ZA200610775B - Substituted 2-alkyl quinazolinone derivatives as PARP inhibitors - Google Patents

Substituted 2-alkyl quinazolinone derivatives as PARP inhibitors Download PDF

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Publication number
ZA200610775B
ZA200610775B ZA200610775A ZA200610775A ZA200610775B ZA 200610775 B ZA200610775 B ZA 200610775B ZA 200610775 A ZA200610775 A ZA 200610775A ZA 200610775 A ZA200610775 A ZA 200610775A ZA 200610775 B ZA200610775 B ZA 200610775B
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South Africa
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formula
compound
hydrogen
parp
compounds
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ZA200610775A
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English (en)
Inventor
Der Aa Marcel Jozef Maria Van
Heertum Henricus Maria Theresia Albert Van
Dun Jacobus Alphonse Josephus Van
Maria Victorina Francisca Somers
Wal Boudewijn Lepold Wouters
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Janssen Pharmaceutica Nv
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Publication of ZA200610775B publication Critical patent/ZA200610775B/en

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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
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ZA200610775A 2004-06-30 2006-12-20 Substituted 2-alkyl quinazolinone derivatives as PARP inhibitors ZA200610775B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04076887 2004-06-30

Publications (1)

Publication Number Publication Date
ZA200610775B true ZA200610775B (en) 2008-03-26

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ID=34928320

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ZA200610772A ZA200610772B (en) 2004-06-30 2006-12-20 Quinazolinone derivatives as PARP inhibitors
ZA200610775A ZA200610775B (en) 2004-06-30 2006-12-20 Substituted 2-alkyl quinazolinone derivatives as PARP inhibitors

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ZA200610772A ZA200610772B (en) 2004-06-30 2006-12-20 Quinazolinone derivatives as PARP inhibitors

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US (5) US7875621B2 (pt)
EP (2) EP1771422B1 (pt)
JP (2) JP4836946B2 (pt)
KR (2) KR101184036B1 (pt)
CN (2) CN1976906B (pt)
AR (2) AR049656A1 (pt)
AT (2) ATE540936T1 (pt)
AU (2) AU2005259188B2 (pt)
BR (2) BRPI0512790A (pt)
CA (2) CA2568835C (pt)
DE (1) DE602005026391D1 (pt)
EA (2) EA012416B1 (pt)
ES (2) ES2380702T3 (pt)
HK (2) HK1105631A1 (pt)
IL (2) IL180382A (pt)
MX (2) MXPA06014543A (pt)
MY (2) MY148322A (pt)
NO (2) NO339883B1 (pt)
NZ (2) NZ551840A (pt)
SG (2) SG154434A1 (pt)
TW (2) TWI361689B (pt)
UA (2) UA85593C2 (pt)
WO (2) WO2006003150A1 (pt)
ZA (2) ZA200610772B (pt)

Families Citing this family (58)

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WO2005054201A1 (en) 2003-11-20 2005-06-16 Janssen Pharmaceutica N.V. 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
CA2546002C (en) 2003-11-20 2012-09-18 Janssen Pharmaceutica N.V. 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
US8080557B2 (en) 2004-06-30 2011-12-20 Janssen Pharmaceutica, Nv Quinazolinedione derivatives as PARP inhibitors
CN1980674B (zh) 2004-06-30 2011-05-25 詹森药业有限公司 作为parp抑制剂的2,3-二氮杂萘衍生物
NZ551840A (en) 2004-06-30 2009-07-31 Janssen Pharmaceutica Nv Substituted 2-alkyl quinzolinone derivatives as PARP inhibitors
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
WO2007011962A2 (en) 2005-07-18 2007-01-25 Bipar Sciences, Inc. Treatment of cancer
AU2007292306A1 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof
US8143447B2 (en) 2006-09-05 2012-03-27 Bipar Sciences, Inc. Treatment of cancer
KR101591656B1 (ko) * 2007-01-10 2016-02-19 엠에스디 이탈리아 에스.알.엘. 폴리(ａｄｐ-리보오스) 폴리머라아제(ｐａｒｐ) 억제제로서의 아미드 치환된 인다졸
JP5545955B2 (ja) * 2007-03-08 2014-07-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐおよびｔａｎｋ阻害剤としてのキノリノン誘導体
ES2448870T3 (es) 2007-10-26 2014-03-17 Janssen Pharmaceutica, N.V. Derivados de quinolina como inhibidores de PARP
EP2217227B1 (en) 2007-11-12 2013-08-21 BiPar Sciences, Inc. Treatment of breast cancer with 4-iodo-3-nitrobenzamide in combination with anti-tumor agents
DK2271626T3 (en) 2008-03-27 2015-02-23 Janssen Pharmaceutica Nv TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS INHIBITORS OF POLYMERIZATION OF PARP AND TUBULIN
WO2009118384A1 (en) 2008-03-27 2009-10-01 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors
WO2010081778A1 (en) 2009-01-17 2010-07-22 Universität Zürich Blockers of parp for the prevention and treatment of helicobacter pylori induced gastric cancer
WO2011058367A2 (en) 2009-11-13 2011-05-19 Astrazeneca Ab Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor
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