ZA200501846B - PyrazoloÄ1,5-aÜpyrimidines compounds as cyclin dependent kinase inhibitors. - Google Patents
PyrazoloÄ1,5-aÜpyrimidines compounds as cyclin dependent kinase inhibitors. Download PDFInfo
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- ZA200501846B ZA200501846B ZA200501846A ZA200501846A ZA200501846B ZA 200501846 B ZA200501846 B ZA 200501846B ZA 200501846 A ZA200501846 A ZA 200501846A ZA 200501846 A ZA200501846 A ZA 200501846A ZA 200501846 B ZA200501846 B ZA 200501846B
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- South Africa
- Prior art keywords
- compound
- aryl
- group
- alkyl
- cycloalkyl
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- 150000001875 compounds Chemical class 0.000 title claims description 73
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 title description 6
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 title description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 51
- 125000003118 aryl group Chemical group 0.000 claims description 48
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 39
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- 229910052736 halogen Inorganic materials 0.000 claims description 24
- 150000002367 halogens Chemical class 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 24
- 125000001072 heteroaryl group Chemical group 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 20
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- 125000003710 aryl alkyl group Chemical group 0.000 claims description 18
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 17
- 238000011282 treatment Methods 0.000 claims description 17
- -1 -C(O2)R® Chemical group 0.000 claims description 16
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 15
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- MWEQTWJABOLLOS-UHFFFAOYSA-L disodium;[[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-oxidophosphoryl] hydrogen phosphate;trihydrate Chemical compound O.O.O.[Na+].[Na+].C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)C(O)C1O MWEQTWJABOLLOS-UHFFFAOYSA-L 0.000 description 1
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- GTVPOLSIJWJJNY-UHFFFAOYSA-N olomoucine Chemical compound N1=C(NCCO)N=C2N(C)C=NC2=C1NCC1=CC=CC=C1 GTVPOLSIJWJJNY-UHFFFAOYSA-N 0.000 description 1
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- Health & Medical Sciences (AREA)
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Applications Claiming Priority (1)
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US40802902P | 2002-09-04 | 2002-09-04 |
Publications (1)
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ZA200501846A ZA200501846B (en) | 2002-09-04 | 2005-03-03 | PyrazoloÄ1,5-aÜpyrimidines compounds as cyclin dependent kinase inhibitors. |
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US (2) | US7067661B2 (ko) |
EP (1) | EP1534712B1 (ko) |
JP (2) | JP4790265B2 (ko) |
KR (1) | KR20050033659A (ko) |
CN (1) | CN1701073B (ko) |
AR (1) | AR041133A1 (ko) |
AT (1) | ATE362474T1 (ko) |
AU (1) | AU2003298571B2 (ko) |
CA (1) | CA2497544C (ko) |
DE (1) | DE60313872T2 (ko) |
ES (1) | ES2283868T3 (ko) |
HK (1) | HK1071572A1 (ko) |
MX (1) | MXPA05002572A (ko) |
MY (2) | MY145332A (ko) |
NZ (1) | NZ539161A (ko) |
PE (1) | PE20041000A1 (ko) |
TW (1) | TWI329645B (ko) |
WO (1) | WO2004026229A2 (ko) |
ZA (1) | ZA200501846B (ko) |
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- 2003-09-03 US US10/653,776 patent/US7067661B2/en not_active Expired - Lifetime
- 2003-09-03 JP JP2004537708A patent/JP4790265B2/ja not_active Expired - Fee Related
- 2003-09-03 AR ARP030103188A patent/AR041133A1/es unknown
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- 2003-09-03 WO PCT/US2003/027491 patent/WO2004026229A2/en active IP Right Grant
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- 2003-09-03 CN CN038247011A patent/CN1701073B/zh not_active Expired - Fee Related
- 2003-09-03 KR KR1020057003527A patent/KR20050033659A/ko not_active Application Discontinuation
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WO2004026229A2 (en) | 2004-04-01 |
MXPA05002572A (es) | 2005-09-08 |
US7067661B2 (en) | 2006-06-27 |
KR20050033659A (ko) | 2005-04-12 |
TWI329645B (en) | 2010-09-01 |
MY137843A (en) | 2009-03-31 |
EP1534712A2 (en) | 2005-06-01 |
JP2006502184A (ja) | 2006-01-19 |
CA2497544A1 (en) | 2004-04-01 |
DE60313872D1 (de) | 2007-06-28 |
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CA2497544C (en) | 2010-11-02 |
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AR041133A1 (es) | 2005-05-04 |
DE60313872T2 (de) | 2008-01-17 |
US7514442B2 (en) | 2009-04-07 |
HK1071572A1 (en) | 2005-07-22 |
US20040106624A1 (en) | 2004-06-03 |
TW200413376A (en) | 2004-08-01 |
CN1701073B (zh) | 2011-06-22 |
JP2010180235A (ja) | 2010-08-19 |
ES2283868T3 (es) | 2007-11-01 |
ATE362474T1 (de) | 2007-06-15 |
PE20041000A1 (es) | 2004-12-29 |
CN1701073A (zh) | 2005-11-23 |
AU2003298571A1 (en) | 2004-04-08 |
NZ539161A (en) | 2006-05-26 |
JP4790265B2 (ja) | 2011-10-12 |
MY145332A (en) | 2012-01-31 |
EP1534712B1 (en) | 2007-05-16 |
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