA200705071A
Other languages
English (en)
Inventor
Zhu Zhaoning
Sun Zhong-Yue
Johannes H Voigt
Elizabeth M Smith
William J Greenlee
Caldwell John
Wang Lingyan
Iserloh Ulrich
Thuy X H Le
Suresh D Babu
Michelle L Morris
Qian Gang
Mckittrick Brian
Yuanzan C Ye
Strickland Corey
Stamford Andrew
Mazzola Robert
Cumming Jared
Wu Yusheng
Guo Tao
Kurt W Saionz
Rachael C Hunter
Gu Huizhong
Tadesse Dawit
Original Assignee
Schering Corp
Pharmacopeia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, Pharmacopeia Inc filed Critical Schering Corp
Publication of ZA200705071B publication Critical patent/ZA200705071B/xx

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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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