ZA200604620B - IP-10 antibodies and their uses - Google Patents

IP-10 antibodies and their uses Download PDF

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Publication number
ZA200604620B
ZA200604620B ZA200604620A ZA200604620A ZA200604620B ZA 200604620 B ZA200604620 B ZA 200604620B ZA 200604620 A ZA200604620 A ZA 200604620A ZA 200604620 A ZA200604620 A ZA 200604620A ZA 200604620 B ZA200604620 B ZA 200604620B
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ZA
South Africa
Prior art keywords
seq
variable region
antibody
chain variable
human
Prior art date
Application number
ZA200604620A
Other languages
English (en)
Inventor
Deshpande Shrikant
Huang Haichun
Srinivasan Mohan
Josephine M Cardarelli
Wang Changyu
Passmore David
Vangipuram S Rangan
Thomas E Lane
Hans S Keirstead
Michael T Liu
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Medarex Inc
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Publication of ZA200604620B publication Critical patent/ZA200604620B/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/521Chemokines
    • C07K14/522Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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ZA200604620A 2003-12-10 2004-12-10 IP-10 antibodies and their uses ZA200604620B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52918003P 2003-12-10 2003-12-10

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US (4) US20050191293A1 (enExample)
EP (3) EP2383295B1 (enExample)
JP (2) JP4942487B2 (enExample)
KR (4) KR101333449B1 (enExample)
CN (2) CN102838675B (enExample)
AU (1) AU2004298492B2 (enExample)
BR (1) BRPI0417429A (enExample)
CA (1) CA2548338C (enExample)
CY (2) CY1113096T1 (enExample)
DK (2) DK2383295T3 (enExample)
ES (2) ES2537163T3 (enExample)
HK (1) HK1209759A1 (enExample)
HR (2) HRP20120702T1 (enExample)
HU (1) HUE025328T2 (enExample)
IL (1) IL175855A (enExample)
MX (1) MXPA06005941A (enExample)
NO (1) NO342278B1 (enExample)
NZ (1) NZ547499A (enExample)
PL (2) PL2383295T3 (enExample)
PT (2) PT2383295E (enExample)
RS (1) RS53984B1 (enExample)
RU (1) RU2486199C2 (enExample)
SI (2) SI2383295T1 (enExample)
WO (1) WO2005058815A2 (enExample)
ZA (1) ZA200604620B (enExample)

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